Abstracts tagged "cytokines"

Abstract Number: 2418 • 2019 ACR/ARP Annual Meeting
Tofacitinib Inhibits Increased Inflammatory Marker Expression in a Human Salivary Cell Line Deficient in Autophagy: A Model of Sjögren’s Syndrome
María José Barrera ¹, Sergio Aguilera², Patricia Carvajal ³, Isabel Castro ⁴, Sergio González ⁵, Claudio Molina ¹, Soledad Matus ⁶, Daniela Jara ³ and María Julieta González ³, ¹Facultad de Odontología, Universidad San Sebastián, Santiago, Chile, ²Clínica INDISA, Santiago, Chile, ³ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile, ⁴Departamento Tecnología Médica, Universidad de Chile, Santiago, Chile, ⁵Escuela de Odontología, Universidad Mayor, Santiago, Chile, ⁶Fundación Ciencia & Vida, Santiago, Chile, Santiago, Chile
Background/Purpose: Sjögren’s syndrome (SS) is an immune-mediated exocrinopathy, where defects in autophagy could contribute to the pathogenesis. Minor labial salivary glands (MLSG) of primary SS…
Abstract Number: 2527 • 2019 ACR/ARP Annual Meeting
Cytokine and Autoantibody Profiles During Treatment with Belimumab in Patients with Systemic Lupus Erythematosus
Ioannis Parodis¹, Emil Åkerström ¹, Christopher Sjöwall ², Azita Sohrabian ³, Andreas Jönsen ⁴, Alvaro Gomez ¹, Martina Frodlund ², Agneta Zickert ¹, Anders Bengtsson ⁴, Johan Rönnelid ³ and Iva Gunnarsson ¹, ¹Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical and Experimental Medicine, Rheumatology/Division of Neuro and Inflammation Sciences, Linköping University, Linköping, Sweden, ³Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁴Lund University, Lund, Sweden
Background/Purpose: The anti-BAFF monoclonal belimumab is approved for the treatment of systemic lupus erythematosus (SLE) since 2011. Effects of belimumab on anti-double stranded (ds)DNA levels,…
Abstract Number: 18 • 2019 ACR/ARP Annual Meeting
Undifferentiated Connective Tissue Disease at Risk for SSc: Potential Role of Circulating CXCL-10, CXCL-11 and IL-33 in Predicting Disease Evolution
Antonella Riccardi¹, Alessia Borgia ², Serena Fasano ¹, Valentina Messiniti ³, Rosaria Irace ³ and Gabriele Valentini ⁴, ¹Rheumatology Unit, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy, Naples, Italy, ²University of Campania L. Vanvitelli, Naples, Italy, ³Rheumatology Unit, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy, Naples, ⁴Dipartimento di Medicina di Precisione, II Policlinico U.O. Reumatologia, Napoli, Italy, Napoli, Italy
Background/Purpose: Higher levels of CXCL10 and CXCL11 in patients with a very early diagnosis of systemic sclerosis (SSc) subsequently shifted to SSc were pointed out…
Abstract Number: 45 • 2019 ACR/ARP Annual Meeting
bDMARD-experienced Filgotinib-treated Patient Samples Exhibit a Partial Reversion to the Peripheral Molecular Profile of a Demographically Matched Healthy Population
Peter Taylor¹, Emon Elboudwarej ², Bryan Downie ³, Lene Vestergaard ², Jinfeng Liu ², Amer M. Mirza ² and Rachael Hawtin ², ¹University of Oxford, Oxford, United Kingdom, ²Gilead Sciences, Inc., Foster City, CA, ³Gilead Sciences, Inc., Foster Citty, CA
Background/Purpose: Filgotinib (FIL), an oral, selective, Janus Kinase 1 (JAK1) inhibitor was effective in Phase 3 studies of active RA in patients (pts) with inadequate…
Abstract Number: 781 • 2019 ACR/ARP Annual Meeting
Is down Syndrome Associated Arthritis (DA) a Distinct Disease from Juvenile Idiopathic Arthritis (JIA)?
