Abstracts tagged "cartilage"

Abstract Number: 2121 • 2016 ACR/ARHP Annual Meeting
Identification of microRNA-181a-5p and microRNA-4454 As Mediators of Facet Cartilage Degeneration
Akihiro Nakamura^1,2, Y. Raja Rampersaud^3,4, Anirudh Sharma^1,2, Stephen J. Lewis^3,5, Brian Wu^1,2, Poulami Datta^1,2, Kala Sundararajan⁶, Helal Endisha^1,2, Evgeny Rossomacha^1,2, Jason S Rockel^1,2, Igor Jurisica⁷ and Mohit kapoor^1,2,8, ¹Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Arthritis Program, University Health Netwok, Toronto, ON, Canada, ³Orthopaedic Surgery and Neurosurgery, Arthritis Program, University Health Network, Toronto, ON, Canada, ⁴Orthopaedics, Toronto Western Hospital, Toronto, ON, Canada, ⁵Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, Toronto, ON, Canada, ⁶Orthopaedic Research Department, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁷Medical Biophysics and Computer Science, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, ⁸Surgery, Laboratory Medicine, and Pathobiology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Osteoarthritis (OA) of spine (facet joints, FJ) is one of the major causes of severe low back pain and disability worldwide. However, specific mechanisms…
Abstract Number: 2124 • 2016 ACR/ARHP Annual Meeting
Maintenance of Chondrocyte Phenotypic Stability By TRPC6 Calcium Channel Activity
Joanna Sherwood¹, Jessica Bertrand², Francesco Dell'Accio³ and Thomas Pap⁴, ¹Institute for Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ²Department of Orthopedic Surgery, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany, ³William Harvey Research Institute,, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁴Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: The ELR+ CXC chemokine CXCL6 is produced by healthy articular chondrocytes and retained within the cartilage matrix via interactions with heparan sulphate proteoglycans. There,…
Abstract Number: 2125 • 2016 ACR/ARHP Annual Meeting
Aggrecan Degradation Is Not Just Aggrecan Degradation:a Study of the Neo-Epitopes Tege and Args Released from Cartilage upon Aggrecanase Activity
Anne Sofie Siebuhr¹, Yi He², Yunyun Lou², Sabine Hoielt³, Morten Asser Karsdal¹ and Anne C. Bay-Jensen¹, ¹Rheumatology, Nordic Bioscience, Herlev, Denmark, ²Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Rheumatology, Nordic Bioscience, Biomarkers and Research, 2730, Denmark
Background/Purpose: Cartilage degradation is a hallmark of arthritic disease. The main constituents of cartilage is aggrecan and type II collagen. Previous studies have shown that…
Abstract Number: 2126 • 2016 ACR/ARHP Annual Meeting
Cytokine Dependent Effects of Anti-Inflammatory Inhibitors Targeting JAK and p38 on Cartilage Turnover
Christian S. Thudium¹, Cecilie F. Kjelgaard-Petersen^1,2, Britt Christensen¹, Morten Asser Karsdal³ and Anne C. Bay-Jensen³, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark, ³Rheumatology, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Rheumatoid arthritis (RA) and inflammatory subtypes of osteoarthritis (iOA) are degenerative joint diseases with an inflammatory component allowing for potential anti-inflammatory treatment benefit. A…
Abstract Number: 2129 • 2016 ACR/ARHP Annual Meeting
Extracellular Adenosine Deficiency Plays a Role in the Pathogenesis of Osteoarthritis (OA) and Adenosine Replacement Prevents Post-Traumatic Osteoarthritis
Carmen Corciulo¹, Matin Lendhey², Tuere Wilder¹, Oran Kennedy² and Bruce Cronstein³, ¹Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Orthopaedic Surgery, NYU-School of Medicine, New York, NY, ³Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Extracellular adenosine is highly regulated and plays an important homeostatic role via occupancy of cell surface receptors (A1R, A2AR, A2BR, A3R). Mice lacking A2AR…
Abstract Number: 2130 • 2016 ACR/ARHP Annual Meeting
Unloading Results in Rapid Loss of TGFβ Signaling in Cartilage: Role of Loading-Induced TGF-Β Signaling in Maintenance of Articular Chondrocyte Phenotype?
