Abstracts tagged "cartilage"

Abstract Number: 2796 • 2014 ACR/ARHP Annual Meeting
A Novel Mouse Model of Osteochondromagenesis By Deleting NFATc1 in Mesenchymal Progenitors and Postnatal Chondrocytes
Xian-Peng Ge¹, Susan Y. Ritter², Julia F. Charles³, Kelly Tsang² and Antonios O. Aliprantis², ¹Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Osteochondromas are the most common benign bone tumor and are characterized by cartilage-capped bony projections from the external surface of bone. These lesions may…
Abstract Number: 208 • 2014 ACR/ARHP Annual Meeting
Correlates of Knee Bone Marrow Lesions in Younger Adults
Benny Samuel Eathakkattu Antony¹, Graeme Jones², Alison Venn³, Lyn March⁴, Flavia Cicutinni⁵, Andrew Halliday⁶, Leigh Blizzard⁷, Marita Cross⁸, Terry Dwyer⁹ and Changhai Ding², ¹Musculoskeletal, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Epidemiology, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁴Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁵Department of Epidemiology and Preventive Medicine, Monash University, Monash University, Melbourne, Australia, Melbourne, Australia, ⁶Radiology, Royal Hobart Hospital, Australia, Hobart, Australia, ⁷Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁸University of Sydney Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia, ⁹Director, Murdoch Children's Research Institute, Melbourne, Australia
Background/Purpose: Bone marrow lesions (BMLs) of the knee joint are a key player in osteoarthritis of the knee. However, little is known of their determinants,…
Abstract Number: 2465 • 2014 ACR/ARHP Annual Meeting
Cyclic Phosphatidic Acid (cPA) Suppresses MMP-3, a Disintegrin and Metalloproteinase with Thrombospondin Motifs(ADAMTS)-4, -5 and Stimulates HAS2 Expression in Inflammatory Rheumatoid Synovial Fibroblasts Induced with IL-1β and/or TNF-α
Ikuko Masuda^1,2, Kodo Okada³, Hisashi Yamanaka⁴ and Shigeki Momohara⁴, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Rheumatology, Jyujyo Takeda Rehabilitation Hospital, Kyoto, Japan, ³SANSHO, Co. Ltd., Tokyo, Japan, ⁴Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose Cyclic phosphatidic acid (cPA) is one of bioactive lipid, has been implicated as an mediator of various biological effects including i) antiproliferative effect on…
Abstract Number: 205 • 2014 ACR/ARHP Annual Meeting
Natural History and Clinical Significance of Meniscal Tears over 8 Years in a Largely Non-Osteoarthritic Cohort
Hussain Ijaz Khan¹, Dawn Aitken¹, Changhai Ding², Leigh Blizzard³, Jean-Pierre Pelletier⁴, Johanne Martel-Pelletier⁴, Flavia Cicutinni⁵ and Graeme Jones², ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁴Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁵Department of Epidemiology and Preventive Medicine, Monash University, Monash University, Melbourne, Australia, Melbourne, Australia
Background/Purpose: Meniscal tears are a key player in knee osteoarthritis (OA) and family history of the disease has been shown to play an important role.…
Abstract Number: 1135 • 2014 ACR/ARHP Annual Meeting
Genes Involved in Cartilage Synthesis and Risk to Knee Osteoarthritis
Abhishek Mishra Sr., Rajeshwar Srivastava II, Divya Sanghi III, Ajai Singh IV and Devendra Parmar V, Deptt of Orthopaedic Surgery, King George's Medical University,, Lucknow, India
Background/Purpose Osteoarthritis (OA), characterized by gradual loss of articular cartilage in the joint, is a leading cause of disability among the elderly people. Though the…
Abstract Number: 127 • 2014 ACR/ARHP Annual Meeting
Metacarpophalangeal Cartilage Loss in Rheumatoid Arthritis. a Simple and Fast Ultrasonographic Assessment Comparing Patients and Healthy Controls
Tomas Cazenave¹, Christian A. Waimann², Marwin Gutierrez³, Emilio Filippucci⁴, Gustavo Citera⁵ and Marcos G. Rosemffet¹, ¹Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ²Rheumatology section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ³Università Politecnica delle Marche, Jesi, Italy, ⁴Department of Rheumatology, University of Ancona, Jesi, Italy, ⁵Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina
