Abstract Number: 479 • 2016 ACR/ARHP Annual Meeting
Type II Collagen Secreted from Articular Chondrocytes Is Mainly Destroyed By Cathepsin S in RA Mice
Background/Purpose: Mast cells have long been recognized to increase strikingly in number in the synovial membrane of rheumatoid arthritis（RA），accounting for 5% of the surface synovial…Abstract Number: 2119 • 2016 ACR/ARHP Annual Meeting
Wogonin, a Plant-Derived Flavonoid, Exert Anti-Inflammatory and Chondroprotective Effects through the Activation Nrf2/HO-1 Signaling in Human OA Chondrocytes
Background/Purpose: Methods: Primary human OA chondrocytes were isolated by enzymatic digestion of the cartilage obtained from OA patients who underwent total knee arthroplasty at…Abstract Number: 2123 • 2016 ACR/ARHP Annual Meeting
Follistatin-like Protein 1 Is a Potent Regulator of Articular Chondrocytes in Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is the most common degenerative disease of the joints, affecting nearly 30 million Americans. It is characterized by a change in chondrocyte…Abstract Number: 2131 • 2016 ACR/ARHP Annual Meeting
Transient Receptor Potential Ankyrin 1 (TRPA1) Is Functionally Expressed in Primary Human Osteoarthritic Chondrocytes and Mediates Cartilage Destruction and Joint Pain in the Mia-Model of Osteoarthritis
Background/Purpose: Transient receptor potential ankyrin 1 (TRPA1) is a membrane associated cation channel, which is widely expressed in neuronal cells and known to be involved…Abstract Number: 2994 • 2016 ACR/ARHP Annual Meeting
Binding of Periostin to Discoidin Domain Receptor-1 (DDR1) Promotes Cartilage Degeneration By Inducing MMP-13 Expression
Background/Purpose: We and others have previously shown that periostin (Postn) expression is dramatically elevated in cartilage and sub-chondral bone in OA patients and surgical models…Abstract Number: 1138 • 2015 ACR/ARHP Annual Meeting
Suppressor of Cytokine Signaling 1 Inhibits Interleukin-1β Induced Matrix Metalloproteinases Expression in Human Chondrocytes By Modulating p38-CREB- C/Ebpβ Pathway
Background/Purpose: CAAT/enhancer-binding protein-beta (C/EBPb) is known to be a transcription factor regulating IL-1b-induced catabolic pathways, including the expression of matrix metalloproteinases (MMPs), in chondrocytes. Suppressor…Abstract Number: 1143 • 2015 ACR/ARHP Annual Meeting
Reduced Hydrogen Sulfide Synthesis in the Joint, a New Player in the Pathogenesis of Osteoarthritis
Background/Purpose: Hydrogen sulfide (H2S) is, next to NO and CO, the third endogenous gasotransmitter. It has been shown that in some pathologies, such as hypertension,…Abstract Number: 1147 • 2015 ACR/ARHP Annual Meeting
TGFß1 Blocks Chondrocyte Hypertrophy and Increases Cell Viability in Cultured Cartilage Explants but Does Not Protect Against Proteoglycan Loss
Background/Purpose: In osteoarthritis, cartilage degradation is partly due to chondrocytes gaining a hypertrophy-like phenotype. TGFβ1 is considered to be a protective factor for articular cartilage by blocking…Abstract Number: 2010 • 2015 ACR/ARHP Annual Meeting
Adenosine A2A Receptor, but Not A2B Receptor, Deletion Leads to Development of Osteoarthritis (OA) in Mice and Administration of a Liposomal Suspension of Adenosine Prevents/Treats Osteoarthritis in Rats
Background/Purpose: Adenosine, acting at its receptors, regulates chondrocyte function and inflammation, two components of OA. Mice lacking adenosine A2A receptors (A2AR) have increasing difficulty walking…Abstract Number: 2722 • 2015 ACR/ARHP Annual Meeting
Cyclic Phosphatidic Acid (CPA) Suppresses Expression of Cartilage Degrading Enzymes Such As MMP-3, MMP-13 and Adamts-4 in Inflammatory Synovial Fibroblasts and Articular Chondrocytes Induced By IL-1 Beta and/or TNF ALFA
Background/Purpose: Cyclic phosphatidic acid (cPA) is one of bioactive lipid, has been implicated as an mediator of various biological effects including inhibitory effects of proliferation,…Abstract Number: 1128 • 2015 ACR/ARHP Annual Meeting
Insulin-Induced Cartilage Degradation in Osteoarthritis Is Associated to Defective Autophagy
Background/Purpose: Autophagy, a key cellular quality control mechanism, is defective in Osteoarthritis (OA) and Type 2 Diabetes (T2D). T2D has been proposed as a risk…Abstract Number: 1131 • 2015 ACR/ARHP Annual Meeting
A Histone Deacetylase Inhibitor SAHA Induce MCPIP1 Expression and Suppress IL-6 Expression By Upregulating Cebpα Expression and Downregulating the Expression of Mir-9 in Human OA Chondrocytes
Background/Purpose: Histone deacetylase inhibitors (HDACi) are a class of compounds that inhibits the histone deacetylase activity. MCPIP1 is a negative regulator of IL-6 expression…Abstract Number: 1026 • 2014 ACR/ARHP Annual Meeting
Monosodium Urate Monohydrate Crystals Induces the Expression of Ihh and MMP-13 in ATDC5 Cells: Implications in Osteoarthritis (OA) Development.
Background/Purpose: Cartilage damage is often observed in affected joints with advance gout1. Musculoskeletal ultrasound studies have highlighted the close relationship between monosodium urate (MSU) crystals…Abstract Number: 1014 • 2014 ACR/ARHP Annual Meeting
Harpagide, a Low Molecular Weight Natural Product, Suppresses IL-1â-Induced IL-6 Expression By Blocking the Activation of p38 MAPK and Transcription Factors CEBPâ and AP-1 in Primary Human Osteoarthritis Chondrocytes
Background/Purpose: There is growing evidence that shows the involvement of IL-6 in cartilage degradation during OA. Significant correlation between IL-6 levels in serum as well…Abstract Number: 1012 • 2014 ACR/ARHP Annual Meeting
Role of High Glucose Environment on Chondrocyte Activation and Characterization of Diabetic Osteoarthritic Cartilage: Toward Pathophysiological Delineation of Diabetes Mellitus-Related Osteoarthritis
Background/Purpose: Recent epidemiological studies have suggested an association between type 2 diabetes/hyperglycemia and osteoarthritis (OA) but experimental evidences are lacking (1). We aimed i) to…
ACR Meeting Abstracts