Abstracts tagged "cartilage"

Abstract Number: 1003 • 2014 ACR/ARHP Annual Meeting
Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis
Raquel Gago-Fuentes¹, Patricia Fernández-Puente^2,3, Paula Carpintero-Fernández¹, Jesus Mateos^2,3, Maria Dolores Mayan¹ and Francisco Javier Blanco^2,3, ¹Cartilage Biology Research Group, Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ³Rheumatology Division, CIBER-BBN/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
Background/Purpose: We have previously reported that articular chondrocytes in tissue contain long cytoplasmic arms that physically connect two distant cells. Cell-to-cell communication occurs through connexin…
Abstract Number: 1019 • 2014 ACR/ARHP Annual Meeting
Targeting the Bone-Driven Metabolic OA Phenotype By a Novel Dual Amylin Calcitonin Receptor Agonist, KBP-056
Ditte Reker, Sara Toftegaard Hjuler, Kim Andreassen, Morten Asser Karsdal, Kim Henriksen and Anne C. Bay-Jensen, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose: Osteoarthritis (OA) may be segregated into different disease phenotypes based on disease drivers; cartilage damage, joint inflammation or subchondral bone remodelling. Each phenotype may…
Abstract Number: 629 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Chondrocyte Activity Are Increased in Psoriasis Arthritis and Spondyloarthritis
Natasja Stæhr Gudman¹, Heidi Lausten Munk², Anne Friesgaard Christensen³, Leif Ejstrup⁴, Grith Lykke Sørensen⁵, Anne Gitte Loft³, Morten A. Karsdal⁶, Anne C. Bay-Jensen⁷, Yi He⁸, Anne Sofie Siebuhr⁹ and Peter Junker², ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Department of Rheumatology, Odense University Hospital, Odense, Denmark, ³Department of Rheumatology, Vejle Hospital, Vejle, Denmark, ⁴Department of Rheumatology, Esbjerg Hospital, Esbjerg, Denmark, ⁵Cardiovascular and Renal Research, Institute of Molecular Medicin, University of Southern Denmark, Odense, Denmark, ⁶Research & Development, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ⁷Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁸Nordic Bioscience, Herlev, Denmark, ⁹Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose: Psoriasis arthritis (PsA) and spondyloarthritis (SpA) are both inflammatory joint diseases in which the pathogenesis is not fully understood. However, both pathologies are associated…
Abstract Number: 541 • 2014 ACR/ARHP Annual Meeting
Collagen II Neo-Epitopes in Spondyloarthritis.
Heidi Lausten Munk¹, Natasja Staehr Gudmann², Anne Friesgaard Christensen³, Leif Ejstrup⁴, Grith Lykke Sørensen⁵, Anne Gitte Loft³, Anne C. Bay-Jensen², Anne Sofie Siebuhr² and Peter Junker¹, ¹Department of Rheumatology, Odense University Hospital, Odense, Denmark, ²Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ³Department of Rheumatology, Vejle Hospital, Vejle, Denmark, ⁴Department of Rheumatology, Esbjerg Hospital, Esbjerg, Denmark, ⁵Cardiovascular and Renal Research, Institute of Molecular Medicin, University of Southern Denmark, Odense, Denmark
Background/Purpose Spondyloarthritis (SpA) is characterized by aseptic inflammation of the axial skeleton which may ultimately lead to irreversible deformities due to bony ankylosis. Occasionally, peripheral…
Abstract Number: 436 • 2014 ACR/ARHP Annual Meeting
Increasing Cartilage Turnover in Smokers Developing Rheumatoid Arthritis Is Associated with High Disease Activity in Early Disease