Background/Purpose There is evidence supporting the use of ultrasonography (US) as a valid and reliable imaging tool to evaluate cartilage in patients with arthritis. The…
Abstract Number: 1878 • 2013 ACR/ARHP Annual Meeting
Proteomics Analysis Of Cartilage Secretome: A Powerful Tool For The Discovery Of OA Biomarkers
Lucía Lourido¹, Valentina Calamia¹, Patricia Fernández-Puente¹, Jesus Mateos¹, Beatriz Rocha², Carolina Fernández-Costa², Francisco J. Blanco¹ and Cristina Ruiz-Romero³, ¹Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, ²Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ³Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain
Background/Purpose: Osteoarthritis (OA) is characterized by the progressive loss of cartilage structural extracellular matrix (ECM) components, mainly collagenous and non-collagenous proteins. The release of these…
Abstract Number: 63 • 2013 ACR/ARHP Annual Meeting
Investigations On The Role Of Delta/Notch Like EGF-Related Receptor In The Pathogenesis Of Osteoarthritis
Lucija Berninger¹, Anna Balkenhol¹, Clemens Baier², Stefan Rehart³, Markus Rickert⁴, Ulf Müller-Ladner¹, Elena Neumann⁵ and Matthias Geyer¹, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Orthopaedic surgery, University of Regensburg, Bad Abbach, Germany, ³Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁴Dept of Orthopedics and Orthopedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, ⁵Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: Delta/Notch like EGF-related receptor (DNER) is a single-pass transmembrane protein with characteristic EGF-like repeats in the extracellular domain, similar to those of the Notch…
Abstract Number: 1849 • 2013 ACR/ARHP Annual Meeting
Proteomic Analysis Of Connexin 43 Reveals Association With Proteins Dysfunctional Related With Osteoarthrosis
Patricia Fernández-Puente^1,2, Raquel Gago-Fuentes^1,2, Paula Carpintero-Fernández¹, Jesús Mateos¹, Maria Dolores Mayan^1,3 and Francisco J. Blanco^4,5, ¹Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, Xubias de Arriba 84, 15006, A Coruña, Spain, ²These authors contribute equally to this work, A Coruña, Spain, ³Correspondence to: [email protected] and [email protected], A Coruña, Spain, ⁴Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain, ⁵Proteo-Red/ISCIII, Madrid, Spain
Background/Purpose: Human adult articular cartilage is composed of a dense extracellular matrix and specialized cells called chondrocytes. The chondrocytes are found to their own lacuna…
Abstract Number: 64 • 2013 ACR/ARHP Annual Meeting
Fibulin-3 In Joint Aging and Osteoarthritis Pathogenesis
Akihiko Hasegawa^1,2, Tomo Yonezawa¹, Noboru Taniguchi¹, Koji Otabe¹, Yukio Akasaki¹, Tetsuya Matsukawa¹, Masahiko Saito³, Masashi Neo⁴, Lihua Y. Marmorstein⁵ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Orthopaedic Surgery, Osaka Medical College, Takatsuki, Osaka, Japan, ³Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan, ⁴Department of Orthopedic Surgery, Osaka Medical College, Osaka, Japan, ⁵Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ
Background/Purpose: Osteoarthritis (OA) is the most common joint disease. Among the earliest lesions during OA development is disruption of the superficial zone (SZ) of articular…
Abstract Number: 1399 • 2013 ACR/ARHP Annual Meeting
Citrullinated Proteoglycan (Aggrecan) Present In Human Cartilage Is Recognized By Serum Antibodies From Rheumatoid Arthritis Patients
Timea Ocsko¹, Beata Tryniszewska¹, Andras Vida¹, Janos Gal², Gyorgyi Soos², Zoltan Szekanecz³, Tibor A. Rauch¹, Joshua Jacobs¹, Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, Bacs-Kiskun County Hospital, Kecskemet, Hungary, ³Rheumatology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
Background/Purpose: Citrullination is a post-translational protein modification, where arginine (Arg) is converted to citrulline (Cit) by peptidyl arginine deiminases (PADI). The presence of anti-citrullinated protein…
