Abstracts tagged "cartilage"

Abstract Number: 127 • 2014 ACR/ARHP Annual Meeting
Metacarpophalangeal Cartilage Loss in Rheumatoid Arthritis. a Simple and Fast Ultrasonographic Assessment Comparing Patients and Healthy Controls
Tomas Cazenave¹, Christian A. Waimann², Marwin Gutierrez³, Emilio Filippucci⁴, Gustavo Citera⁵ and Marcos G. Rosemffet¹, ¹Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ²Rheumatology section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ³Università Politecnica delle Marche, Jesi, Italy, ⁴Department of Rheumatology, University of Ancona, Jesi, Italy, ⁵Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina
Background/Purpose There is evidence supporting the use of ultrasonography (US) as a valid and reliable imaging tool to evaluate cartilage in patients with arthritis. The…
Abstract Number: 1127 • 2014 ACR/ARHP Annual Meeting
Mass Spectrometry Imaging Revealed Potential Lipid Chondrogenic Biomarkers for Cell-Based Therapy in Cartilage
Beatriz Rocha¹, Berta Cillero-Pastor², Gert Eijkel², Valentina Calamia¹, Lucia Lourido¹, Carolina Fernández-Costa¹, Patricia Fernandez-Puente¹, Jesus Mateos¹, Cristina Ruiz-Romero^1,3, Ron MA Heeren² and Francisco J. Blanco Garcia¹, ¹Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ²1Biomolecular Imaging Mass Spectrometry (BIMS) Molecular Nanophotonics Department, AMOLF, Amsterdam, Netherlands, ³CIBER-BBN, INIBIC-CHUAC, A Coruña, Spain
Background/Purpose: Recent studies highlight the importance of lipid metabolism in the modulation of chondrogenesis. Specifically, the positive chondrogenic effect of acid ceramidase, which is necessary…
Abstract Number: 1034 • 2014 ACR/ARHP Annual Meeting
Therapeutic Potential of Targeting Sialic Acid Modified Receptors in Osteoarthritis
Maria Dolores Mayan^1,2, Paula Carpintero-Fernández¹, Raquel Gago-Fuentes¹, Marta Varela-Eirin¹, Gary S. Goldberg³ and Francisco Javier Blanco^1,4,5, ¹Cartilage Biology Research Group, Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Email: [email protected], A Coruña, Spain, ³Rowan University, Department of Molecular Biology, School of Osteopathic Medicine, Stratford, NJ, ⁴Rheumatology Division, CIBER-BBN/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁵Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
Background/Purpose: Glycosylated proteins are essential components of the extracellular matrix (ECM) of cartilage and contribute to the maintenance of its function. A shift from a-2,6-…
Abstract Number: 1026 • 2014 ACR/ARHP Annual Meeting
Monosodium Urate Monohydrate Crystals Induces the Expression of Ihh and MMP-13 in ATDC5 Cells: Implications in Osteoarthritis (OA) Development.
