ACR Meeting Abstracts

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Abstracts tagged "Cognitive dysfunction"

  • Abstract Number: 2446 • ACR Convergence 2023

    Intermittent Fasting Attenuates Cognitive Dysfunction in Murine Systemic Lupus Erythematosus

    Yi Feng, Jiayu Qin, Lijuan Zheng, Hao Ren, Min Yang and Qin Huang, Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China

    Background/Purpose: Cognitive dysfunction is one of the most common manifestations of neuropsychiatric systemic lupus erythematosus (NPSLE) and severely affects patients' health-related quality of life. Intermittent…
  • Abstract Number: 0558 • ACR Convergence 2023

    Elevated Serum Levels of S100A8/A9 Discriminate Systemic Lupus Erythematosus Patients with Cognitive Impairment from Patients Without Impairment

    Carolina Munoz-Grajales1, Michelle Barraclough2, Juan Pablo Diaz Martinez3, Jiandong Su2, Kathleen Bingham2, Mahta Kakvan4, Roberta Kretzmann5, Carmela Tartaglia6, Lesley Ruttan7, May Choi8, Simone Appenzeller9, Sherief Marzouk5, Dennisse Bonilla2, Patti Katz10, Dorcas Beaton11, Robin Green5, Joan Wither2 and Zahi Touma5, 1UHN/TWH, Toronto, ON, Canada, 2University Health Network, Toronto, ON, Canada, 3Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada, 4University Health Network, University of Toronto, Toronto, ON, Canada, 5University of Toronto, Toronto, ON, Canada, 6Krembil Brain Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 7University Health Network, Toronto Rehabilitation Institute, Toronto, ON, Canada, 8University of Calgary, Calgary, AB, Canada, 9UNICAMP, Campinas, Brazil, 10University of California San Francisco, San Rafael, CA, 11Institute for Work & Health, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is one of the most common manifestations of Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). Studies have reported that SLE patients with different…
  • Abstract Number: 2449 • ACR Convergence 2023

    Cognitive Functioning Among Individuals with Systemic Lupus Erythematosus: A Population-Based Study

    Laura Plantinga1, C. Barrett Bowling2, Charmayne Dunlop-Thomas1, Courtney Hoge1, Bradley Pearce1, Cristina Drenkard1 and S. Sam Lim1, 1Emory University, Atlanta, GA, 2Duke University, Durham, NC

    Background/Purpose: Studies of objectively measured cognitive dysfunction in SLE are often limited by small sample size, limited generalizability, and lack of diversity. We sought to…
  • Abstract Number: 041 • 2023 Pediatric Rheumatology Symposium

    Cognitive Performance Score of the Pediatric Automated Neuropsychological Assessment Metrics Software in a Brazilian Cohort

    Jaqueline De Amorim1, Simone Kishimoto1, Paula Fernandes1, Roberto Marini1, Lilian Costallat1, Zahi Touma2, Hermine Brunner3 and Simone Appenzelle4, 1UNICAMP, São Paulo, Brazil, 2University of Toronto, Toronto, ON, Canada, 3Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4University of Campinas, Campinas, Sao Paulo, Brazil

    Background/Purpose: The PedAnam (Pediatric Automated Neuropsychological Assessment Metrics) is an automatic software to evaluate cognitive performance that has recently been validated into Portugues (Brazil). The…
  • Abstract Number: 1198 • ACR Convergence 2022

    Validation of Remote Physical Performance and Cognitive Functioning Measures Among Individuals with Systemic Lupus Erythematosus

    Courtney Hoge1, C. Barrett Bowling2, Charmayne Dunlop-Thomas1, Bradley Pearce1, S. Sam Lim1, Cristina Drenkard1 and Laura Plantinga1, 1Emory University, Atlanta, GA, 2Duke University, Durham, NC

    Background/Purpose: The disruption of the COVID-19 pandemic presented an opportunity for researchers to develop and administer remote versions of measures for ongoing studies. In an…
  • Abstract Number: 1386 • ACR Convergence 2022

    The Association of Depression with Executive Function Skills and Health-Related Quality of Life in Youth with Systemic Lupus Erythematosus