Abstract Number: 66 • 2013 ACR/ARHP Annual Meeting
Follistatin-Like Protein 1 Is An Important Regulator Of Chondrogenesis
Yury Chaly¹, Sonja Smith², Daniel Bushnell³, Brian Campfield⁴, Harry Blair⁵ and Raphael Hirsch⁶, ¹Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ²University of Iowa Carver College of Medicine, Iowa City, IA, ³Division of Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁴Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁵University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁶Department of Pediatrics,, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Chondrocytes play a pivotal role in osteoarthritis (OA) because they are the only cells in the articular cartilage that are responsible for maintenance of…
Abstract Number: 1132 • 2013 ACR/ARHP Annual Meeting
Sensitivity To Change Of Radiographic Fixed-Location and Magnetic Resonance Imaging-Based Cartilage Thickness Measures In The Lateral Compartment Of Knees With Radiographic Osteoarthritis – Data From The Osteoarthritis Initiative
Wolfgang Wirth¹, Jeffrey W. Duryea², Michael C. Nevitt³, Robert J. Buck⁴, David Hunter⁵ and Felix Eckstein¹, ¹Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ²Radiology, Brigham and Women's Hospital, Boston, MA, ³Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁴StatAnswers Consulting, Minneapolis, MN, ⁵Royal North Shore Hospital, St. Leonards, Australia
Background/Purpose: Radiographic joint space width (JSW) is frequently employed to indirectly assess structural progression in the medial femorotibial compartment, but it is unclear whether assessment…
Abstract Number: 75 • 2013 ACR/ARHP Annual Meeting
Decorin-Deficiency Alters Cartilage Stiffness and Attenuates The Development Of Osteoarthritis In Mice
Tobias Gronau¹, Uwe Hansen², Daniela Seidler², Renato Iozzo³, Attila Aszodi⁴, Carina Prein⁵, Hauke Clausen-Schaumann⁵, Karsten Krüger⁶, Frank Mooren⁶, Jessica Bertrand¹, Thomas Pap⁷, Peter Bruckner² and Rita Dreier², ¹Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ²Institute for Physiological Chemistry & Pathobiochemistry, University Hospital Münster, Münster, Germany, ³Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, ⁴Experimental Surgery and Regenerative Medicine, Ludwig-Maximilians-University Munich, Munich, Germany, ⁵Department of Applied Sciences and Mechatronics, Munich University of Applied Sciences, Munich, Germany, ⁶Institute of Sports Medicine, Justus-Liebig University Giessen, Giessen, Germany, ⁷Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: In articular (AC) and growth plate (GP) cartilage, the small leucine-rich proteoglycan decorin is mainly present within the interterritorial regions (ITs) of the extracellular…
Abstract Number: 1127 • 2013 ACR/ARHP Annual Meeting
Semiquantitative MRI Features Of Knee Osteoarthritis Show Compartment-Specific Relationships With Quantitative Cartilage Thickness Loss: The Multicenter Osteoarthritis Study
Ali Guermazi¹, Felix Eckstein², Daichi Hayashi³, Frank Roemer⁴, Wolfgang Wirth², Tianzhong Yang⁵, Jingbo Niu⁶, Leena Sharma⁷, Michael C. Nevitt⁸, Cora E. Lewis⁹, James Torner¹⁰ and David T. Felson¹¹, ¹Boston University, Boston, MA, ²Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ³Department of Radiology, Boston University School of Medicine, Boston, MA, ⁴Radiology, Boston University School of Medicine, Boston, MA, ⁵Clinical Epidemiology, Boston University School of Medicine, Boston, MA, ⁶Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁷Northwestern University, Chicago, IL, ⁸Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁹Preventive Medicine, University of Alabama, Birmingham, Birmingham, AL, ¹⁰Epidemiology, University of Iowa, Iowa City, Iowa City, IA, ¹¹Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Structural progression of knee OA has been associated with several radiographic and MRI-measured pathological features of OA, including malalignment, meniscal pathology and bone marrow…

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