Abstracts tagged "cartilage"

Abstract Number: 2134 • 2016 ACR/ARHP Annual Meeting
Bone Replaces Cartilage in Non-Weight Bearing Regions of Immobilized Knees
T Mark Campbell¹, Katherine Reilly², Odette Laneuville³, Hans Uhthoff⁴ and Guy Trudel⁵, ¹Physical Medicine and Rehabilitation, Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa, ON, Canada, ³Biology, University of Ottawa, Ottawa, ON, Canada, ⁴Surgery, The Ottawa Hospital, Ottawa, ON, Canada, ⁵Medicine, The Ottawa Hospital Rehabilitation Centre, Ottawa, ON, Canada
Bone Replaces Cartilage In Non-Weight Bearing Regions Of Immobilized KneesBackground/Purpose: Osteoarthritis causes pain, restricts joint range of motion, reduces function, is highly prevalent worldwide and…
Abstract Number: 139 • 2016 ACR/ARHP Annual Meeting
Reliability of Ultrasound in Detecting Cartilage Change in Patients with Rheumatoid Arthritis: A Study By Omeract Ultrasound Task Force
Peter Mandl¹, Emilio Filippucci², Farideh Alasti¹, Artur Bachta³, Marina Backhaus⁴, David Bong⁵, George A. W. Bruyn⁶, Paz Collado⁷, Nemanja Damjanov⁸, Christian Dejaco⁹, Andrea Delle Sedie¹⁰, Christina Duftner¹¹, Marwin Gutierrez¹², Hilde B. Hammer¹³, Cristina Hernandez-Diaz¹⁴, Annamaria Iagnocco¹⁵, Kei Ikeda¹⁶, David Kane¹⁷, Helen I. Keen¹⁸, Stephen Kelly¹⁹, Eszter Kővári²⁰, Eugenio De Miguel²¹, Ingrid Möller²², Uffe Møller Døhn²³, Esperanza Naredo²⁴, Juan Carlos Nieto²⁵, Carlos Pineda²⁶, Ana Rodriguez²⁷, Wolfgang A. Schmidt²⁸, Marcin Szkudlarek²⁹, Ralf G. Thiele³⁰, Lene Terslev³¹, Richard J. Wakefield³², Daniel Windschall³³, Maria Antonietta D'Agostino³⁴ and Peter Balint³⁵, ¹Department of Internal Medicine III; Division of Rheumatology, Medical University Vienna, Vienna, Austria, ²Università Politecnica delle Marche, Jesi, Italy, ³Military Medical Institute, Warsaw, Poland, ⁴Rheumatology, Park-Klinik Weissensee, Berlin, Germany, ⁵Rheumatology, Instituto Poal de Reumatologia, Barcelona, Spain, ⁶Rheumatology, MC Groep, Loenga, Netherlands, ⁷Rheumatology, Pediatric Rheumatology Unit, Hospital Universitario Severo Ochoa, Madrid, Spain, ⁸Institute of Rheumatology, University of Belgrade Medical School, Belgrade, Serbia, ⁹Rheumatology and Immunology, Medical University Graz, Graz, Austria, ¹⁰Department Rheumatology, University of Pisa, Pisa, Italy, ¹¹Medical University Innsbruck, Innsbruck, Austria, ¹²Instituto Nacional de Rehabilitación, Mexico, Mexico, ¹³Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway, ¹⁴Instituto Nacional de Rehabilitación, Mexico City, Mexico, ¹⁵Sapienza Università Di Roma,, Roma, Italy, ¹⁶Chiba University Hospital, Chiba, Japan, ¹⁷Rheumatology, Adelaide, Meath hospital Dublin (incorporating the National Children's hospital), Dublin 24, Ireland, ¹⁸School of Medicine and Pharmacology, University of Western Australia, Perth, Australia, ¹⁹18Mile End Hospital, Barts Health NHS Trust, London, United Kingdom, ²⁰III Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ²¹Hospital Universitario La Paz, Madrid, Spain, ²²Instituto Poal de Reumatologia, Barcelona, Spain, ²³Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Glostrup, Denmark, ²⁴Rheumatology, Hospital General Universitario Gregorio Marañón and Universidad Complutense, Madrid, Spain, ²⁵Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain, ²⁶Instituto Nacional de Rehabilitation, Mexico, Mexico, ²⁷Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, ²⁸Immanuel Krankenhaus Berlin, Med Ctr for Rheumatology Berlin-Buch, Berlin, Germany, ²⁹Copenhagen University Hospital at Køge, Køge, Denmark, ³⁰Medicine, University of Rochester Medical Center, Rochester, NY, ³¹Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, ³²University of Leeds, Leeds, United Kingdom, ³³Pediatric Clinic, Asklepios Hospital Weissenfels, Weissenfels, Germany, ³⁴Rheumatology, Versailles-Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ³⁵Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary
