ACR Meeting Abstracts

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Abstracts tagged "Cutaneous manifestations"

  • Abstract Number: 246 • 2019 ACR/ARP Annual Meeting

    Smoking Exposure in Pack-Years Predicts Cutaneous Manifestations of Lupus

    Nnenna Ezeh1, Trevor McKown 1, Shivani Garg 1 and Christie Bartels 1, 1University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose: Patients of color are more likely to have systemic lupus erythematosus (SLE) and a smoking history. Prior literature notes that both smoking and race…
  • Abstract Number: 465 • 2018 ACR/ARHP Annual Meeting

    Seasonal Variation in Cutaneous Flares for Pediatric Lupus

    Tamara Tanner1, Marija Dionizovik-Dimanovski2, Dawn Wahezi3 and Tamar Rubinstein3, 1Albert Einstein College of Medicine/ Children's Hospital at Montefiore, Albert Einstein College of Medicine/ Children's Hospital at Montefiore, Bronx, NY, 2Pediatric Rheumatology, Children's Hospital at Montefiore, Bronx, NY, 3Pediatric Rheumatology, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY

    Background/Purpose: Exposure to sunlight has been proposed as a possible environmental trigger for lupus flares, particularly cutaneous disease. Contradictory findings exist regarding seasonal variation in…
  • Abstract Number: 2284 • 2018 ACR/ARHP Annual Meeting

    Safety and Efficacy of Lenabasum in Refractory Skin-Predominant Dermatomyositis Subjects Treated on an Open-Label Extension of Trial JBT101-DM-001

    Victoria P. Werth1,2, David Pearson1,2, Joyce Okawa1,2, Rui Feng3, Josef Concha1,2, Basil Patel1,2, Emily Hejazi1,2, Caitlin Cornwall4, Scott Constantine4 and Barbara White4, 1University of Pennsylvania, Philadelphia, PA, 2Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, 3University of Pennsylvania, Philadelphia', PA, 4Corbus Pharmaceuticals, Inc., Norwood, MA

    Background/Purpose: Lenabasum is a synthetic, non-immunosuppressive, selective cannabinoid receptor type 2 agonist that activates resolution of innate immune responses. Lenabasum had acceptable safety and tolerability…
  • Abstract Number: 2287 • 2018 ACR/ARHP Annual Meeting

    Interim Results of an Open-Label Study Assessing Efficacy and Safety of Adrenocorticotropic Hormone Gel for Treatment of Refractory Cutaneous Manifestations of Dermatomyositis

    Anthony Fernandez, Dermatology and Pathology, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Cutaneous dermatomyositis (DM) is often refractory to multiple medications, suggesting better treatments are needed.  Adrenocorticotropic hormone gel is a repository corticotropin injection that is…
  • Abstract Number: 2853 • 2018 ACR/ARHP Annual Meeting

    A Protective Langerhans Cell-Keratinocyte Axis That Is Dysfunctional in Photosensitivity

    William D. Shipman1,2,3, Susan Chyou1, Anusha Ramanathan1, Peter M. Izmirly4, Sneh Sharma5, Tania Pannellini6, Dragos Dasoveanu1, Xiaoping Qing7, Cynthia Magro8, Richard Granstein9, Michelle Lowes10, Eric Pamer11, Daniel Kaplan12, Jane E. Salmon13,14, Babak Mehrara15, James Young10,11,16,17, Robert M. Clancy18, Carl Blobel14,19,20 and Theresa T. Lu2,3,21, 1Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, 2Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, 3Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, 4Rheumatology, NYU School of Medicine, New York, NY, 5Laboratory of Cellular Immunobiology, Memorial Sloan Kettering Cancer Center, New York, NY, 6Hospital for Special Surgery, New York, NY, 7Program in Inflammation and Autoimmunity, Hospital for Special Surgery, New York, NY, 8Pathology, Weill Cornell Medicine, New York, NY, 9Dermatology, Weill Cornell Medicine, New York, NY, 10Rockefeller University, New York, NY, 11Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 12Immunology, University of Pittsburgh, New, NY, 13Medicine/Rheumatology, Hospital for Special Surgery, New York, NY, 14Weill Cornell Medicine, New York, NY, 15Plastic Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 16Immunology, Memorial Sloan Kettering Cancer Center, New York, NY, 17Medicine, Weill Cornell Medicine, New York, NY, 18Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 19Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, 20Institute of Advanced Studies, Technical University of Munich, New York, NY, 21Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY

    Background/Purpose: Photosensitivity, or skin sensitivity to ultraviolet radiation (UVR), is a feature of lupus erythematosus (LE) and other autoimmune conditions. Photosensitive lesions can be disfiguring…
  • Abstract Number: 2977 • 2018 ACR/ARHP Annual Meeting