    Busisiwe Zapparoli1, Sarah Mossad1, Stephanie Fevrier2, Victoria Lishak3, Tala El Tal4, Lawrence Ng1, Paris Moaf1, Joanna Law1, Ibrahim Mohamed5, Linda Hiraki6, Deborah Levy7, ashley Danguecan1 and Andrea Knight4, 1The Hospital for Sick Children, Toronto, ON, Canada, 2The Hospital for Sick Children/University of Toronto, Toronto, ON, Canada, 3The Hospital for Sick Children, Department of Psychology, University of Toronto, Toronto, ON, Canada, 4The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 5The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, ON, Canada 3Institute of Biomedical Engineering, University of Toronto, Brampton, ON, Canada, 6The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada, 7Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Depression is a frequent symptom in childhood-onset SLE (cSLE), and is likely multifactorial. Executive function (EF) refers to conscious and volitional efforts to regulate…
  • Abstract Number: 1397 • ACR Convergence 2022

    The Impact of Disease Activity on Patient-Reported Cognitive Dysfunction in Rheumatoid Arthritis

    Ozlem Pala1, Dimitrios Pappas2, George Reed3 and Joel Kremer4, 1University of Miami, Fort Lauderdale, FL, 2Corrona Research Foundation; CorEvitas, LLC, Albany, NY, 3University of Massachusetts Medical School, Worcester, MA, 4The Corrona Research Foundation, Delray Beach, FL

    Background/Purpose: Rheumatoid Arthritis (RA) is a systemic, inflammatory disease, and its burden extends beyond joint disease. RA is not commonly associated with central nervous system…
  • Abstract Number: 1447 • ACR Convergence 2022

    Serum Cytokine Profiling Reveals Elevated Levels of S100A8/A9 and MMP-9 in Systemic Lupus Erythematosus Patients with Cognitive Impairment Independently of Disease Activity and Inflammatory Markers

    Carolina Munoz1, Michelle Barraclough2, Juan Pablo Diaz-Martinez1, Jiandong Su1, Kathleen Bingham3, Mahta Kakvan1, Maria Carmela Tartaglia4, Leslet Ruttan5, May Choi6, Dennisse Bonilla1, Simone Appenzeller7, Patricia Katz8, Dorcas Beaton9, Robin Green5, Joan Wither10 and Zahi Touma1, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, 3Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 4University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 5University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 6Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 7Unicamp, Campinas, São Paulo, Brazil, 8UCSF, San Rafael, CA, 9Institute for Work & Health, Toronto, ON, Canada, 10Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is one of the most common manifestations of neuropsychiatric lupus(NPSLE), which may occur in the absence of active Systemic Lupus Erythematosus…
  • Abstract Number: 1458 • ACR Convergence 2022

    Systemic Lupus Erythematosus (SLE) Patients with Cognitive Impairment Experience More Fatigue Compared to Patients Without Impairment

    Delansie Lawrence1, Jiandong Su1, Andrea Knight2, Kathleen Bingham3, Mahta Kakvan1, Maria Carmela Tartaglia4, Leslet Ruttan5, Joan Wither6, May Choi7, Simone Appenzeller8, Nicole Anderson1, Dennisse Bonilla1, Patricia Katz9, Dorcas Beaton10, Robin Green5, Zahi Touma1 and Michelle Barraclough11, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 2The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 3Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 4University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 5University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 6Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 7Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 8Unicamp, Campinas, São Paulo, Brazil, 9UCSF, San Rafael, CA, 10Institute for Work & Health, Toronto, ON, Canada, 11Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is highly prevalent in patients with systemic lupus erythematosus (SLE). Objective prevalence rates are reported as 38% [range: 20% to 80%]…
  • Abstract Number: 1459 • ACR Convergence 2022

    Evolution of Subjective Cognitive Impairment Overtime in SLE Patients: Bayesian Longitudinal Item Response Theory Modelling

    Michelle Barraclough1, Juan Pablo Diaz-Martinez2, Andrea Knight3, Kathleen Bingham4, Jiandong Su2, Mahta Kakvan5, Carolina Munoz2, Maria Carmela Tartaglia6, Leslet Ruttan7, Joan Wither5, May Choi8, Nicole Anderson9, Dennisse Bonilla2, Simone Appenzeller10, Ben Parker11, Patricia Katz12, Dorcas Beaton13, Robin Green7, Ian N. Bruce14 and Zahi Touma2, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 3The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 4Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 5Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 6University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 7University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 8Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 9Schroeder Arthritis Institute, Krembil Research Institute and University Health Network, University of Toronto, Toronto, ON, Canada, 10Unicamp, Campinas, São Paulo, Brazil, 11Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 12UCSF, San Rafael, CA, 13Institute for Work & Health, Toronto, ON, Canada, 14Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Subjective cognitive impairment (SCI) is a significant problem in SLE and there are a lack of studies assessing change over time in SCI. The…
  • Abstract Number: 1468 • ACR Convergence 2022

