ACR Meeting Abstracts

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Abstracts tagged "cartilage"

  • Abstract Number: 1658 • ACR Convergence 2024

    IGF1 Drives Wnt-induced Joint Damage and Is a Therapeutic Target for Osteoarthritis

    Ana Escribano-Nunez1, Frederique Cornelis2, Astrid Deroover1, An Sermon1, Frederic Cailotto3, Rik Lories2 and Silvia Monteagudo4, 1KU Leuven, Leuven, Vlaams-Brabant, Belgium, 2Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, Leuven, Belgium, 3Université Lorraine, Nancy, Lorraine, France, 4KU Leuven, Leuven, Belgium

    Background/Purpose: Osteoarthritis is the most common joint disease and a global leading cause of pain and disability. Its multifactorial etiology includes excessive activation of Wnt…
  • Abstract Number: 1710 • ACR Convergence 2024

    Extl3 Involved in the Regulation of Endochondral Ossification in Axial SpA

    Stéphane Hilliquin1, OLIVIER FOGEL2, Mathilde Tissier3, Chahrazad Cherifi4, Karim Ibrahim5, Judith Melki6, Robert Olaso7, Brigitte Baroukh5, Philippe Dieudé8, Lars Rogge3, Elisabetta Bianchi3, Marcio Do Cruzeiro9, Frederique Cornelis10, Rik Lories10, Patricia Albanese4, Xavier Houard11, Claire Bardet5 and Corinne MICELI12, 1Département de Rhumatologie, Hôpital Cochin, Assistance publique des Hôpitaux de Paris, Université Paris-Cité, Paris, France, PARIS, France, 2AP-HP, Paris, France, 3Institut Pasteur, Université Paris Cité, Immunoregulation Unit, F-75015 Paris, France, PARIS, France, 4Laboratoire Gly-CREET, Université Paris-Est Créteil Val de Marne (UPEC) Faculté des sciences et technologies, Créteil, France, 5Université Paris Cité, Institut des maladies musculo-squelettiques, Laboratory Orofacial Pathologies, Imaging and Biotherapies URP2496 and FHU-DDS-Net, Dental School, and Plateforme d’Imagerie du Vivant (PIV), Montrouge, France,, Montrouge, France, 6Université Paris-Saclay, Laboratory Diseases and Hormones of the Nervous Systems, Inserm U1195, Le Kremlin Bicêtre, France, Le Kremlin Bicêtre, France, 7Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, Evry, France, 8Departement of Rheumatology, AP-HP, Bichat Hospital, Paris, France, 9Plateformes PDA et MouseT'IC, Institut Cochin, Université Paris Cité, Paris, France, PARIS, France, 10Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, Leuven, Belgium, 11Centre de Recherche Saint-Antoine, UMR_S938 INSERM /Sorbonne Université, Paris, France, Paris, France, 12Université de Paris Cité, APHP, Paris, France

    Background/Purpose: Spondyloarthritis (SpA) is an inflammatory rheumatic disease characterized, in its axial form, by lesions affecting the spine and/or sacroiliac joints (SIJ). Severe forms of…
  • Abstract Number: 2087 • ACR Convergence 2024

    Association of MRI-Defined Structure Features at Baseline with Knee Pain and Function Trajectories: Data from the Osteoarthritis Initiative (OAI)

    Shen Liu1, Thang Doung2, Yong Ge3, Xiaoxiao Sun4, Yvonne Golightly5, Amanda Nelson6, Tuhina Neogi7, Jeffery Duryea8 and Kent Kwoh9, and Osteoarthritis Initiative (OAI) and Pivotal Osteoarthritis MRI Analyses (POMA) investigators, 1Department of Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, 2Department of Computer Science, University of Arizona College of Science, Tucson, AZ, 3Department of Information Sciences, Eller College of Manangement, University of Arizona, Tucson, AZ, 4Department of Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, 5University of Nebraska Medical Center, Omaha, NE, 6University of North Carolina at Chapel Hill, Chapel Hill, NC, 7Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 8Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 9University of Arizona, Tucson, AZ