Carl Turesson¹, Christina Book², Ulf Bergström², Lennart Jacobsson^2,3 and Tore Saxne⁴, ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, ⁴Dept of Rheumatology, Dept of Clinical Sciences Lund, Section of Rheumatology, Lund, Sweden
Background/Purpose Autoantibodies and other biomarkers of rheumatoid arthritis (RA) that may be detected years before disease onset in a subset of investigated individuals could be…
Abstract Number: 218 • 2014 ACR/ARHP Annual Meeting
Surface Area and Fatty Infiltration of Vastus Medialis Measured By Magnetic Resonance Imaging Are Risk Factors for the Progression of Knee Osteoarthritis and Discriminate Two Osteoarthritis Phenotypes
Johanne Martel-Pelletier¹, Jean-Pierre Raynauld¹, François Abram², Marc Dorais³, Yuanyuan Wang⁴, Jessica Fairley⁴, Flavia Cicuttini⁴ and Jean-Pierre Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³StatSciences Inc., Notre-Dame de l’Île Perrot, QC, Canada, ⁴Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: Osteoarthritis (OA) is the most common arthritic condition but its treatment still remains symptomatic. Understanding factors affecting the progression of this disease may enable…
Abstract Number: 2669 • 2013 ACR/ARHP Annual Meeting
Treatment Of Knee Osteoarthritis Patients With Strontium Ranelate Reduces The Loss Of Cartilage Volume and Bone Marrow Lesions As Assessed By Magnetic Resonance Imaging: Data From The Phase III Strontium Ranelate Efficacy In Knee Osteoarthrtis Trial
Johanne Martel-Pelletier¹, Camille Roubille¹, Jean-Pierre Raynauld¹, François Abram², Marc Dorais³, Philippe Delorme¹ and Jean-Pierre Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³StatSciences Inc., Notre-Dame de l’Île Perrot, QC, Canada
Background/Purpose: This study aimed to evaluate in a subpopulation of osteoarthritis (OA) patients from the SEKOIA Phase III trial the disease-modifying (DMOAD) effect of strontium…
Abstract Number: 84 • 2013 ACR/ARHP Annual Meeting
New Formulation With Potential To Prevent and Treat Osteoporosis and Osteoarthritis
A. Torrent¹, E. Montell², J. Vergés¹, P. Dalmau³, R. Ruhí³, M.C. Carceller⁴, A. Blanco⁴, M.C. Terencio⁴, M.L. Ferrándiz⁴ and M.J. Alcaraz⁵, ¹Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain, ²Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain, ³Technological Extraction Dept, BIOIBERICA S.A., Palafolls, Spain, ⁴Department of Pharmacology and IDM, University of Valencia, Burjassot, Spain, ⁵University of Valencia, Burjasot, Valencia, Spain
Background/Purpose: Osteoarthritis (OA) is a multidimensional disease that affects all anatomical joint structures, particularly cartilage, synovium and subchondral bone. In turn, osteoporosis (OP) is a…
Abstract Number: 2670 • 2013 ACR/ARHP Annual Meeting
Does Change In Femorotibial Cartilage Thickness Differ Between Acutely Anterior-Cruciate Ligament Injured Knees Treated With and Without Reconstructive Surgery
Wolfgang Wirth¹, Felix Eckstein¹, Martin Hudelmaier², Stefan Lohmander³ and Richard Frobell⁴, ¹Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ²Paracelsus Medical University, Salzburg, Austria, ³Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden, ⁴Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden
Background/Purpose: An ACL tear is a serious knee injury, involving chronic alterations in joint biomechanics. The risk of developing knee OA after an ACL tear…
Abstract Number: 85 • 2013 ACR/ARHP Annual Meeting
Cartilaginous Uric Acid Deposition In Advanced Osteoarthritis: Innocent Bystander Or Promotor Of Cartilage Destruction?
