ACR Meeting Abstracts

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Abstracts tagged "Cognitive dysfunction"

  • Abstract Number: 1456 • ACR Convergence 2023

    Systematic Review of Effects of Systemic Lupus Erythematosus on Brain Structure and Structural Connectivity and Its Relationship with Cognitive Dysfunction Through an Advanced Neuroimaging Lens

    Ibrahim Mohamed1, Tala El Tal2, santiago arciniegas3, Stephanie Fevrier4, justine ledochowski5 and Andrea Knight4, 1The Hospital for Sick Children, Brampton, ON, Canada, 2Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada, 3University of Toronto, Toronto, ON, Canada, 4The Hospital for Sick Children, Toronto, ON, Canada, 5Department of Psychology, The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: Cognitive dysfunction (CD) is highly prevalent in systemic lupus erythematosus (SLE), and advanced structural magnetic resonance imaging (MRI) has revealed brain abnormalities in patients…
  • Abstract Number: 1461 • ACR Convergence 2023

    Association of Serum Analytes with SLE Cognitive Impairment Phenotypes Formed by Machine Learning: MMP-9, S100A8/A9, IL-6, IL-10, and NGAL

    Michelle Barraclough1, Carolina Munoz-Grajales2, Lauren Erdman3, Juan Pablo Diaz Martinez4, Kathleen Bingham1, Mahta Kakvan5, Roberta Kretzmann6, Carmela Tartaglia7, Lesley Ruttan8, May Choi9, Simone Appenzeller10, Sherief Marzouk6, Dennisse Bonilla4, Patti Katz11, Dorcas Beaton12, Anna Goldenberg13, Robin Green6, Joan Wither1 and Zahi Touma6, 1University Health Network, Toronto, ON, Canada, 2UHN/TWH, Toronto, ON, Canada, 3Hospital for SickKids, Toronto, Toronto, ON, Canada, 4Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada, 5University Health Network, University of Toronto, Toronto, ON, Canada, 6University of Toronto, Toronto, ON, Canada, 7Krembil Brain Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 8University Health Network, Toronto Rehabilitation Institute, Toronto, ON, Canada, 9University of Calgary, Calgary, AB, Canada, 10UNICAMP, Campinas, Brazil, 11University of California San Francisco, San Rafael, CA, 12Institute for Work & Health, Toronto, ON, Canada, 13Hospital for SickKids, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is highly prevalent in patients with SLE [prevalence of 38% (range: 20%-80%)]. The exact mechanisms underlying CI is complex and multifactorial.…
  • Abstract Number: 1463 • ACR Convergence 2023

    Predictors of Cognitive Impairment in Individuals with Systemic Lupus Erythematosus

    Alexandra Lee1, Sharon Phillips2 and Leslie Crofford3, 1Meharry Medical College, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN, 3Vanderbilt University Medical Center, Melbourne, AR

    Background/Purpose: The purpose of this study was to investigate factors associated with objective cognitive impairment in patients diagnosed with Systemic Lupus Erythematous (SLE). Subjective complaints…
  • Abstract Number: 041 • 2023 Pediatric Rheumatology Symposium

    Cognitive Performance Score of the Pediatric Automated Neuropsychological Assessment Metrics Software in a Brazilian Cohort

    Jaqueline De Amorim1, Simone Kishimoto1, Paula Fernandes1, Roberto Marini1, Lilian Costallat1, Zahi Touma2, Hermine Brunner3 and Simone Appenzelle4, 1UNICAMP, São Paulo, Brazil, 2University of Toronto, Toronto, ON, Canada, 3Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4University of Campinas, Campinas, Sao Paulo, Brazil

    Background/Purpose: The PedAnam (Pediatric Automated Neuropsychological Assessment Metrics) is an automatic software to evaluate cognitive performance that has recently been validated into Portugues (Brazil). The…
  • Abstract Number: 0062 • ACR Convergence 2022

    Comparing Alzheimer’s Disease Risk in Patients with Chronic Inflammatory Autoimmune Diseases: A Medicare Cohort Study

    Justin Levinson1, Jonathan Katz2, Yi Chen3, W. Ryan Powell4, Andrea Gilmore-Bykovskyi5, Amy J. Kind6 and Christie Bartels7, 1University of Wisconsin School of Medicine and Public Health, Department of Medicine, Rheumatology Division, Madison, WI, 2University of Wisconsin Hospitals and Clinics, Madison, WI, 3University of Wisconsin School of Medicine and Public Health, Department of Medicine, Department of Biostatistics and Informatics, Madison, WI, 4University of Wisconsin School of Medicine and Public Health, Center for Health Disparities Research, Thousand Oaks, CA, 5University of Wisconsin School of Medicine and Public Health, Department of Emergency Medicine; and the Center for Health Disparities Research, Madison, WI, 6University of Wisconsin School of Medicine and Public Health, Department of Medicine, Geriatrics Division & Center for Health Disparities Research, Madison, WI, 7University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose: Chronic inflammatory diseases have been associated with an increased risk of Alzheimer’s disease (AD), yet emerging research in rheumatoid arthritis (RA) and psoriasis suggests…
  • Abstract Number: 1708 • ACR Convergence 2022