    Lenabasum, a Cannabinoid Type 2 Receptor Agonist, Reduces T-Cell Population and Downregulates Type 1 and 2 Interferon Activities in Lesional Dermatomyositis Skin

    Nithin Reddy1,2, Majid Zeidi1,2, Barbara White3 and Victoria P. Werth1,2, 1University of Pennsylvania, Philadelphia, PA, 2Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, 3Corbus Pharmaceuticals, Inc., Norwood, MA

    Background/Purpose: Lenabasum is a synthetic, non-immunosuppressive, selective cannabinoid receptor type 2 (CB2) agonist that activates resolution of innate immune responses. CB2 is a G-protein coupled…
  • Abstract Number: 2156 • 2017 ACR/ARHP Annual Meeting

    Comparison of Patients with Dermatomyositis in a Specialty Clinic Versus Clinical Trial with Anabasum (JBT-101), a Cannabinoid Receptor Type 2 Agonist

    Victoria P Werth1, Emily Hejazi2, Sandra M. Pena3, Jessica S. Haber4, Joyce Okawa3, Rui Feng5, Kirubel Gabre2, Josef Concha2, Scott Constantine6 and Barbara White6, 1University of Pennsylvania and the VA Medical Center, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 4Department of Dermatology, University of Pennsylvania, Philadelphia, PA, 5Department of Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania, Philadelphia, PA, 6Corbus Pharmaceuticals, Inc., Norwood, MA

    Background/Purpose: There are limited treatment options and no published double-blind randomized placebo-controlled trials for the treatment of skin manifestations of dermatomyositis (DM).  There is no…
  • Abstract Number: 2157 • 2017 ACR/ARHP Annual Meeting

    Factors Associated with Clinical Remission of Skin Disease in Dermatomyositis

    Paige Wolstencroft1, Lorinda Chung2, Shufeng Li1, Livia Casciola-Rosen3 and David Fiorentino4, 1Dermatology, Stanford University School of Medicine, Stanford, CA, 2Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 3Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 4Department of Dermatology, Stanford University School of Medicine, Palo Alto, CA

    Background/Purpose: Quantitative estimates of the duration and severity of cutaneous disease are lacking for adult dermatomyositis (DM) patients. The Cutaneous Dermatomyositis Disease Area and Severity…
  • Abstract Number: 2749 • 2017 ACR/ARHP Annual Meeting

    Four-Distinct Phenotypes of Patients with Necrotizing Arteritis of Medium and Small Arteries

    Tsuyoshi Shirai1, Hiroshi Fujii1, Yoko Fujita2, Yuko Shirota1, Tomonori Ishii1 and Hideo Harigae1, 1Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, 2Department of Hematolgy and Rheumatolgy, Tohoku University Graduate School of Medicine, Sendai, Japan

    Background/Purpose: Polyarteritis nodosa (PAN) is a necrotizing arteritis of medium and small arteries. PAN is divided into systemic and cutaneous PAN (cPAN). cPAN can be…
  • Abstract Number: 1186 • 2016 ACR/ARHP Annual Meeting

    The Use of Clinical Mucosal Manifestations to Differentiate Patients with Lupus and Dermatomyositis: Transversal, Retrospective and Analytical Study of 116 Patients

    Cristián Vera-Kellet Sr., Pablo del Barrio-Díaz Sr., Jorge Manríquez-Moreno Sr. and Carlos Reyes-Vivanco Sr., Dermatology, Pontificia Universidad Católica de Chile, Santiago, Chile

    Background/Purpose: There are few studies comparing oral manifestations in patients with Cutaneous Lupus (CL), Systemic Lupus Erythematosus (SLE) and Dermatomyositis (DM). Our objective was to…
  • Abstract Number: 1949 • 2016 ACR/ARHP Annual Meeting

    Presentation, Prognosis and Clinical-Pathological Correlations of Cutaneous Manifestations in ANCA-Associated Vasculitides

    Laure Frumholtz1, Sara Laurent2, Olivier Aumaître3, Francois Maurier4, Guillaume Le Guenno5, Agnès Carlotti2, Alexiane Dallot2, Jean-Louis Kemeny6, Laurent Antunes7, Nicolas Froment7, Sylvie Fraitag8, Jonathan London9, Claire Le Jeunne10, Benoit Terris2, Luc Mouthon10, Selim Aractingi11, Loïc Guillevin10, Nicolas Dupin11 and Benjamin Terrier12, 1Internal Medicine, Cochin Hospital, Paris, France, 2Pathology, Cochin Hospital, Paris, France, 3CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, 4Department of Internal Medicine, HP Metz Belle Isle Hospital, Metz, France, 5Internal Medicine department, Clermont-Ferrand, France, 6Pathology, CHU, Clermont-Ferrand, France, 7Pathology, CH, Metz, France, 8Pathology, Necker, Paris, France, 9INSERM U1016, Institut Cochin, Equipe Neutrophiles et Vascularites, Paris, France, 10Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, 11Dermatology, Cochin Hospital, Paris, France, 12National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France