Tim Bongartz¹, Andre M Oliveira², Rafael J Sierra³, Arlen D Hanssen³ and Michael J Taunton³, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Pathology, Mayo Clinic, Rochester, MN, ³Orthopedic Surgery, Mayo Clinic, Rochester, MN
Background/Purpose: Recent studies have suggested that synovial fluid uric acid could contribute to tissue inflammation, disease severity and progression of osteoarthritis (OA). Intraarticular uric acid…
Abstract Number: 1950 • 2013 ACR/ARHP Annual Meeting
Relationship Between Radiographic Joint Space Narrowing, Sonographic Cartilage Thickness and Anatomy In Rheumatoid Arthritis and Control Joints
Peter Mandl¹, Gabriela Supp², Gabor Baksa³, Daniel Aletaha⁴, Reka Kurucz⁵, Dora Niedermayer⁶, Helga Radner⁷, Paul Studenic⁸, Peter V. Balint⁹ and Josef S. Smolen¹⁰, ¹Medical University of Vienna, Vienna, Austria, ²Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Semmelweis University, Budapest, Hungary, ⁴Department of Internal Medicine III, Division of Rheumatology, Medical University Vienna, Vienna, Austria, ⁵National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ⁶PsAID taskforce, EULAR, Zurich, Switzerland, ⁷Department of Internal Medicine III; Division of Rheumatology, Medical University Vienna, Vienna, Austria, ⁸Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁹Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ¹⁰Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: To validate ultrasound (US) for measuring cartilage thickness, by evaluating cartilage thickness on cadaver specimens of metacarpophalangeal (MCP) joints by US and conventional measurement.…
Abstract Number: 60 • 2013 ACR/ARHP Annual Meeting
O-Linked N-Acetylglucosamine Modified Proteome Of Human Osteoarthritic Cartilage: Biological Significance
Jessica Andrés-Bergós^1,2, María Luisa Hernáez³, Miguel Otero², Ane Larranaga-Vera¹, Sandra Pérez-Baos¹, Mary B. Goldring², Gabriel Herrero-Beaumont¹ and Raquel Largo⁴, ¹Joint and Bone Research Unit. IIS-Fundación Jiménez Díaz. UAM, Madrid, Spain, ²Tissue Engineering Repair and Regeneration Program, Hospital for Special Surgery and Weill Cornell Medical College, New York, NY, ³Proteomics Unit, Universidad Complutense de Madrid-Parque Científico de Madrid, ProteoRed ISCIII, Madrid, Spain, ⁴Bone and Joint Research Unit, IIS-Fundación Jiménez Díaz, Madrid, Spain
Background/Purpose: O-linked N-acetylglucosamine (O-GlcNAc) post-translational modifications have been implicated in the control of different signaling cascades and in the development and progression of degenerative and…
Abstract Number: 1898 • 2013 ACR/ARHP Annual Meeting
Repression Of Wolf-Hischhorn Syndrome Candidate-1 (WHSC1) Contributes To The Osteoarthritis-Inducing Cartilage Loss Of Functions
Francisco Espinoza¹, Yves-Marie Pers², Paul Chuchana³, Jean Marc Brondello⁴ and Christian Jorgensen², ¹INSERM U844, MONTPELLIER, France, ²Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, ³INSERM U844, Montpellier, France, ⁴Inserm U844, UM1, Montpellier, France
Background/Purpose: Accumulation of senescent p16INK4A-positive cells within numerous tissues through out life span contributes to the onset of several age-related disease such as intervertebral disc…
Abstract Number: 61 • 2013 ACR/ARHP Annual Meeting
Epigenome-Wide DNA Methylation Study Reveals Hypermethylated Collagen Genes and Suggests a Role for TGFβ in Osteoarthritis
Matlock A. Jeffries^1,2, Amr H. Sawalha³ and Judith A. James⁴, ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic disability in the U.S., affecting 40% of individuals over the age of 70 and costing $128…
Abstract Number: 1878 • 2013 ACR/ARHP Annual Meeting
Proteomics Analysis Of Cartilage Secretome: A Powerful Tool For The Discovery Of OA Biomarkers
Lucía Lourido¹, Valentina Calamia¹, Patricia Fernández-Puente¹, Jesus Mateos¹, Beatriz Rocha², Carolina Fernández-Costa², Francisco J. Blanco¹ and Cristina Ruiz-Romero³, ¹Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, ²Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ³Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain
Background/Purpose: Osteoarthritis (OA) is characterized by the progressive loss of cartilage structural extracellular matrix (ECM) components, mainly collagenous and non-collagenous proteins. The release of these…

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