Session Type: Abstract Session
Session Time: 2:00PM-3:30PM
Background/Purpose: Cognitive dysfunction is one of the most common manifestations of neuropsychiatric systemic lupus erythematosus (NPSLE) and severely affects patients’ health-related quality of life. Intermittent fasting (IF) has been shown promising therapeutic effects in neurodegenerative diseases. In this study, we evaluated the impact of intermittent fasting on cognitive function in lupus-prone mice.
Methods: MRL/lpr mice, as an animal model for studying NPSLE, can spontaneously exhibit cognitive dysfunction. After 8 weeks of alternate-day fasting, novel object recognition and Morris water maze tests were used to assess cognitive manifestation. The number of microglia (IBA-1+) was evaluated by immunofluorescence staining. Expression levels of IL-1β, IL-6 and TNF-α were detected by qRT-PCR. The blood-brain barrier permeability and autophagy levels were evaluated by western blotting.
Results: We found that IF improves cognitive function of MRL/lpr mice in the behavioral tests. IF also decreased hippocampal microglia activation and expression of inflammatory cytokines in MRL/lpr mice. In addition, we demonstrated that IF reduced blood-brain barrier permeability. Furthermore, IF inhibited mTOR signaling and increased autophagy levels.
Conclusion: These data indicate that IF improves cognitive function in lupus-prone mice.
To cite this abstract in AMA style:Feng Y, Qin J, Zheng L, Ren H, Yang M, Huang Q. Intermittent Fasting Attenuates Cognitive Dysfunction in Murine Systemic Lupus Erythematosus [abstract]. Arthritis Rheumatol. 2023; 75 (suppl 9). https://acrabstracts.org/abstract/intermittent-fasting-attenuates-cognitive-dysfunction-in-murine-systemic-lupus-erythematosus/. Accessed .
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/intermittent-fasting-attenuates-cognitive-dysfunction-in-murine-systemic-lupus-erythematosus/