Melissa Ramirez¹, Josh Potvin¹, Diana Ramirez² and Anthony M. Reginato³, ¹Division of Rheumatology, The Warren Alpert School of Medicine at Brown University, Providence, RI, ²Department of Orthopaedic Surgery, The Warren Alpert School of Medicine at Brown University, Providence, RI, ³Rheumatology, The Warren Alpert School of Medicine at Brown University, Providence, RI
Background/Purpose: Cartilage damage is often observed in affected joints with advance gout1. Musculoskeletal ultrasound studies have highlighted the close relationship between monosodium urate (MSU) crystals…
Abstract Number: 1011 • 2014 ACR/ARHP Annual Meeting
Fibroblast Growth Factor-2 and Its Receptor Antagonists in Osteoarthritis
Elina Nummenmaa¹, Mari Hamalainen¹, Teemu Moilanen^1,2, Katriina Vuolteenaho¹ and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: The fibroblast growth factor (FGF) family represents an interesting group of molecules which are involved in the regulation of connective tissue development and metabolism.…
Abstract Number: 1127 • 2013 ACR/ARHP Annual Meeting
Semiquantitative MRI Features Of Knee Osteoarthritis Show Compartment-Specific Relationships With Quantitative Cartilage Thickness Loss: The Multicenter Osteoarthritis Study
Ali Guermazi¹, Felix Eckstein², Daichi Hayashi³, Frank Roemer⁴, Wolfgang Wirth², Tianzhong Yang⁵, Jingbo Niu⁶, Leena Sharma⁷, Michael C. Nevitt⁸, Cora E. Lewis⁹, James Torner¹⁰ and David T. Felson¹¹, ¹Boston University, Boston, MA, ²Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ³Department of Radiology, Boston University School of Medicine, Boston, MA, ⁴Radiology, Boston University School of Medicine, Boston, MA, ⁵Clinical Epidemiology, Boston University School of Medicine, Boston, MA, ⁶Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁷Northwestern University, Chicago, IL, ⁸Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁹Preventive Medicine, University of Alabama, Birmingham, Birmingham, AL, ¹⁰Epidemiology, University of Iowa, Iowa City, Iowa City, IA, ¹¹Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Structural progression of knee OA has been associated with several radiographic and MRI-measured pathological features of OA, including malalignment, meniscal pathology and bone marrow…
Abstract Number: 77 • 2013 ACR/ARHP Annual Meeting
Human Mesenchymal Stem Cells Cultured On Collagen Scaffolds For Cartilage Tissue Engineering
Clara Sanjurjo-Rodríguez¹, Adela Helvia Martínez-Sánchez², Tamara Hermida-Gómez¹, Isaac M. Fuentes-Boquete^1,2, Francisco J. De Toro^2,3, Julia Buján⁴, Silvia Díaz-Prado^2,3 and Francisco J. Blanco², ¹Grupo de Bioingeniería Tisular y Terapia Celular (CBTTC-CHUAC). CIBER-BBN/ISCIII. Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de Coruña (CHUAC). SERGAS. Universidade de A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain, ³INIBIC-Universidade da Coruña, A Coruña, Spain, ⁴University of Alcalá de Henares, Department of Medical Specialties, Madrid, Spain
Background/Purpose: Osteoarthritis is a degenerative disease without a treatment. Tissue Engineering could provide an alternative tool for cartilage repair. The aim of this study was…
Abstract Number: 1129 • 2013 ACR/ARHP Annual Meeting
Development and Validation Of a Rapid Knee Cartilage Quantification Method
Ming Zhang¹, Jeffrey B. Driban², Lori Lyn Price³, Daniel Harper¹, Grace H. Lo⁴, Eric Miller⁵, Robert J. Ward⁶ and Timothy E. McAlindon⁷, ¹Rheumotology, Tufts Medical Center, Boston, MA, ²Rheumatology, Tufts Medical Center, Boston, MA, ³Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁴VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ⁵Department of Electrical and Computer Engineering, Tufts University, Medford, MA, ⁶Radiology, Tufts Medical Center, Boston, MA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Cartilage morphometry on magnetic resonance images (MRIs) may become an acceptable outcome measure for clinical trials among patients with knee osteoarthritis (OA). However, obtaining…
Abstract Number: 78 • 2013 ACR/ARHP Annual Meeting
Norepinephrine (NE) Inhibits Mesenchymal Stem Cell (MSCs) Chondrogenesis By Accelerating Hypertophy – Relevance For Cartilage Regeneration