    A Role for the RAGE Receptor in Chronic Neurotoxicity After Exposure to SLE Antibodies That Cross React with dsDNA and the NMDA Receptor

    Bahtiyar Toz1, Jeffrey C wingard2, Bruce Volpe2 and Betty Diamond2, 1Resident in Queens Hospital Center, Jamaica, NY, 2Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Neurologic dysfunction occurs in up to 80% of SLE patients. Cognitive impairment is one of the most frequent manifestations of neuropsychiatric SLE (NPSLE). There…
  • Abstract Number: 0322 • ACR Convergence 2022

    Are Virtual Cognitive Assessments Comparable to In-person Assessments in a Systemic Lupus Erythematosus Cohort?

    Michelle Barraclough1, Juan Pablo Diaz-Martinez2, Andrea Knight3, Kathleen Bingham4, Jiandong Su2, Mahta Kakvan2, Carolina Munoz2, Maria Carmela Tartaglia5, Leslet Ruttan6, Joan Wither7, May Choi8, Dennisse Bonilla2, Nicole Anderson2, Simone Appenzeller9, Ben Parker10, Patricia Katz11, Dorcas Beaton12, Robin Green6, Ian N. Bruce13 and Zahi Touma2, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 3The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 4Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 5University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 6University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 7Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 8Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 9Unicamp, Campinas, São Paulo, Brazil, 10Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 11UCSF, San Rafael, CA, 12Institute for Work & Health, Toronto, ON, Canada, 13Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Many in-person research studies, such as ours examining cognitive impairment (CI) in SLE, were paused for safety reasons during the COVID-19 pandemic. To restart…
  • Abstract Number: 1754 • ACR Convergence 2022

    Association of Cognitive Impairment and Symptomatic Lower Extremity Osteoarthritis by Level of Physical Activity: Preliminary Data from the Johnston County Health Study

    Kharma Foucher1, Amanda Nelson2, Leigh Callahan3 and Yvonne Golightly4, 1University of Illinois at Chicago, Chicago, IL, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, 3University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, 4University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: While osteoarthritis (OA) is associated with an increased risk of dementia,1 the frequency of milder cognitive impairment is unknown. Mild to moderate cognitive impairment…
  • Abstract Number: 0330 • ACR Convergence 2022

    Assessing the Utility of the Montreal Cognitive Assessment as a Screening Tool for Cognitive Impairment in Patients with SLE Using a Bayesian Item-Response Theory Model

    Juan Pablo Diaz-Martinez1, Michelle Barraclough2, Kimberley Yuen3, Oshrat Tayer-Shifman4, Andrea Knight5, Kathleen Bingham6, Jiandong Su1, Mahta Kakvan1, Carolina Munoz1, Maria Carmela Tartaglia7, Leslet Ruttan8, Joan Wither9, May Choi10, Dennisse Bonilla1, Simone Appenzeller11, Patricia Katz12, Dorcas Beaton13, Robin Green8 and Zahi Touma1, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, 3Queen's University School of Medicine, Toronto, ON, Canada, 4Meir Medical Center, Kfar Saba, Israel, 5The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 6Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 7University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 8University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 9Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 10Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 11Unicamp, Campinas, São Paulo, Brazil, 12UCSF, San Rafael, CA, 13Institute for Work & Health, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is one of the most common manifestations of neuropsychiatric syndromes in patients with SLE, with a prevalence ranging from 20% to…
  • Abstract Number: 2058 • ACR Convergence 2022

    Evidence on the Construct Validity of the Perceived Deficits Questionnaire Among Adult Patients with Systemic Lupus Erythematosus

    Stefan Perera1, Jiandong Su2, Kathleen Bingham3, Mahta Kakvan1, Maria Carmela Tartaglia4, Leslet Ruttan5, Joan Wither1, May Choi6, Simone Appenzeller7, Dorcas Beaton8, Dennisse Bonilla2, Patricia Katz9, Robin Green5, Michelle Barraclough10 and Zahi Touma2, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 3Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 4University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 5University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 6Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 7Unicamp, Campinas, São Paulo, Brazil, 8Institute for Work & Health, Toronto, ON, Canada, 9UCSF, San Rafael, CA, 10Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is prevalent in SLE and negatively impacts social and occupational engagement. There is a need for a patient-reported outcome measure (PROM)…
  • Abstract Number: 0363 • ACR Convergence 2022

