Abstracts tagged "CD T cells"

Abstract Number: 1033 • 2019 ACR/ARP Annual Meeting
Mass Cytometric Immunophenotyping Highlights a Dysregulated T cell-B Cell Axis in Patients with New-onset Lupus
Ye Cao¹, Stephen Alves ², Corine Sinnette ³, Cameron Speyer ³, Gregory Keras ¹, Yujie Qu ², Joshua Keegan ⁴, James Lederer ⁴, Deepak Rao ³ and Karen Costenbader ³, ¹Brigham and Women's Hospital, Boston, ²Merck, boston, ³Brigham and Women's Hospital, Boston, MA, ⁴BWH, Boston
Background/Purpose: The immune cell subsets most altered early in SLE disease course remain unclear. Defining abnormalities in lymphocyte populations in patients with new-onset SLE may…
Abstract Number: 1104 • 2018 ACR/ARHP Annual Meeting
Mass Cytometry Analysis Detects Dysregulated T Cell Complement Responses in Diffuse Cutaneous Systemic Sclerosis
Giuseppina Arbore¹, Shahram Kordasti², Claudia Kemper^3,4,5, Dennis Hourcade⁶, Benedetta Costantini², Leo Placais³, Lynne Mitchell⁶, Richard Ellis⁴, Christopher P. Denton⁷, David Abraham⁸ and Voon H. Ong⁸, ¹Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy, ²Systems Cancer Immunology Lab, King's College London, London, United Kingdom, ³Laboratory of Molecular Immunology and the Immunology Center, National Institutes of Health, Washington, WA, ⁴School of Immunology and Microbial Sciences, King's College London, London, United Kingdom, ⁵Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany, ⁶Division of Rheumatology, Washington University School of Medicine, St Louis, WA, ⁷UCL Division of Medicine, Royal Free Campus, London, United Kingdom, ⁸Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Aberrant CD4+ T cell activation is implicated in disease progression in systemic sclerosis (SSc). Activated T cells release various cytokines that may drive inflammation,…
Abstract Number: 2799 • 2018 ACR/ARHP Annual Meeting
Sjogren’s Syndrome Minor Salivary Gland CD4+ T Cells Associate with Oral Disease Features and Have a T Follicular Helper-like Transcriptional Profile
Michelle L. Joachims¹, Kerry M. Leehan¹, Mikhail Dozmorov^1,2, Zijian Pan¹, Astrid Rasmussen¹, Lida Radfar³, David M. Lewis⁴, Donald U. Stone^5,6, Kiely Grundahl⁷, R. Hal Scofield^1,8,9, Christopher J. Lessard¹, Jonathan Wren¹, Linda F. Thompson¹, Kathy L. Sivils¹⁰, Jacen Maier-Moore^1,11 and A. Darise Farris¹, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Biostatistics, Virginia Commonwealth University, Richmond, VA, ³Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁴Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁵Ophthalmology, Johns Hopkins University, Baltimore, MD, ⁶King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁷Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ⁸Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma, OK, ¹¹Clinical Laboratory Science, University of Texas at El Paso, El Paso, TX
Background/Purpose: The predominant salivary gland (SG) T cell types contributing to disease in Sjögren’s syndrome (SS) are unclear. This study assessed the frequency and number…
Abstract Number: 85 • 2017 ACR/ARHP Annual Meeting
Enhanced IFN-γ STAT1 Signaling in CD4 T Cell Populations and Attenuated IL-2 STAT5 Signaling Contribute to the Pathogenesis of Rheumatoid Arthritis (RA)
Brandon Pope¹, Vishal Sharma², Molly Boland², Richard Reynolds², S. Louis Bridges Jr.³ and Chander Raman⁴, ¹Medicine, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, ⁴Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Type I (IFN-α) and type II (IFN-γ) interferons are important mediators of autoimmunity. However, there is conflicting evidence regarding the contribution of IFN-γ to…
Abstract Number: 1727 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Analysis in Systemic Sclerosis Reveals Hypomethylation of Interferon-Associated Genes in CD4+ and CD8+ T Cells
