Abstracts tagged "cartilage"

Abstract Number: 2087 • ACR Convergence 2024
Association of MRI-Defined Structure Features at Baseline with Knee Pain and Function Trajectories: Data from the Osteoarthritis Initiative (OAI)
Shen Liu¹, Thang Doung², Yong Ge³, Xiaoxiao Sun⁴, Yvonne Golightly⁵, Amanda Nelson⁶, Tuhina Neogi⁷, Jeffery Duryea⁸ and Kent Kwoh⁹, and Osteoarthritis Initiative (OAI) and Pivotal Osteoarthritis MRI Analyses (POMA) investigators, ¹Department of Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, ²Department of Computer Science, University of Arizona College of Science, Tucson, AZ, ³Department of Information Sciences, Eller College of Manangement, University of Arizona, Tucson, AZ, ⁴Department of Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, ⁵University of Nebraska Medical Center, Omaha, NE, ⁶University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁷Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁸Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁹University of Arizona, Tucson, AZ
Background/Purpose: Characterizing knee symptom (i.e., pain and function) trajectories and understanding differences among symptom trajectories have the potential to promote the development of customized treatment…
Abstract Number: 2649 • ACR Convergence 2024
Defining Clinical Subgroups of Patients with Relapsing Polychondritis: A Latent Class and Decision Tree Analysis in Two Independent Prospective Cohorts
Shubhasree Banerjee¹, Carol McAlear², Peter Merkel³, Peter Grayson⁴ and Marcela Ferrada⁵, ¹University of Pennsylvania, Philadelphia, ²University of Pennsylvania, Philadelphia, PA, ³Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, ⁴National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Chevy Chase, MD, ⁵University of Maryland, Baltimore, MD
Background/Purpose: Lack of awareness and disease heterogeneity are common factors associated with diagnosis delay in patients with Relapsing polychondriytis (RP). Using latent class analysis (LCA),…
Abstract Number: 0030 • ACR Convergence 2024
The Impact of Treadmill Exercise on Various Stages of Osteoarthritis Progression in a Murine Osteoarthritis Model
Mengcun Chen¹, Mingshu Cui², Yangmei Yang³ and Bin Wang¹, ¹Thomas Jefferson University, Philadelphia, PA, ²Thomas Jefferson University, Philadelpha, ³Thomas Jefferson University, Philadephia
Background/Purpose: Evidence supports the benefits of exercise on joint health and its protective effects against osteoarthritis (OA) progression [Allen J, A&R, 2010]. However, most animal…
Abstract Number: 0031 • ACR Convergence 2024
Beyond Pain and Inflammation: Intra-articular Liraglutide’s Comprehensive Benefits on Synovial Health and Cartilage in Osteoarthritis Compared to Dexamethasone
Coralie Meurot¹, Celine Martin¹, Margot Vieubled¹, Jerome Breton¹, Indira Toillon², Revital Rattenbach³ and Francis Berenbaum², ¹4Moving Biotech, lille, France, ²Sorbonne University, Paris, France, ³4Moving Biotech, Paris, France
Background/Purpose: Osteoarthritis (OA) is an age-related joint disease that causes chronic pain and limited mobility. Patients mainly have access to therapies aimed at reducing inflammation…
Abstract Number: 0296 • ACR Convergence 2024
Musculoskeletal Manifestations in Patients Diagnosed with Marfan Syndrome
Laura Mas Sánchez¹, JOSE ELOY OLLER RODRIGUEZ², Elena Grau García³, Carmen Riesco Barcena⁴, SAMUEL LEAL⁵, Marta de la Rubia navarro⁶, Anderson Huaylla Quispe⁷, Pablo Muñoz Martínez⁸, Alba Torrat noves⁹, Daniel Ramos Castro¹⁰, Iago Alcantara Alvarez¹¹, Belén Villanueva Mañés¹¹, Miguel Simeo Vinaixa¹², Andrés Pérez Hurtado¹³ and Jose A Román-Ivorra¹⁴, ¹Resident at Hospital Universitari i Politecnic La Fe, Valéncia, Spain, ²HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE, VALENCIA, Spain, ³HUP La Fe, Valencia, Spain, ⁴Hospital Universitario i Politecnic La Fe (Valencia-Spain), Valéncia, Spain, ⁵Hospital La Fe, Valencia, Spain, ⁶Rheumatology department, Hospital La Fe, Valéncia, Spain, ⁷Medicina, Valéncia, Spain, ⁸Hospital Universitario y Politècnico La Fe, Sagunto, Spain, ⁹Hospital Universitari i Politècnic La Fe de Valencia, Valencia, Comunidad Valenciana, Spain, ¹⁰Hospital Universitario y Politècnico La Fe, Valencia, Spain, ¹¹Rheumatology Department. HUP La Fe, Valencia, Comunidad Valenciana, Spain, ¹²Hospital Universitari i Politecnic La Fe, Valencia, Spain, ¹³Rheumatology Department. HUP La Fe, Valencia, Spain, ¹⁴Hospital Universitari i Politècnic la Fe, Valencia, Comunidad Valenciana, Spain
Background/Purpose: There is limited information about musculoskeletal involvement in Marfan syndrome (MS), especially concerning bone metabolism.Methods: We conducted a retrospective and descriptive study of patients…
Abstract Number: 0460 • ACR Convergence 2024
Cartilage Damage or (sub)luxation of Finger Joints: Impact on Physical Function in Patients with Rheumatoid Arthritis
Takehisa Ogura¹, Yasuto Minegishi², Chihiro Imaizumi¹, Reina Maezawa¹, Takaharu Katagiri¹ and Hideto Kameda¹, ¹Toho university, Tokyo, Japan, ²Toho University, Tokyo
Background/Purpose: It has been reported that radiographic joint space narrowing (JSN) score affects the health assessment questionnaire-disability index (HAQ-DI) score in rheumatoid arthritis (RA) patients.…