Zsuzsa Jenei-Lanzl¹, Peter Angele², Frieder Kees³, Georg Pongratz⁴ and Rainer H. Straub⁵, ¹Department of Internal Medicine, University Hospital Regensburg, 1Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Regensburg, Germany, ²Department of Trauma Surgery, University Hospital Regensburg, Germany, Regensburg, Germany, ³Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany, ⁴Internal Medicine, University Hospital Regensburg, Regensburg, Germany, ⁵Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose: The high potential of mesenchymal stem cells (MSCs) in cartilage regeneration is undoubtful. The presence of MSCs in healthy or arthritic cartilage has also…
Abstract Number: 769 • 2013 ACR/ARHP Annual Meeting
Synovial Wnt and WISP1 Expression Induces Expression Of Cartilage-Degrading Metalloproteinases In The Synovium
Martijn H. van den Bosch¹, Arjen B. Blom¹, Sylvia W. Suen², Anke E. van Erp², Fons A. van de Loo³, Esmeralda N. Blaney Davidson¹, Peter M. van der Kraan³, Peter L. van Lent⁴ and Wim B. van den Berg⁵, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. Previously, we found strong upregulation of Wnts 2b and 16 and…
Abstract Number: 59 • 2013 ACR/ARHP Annual Meeting
Downregulated Forkhead-Box Class O Transcription Factors Attenuate Oxidative Stress Resistance In Human Chondrocytes
Yukio Akasaki and Martin K. Lotz, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA
Background/Purpose: Aging-associated changes in articular chondrocytes represent a major risk factor for osteoarthritis (OA). The major signaling pathway that regulates cellular aging is the Insulin/IGF-1/Pl3k/Akt/forkhead-box…
Abstract Number: 151 • 2013 ACR/ARHP Annual Meeting
The mtDNA Haplogroups Influence The Cartilage Integrity In Osteoarthritis. Data From The Osteoarthritis Initiative (OAI)
Ignacio Rego-Pérez¹, Angel Soto-Hermida², Mercedes Fernández-Moreno², Sonia Pértega-Díaz³, Juan Fernández-Tajes², María Eugenia Vázquez-Mosquera², Estefanía Cortés-Pereira², Sara Relaño-Fernández², Natividad Oreiro-Villar², Carlos Fernández-López² and Francisco J. Blanco^4,5,6, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁴Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain, ⁵Proteo-Red/ISCIII, Madrid, Spain, ⁶CIBER-BBN-ISCIII, Madrid, Spain
Background/Purpose: Magnetic resonance imaging (MRI) is ideally suited for detect structural changes and degradation in cartilage against the limitations of radiographic common methods. Changes in…
Abstract Number: 770 • 2013 ACR/ARHP Annual Meeting
Suppressor Of Cytokine Signaling-3 Is a Critical Regulator Of gp130 Cytokine Signaling In Articular Chondrocytes
Xiao Liu^1,2, Kate E Lawlor^1,2, Ben A Croker¹ and Ian P Wicks^1,2,3, ¹Inflammation Division, Walter & Eliza Hall Institute of Medical Research, Parkville, Australia, ²Department of Medical Biology, University of Melbourne, Parkville, Australia, ³Department of Rheumatology, The Royal Melbourne Hospital, Melbourne, Australia
Background/Purpose: Cartilage damage is a key feature of inflammatory and degenerative arthritis and an important determinant of patient outcomes. Chondrocytes are the only cells in…
Abstract Number: 58 • 2013 ACR/ARHP Annual Meeting
Saturated Fatty Acids Act Synergistically With Interleukin 1 Beta To Increase Inflammation, Endoplasmic Reticulum Stress and Cell Death In Human Articular Chondrocytes
Oscar Alvarez-Garcia¹, Nicole H Rogers², Roy G Smith³ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²California Institute for Biomedical Research (Calibr), La Jolla, CA, ³Department of Metabolism and Aging, Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL
Background/Purpose: Obesity is a major risk factor for the development of osteoarthritis (OA). Altered biomechanics have been postulated as the main causative mechanism, but recent…
Abstract Number: 156 • 2013 ACR/ARHP Annual Meeting
Cartilage Peptide Profiling: Identifying Novel OA Biomarkers For Early Disease Detection
Valentina Calamia¹, Lucía Lourido¹, Diego López¹, Jesus Mateos¹, Patricia Fernández-Puente¹, Carolina Fernández-Costa², Beatriz Rocha², Cristina Ruiz-Romero³ and Francisco J. Blanco¹, ¹Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, ²Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ³Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain
Background/Purpose: Cartilage secretome contains a complex matrix of proteolytically derived peptides that may provide useful information of the biological events occurring in the articular joint…

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