    Apathy Measurement in a Cohort of Systemic Lupus Erythematosus

    Mike Putman1, David Gazeley2 and Ikechukwu Mbonu3, 1The Medical College of Wisconsin, Milwaukee, WI, 2Medical College of Wisconsin, Wauwatosa, WI, 3Medical College of Wisconsin, Milwaukee, WI

    Background/Purpose: Up to 40% of patients with systemic lupus erythematosus (SLE) have measurable cognitive dysfunction on neuropsychiatric testing. Around 83% of patients are nonadherent with…
  • Abstract Number: 1474 • ACR Convergence 2022

    Quinolinic Acid, a Kynurenine/Tryptophan Pathway Metabolite, Correlates with Abnormalities in Brain Structure and Function in SLE

    Erik Anderson, Chris Tang, An Vo, Cynthia Aranow, Bruce Volpe, Betty Diamond and Meggan Mackay, Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Stimulation of the kynurenine/tryptophan pathway by interferons alpha and gamma, both known contributors to SLE pathogenesis, leads to a potentially neurotoxic imbalance of pathway…
  • Abstract Number: 0062 • ACR Convergence 2022

    Comparing Alzheimer’s Disease Risk in Patients with Chronic Inflammatory Autoimmune Diseases: A Medicare Cohort Study

    Justin Levinson1, Jonathan Katz2, Yi Chen3, W. Ryan Powell4, Andrea Gilmore-Bykovskyi5, Amy J. Kind6 and Christie Bartels7, 1University of Wisconsin School of Medicine and Public Health, Department of Medicine, Rheumatology Division, Madison, WI, 2University of Wisconsin Hospitals and Clinics, Madison, WI, 3University of Wisconsin School of Medicine and Public Health, Department of Medicine, Department of Biostatistics and Informatics, Madison, WI, 4University of Wisconsin School of Medicine and Public Health, Center for Health Disparities Research, Thousand Oaks, CA, 5University of Wisconsin School of Medicine and Public Health, Department of Emergency Medicine; and the Center for Health Disparities Research, Madison, WI, 6University of Wisconsin School of Medicine and Public Health, Department of Medicine, Geriatrics Division & Center for Health Disparities Research, Madison, WI, 7University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose: Chronic inflammatory diseases have been associated with an increased risk of Alzheimer’s disease (AD), yet emerging research in rheumatoid arthritis (RA) and psoriasis suggests…
  • Abstract Number: 1708 • ACR Convergence 2022

    A Role for the RAGE Receptor in Chronic Neurotoxicity After Exposure to SLE Antibodies That Cross React with dsDNA and the NMDA Receptor

    Bahtiyar Toz1, Jeffrey C wingard2, Bruce Volpe2 and Betty Diamond2, 1Resident in Queens Hospital Center, Jamaica, NY, 2Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Neurologic dysfunction occurs in up to 80% of SLE patients. Cognitive impairment is one of the most frequent manifestations of neuropsychiatric SLE (NPSLE). There…
  • Abstract Number: 0322 • ACR Convergence 2022

    Are Virtual Cognitive Assessments Comparable to In-person Assessments in a Systemic Lupus Erythematosus Cohort?

    Michelle Barraclough1, Juan Pablo Diaz-Martinez2, Andrea Knight3, Kathleen Bingham4, Jiandong Su2, Mahta Kakvan2, Carolina Munoz2, Maria Carmela Tartaglia5, Leslet Ruttan6, Joan Wither7, May Choi8, Dennisse Bonilla2, Nicole Anderson2, Simone Appenzeller9, Ben Parker10, Patricia Katz11, Dorcas Beaton12, Robin Green6, Ian N. Bruce13 and Zahi Touma2, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 3The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 4Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 5University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 6University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 7Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 8Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 9Unicamp, Campinas, São Paulo, Brazil, 10Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 11UCSF, San Rafael, CA, 12Institute for Work & Health, Toronto, ON, Canada, 13Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Many in-person research studies, such as ours examining cognitive impairment (CI) in SLE, were paused for safety reasons during the COVID-19 pandemic. To restart…
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