Background/Purpose: The assessment of cartilage and bone damage in rheumatoid arthritis (RA) has traditionally relied on radiographical analyses in which joint space loss served as…
Abstract Number: 2281 • 2016 ACR/ARHP Annual Meeting
Monosodium Urate Monohydrate (MSU) Crystals Induces Cartilage Degeneration By Accelerating Hypertrophy and Mineralization.
Nicole Yang¹, Anthony M. Reginato² and Changqi Sun³, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, ²Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ³Division of Rheumatology, Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI
Background/Purpose: Previous studies have shown that abnormal loads induce meniscus cell damage and matrix degradation both in-vivo and in-vitro1,2. Monosodium urate (MSU) crystal is considered…
Abstract Number: 306 • 2016 ACR/ARHP Annual Meeting
MRI-Detected Cartilage Damage, Meniscal Damage, and Meniscal Extrusion Prior to Incident Radiographic Osteoarthritis and the Subsequent Trajectory of Joint Space Loss
C. Kent Kwoh¹, Frank Roemer^2,3, Erin L. Ashbeck⁴, Charles Ratzlaff⁴, Jeffrey Duryea⁵ and Ali Guermazi⁶, ¹1501 N. Campbell Avenue, Room 8303, The University of Arizona Arthritis Center, Tucson, AZ, ²Department of Radiology, Boston University School of Medicine, Boston, MA, ³Radiology, University of Erlangen, Erlangen, Germany, ⁴The University of Arizona Arthritis Center, Tucson, AZ, ⁵Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ⁶Boston University School of Medicine, Boston, MA
Background/Purpose: Loss of joint space width (JSW) on x-ray is the recommended standard to define osteoarthritis progression. However, both cartilage and meniscal damage contribute to…
Abstract Number: 3053 • 2016 ACR/ARHP Annual Meeting
Cartilage Loss Primarily Occurs in the Most Affected Tibiofemoral Compartment with No Evidence of a Ceiling Effect Among Advanced-Stage Disease: A Two-Year Longitudinal Study of Data from the Osteoarthritis
Ming Zhang¹, Lori Lyn Price², Amanda R. Canavatchel¹, Jeffrey B. Driban³, Puwei Yuan⁴, Grace H. Lo⁵ and Timothy E. McAlindon⁶, ¹Tufts Medical Center, Boston, MA, ²Clinical Care Research, Tufts Medical Center, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA, ⁴the Fourth OA Department, Shaanxi University of Chinese Medicine, Xian Yang, China, ⁵Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁶Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Cartilage morphometry on magnetic resonance images (MRIs) is an important outcome measure for clinical trials among individuals with knee osteoarthritis (KOA). However, it remains…
Abstract Number: 310 • 2016 ACR/ARHP Annual Meeting
A Novel One Stage Technique Applicable during Arthroscopy for the Mobilization of Synovial Mesenchymal Stromal Cells Towards Joint Regeneration
Alam Khalil-Khan¹, Thomas Baboolal², Elena Jones³, Owen Wall⁴ and Dennis McGonagle³, ¹Faculty of Medicine, Leeds institute of Rheumatic and Musculoskeletal Medicine,, Leeds, United Kingdom, ²PhD, Leeds, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Orthopaedic Surgery, Department of Trauma and Orthopaedics, Leeds, United Kingdom