    Centrally-Acting Angiotensin Converting Enzyme Inhibitor (cACEi) and Angiotensin Receptor Blocker (cARB) Use and Cognitive Dysfunction in Patients with Systemic Lupus

    Chrisanna Dobrowolski1, Michelle Barraclough2, Jiandong Su3, Milica Tanic4, Kathleen Bingham5, Leslet Ruttan6, Dorcas Beaton7, Joan Wither8, Maria Carmela Tartaglia9, Mahta Kakvan3, Nicole Anderson3, Dennisse Bonilla3, Robin Green6 and Zahi Touma3, 1Icahn School of Medicine at Mount Sinai, New York, NY, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, 3Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 4McMaster University, Toronto, ON, Canada, 5Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 6University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 7Institute for Work & Health, Toronto, ON, Canada, 8Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 9University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada

    Background/Purpose: Cognitive dysfunction (CD) is detectable in 40% of patients with systemic lupus erythematosus (SLE). Despite this high prevalence, there are limited treatment options for…
  • Abstract Number: 2074 • ACR Convergence 2022

    Poor Executive Function Correlates with Increased Disease Damage and Impaired Patient-Reported Outcomes in Youth with Childhood-Onset Lupus: A Cross-Sectional Study

    Tala El Tal1, Santiago Arciniegas2, Sarah Mossad3, Ibrahim Mohamed4, Victoria Lishak5, Stephanie Fevrier6, Lawrence Ng3, Paris Moaf3, Joanna Law3, ashley Danguecan3, Linda Hiraki7, Deborah Levy8 and Andrea Knight1, 1The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 2University of Toronto/Hospital for Sick Children, Toronto, ON, Canada, 3The Hospital for Sick Children, Toronto, ON, Canada, 4The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, ON, Canada 3Institute of Biomedical Engineering, University of Toronto, Brampton, ON, Canada, 5The Hospital for Sick Children, Department of Psychology, University of Toronto, Toronto, ON, Canada, 6The Hospital for Sick Children/University of Toronto, Toronto, ON, Canada, 7The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada, 8Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Cognitive dysfunction affects up to 60% of youth with childhood-onset systemic lupus erythematosus (cSLE), particularly executive dysfunction (ED), with adverse effects on treatment adherence,…
  • Abstract Number: 0517 • ACR Convergence 2022

    Cortical Surface Area Correlates with Cognitive Efficiency and Disease Measures in Childhood-Onset Systemic Lupus Erythematosus

    Santiago Arciniegas1, Sarah Mossad2, Tala El Tal3, Victoria Lishak4, Stephanie Fevrier5, Ibrahim Mohamed6, Joanna Law2, Lawrence Ng2, Paris Moaf2, Helen Branson2, Adrienne Davis2, Linda Hiraki7, Deborah Levy8, ashley Danguecan2, George Ibrahim5 and Andrea Knight3, 1University of Toronto/Hospital for Sick Children, Toronto, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 4The Hospital for Sick Children, Department of Psychology, University of Toronto, Toronto, ON, Canada, 5The Hospital for Sick Children/University of Toronto, Toronto, ON, Canada, 6The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, ON, Canada 3Institute of Biomedical Engineering, University of Toronto, Brampton, ON, Canada, 7The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada, 8Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Cognitive difficulties are common in children with childhood-onset SLE (cSLE), but neuropsychiatric lupus (NPSLE) remains challenging to diagnose and treat. To increase understanding of…
  • Abstract Number: 0665 • ACR Convergence 2022

    Screening for Neurocognitive Demands in Childhood-onset Systemic Lupus Erythematosus Patients Using Pediatric Automated Neuropsychological Assessment Metrics and Association with Magnetic Resonance Imaging

    Jaqueline De Amorim1, Simone Kishimoto1, Danilo Pereira1, Letícia Rittner1 and Simone Appenzeller2, 1University of Campinas, Campinas, São Paulo, Brazil, 2Unicamp, Campinas, São Paulo, Brazil

    Background/Purpose: Neuropsychiatric manifestations are frequently seen in patients with childhood-onset erythematosus (cSLE) and may include neurocognitive dysfunction. These symptoms are difficult to diagnose and classify…
  • Abstract Number: 0793 • ACR Convergence 2022

    Autonomic Nervous System Dysfunction Common Among Patients with Long COVID: An Exploratory Evaluation

    Norman Gaylis1, Odense DeLaRosa1, Nayak Polissar2, Nirnaya Miljacic2 and Andrew Holman3, 1Arthritis & Rheumatic Disease Specialties, Aventura, FL, 2Mountain Whisper Light, Seattle, WA, 3Inmedix Inc, Seattle, WA

    Background/Purpose: Up to 70% of the 236 million people who have been diagnosed with SARS-CoV-2 develop post-COVID symptoms. (1) This has been defined by the…
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