Abstracts tagged "Cognitive dysfunction"

Abstract Number: 3123 • 2015 ACR/ARHP Annual Meeting
Evidence of Altered Blood Brain Barrier Permeability in Systemic Lupus Erythematosus Using Magnetic Resonance Imaging
Gaurav Gulati¹, Jordan T. Jones², Mekibib Altaye³, Jamie Meyers Eaton⁴, Kasha Wiley², Mark DiFrancesco⁵ and Hermine I. Brunner⁶, ¹Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Biostatistics and Epidemiology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁴Division of Pediatric Rheumatology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁵Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Neurocognitive dysfunction is a common manifestation of childhood-onset Systemic Lupus Erythematosus (cSLE). Murine models suggest that loss of the blood-brain barrier (BBB) integrity allows…
Abstract Number: 2916 • 2014 ACR/ARHP Annual Meeting
Effects of Exercise on Body Composition, Cardiovascular Fitness, Muscle Strength, and Cognition in Patients with Rheumatoid Arthritis: A Randomised Controlled Trial of a Patient-Specific Exercise Programme
Maha Azeez¹, Ciara Clancy², Tom O'Dwyer³, Fiona Wilson³ and Gaye Cunnane⁴, ¹Rheumatology, St James's Hospital and Trinity College Dublin, Dublin, Ireland, ²Department of Physiotherapy, Trinity College Dublin, Dublin, Ireland, ³Physiotherapy, Trinity College Dublin, Dublin, Ireland, ⁴Dept of Rheumatology, St James's Hospital and Trinity College Dublin, Dublin, Ireland
Background/Purpose Rheumatoid Arthritis (RA) patients have lower levels of physical activity compared to their non-RA counterparts. Large proportions of patients with RA are overweight or…
Abstract Number: 2654 • 2014 ACR/ARHP Annual Meeting
Cognitive Function in Systemic Lupus Erythematosus Patients with Past History of Neuropsychiatric Manifestations : A Longitudinal Study
Yang Gao¹, Yi Lo¹, Jacky Wan², Esther YY Lau² and Mo Yin Mok¹, ¹Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong, ²Department of Psychology, University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Cognitive impairment is commonly reported in patients with systemic lupus erythematosus (SLE) and its associations with neuropsychiatric involvement (NPSLE) and psychiatric factors have been…
Abstract Number: 2660 • 2014 ACR/ARHP Annual Meeting
Metabolic Syndrome Features Can Influenciate Cognitive Functions and Brain Lesions in Childhood-Onset Systemic Lupus Erythematosus
Nailu A. Sinicato¹, Aline T. Lapa¹, Mariana Postal¹, Bruna Bellini¹, Paula T Fernandes², Roberto Marini³ and Simone Appenzeller⁴, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Faculty of Physical Education, State University of Campinas, Campinas, Brazil, ³Departament of Pediatrics, State University of Campinas, Campinas, Brazil, ⁴Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose: The underlying factor for an association between the metabolic syndrome (MetS) and cognitive decline might be a subclinical inflammation. Inflammatory mechanisms are hypothesized to…
Abstract Number: 2658 • 2014 ACR/ARHP Annual Meeting
Cognitive Symptoms and Associated Disease and Non-Disease Related Factors in Patients with Systemic Lupus Erythematosus : A Longitudinal Study
Yang Gao, Yi Lo and Mo Yin Mok, Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Cognitive impairment is commonly reported in patients with systemic lupus erythematosus (SLE). Its associated disease and non-disease related factors have been inconsistently reported. Objective:…
Abstract Number: 1401 • 2014 ACR/ARHP Annual Meeting
Higher-Order Neuropsychological Deficits Are Frequent and Occur Early in RA and SLE: The Impact of Basic Processing Abilities on Psychological Well-Being
Giorgia Dimitraki¹, Georgia Ktistaki¹, Emmanouil Papastefanakis¹, Antonis Fanouriakis², Irini Gergiannaki², George Bertsias³, Nikolaos Kougkas², Argyro Repa³, Evangelos Karademas¹, Prodromos Sidiropoulos³ and Panagiotis Simos¹, ¹Department of Psychology, University of Crete, Rethymnon, Greece, ²Rheumatology, Clinical Immunology and Allergy, University of Crete, Heraklion, Greece, ³Rheumatology, Clinical Immunology, and Allergy, University of Crete, Heraklion, Greece
Background/Purpose Deficits in higher-order cognitive abilities (episodic memory, executive functions) have been reported in patients with chronic inflammatory disorders, albeit inconsistently. We investigated whether such…
Abstract Number: 1107 • 2014 ACR/ARHP Annual Meeting
A Strong Association Between Memory Loss and Word Finding Difficulties in Fibromyalgia
Robert S. Katz¹ and Frank Leavitt², ¹Rush Medical College, Chicago, IL, ²Rush University Medical Center, Chicago, IL
Background/Purpose: A core feature of fibromyalgia (FMS) is cognitive dysfunction. The predominant clinical manifestations is memory loss; however impaired word retrieval frequently referred to…
Abstract Number: 1260 • 2013 ACR/ARHP Annual Meeting
Serum S100β Is Associated With Neuropsychiatric Manifestations In Childhood-Onset Systemic Lupus Erythematosus