    Background/Purpose: Cutaneous involvement is frequent during ANCA-associated vasculitis (AAV) and can reveal the disease. However, no large study on presentation and clinical-pathological correlations is available.…
  • Abstract Number: 2969 • 2016 ACR/ARHP Annual Meeting

    10 Year Retrospective Analysis of 276 Cases of Histopathologically Confirmed Leukocytoclastic Vasculitis

    Shazdeh Butt1 and Thomas Olenginski2, 1Rheumatology, Geisinger Medical Center, Danville, PA, 2Department of Rheumatology, Geisinger Medical Center, Danville, PA

    Background/Purpose: We identified leukocytoclastic vasculitis (LCV) patients seen over 10 years at our institution.  Aims included 1) define cause; 2) record lab, imaging, and ancillary…
  • Abstract Number: 1462 • 2015 ACR/ARHP Annual Meeting

    Farber Disease: Important Differential Diagnostic Information for JIA and Other Inflammatory Arthritis Phenotypes Is Revealed By Data from the Largest Clinical Cohort to Date

    Alexander Solyom1, Boris Huegle2, Bo Magnusson3, Balahan Makay4, Nur Arslan5, John Mitchell6, Pranoot Tanpaiboon7, Norberto Guelbert8, Ratna Puri9, Lawrence Jung10, Giedre Grigelioniene11, Karoline Ehlert12, Michael Beck13, Calogera Simonaro14 and Edward Schuchman15, 1Pediatrics, University of Pecs, Pecs, Hungary, 2Pediatric Rheumatology, German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany, 3Pediatric Rheumatology, Karolinska University Hospital, Stockholm, Sweden, 4Pediatric Rheumatology, Eylul University, Izmir, Turkey, 5Eylul University, Izmir, Turkey, 6Pediatric Endocrinology, Montreal Children's Hospital, Montreal, QC, Canada, 7Genetics and Metabolism, Children's National Medical Center, Washington, DC, 8Metabolic Diseases Section, Children’s Hospital of Cordoba, Cordoba, Argentina, 9Medical Genetics, Sir Ganga Ram Hospital, New Delhi, India, 10Pediatric Rheumatology, Children's National Med Ctr, Washington, DC, 11Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden, 12University Medical Center - Greifswald, Greifswald, Germany, 13Institute of Human Genetics, University Medical Center - Mainz, Mainz, Germany, 14Genetics and Genomic Sciences, Icahn School of Medicine at Mt. Sinai, New York, NY, 15Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Farber disease (Farber lipogranulomatosis; acid ceramidase deficiency) is a rare lysosomal storage disorder resulting from the inherited deficiency of the enzyme acid ceramidase due…
  • Abstract Number: 3033 • 2015 ACR/ARHP Annual Meeting

    Polyarteritis Nodosa and Cutaneous Arteritis: Are They Distinct Diseases?

    Fatma Alibaz-Oner1, Matthew J. Koster2, Cynthia S. Crowson3, Ashima Makol2, Steven R. Ytterberg2, Eric L. Matteson2 and Kenneth J. Warrington2, 1Department Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, 2Rheumatology, Mayo Clinic, Rochester, MN, 3Health Sciences Research, Mayo Clinic, Rochester, MN

    Background/Purpose: Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis predominantly targeting medium-sized visceral arteries.  Cutaneous arteritis (CA) is generally limited to the medium-sized vessels…
  • Abstract Number: 62 • 2015 ACR/ARHP Annual Meeting

    Patient Perception of Disease Burden in Diffuse Cutaneous Systemic Sclerosis

    Dinesh Khanna1, Yannick Allanore2, Christopher P. Denton3, Marco Matucci-Cerinic4, Janet E. Pope5, Barbara Hinzmann6, Siobhan Briody7, Janethe de Oliveira Pena8 and Oliver Distler9, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Immunogenetics, Cochin Institute, Paris, France, 3Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 4Department of Medicine, Division of Rheumatology, University of Florence, Florence, Italy, 5University of Western Ontario, London, ON, Canada, 6Bayer Pharma AG, Berlin, Germany, 7Blueprint Partnership, Manchester, United Kingdom, 8Bayer HealthCare Pharma, Whippany, NJ, 9Research of Systemic Autoimmune Diseases, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Diffuse cutaneous SSc (dcSSc) is associated with high morbidity and mortality, and reduced quality of life. Patient priorities are rarely discussed, with physicians traditionally…
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