Abstract Number: 1210 • ACR Convergence 2024
Optimal Definitions of Worsening Cartilage Using Sequential MRI OsteoArthritis Knee Scores (MOAKS)
Kathryn Bacon¹, mike LaValley², Tuhina Neogi³, Ali Guermazi³, Frank Roemer³, Neil Segal⁴, Cora Lewis⁵, Michael Nevitt⁶, David Felson⁷ and John Lynch⁸, ¹Boston University, Webster, NH, ²Boston University School of Public Health, Arlington, MA, ³Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁴University of Kansas, Kansas City, KS, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶University of California, San Francisco, San Francisco, CA, ⁷Boston University, Boston, MA, ⁸UCSF, San Francisco, CA
Background/Purpose: The MRI OsteoArthritis Knee Score (MOAKS) is increasingly used in studies of knee osteoarthritis. Our aim was to evaluate methods using MOAKS scores to…
Abstract Number: 0822 • ACR Convergence 2023
From Biomarkers to Endotypes: Data-driven Identification of Knee Osteoarthritis Patients Subtypes
Monica Hannani¹, Zofia Lisowska-Petersen², Morten Karsdal², Cecilie Bager², Anne-Christine Bay-Jensen² and Christian Thudium², ¹University of Copenhagen, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark
Background/Purpose: Osteoarthritis (OA) is a diverse and multifaceted condition. Despite its widespread incidence, the core mechanisms of the disease remain elusive, and therapeutic interventions are…
Abstract Number: 0874 • ACR Convergence 2023
RNA-Binding Proteins That Are Highly Expressed and Enriched in Healthy Cartilage but Suppressed in Osteoarthritis
Hannah Swahn, Merissa Olmer and Martin K Lotz, Scripps Research Institute, La Jolla, CA
Background/Purpose: RNA-binding proteins (RBPs) have diverse and essential biological functions, but their role in cartilage health and disease is largely unknown. The objectives of this…
Abstract Number: 0877 • ACR Convergence 2023
Loss of Transient Receptor Potential Channel 1 (TRPC1) Links Regulation of Intracellular Calcium to Cellular Senescence and Leads to Development of Osteoarthritis
Meike Sambale¹, starlee lively², Osvaldo Espin-Garcia², Pratibha Potla², Chiara Pastrello³, Alexandra Schaefer¹, Jessica Bertrand⁴, Mohit Kapoor⁵, Thomas Pap¹ and Joanna Sherwood¹, ¹University Hospital Münster, Münster, Germany, ²University Health Network, Toronto, ON, Canada, ³Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, ⁴Department of Orthopaedic Surgery, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany, ⁵Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane. It is crucial for the…
Abstract Number: 0882 • ACR Convergence 2023
Activation of Ovarian Cancer G-Protein Coupled Receptor (OGR1) Attenuates Chondrocytes Inflammation via ERK1/2 Signaling Pathways in an in Vitro Model of Osteoarthritis
Omar Syed, Bhakti Patel, William Martin, Martha Diaz-Hernandez, Hicham Drissi and Mohd Nazir Khan, Emory University, Atlanta, GA
Background/Purpose: Osteoarthritis (OA) is the most prevalent joint disease, accounting for 50% of the musculoskeletal burden. Inflammation plays a crucial role in the development of…
Abstract Number: 0883 • ACR Convergence 2023
The Role of Plasmin and Fibrinolysis Pathways in Osteoarthritis
Qian Wang, heidi Wong, Audrey Bai, Zelda Love, Constance Chu and William Robinson, Stanford School of Medicine, Stanford, CA
Background/Purpose: Osteoarthritis (OA) is the major cause of joint failure. Increasing evidence suggests that activation of fibrinolysis is involved in the pathogenesis of OA. Here…
Abstract Number: 0884 • ACR Convergence 2023
Identification of a Mast Cell-high Synovial Pathotype of Osteoarthritis
Shady Younis, Audrey Bai, heidi Wong, Zelda Love, Qian Wang and William Robinson, Stanford School of Medicine, Stanford, CA
Background/Purpose: Mast cells in the osteoarthritis (OA) synovium correlate with disease severity. This study aimed to further elucidate the role of mast cells in OA…
Abstract Number: 0885 • ACR Convergence 2023
Mice Fed a Well-formulated Ketogenic Diet After OA Induction Develop Worse OA Outcomes and Increased Pain Sensitivity
Montana Barrett¹, Gabby Dyson², Meeshal Khan³, Nicholas Hanebutt², Cindy Miranda², Leoni Schlupp², Emmaline Holmlund² and Matlock Jeffries², ¹Oklahoma State University, Guthrie, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: A ketogenic diet (KD) has beneficial effects in preclinical models of a variety of systemic autoimmune diseases. In this study, we set out to…
Abstract Number: 1581 • ACR Convergence 2023
Microbiome Transplantation Prevents Osteoarthritis in Mice and Is Associated with Immunophenotype Changes
Gabby Dyson¹, Montana Barrett², Meeshal Khan³, Cindy Miranda¹, Nicholas Hanebutt¹, Christopher Dunn³ and Matlock Jeffries¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma State University, Guthrie, OK, ³University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: MRL/MpJ mice are protected from developing post-traumatic osteoarthritis (OA). We have previously shown transplantation prior to OA induction prevents OA development. We now extend…

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