Aline T. Lapa¹, Mariana Postal¹, Nailu A. Sinicato¹, Bruna Bellini¹, Paula T Fernandes², Roberto Marini³ and Simone Appenzeller⁴, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Faculty of Physical Education, State University of Campinas, Campinas, Brazil, ³State University of Campinas, Campinas, Brazil, ⁴Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose: Involvement of the central nervous system (CNS) in systemic lupus erythematosus (SLE) is an important source of morbidity and mortality. S100β has been considered…
Abstract Number: 1108 • 2013 ACR/ARHP Annual Meeting
Methylphenidate Improves Concentration, Energy and Mood In Fibromyalgia
Robert S. Katz¹, Hannah Bond² and Frank Leavitt³, ¹Rush Medical College, Chicago, IL, ²Rheumatology Associates, Chicago, IL, ³Rush University Medical Center, Chicago, IL
Background/Purpose: Central nervous system stimulants such as methylphenidate appear to have short term benefits for naming speed and cognitive functioning in fibromyalgia (FMS). Methylphenidate quickly…
Abstract Number: 2202 • 2013 ACR/ARHP Annual Meeting
TNF-α Is Associated With Cognitive Impairment In Childhood-Onset Systemic Lupus Erythematosus
Mariana Postal¹, Nailu A. Sinicato¹, Aline T. Lapa¹, Karina Peliçari¹, Bruna Bellini¹, Paula T Fernandes², Roberto Marini³ and Simone Appenzeller⁴, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Faculty of Physical Education, State University of Campinas, Campinas, Brazil, ³State University of Campinas, Campinas, Brazil, ⁴Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose: Cognitive impairment is common in over 50% of SLE patients with active neurological and psychiatric disorders. Cytokine dysregulation and inﬂammation are mechanisms that may…
Abstract Number: 1602 • 2013 ACR/ARHP Annual Meeting
Autoantibodies, Cytokines and Chemokines In Serum and Cerebrospinal Fluid Of SLE Patients With Cognitive Dysfunction
Hilda Fragoso-Loyo¹, Alí Duarte-García², Sandra Juárez-Arellano³, Alba Cicero-Casarrubias⁴, Juanita Romero-Díaz⁵, Luis LLorente-Peters¹ and Jorge Sánchez-Guerrero⁶, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ²Department of Medicine, Tufts Medical Center, Boston, MA, ³Department of Neurology, Instituto Nacional de Ciencias Medicas y Nutricion S.Z., Mexico city, Mexico, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ⁶Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada
Background/Purpose: The nature and pathogenesis and cognitive dysfunction (CD) in patients with SLE is unkown.To determine the presence and levels of autoantibodies, cytokines and chemokines…
Abstract Number: 2644 • 2012 ACR/ARHP Annual Meeting
Functional Magnetic Resonance Imaging of Working Memory in Fibromyalgia: Support for a “Competing Demands” Theory of Cognitive Function in Chronic Pain
Anson E. Kairys¹, Gabriela Ramirez¹, Eric Ichesco², Johnson P. Hampson², Richard E. Harris², Daniel J. Clauw³, Tobias Schmidt-Wilcke² and Jennifer M. Glass⁴, ¹Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, ²Anesthesiology, University of Michigan, Ann Arbor, MI, ³Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI, ⁴Psychiatry, University of Michigan, Ann Arbor, MI
Background/Purpose: The primary symptom of fibromyalgia (FM) is chronic widespread pain; however, patients report additional symptoms including decreased concentration and memory. Deficits are seen mainly…
Abstract Number: 1878 • 2012 ACR/ARHP Annual Meeting
Cognitive Manifestations of Fibromyalgia and Lupus
Robert S. Katz and Frank Leavitt, Rush University Medical Center, Chicago, IL
Background/Purpose: Similar cognitive complaints for patients with fibromyalgia and systemic lupus erythematosus (SLE) have been reported; however, inherently different deficits can share superficial similarities. The…
Abstract Number: 1451 • 2012 ACR/ARHP Annual Meeting
Estrogen Receptor Alpha Deficiency Protects Against Cognitive Defects in Murine Lupus
Melissa A. Cunningham¹, Osama S. Naga², Heather A. Boger³, Ann-Charlotte E. Granholm-Bentley³ and Gary S. Gilkeson⁴, ¹Med/Rheumatology, MUSC, Charleston, SC, ²Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ³Neuroscience, Medical University of SC, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Up to 80% of SLE patients have cognitive defects or affective disorders. The mechanism of CNS injury responsible for cognitive impairment is unknown. Anti-dsDNA…
Abstract Number: 611 • 2012 ACR/ARHP Annual Meeting
Impaired Diffusion Tensor Imaging Findings in the Corpus Callosum and Cingulum May Underlie Impaired Learning and Memory Abilities in Systemic Lupus Erythematosus
Daphna Paran¹, Elissa Ash², Ira Litinsky¹, Valerie Aloush¹, Marina Anouk¹, Dan Caspi³, Talma Hendler⁴ and Irit Shapira-Lichter⁴, ¹Rheumatology, Tel Aviv Sourasky Medical Ctr, Tel-Aviv University, Tel Aviv, Israel, ²Neurology, Tel Aviv Sourasky Medical Ctr, Tel-Aviv University, Tel Aviv, Israel, ³Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁴Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Ctr, Tel-Aviv University, Tel Aviv, Israel
Background/Purpose: Memory impairment is prevalent in systemic lupus erythematosus (SLE), however the pathogenesis is unknown. In a previous functional Magnetic Resonance Imaging (MRI) study we…

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