Abstracts tagged "cartilage"

Abstract Number: 310 • 2016 ACR/ARHP Annual Meeting
A Novel One Stage Technique Applicable during Arthroscopy for the Mobilization of Synovial Mesenchymal Stromal Cells Towards Joint Regeneration
Alam Khalil-Khan¹, Thomas Baboolal², Elena Jones³, Owen Wall⁴ and Dennis McGonagle³, ¹Faculty of Medicine, Leeds institute of Rheumatic and Musculoskeletal Medicine,, Leeds, United Kingdom, ²PhD, Leeds, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Orthopaedic Surgery, Department of Trauma and Orthopaedics, Leeds, United Kingdom
Background/Purpose: , The discovery of MSCs in the synovium and synovial fluid (SF) provided a potential mechanism for repairing cartilage “from the top down”. Indeed,…
Abstract Number: 1107 • 2016 ACR/ARHP Annual Meeting
Combining Scaffold-Free Cartilage Transplants to Controlled Gene Expression for Therapeutic Application in Rheumatic Disorders
Johannes Neuhaus^1,2, Igor Ponomarev³, Frank Buttgereit^1,2, Timo Gaber^1,2 and Annemarie Lang^1,2,4, ¹Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, ²German Rheumatism Research Center (DRFZ), Berlin, Germany, ³Research Center of Medical Technology and Biotechnology, Bad Langensalza, Germany, ⁴Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany
Background/Purpose: Cartilage destruction is accompanied by a tremendous loss of life quality due to deprivation of agility, flexibility and pain. Additionally, increased catabolic mediators such…
Abstract Number: 1126 • 2016 ACR/ARHP Annual Meeting
Interleukin-1 Is Not Involved in Synovial Inflammation and Cartilage Destruction in Collagenase-Induced Osteoarthritis
Stephanie van Dalen¹, Arjen Blom¹, Annet Sloetjes¹, Monique M. Helsen¹, Johannes Roth², Thomas Vogl², Wim B. van den Berg¹, Martijn van den Bosch¹ and Peter L. E. M. van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Institute of Immunology, University of Münster, Münster, Germany
Background/Purpose: Osteoarthritis (OA) is characterized by severe cartilage destruction, with a putative role for synovial macrophages. Up to 50% of the patients also show low…
Abstract Number: 1128 • 2016 ACR/ARHP Annual Meeting
Anti-Fractalkine Monoclonal Antibody Inhibits Cartilage Destruction and Bone Erosion in Collagen-Induced Arthritis Model
Kana Hoshino¹, Masayoshi Ohkuro², Wataru Ikeda¹, Tomoya Nakatani¹, Yoshikazu Kuboi³, Naoto Ishii¹, Toshihiko Yamauchi¹, Nobuyuki Yasuda¹ and Toshio Imai¹, ¹KAN Research Institute Inc., Chuo-ku, Kobe-shi, Japan, ²Research Project Promotion Group, EA Pharma Co., Ltd., Kawasaki-ku, Kawasaki-shi, Japan, ³Medicine Creation. Neuro Business Group, Eisai Co., Ltd., Tsukuba-shi, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. In the previous Phase 1/2 clinical study, E6011, a novel humanized anti-fractalkine (FKN)…
Abstract Number: 1203 • 2016 ACR/ARHP Annual Meeting
Differential Synovial Expression Patterns in Early Osteoarthritis Predict Pain and Progression of Joint Damage
Arjen B. Blom¹, Martijn H. van den Bosch¹, Hans Cats², F van den Hoogen³, Floris PJ Lafeber⁴, Wim B. van den Berg¹, Peter L. van Lent¹ and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Hengstdal 3, Sint Maartenskliniek, Ubbergen, Netherlands, ³Rheumatology, Radboud UMC, Nijmegen, Netherlands, ⁴Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: The cause for chronic pain in OA is largely unknown. Over 50% of osteoarthritis (OA) patients show synovial inflammation, even at early stages of…
Abstract Number: 2121 • 2016 ACR/ARHP Annual Meeting
Identification of microRNA-181a-5p and microRNA-4454 As Mediators of Facet Cartilage Degeneration
Akihiro Nakamura^1,2, Y. Raja Rampersaud^3,4, Anirudh Sharma^1,2, Stephen J. Lewis^3,5, Brian Wu^1,2, Poulami Datta^1,2, Kala Sundararajan⁶, Helal Endisha^1,2, Evgeny Rossomacha^1,2, Jason S Rockel^1,2, Igor Jurisica⁷ and Mohit kapoor^1,2,8, ¹Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Arthritis Program, University Health Netwok, Toronto, ON, Canada, ³Orthopaedic Surgery and Neurosurgery, Arthritis Program, University Health Network, Toronto, ON, Canada, ⁴Orthopaedics, Toronto Western Hospital, Toronto, ON, Canada, ⁵Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, ON, Canada, ⁶Orthopaedic Research Department, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁷Medical Biophysics and Computer Science, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, ⁸Surgery, Laboratory Medicine, and Pathobiology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Osteoarthritis (OA) of spine (facet joints, FJ) is one of the major causes of severe low back pain and disability worldwide. However, specific mechanisms…
Abstract Number: 2124 • 2016 ACR/ARHP Annual Meeting
Maintenance of Chondrocyte Phenotypic Stability By TRPC6 Calcium Channel Activity
Joanna Sherwood¹, Jessica Bertrand², Francesco Dell'Accio³ and Thomas Pap⁴, ¹Institute for Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ²Department of Orthopedic Surgery, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany, ³William Harvey Research Institute,, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁴Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: The ELR+ CXC chemokine CXCL6 is produced by healthy articular chondrocytes and retained within the cartilage matrix via interactions with heparan sulphate proteoglycans. There,…