Weilin Pu¹, Weifeng Ding², Lei Wang³, Shuai Jiang⁴, Wenzhen Tu³, Shicheng Guo⁵, Qingmei Liu⁶, Yanyun Ma⁴, Sidi Chen⁷, Wenyu Wu⁶, Xiaodong Zhou⁸, Maureen D. Mayes⁹, Shervin Assassi⁹, John D. Reveille⁹, Li Jin¹⁰ and Jiucun Wang¹⁰, ¹State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences,, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China, ²Medical Laboratory Center, Medical Laboratory Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China, Nantong, China, ³Division of Rheumatology, Division of Rheumatology, Shanghai TCM-integrated Hospital, Shanghai, China, Shanghai, China, ⁴Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, Shanghai, China, ⁵Department of Bioengineering, Department of Bioengineering, University of California at San Diego, CA, USA, San Diego, CA, ⁶Department of Dermatology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China, ⁷State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences,, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China, ⁸Internal Medicine-Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁹University of Texas McGovern Medical School, Houston, TX, ¹⁰State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China
Background/Purpose: Systemic sclerosis (SSc) is a complex systemic autoimmune disease caused by complicated interaction between genetic, epigenetic and environmental risk factors. Evidence showed epigenetic modifications,…
Abstract Number: 128 • 2017 Pediatric Rheumatology Symposium
Treatment Response in Polyarticular Juvenile Idiopathic Arthritis is Associated With Transcriptional Changes and Chromatin Reorganization in CD4+ T cells
Evan Tarbell¹, Kaiyu Jiang², Yanmin Chen², Tao Liu³ and James Jarvis⁴, ¹Biochemistry, University at Buffalo, Buffalo, NY, ²Pediatrics, University at Buffalo, Buffalo, NY, ³Department of Biochemistry, University at Buffalo, Buffalo, NY, ⁴Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY
Background/Purpose: The polyarticular form of JIA is associated with well-documented transcriptional abnormalities in peripheral blood cells. The abnormalities can be observed in neutrophils, peripheral blood…
Abstract Number: 2418 • 2016 ACR/ARHP Annual Meeting
Rnaseq Reveals Treatment-Associated Gene Expression Dynamics in Juvenile Idiopathic Arthritis CD4+ T Cells
Kaiyu Jiang¹, Lai Ping Wong¹, Yanmin Chen¹ and James Jarvis², ¹Pediatrics, University at Buffalo, Buffalo, NY, ²Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY
Background/Purpose: While the field of pediatric rheumatology has made enviable strides in improving the lives of children with juvenile idiopathic arthritis (JIA), there is still…
Abstract Number: 3108 • 2016 ACR/ARHP Annual Meeting
Citrullinated Aggrecan Peptides Are Targets of Auto-Reactive CD4+ T-Cells in Rheumatoid Arthritis
Hannes Uchtenhagen¹, Cliff Rims¹, Eddie James² and Jane H. Buckner², ¹Translational Research, Benaroya Research Institute at Virginia Mason, Seattle, WA, ²Benaroya Research Institute at Virginia Mason, Seattle, WA
Background/Purpose: T-cell frequencies against citrullinated epitopes derived from major auto-antibody targets (vimentin, fibrinogen, α-enolase) are increased in rheumatoid arthritis (RA). Emerging serologic data suggests antibody reactivity…
Abstract Number: 1255 • 2015 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Patterns in CD4+ T Reveal Significant Contribution of DNA Methylation to Rheumatoid Arthritis
Shicheng Guo^1,2, Ting Jiang^1,2, Rongsheng Wang^1,2, Yi Shen^1,2, Xiao Zhu³, Fengmin Bai^1,2, Qin Ding^1,2, Guangjie Chen⁴ and Dongyi He^1,2, ¹Department of Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, China, ²Arthritis Institute of integrated Traditional and Western medicine, Shanghai Chinese Medicine Research Institute, Shanghai, China, ³Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Guangzhou, China, ⁴Department of Immunology and Microbiology, Shanghai JiaoTong University School of Medicine, Shanghai, China
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Recent evidence showed more and more importance of the epigenetic…
Abstract Number: 1940 • 2015 ACR/ARHP Annual Meeting
A Circulating Reservoir of Pathogenic-like CD4+ T Cells Shares a Genetic and Phenotypic Signature with the Inflamed Synovial Micro-Environment
Roberto Spreafico^1,2, Maura Rossetti^1,2, Jorg van Loosdregt¹, Carol A. Wallace³, Margherita Massa⁴, Silvia Magni-Manzoni⁵, Marco Gattorno⁶, Alberto Martini⁷, Daniel Lovell^8,9 and Salvatore Albani^2,10, ¹Sanford-Burnham Medical Research Institute, La Jolla, CA, ²SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ³Seattle Children’s Hospital and Research Institute, Seattle, WA, ⁴Lab Biotecnologie, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, ⁵Pediatric Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ⁶Instituto Giannina Gaslini and University of Genova, Genova, Italy, ⁷Istituto G. Gaslini, Universita' di Genova, Genova, Italy, ⁸Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁰Duke-National University of Singapore Graduate Medical School, Singapore, Singapore