Arjan van Caam¹, Wojciech Madej², Esmeralda Blaney Davidson¹, Pieter Buma² and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Orthopaedic Research Lab, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Absence of joint loading leads to cartilage atrophy and degeneration for unknown reason. We hypothesized that in vivo chondrocytes are exposed to permanent, loading…
Abstract Number: 2131 • 2016 ACR/ARHP Annual Meeting
Transient Receptor Potential Ankyrin 1 (TRPA1) Is Functionally Expressed in Primary Human Osteoarthritic Chondrocytes and Mediates Cartilage Destruction and Joint Pain in the Mia-Model of Osteoarthritis
Elina Nummenmaa¹, Lauri J Moilanen¹, Mari Hämäläinen¹, Erja-Leena Paukkeri¹, Riina Nieminen¹, Teemu Moilanen², Katriina Vuolteenaho¹ and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: Transient receptor potential ankyrin 1 (TRPA1) is a membrane associated cation channel, which is widely expressed in neuronal cells and known to be involved…
Abstract Number: 2133 • 2016 ACR/ARHP Annual Meeting
Simulation of Cartilage Damage in Osteoarthritis Using Patient-Derived Induced Pluripotent Stem Cells
Seung Min Jung¹, Yoojun Nam², Yeri Alice Rim², Yong-Beom Park¹, Seung-Ki Kwok³, Sung-Hwan Park⁴ and Ji Hyeon Ju⁵, ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ³[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine,, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease, leading to pain and functional limitation. Although OA is a most common form of musculoskeletal disease, the…
Abstract Number: 2134 • 2016 ACR/ARHP Annual Meeting
Bone Replaces Cartilage in Non-Weight Bearing Regions of Immobilized Knees
T Mark Campbell¹, Katherine Reilly², Odette Laneuville³, Hans Uhthoff⁴ and Guy Trudel⁵, ¹Physical Medicine and Rehabilitation, Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa, ON, Canada, ³Biology, University of Ottawa, Ottawa, ON, Canada, ⁴Surgery, The Ottawa Hospital, Ottawa, ON, Canada, ⁵Medicine, The Ottawa Hospital Rehabilitation Centre, Ottawa, ON, Canada
Bone Replaces Cartilage In Non-Weight Bearing Regions Of Immobilized KneesBackground/Purpose: Osteoarthritis causes pain, restricts joint range of motion, reduces function, is highly prevalent worldwide and…
Abstract Number: 139 • 2016 ACR/ARHP Annual Meeting
Reliability of Ultrasound in Detecting Cartilage Change in Patients with Rheumatoid Arthritis: A Study By Omeract Ultrasound Task Force
Peter Mandl¹, Emilio Filippucci², Farideh Alasti¹, Artur Bachta³, Marina Backhaus⁴, David Bong⁵, George A. W. Bruyn⁶, Paz Collado⁷, Nemanja Damjanov⁸, Christian Dejaco⁹, Andrea Delle Sedie¹⁰, Christina Duftner¹¹, Marwin Gutierrez¹², Hilde B. Hammer¹³, Cristina Hernandez-Diaz¹⁴, Annamaria Iagnocco¹⁵, Kei Ikeda¹⁶, David Kane¹⁷, Helen I. Keen¹⁸, Stephen Kelly¹⁹, Eszter Kővári²⁰, Eugenio De Miguel²¹, Ingrid Möller²², Uffe Møller Døhn²³, Esperanza Naredo²⁴, Juan Carlos Nieto²⁵, Carlos Pineda²⁶, Ana Rodriguez²⁷, Wolfgang A. Schmidt²⁸, Marcin Szkudlarek²⁹, Ralf G. Thiele³⁰, Lene Terslev³¹, Richard J. Wakefield³², Daniel Windschall³³, Maria Antonietta D'Agostino³⁴ and Peter Balint³⁵, ¹Department of Internal Medicine III; Division of Rheumatology, Medical University Vienna, Vienna, Austria, ²Università Politecnica delle Marche, Jesi, Italy, ³Military Medical Institute, Warsaw, Poland, ⁴Rheumatology, Park-Klinik Weissensee, Berlin, Germany, ⁵Rheumatology, Instituto Poal de Reumatologia, Barcelona, Spain, ⁶Rheumatology, MC Groep, Loenga, Netherlands, ⁷Rheumatology, Pediatric Rheumatology Unit, Hospital Universitario Severo Ochoa, Madrid, Spain, ⁸Institute of Rheumatology, University of Belgrade Medical School, Belgrade, Serbia, ⁹Rheumatology and Immunology, Medical University Graz, Graz, Austria, ¹⁰Department Rheumatology, University of Pisa, Pisa, Italy, ¹¹Medical University Innsbruck, Innsbruck, Austria, ¹²Instituto Nacional de Rehabilitación, Mexico, Mexico, ¹³Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway, ¹⁴Instituto Nacional de Rehabilitación, Mexico City, Mexico, ¹⁵Sapienza Università Di Roma,, Roma, Italy, ¹⁶Chiba University Hospital, Chiba, Japan, ¹⁷Rheumatology, Adelaide, Meath hospital Dublin (incorporating the National Children's hospital), Dublin 24, Ireland, ¹⁸School of Medicine and Pharmacology, University of Western Australia, Perth, Australia, ¹⁹18Mile End Hospital, Barts Health NHS Trust, London, United Kingdom, ²⁰III Department of Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ²¹Hospital Universitario La Paz, Madrid, Spain, ²²Instituto Poal de Reumatologia, Barcelona, Spain, ²³Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Glostrup, Denmark, ²⁴Rheumatology, Hospital General Universitario Gregorio Marañón and Universidad Complutense, Madrid, Spain, ²⁵Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Spain, ²⁶Instituto Nacional de Rehabilitation, Mexico, Mexico, ²⁷Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, ²⁸Immanuel Krankenhaus Berlin, Med Ctr for Rheumatology Berlin-Buch, Berlin, Germany, ²⁹Copenhagen University Hospital at Køge, Køge, Denmark, ³⁰Medicine, University of Rochester Medical Center, Rochester, NY, ³¹Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, ³²University of Leeds, Leeds, United Kingdom, ³³Pediatric Clinic, Asklepios Hospital Weissenfels, Weissenfels, Germany, ³⁴Rheumatology, Versailles-Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ³⁵Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary
Background/Purpose: The assessment of cartilage and bone damage in rheumatoid arthritis (RA) has traditionally relied on radiographical analyses in which joint space loss served as…
Abstract Number: 2281 • 2016 ACR/ARHP Annual Meeting
Monosodium Urate Monohydrate (MSU) Crystals Induces Cartilage Degeneration By Accelerating Hypertrophy and Mineralization.