Background/Purpose: , The discovery of MSCs in the synovium and synovial fluid (SF) provided a potential mechanism for repairing cartilage “from the top down”. Indeed,…
Abstract Number: 1107 • 2016 ACR/ARHP Annual Meeting
Combining Scaffold-Free Cartilage Transplants to Controlled Gene Expression for Therapeutic Application in Rheumatic Disorders
Johannes Neuhaus^1,2, Igor Ponomarev³, Frank Buttgereit^1,2, Timo Gaber^1,2 and Annemarie Lang^1,2,4, ¹Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, ²German Rheumatism Research Center (DRFZ), Berlin, Germany, ³Research Center of Medical Technology and Biotechnology, Bad Langensalza, Germany, ⁴Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany
Background/Purpose: Cartilage destruction is accompanied by a tremendous loss of life quality due to deprivation of agility, flexibility and pain. Additionally, increased catabolic mediators such…
Abstract Number: 1126 • 2016 ACR/ARHP Annual Meeting
Interleukin-1 Is Not Involved in Synovial Inflammation and Cartilage Destruction in Collagenase-Induced Osteoarthritis
Stephanie van Dalen¹, Arjen Blom¹, Annet Sloetjes¹, Monique M. Helsen¹, Johannes Roth², Thomas Vogl², Wim B. van den Berg¹, Martijn van den Bosch¹ and Peter L. E. M. van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Institute of Immunology, University of Münster, Münster, Germany
Background/Purpose: Osteoarthritis (OA) is characterized by severe cartilage destruction, with a putative role for synovial macrophages. Up to 50% of the patients also show low…
Abstract Number: 1128 • 2016 ACR/ARHP Annual Meeting
Anti-Fractalkine Monoclonal Antibody Inhibits Cartilage Destruction and Bone Erosion in Collagen-Induced Arthritis Model
Kana Hoshino¹, Masayoshi Ohkuro², Wataru Ikeda¹, Tomoya Nakatani¹, Yoshikazu Kuboi³, Naoto Ishii¹, Toshihiko Yamauchi¹, Nobuyuki Yasuda¹ and Toshio Imai¹, ¹KAN Research Institute Inc., Chuo-ku, Kobe-shi, Japan, ²Research Project Promotion Group, EA Pharma Co., Ltd., Kawasaki-ku, Kawasaki-shi, Japan, ³Medicine Creation. Neuro Business Group, Eisai Co., Ltd., Tsukuba-shi, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. In the previous Phase 1/2 clinical study, E6011, a novel humanized anti-fractalkine (FKN)…
Abstract Number: 1203 • 2016 ACR/ARHP Annual Meeting
Differential Synovial Expression Patterns in Early Osteoarthritis Predict Pain and Progression of Joint Damage
Arjen B. Blom¹, Martijn H. van den Bosch¹, Hans Cats², F van den Hoogen³, Floris PJ Lafeber⁴, Wim B. van den Berg¹, Peter L. van Lent¹ and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Hengstdal 3, Sint Maartenskliniek, Ubbergen, Netherlands, ³Rheumatology, Radboud UMC, Nijmegen, Netherlands, ⁴Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: The cause for chronic pain in OA is largely unknown. Over 50% of osteoarthritis (OA) patients show synovial inflammation, even at early stages of…
Abstract Number: 2121 • 2016 ACR/ARHP Annual Meeting
Identification of microRNA-181a-5p and microRNA-4454 As Mediators of Facet Cartilage Degeneration