Background/Purpose: Systemic immunological processes are profoundly shaped by the micro-environments where antigen recognition occurs. Identifying molecular signatures distinctive of such processes is pivotal to understand…
Abstract Number: 2410 • 2013 ACR/ARHP Annual Meeting
Effects Of Leptin and Adiponectin On Proliferation and Activation Were Are Significantly Increased In CD4⁺ T Cells From Rheumatoid Arthritis Patients
Daniel Xibille-Friedmann¹, Carolina Bustos-Rivera Bahena², Marisol Sandoval-Rios³ and Jose Luis Montiel-Hernandez³, ¹Rheumatology, Hospital General de Cuernavaca, Cuernavaca, Mexico, ²Universidad Autonoma del Estado de Morelos, Facultad de Ciencias, Cuernavaca, Mexico, ³Universidad Autonoma del Estado de Morelos, Facultad de Farmacia, Cuernavaca, Mexico
Background/Purpose: In vitro and in vivo studies suggest that leptin and adiponectin are involved in the development of inflammation in RA patients. Previous findings by…
Abstract Number: 2356 • 2013 ACR/ARHP Annual Meeting
Soluble Interleukin-2 Receptor Levels and The CD4/CD8 Ratio As Predictors Of The Efficacy Of Abatacept In Biologics-naïve Rheumatoid Arthritis Patients
Hajime Sano¹, Masahiro Sekiguchi¹, Masayasu Kitano¹, Naoto Azuma¹, Shinichiro Tsunoda¹, Kiyoshi Matsui¹ and Tsuyoshi Iwasaki², ¹Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya-city, Japan, ²Department of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan
Background/Purpose: Abatacept (ABT) is a recombinant fusion protein consisting of the extracellular domain of human CTLA-4, binding to CD80/86 on antigen presenting cells and thereby…
Abstract Number: 2301 • 2013 ACR/ARHP Annual Meeting
T Cell Proliferative Response To Type II Collagen In Patients With Rheumatoid Arthritis
Nida Saleem¹, Tahir Aziz Ahmed², Javaid Mahmood Malik³, Mushtaq Ahmed⁴ and Mukarram Bashir⁵, ¹IMMUNOLOGY, Armed Forces Institute Of Pathology, RAWALPINDI, Pakistan, ²Dept of Immunology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, ³Rahmat Noor Clinic and Arthritis Research Centre, Rawalpindi, Pakistan, ⁴Medicine, Military Hospital Rawalpindi, rawalpindi, Pakistan, ⁵IMMUNOLOGY, Armed Forces Institute Of Pathology, rawalpindi, Pakistan
Background/Purpose: To compare the frequency of Collagen II reactive T cells in RA patients and healthy control and evaluating the relationship of Collagen II reactive…
Abstract Number: 492 • 2013 ACR/ARHP Annual Meeting
Distinction Between Glucocorticoid-Responders and Non-Responders In Rheumatoid Arthritis: A New Role For Endoplasmic Reticulum Aminopeptidase 2
Ruth Fritsch-Stork¹, Sandra Cardoso¹, Jasper Broen¹, Marian Groot-Koerkamp², Arno Concepcion¹, Floris Lafeber¹ and Johannes W.J. Bijlsma¹, ¹Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Molecular Cancer Research, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Glucocorticoids (GC) have been a cornerstone of Rheumatoid arthritis (RA)-therapy for the last decades. However, about a third of RA-patients do not respond adequately.…
Abstract Number: 2602 • 2013 ACR/ARHP Annual Meeting
Reduced Frequencies Of Circulating CD8 T Cells In Early Diffuse Cutaneous Systemic Sclerosis Is Associated With Worse Skin Scores
Marie Hudson¹, Maximilien Lora², Christopher Di Ioia³, Solene Tatibouet⁴, Sasha Bernatsky⁵ and Ines Colmegna⁶, ¹Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ²Rheumatology, McGill University Health Centre, Montréal, QC, Canada, ³McGill University, Montreal, QC, Canada, ⁴Jewish General Hospital, McGill University, Montreal, QC, Canada, ⁵Division of Clinical Epidemiology, McGill University Health Center, Montreal, QC, Canada, ⁶Rheumatology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Diffuse cutaneous systemic sclerosis (dcSSc) is associated with significant morbidity and mortality. Measurement of skin thickness (modified Rodnan skin score (mRss)) is a surrogate…

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