Charlene Foley¹, Achilleas Floudas ², Sharon Ansboro ², Mary Canavan ², Monika Biniecka ², Emma Jane MacDermott ³, Ronan Mullan ⁴, Gerry Wilson ⁵, Ursula Fearon ⁶ and Orla Killeen ⁷, ¹Great Ormond Street Hospital, London, Ireland, ²TBSI, Dublin, Ireland, ³OLCHC, Dublin, Ireland, ⁴Tallaght Hospital, Dublin, Ireland, ⁵UCD, Dublin, Ireland, ⁶TBSI, Dublin, ⁷National Centre for Paediatric Rheumatology (NCPR), Our Lady’s Children’s Hospital Crumlin (OLCHC), Dublin, Ireland
Background/Purpose: Down syndrome associated Arthritis (DA) is 20 times more common than JIA. It is an erosive, polyarticular RF negative arthritis with predominance in the…
Abstract Number: 2047 • 2018 ACR/ARHP Annual Meeting
Synovial Fluid Cytokines /Chemokines and Proteins from the Knees of Symptomatic RA and OA Patients Which Correlate with the Magnitude of the Inflammatory Response As Measured By Synovial Fluid WBC Levels
Richard Meehan¹, Eric Hoffman², Mary Wolf³, Elizabeth Regan⁴, Prashant Parmar⁵, Karin Pacheco⁶, Jim Crooks⁷ and Vijaya Knight⁸, ¹MEDICINE, National Jewish Health, Denver, CO, ²Medicine/Rheumatology, National Jewish Health, Denver, CO, ³Pathology Department, National Jewish Health, Denver, CO, ⁴Medicine, National Jewish Health, Denver, CO, ⁵Internal Medicine, St Joseph Hospital, Denver, CO, ⁶MEDICINE/ Occupational Medince, National Jewish Health, Denver, CO, ⁷Biostatistics, National Jewish Health, Denver, CO, ⁸Pathology, ADX laboratory, National Jewish Health, Denver, CO
Background/Purpose: Synovial fluid (SF) provides nutritional support for cartilage and contains numerous catabolic and anabolic cytokines, chemokines and proteins. The precise role of these proteins…
Abstract Number: 844 • 2018 ACR/ARHP Annual Meeting
Differential Roles of Tnfα-TNFR1 and Tnfα-TNFR2 in the Differentiation and Function of Induced CD4+Foxp3+ Treg Cells in Autoimmune Diseases
SONGGUO ZHENG¹, Su-juan Yang², Julie Wang¹ and Rayford June¹, ¹Medicine, Milton S. Hershey Medical School at Penn State University, HERSHEY, PA, ²Medicine, The Third Affiliated Hospital at Sun Yat-sen University, Guangzhou, China
Background/Purpose: Tumor Necrosis Factor (TNF) α exerts it pro-inflammatory or anti-inflammatory function. This study hypothesizes that TNFα has multi-function through binding the different receptor 1…
Abstract Number: 2059 • 2018 ACR/ARHP Annual Meeting
Inhibition of the Transcription Factor That Drives IL-17 Expression Suppresses Inflammation, Joint Damage, and New Bone Formation in Experimental Spondyloarthritis in HLA-B27 Transgenic Rats
Joel Taurog¹, Jiankun Zhu¹, Michael Kort², Shaughn Bryant³, Lucy Phillips³ and Wendy Waegell³, ¹Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX, ²AbbVie, Inc., North Chicago, IL, ³AbbVie, Inc., Worcester, MA
Background/Purpose: The IL-17 axis has been identified as a central pathway in SpA pathogenesis. Targeting this axis in AS and PsA significantly suppresses inflammation and…
Abstract Number: 983 • 2018 ACR/ARHP Annual Meeting
A MAPK Activated Kinase 2 Inhibitor Attenuates Inflammatory and Destructive Arthritis in Human Ex Vivo Models
Tue Wenzel Kragstrup^1,2, Anders Mellemkjær³, Morten Aagaard Nielsen⁴, Line Dam Heftdal², Marie Iversen³, Peter Schafer⁵ and Bent Deleuran², ¹Randers Regional Hospital, Randers, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, ³Aarhus University, Aarhus, Denmark, ⁴Of Biomedicine, Aarhus University, Aarhus, Denmark, ⁵Celgene Corporation, Summit, NJ
Background/Purpose: Targeting intracellular pathways with oral small molecules is an attractive therapeutic approach for treating immune mediated inflammatory diseases. The mitogen-activated protein kinase (MAPK) pathway…
Abstract Number: 2066 • 2018 ACR/ARHP Annual Meeting