Akihiro Nakamura^1,2, Y. Raja Rampersaud^3,4, Anirudh Sharma^1,2, Stephen J. Lewis^3,5, Brian Wu^1,2, Poulami Datta^1,2, Kala Sundararajan⁶, Helal Endisha^1,2, Evgeny Rossomacha^1,2, Jason S Rockel^1,2, Igor Jurisica⁷ and Mohit kapoor^1,2,8, ¹Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Arthritis Program, University Health Netwok, Toronto, ON, Canada, ³Orthopaedic Surgery and Neurosurgery, Arthritis Program, University Health Network, Toronto, ON, Canada, ⁴Orthopaedics, Toronto Western Hospital, Toronto, ON, Canada, ⁵Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, ON, Canada, ⁶Orthopaedic Research Department, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁷Medical Biophysics and Computer Science, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, ⁸Surgery, Laboratory Medicine, and Pathobiology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Osteoarthritis (OA) of spine (facet joints, FJ) is one of the major causes of severe low back pain and disability worldwide. However, specific mechanisms…
Abstract Number: 2124 • 2016 ACR/ARHP Annual Meeting
Maintenance of Chondrocyte Phenotypic Stability By TRPC6 Calcium Channel Activity
Joanna Sherwood¹, Jessica Bertrand², Francesco Dell'Accio³ and Thomas Pap⁴, ¹Institute for Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ²Department of Orthopedic Surgery, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany, ³William Harvey Research Institute,, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁴Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: The ELR+ CXC chemokine CXCL6 is produced by healthy articular chondrocytes and retained within the cartilage matrix via interactions with heparan sulphate proteoglycans. There,…
Abstract Number: 2125 • 2016 ACR/ARHP Annual Meeting
Aggrecan Degradation Is Not Just Aggrecan Degradation:a Study of the Neo-Epitopes Tege and Args Released from Cartilage upon Aggrecanase Activity
Anne Sofie Siebuhr¹, Yi He², Yunyun Lou², Sabine Hoielt³, Morten Asser Karsdal¹ and Anne C. Bay-Jensen¹, ¹Rheumatology, Nordic Bioscience, Herlev, Denmark, ²Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Rheumatology, Nordic Bioscience, Biomarkers and Research, 2730, Denmark
Background/Purpose: Cartilage degradation is a hallmark of arthritic disease. The main constituents of cartilage is aggrecan and type II collagen. Previous studies have shown that…
Abstract Number: 2126 • 2016 ACR/ARHP Annual Meeting
Cytokine Dependent Effects of Anti-Inflammatory Inhibitors Targeting JAK and p38 on Cartilage Turnover
Christian S. Thudium¹, Cecilie F. Kjelgaard-Petersen^1,2, Britt Christensen¹, Morten Asser Karsdal³ and Anne C. Bay-Jensen³, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark, ³Rheumatology, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Rheumatoid arthritis (RA) and inflammatory subtypes of osteoarthritis (iOA) are degenerative joint diseases with an inflammatory component allowing for potential anti-inflammatory treatment benefit. A…
Abstract Number: 1312 • 2015 ACR/ARHP Annual Meeting
Radiocarpal Cartilage Matrix Changes 3-Months after Anti-TNF Treatment for Rheumatoid Arthritis – Feasibility Study Using MR T1ρ� Imaging
Eric Ku¹, Valentina Pedoia², Matthew Tanaka³, Ursula Heilmeier¹, John Imboden⁴, Jonathan D. Graf⁵, Thomas M. Link⁶ and Xiaojuan Li⁷, ¹Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ²Department of Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, ³University of California Berkeley, Berkeley, CA, ⁴Rheumatology, Rheumatology, University of California San Francisco, San Francisco, CA, ⁵Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁶Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁷Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA
Background/Purpose: Standard assessment of Rheumatoid Arthritis (RA) on MRI relies on semi-quantitative joint space narrowing scores that are not sensitive to cartilage focal lesions or…

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