Nicole Yang¹, Anthony M. Reginato² and Changqi Sun³, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, USA., Boston, MA, ²Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI, ³Division of Rheumatology, Rhode Island Hospital, The Warren Alpert School of Medicine at Brown University, Providence, RI
Background/Purpose: Previous studies have shown that abnormal loads induce meniscus cell damage and matrix degradation both in-vivo and in-vitro1,2. Monosodium urate (MSU) crystal is considered…
Abstract Number: 306 • 2016 ACR/ARHP Annual Meeting
MRI-Detected Cartilage Damage, Meniscal Damage, and Meniscal Extrusion Prior to Incident Radiographic Osteoarthritis and the Subsequent Trajectory of Joint Space Loss
C. Kent Kwoh¹, Frank Roemer^2,3, Erin L. Ashbeck⁴, Charles Ratzlaff⁴, Jeffrey Duryea⁵ and Ali Guermazi⁶, ¹1501 N. Campbell Avenue, Room 8303, The University of Arizona Arthritis Center, Tucson, AZ, ²Department of Radiology, Boston University School of Medicine, Boston, MA, ³Radiology, University of Erlangen, Erlangen, Germany, ⁴The University of Arizona Arthritis Center, Tucson, AZ, ⁵Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ⁶Boston University School of Medicine, Boston, MA
Background/Purpose: Loss of joint space width (JSW) on x-ray is the recommended standard to define osteoarthritis progression. However, both cartilage and meniscal damage contribute to…
Abstract Number: 3053 • 2016 ACR/ARHP Annual Meeting
Cartilage Loss Primarily Occurs in the Most Affected Tibiofemoral Compartment with No Evidence of a Ceiling Effect Among Advanced-Stage Disease: A Two-Year Longitudinal Study of Data from the Osteoarthritis
Ming Zhang¹, Lori Lyn Price², Amanda R. Canavatchel¹, Jeffrey B. Driban³, Puwei Yuan⁴, Grace H. Lo⁵ and Timothy E. McAlindon⁶, ¹Tufts Medical Center, Boston, MA, ²Clinical Care Research, Tufts Medical Center, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA, ⁴the Fourth OA Department, Shaanxi University of Chinese Medicine, Xian Yang, China, ⁵Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁶Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Cartilage morphometry on magnetic resonance images (MRIs) is an important outcome measure for clinical trials among individuals with knee osteoarthritis (KOA). However, it remains…
Abstract Number: 310 • 2016 ACR/ARHP Annual Meeting
A Novel One Stage Technique Applicable during Arthroscopy for the Mobilization of Synovial Mesenchymal Stromal Cells Towards Joint Regeneration
Alam Khalil-Khan¹, Thomas Baboolal², Elena Jones³, Owen Wall⁴ and Dennis McGonagle³, ¹Faculty of Medicine, Leeds institute of Rheumatic and Musculoskeletal Medicine,, Leeds, United Kingdom, ²PhD, Leeds, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Orthopaedic Surgery, Department of Trauma and Orthopaedics, Leeds, United Kingdom
Background/Purpose: , The discovery of MSCs in the synovium and synovial fluid (SF) provided a potential mechanism for repairing cartilage “from the top down”. Indeed,…
Abstract Number: 1018 • 2015 ACR/ARHP Annual Meeting
A 32-Mer Aggrecan Fragment Generated through Adamts-4/5 and MMP-Mediated Cleavage Can Directly Excite Nociceptive Neurons
Rachel E. Miller¹, Richard J. Miller², Abdelhak Belmadani³, Suzanne Golub⁴, Amanda J. Fosang⁴ and Anne-Marie Malfait⁵, ¹Biochemistry, Rush University Medical Center, Chicago, IL, ²Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴University of Melbourne, Melbourne, Australia, ⁵Rush University Medeical Center, Chicago, IL
Background/Purpose: Cleavage of aggrecan in the interglobular domain (E373-374A) by ADAMTS-4/5 is an early event in osteoarthritis pathogenesis. Further cleavage by MMPs (N341-342F) releases a…

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