Serum IL-37 Is an Efficient Biomarker of Disease Activity and Treatment Response in Patients with Ankylosing Spondylitis
Ga Young Ahn¹, Su Man Kang², Juyeon Kang¹, Bora Nam¹, Hyuk-Hee Kwon¹, Tae-Hwan Kim³ and Dae-Hyun Yoo¹, ¹Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ²Institute of Rheumatology, Hanyang University, Seoul, Korea, Republic of (South), ³Rheumatology, The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea, Seoul, Korea, Republic of (South)
Background/Purpose: The measurement of disease activity is mainly dependent on the patient-reported outcome measures in ankylosing spondylitis (AS) patients. Current inflammatory biomarkers have insufficient sensitivity…
Abstract Number: 985 • 2018 ACR/ARHP Annual Meeting
IL-6 and TNF-a Cooperate to Modulate Cell Cycle of RA-FLS Via Cyclin Dependent Kinase 6
Kenta Kaneshiro¹, Kohsuke Yoshida¹, Koto Uchida¹, Alisa Yaekura¹, Ikumi Okumura¹, Koji Tateishi², Yasuhiro Terashima², Nao Shibanuma³, Yoshitada Sakai⁴ and Akira Hashiramoto¹, ¹Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, ²Dept. of Orthopaedic Surgery, Konan Kakogawa Hospital, Kakogawa, Japan, ³Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ⁴Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by a tumor-like synovial overgrowth leading to joint destructions. IL-6 and TNF-a play an important…
Abstract Number: 2109 • 2018 ACR/ARHP Annual Meeting
Activation of T Follicular Helper Cells through Epigenetic Regulation By STAT1 and STAT4 in Lupus Patients
Shingo Nakayamada¹, Xiaoxue Ma¹, Satoshi Kubo¹, Yusuke Miyazaki¹, Kaoru Yamagata¹, Kazuhisa Nakano¹ and Yoshiya Tanaka², ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: During the T cell differentiation, signal transducer and activators of transcription (STAT) family transcription factors play pivotal roles in specifying T cell lineages. T…
Abstract Number: 987 • 2018 ACR/ARHP Annual Meeting
CCL11 Is Involved in Cell Migration in Rheumatoid Arthritis
Kuninobu Wakabayashi, Takeo Isozaki, Shinichiro Nishimi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan
Background/Purpose: Chemokine C-C motif ligand 11 (CCL11) also known as eotaxin-1 is produced by a variety of cell types. By interacting with C-C chemokine receptor…
Abstract Number: 2120 • 2018 ACR/ARHP Annual Meeting
CD47- Signal Regulatory Protein Alpha Interaction Potentiates Proinflammatory Response in Systemic Lupus Erythematosus
Jin Kyun Park¹, Ye Ji Lee², Ji Soo Park³, Eun Young Lee⁴, Eun Bong Lee⁴ and Yeong Wook Song⁵, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), ²Department of Immunology, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ³Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Seoul National University College of Medicine, Seoul, Korea, Republic of (South)
CD47-Signal Regulatory Protein-Alpha Interaction Potentiates Proinflammatory Response in Systemic Lupus Erythematosus.Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease mediated by unbalanced activation of…
Abstract Number: 996 • 2018 ACR/ARHP Annual Meeting
Neutralizing Effect of Anti-Infliximab Antibodies on Infliximab-Stimulated Human Coronary Artery Endothelial Cells
Manca Ogrič¹, Katjuša Mrak Poljšak¹, Katja Lakota^1,2, Polona Žigon¹, Sonja Praprotnik¹, Saša Čučnik^1,3 and Snezna Sodin Semrl^1,2, ¹University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia, ²University of Primorska, Faculty of Mathematics, Natural Science and Information Technology, Koper, Slovenia, ³University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
Background/Purpose: As a consequence of endothelial dysfunction, patients with rheumatoid arthritis (RA) have an increased risk of atherosclerosis and early development of cardiovascular disease. Serum…

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