Abstract Number: 2125 • 2016 ACR/ARHP Annual Meeting
Aggrecan Degradation Is Not Just Aggrecan Degradation:a Study of the Neo-Epitopes Tege and Args Released from Cartilage upon Aggrecanase Activity
Anne Sofie Siebuhr¹, Yi He², Yunyun Lou², Sabine Hoielt³, Morten Asser Karsdal¹ and Anne C. Bay-Jensen¹, ¹Rheumatology, Nordic Bioscience, Herlev, Denmark, ²Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Rheumatology, Nordic Bioscience, Biomarkers and Research, 2730, Denmark
Background/Purpose: Cartilage degradation is a hallmark of arthritic disease. The main constituents of cartilage is aggrecan and type II collagen. Previous studies have shown that…
Abstract Number: 2126 • 2016 ACR/ARHP Annual Meeting
Cytokine Dependent Effects of Anti-Inflammatory Inhibitors Targeting JAK and p38 on Cartilage Turnover
Christian S. Thudium¹, Cecilie F. Kjelgaard-Petersen^1,2, Britt Christensen¹, Morten Asser Karsdal³ and Anne C. Bay-Jensen³, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark, ³Rheumatology, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Rheumatoid arthritis (RA) and inflammatory subtypes of osteoarthritis (iOA) are degenerative joint diseases with an inflammatory component allowing for potential anti-inflammatory treatment benefit. A…
Abstract Number: 2129 • 2016 ACR/ARHP Annual Meeting
Extracellular Adenosine Deficiency Plays a Role in the Pathogenesis of Osteoarthritis (OA) and Adenosine Replacement Prevents Post-Traumatic Osteoarthritis
Carmen Corciulo¹, Matin Lendhey², Tuere Wilder¹, Oran Kennedy² and Bruce Cronstein³, ¹Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Orthopaedic Surgery, NYU-School of Medicine, New York, NY, ³Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Extracellular adenosine is highly regulated and plays an important homeostatic role via occupancy of cell surface receptors (A1R, A2AR, A2BR, A3R). Mice lacking A2AR…
Abstract Number: 2130 • 2016 ACR/ARHP Annual Meeting
Unloading Results in Rapid Loss of TGFβ Signaling in Cartilage: Role of Loading-Induced TGF-Β Signaling in Maintenance of Articular Chondrocyte Phenotype?
Arjan van Caam¹, Wojciech Madej², Esmeralda Blaney Davidson¹, Pieter Buma² and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Orthopaedic Research Lab, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Absence of joint loading leads to cartilage atrophy and degeneration for unknown reason. We hypothesized that in vivo chondrocytes are exposed to permanent, loading…
Abstract Number: 2131 • 2016 ACR/ARHP Annual Meeting
Transient Receptor Potential Ankyrin 1 (TRPA1) Is Functionally Expressed in Primary Human Osteoarthritic Chondrocytes and Mediates Cartilage Destruction and Joint Pain in the Mia-Model of Osteoarthritis
Elina Nummenmaa¹, Lauri J Moilanen¹, Mari Hämäläinen¹, Erja-Leena Paukkeri¹, Riina Nieminen¹, Teemu Moilanen², Katriina Vuolteenaho¹ and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: Transient receptor potential ankyrin 1 (TRPA1) is a membrane associated cation channel, which is widely expressed in neuronal cells and known to be involved…
Abstract Number: 2133 • 2016 ACR/ARHP Annual Meeting
Simulation of Cartilage Damage in Osteoarthritis Using Patient-Derived Induced Pluripotent Stem Cells
Seung Min Jung¹, Yoojun Nam², Yeri Alice Rim², Yong-Beom Park¹, Seung-Ki Kwok³, Sung-Hwan Park⁴ and Ji Hyeon Ju⁵, ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ³[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine,, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease, leading to pain and functional limitation. Although OA is a most common form of musculoskeletal disease, the…
Abstract Number: 170 • 2015 ACR/ARHP Annual Meeting
Relationship Between Finger Joint Cartilage Evaluated By Ultrasound and Clinical Characteristics in Rheumatoid Arthritis (RA)
Takehisa Ogura¹, Ayako Hirata¹, Hideki Ito², Sayaka Takenaka², Kennosuke Mizushina¹, Yuki Fujisawa¹, Naoko Yamashita¹, Munetugu Imamura², Norihide Hayashi² and Hideto Kameda¹, ¹Department of Rheumatology, Toho University Ohashi Medical Center, Tokyo, Japan, ²Toho University Ohashi Medical Center, Tokyo, Japan
Background/Purpose: Joint destruction is the primary lesion by bone and cartilage damage in RA. By X-ray examination, cartilage destruction is evaluated as a joint space…
Abstract Number: 2722 • 2015 ACR/ARHP Annual Meeting
Cyclic Phosphatidic Acid (CPA) Suppresses Expression of Cartilage Degrading Enzymes Such As MMP-3, MMP-13 and Adamts-4 in Inflammatory Synovial Fibroblasts and Articular Chondrocytes Induced By IL-1 Beta and/or TNF ALFA
Ikuko Masuda^1,2, Kodo Okada³, Hisashi Yamanaka¹ and Shigeki Momohara¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Rheumatology, Jyujyo Takeda Rehabilitation Hospital, Kyoto, Japan, ³SANSHO, Co. Ltd., Tokyo, Japan
Background/Purpose: Cyclic phosphatidic acid (cPA) is one of bioactive lipid, has been implicated as an mediator of various biological effects including inhibitory effects of proliferation,…

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