    Background/Purpose: Characterizing knee symptom (i.e., pain and function) trajectories and understanding differences among symptom trajectories have the potential to promote the development of customized treatment…
  • Abstract Number: 2649 • ACR Convergence 2024

    Defining Clinical Subgroups of Patients with Relapsing Polychondritis: A Latent Class and Decision Tree Analysis in Two Independent Prospective Cohorts

    Shubhasree Banerjee1, Carol McAlear2, Peter Merkel3, Peter Grayson4 and Marcela Ferrada5, 1University of Pennsylvania, Philadelphia, 2University of Pennsylvania, Philadelphia, PA, 3Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, 4National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Chevy Chase, MD, 5University of Maryland, Baltimore, MD

    Background/Purpose: Lack of awareness and disease heterogeneity are common factors associated with diagnosis delay in patients with Relapsing polychondriytis (RP). Using latent class analysis (LCA),…
  • Abstract Number: 0030 • ACR Convergence 2024

    The Impact of Treadmill Exercise on Various Stages of Osteoarthritis Progression in a Murine Osteoarthritis Model

    Mengcun Chen1, Mingshu Cui2, Yangmei Yang3 and Bin Wang1, 1Thomas Jefferson University, Philadelphia, PA, 2Thomas Jefferson University, Philadelpha, 3Thomas Jefferson University, Philadephia

    Background/Purpose: Evidence supports the benefits of exercise on joint health and its protective effects against osteoarthritis (OA) progression [Allen J, A&R, 2010]. However, most animal…
  • Abstract Number: 0031 • ACR Convergence 2024

    Beyond Pain and Inflammation: Intra-articular Liraglutide’s Comprehensive Benefits on Synovial Health and Cartilage in Osteoarthritis Compared to Dexamethasone

    Coralie Meurot1, Celine Martin1, Margot Vieubled1, Jerome Breton1, Indira Toillon2, Revital Rattenbach3 and Francis Berenbaum2, 14Moving Biotech, lille, France, 2Sorbonne University, Paris, France, 34Moving Biotech, Paris, France

    Background/Purpose: Osteoarthritis (OA) is an age-related joint disease that causes chronic pain and limited mobility. Patients mainly have access to therapies aimed at reducing inflammation…
  • Abstract Number: 0296 • ACR Convergence 2024

    Musculoskeletal Manifestations in Patients Diagnosed with Marfan Syndrome

    Laura Mas Sánchez1, JOSE ELOY OLLER RODRIGUEZ2, Elena Grau García3, Carmen Riesco Barcena4, SAMUEL LEAL5, Marta de la Rubia navarro6, Anderson Huaylla Quispe7, Pablo Muñoz Martínez8, Alba Torrat noves9, Daniel Ramos Castro10, Iago Alcantara Alvarez11, Belén Villanueva Mañés11, Miguel Simeo Vinaixa12, Andrés Pérez Hurtado13 and Jose A Román-Ivorra14, 1Resident at Hospital Universitari i Politecnic La Fe, Valéncia, Spain, 2HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE, VALENCIA, Spain, 3HUP La Fe, Valencia, Spain, 4Hospital Universitario i Politecnic La Fe (Valencia-Spain), Valéncia, Spain, 5Hospital La Fe, Valencia, Spain, 6Rheumatology department, Hospital La Fe, Valéncia, Spain, 7Medicina, Valéncia, Spain, 8Hospital Universitario y Politècnico La Fe, Sagunto, Spain, 9Hospital Universitari i Politècnic La Fe de Valencia, Valencia, Comunidad Valenciana, Spain, 10Hospital Universitario y Politècnico La Fe, Valencia, Spain, 11Rheumatology Department. HUP La Fe, Valencia, Comunidad Valenciana, Spain, 12Hospital Universitari i Politecnic La Fe, Valencia, Spain, 13Rheumatology Department. HUP La Fe, Valencia, Spain, 14Hospital Universitari i Politècnic la Fe, Valencia, Comunidad Valenciana, Spain

    Background/Purpose: There is limited information about musculoskeletal involvement in Marfan syndrome (MS), especially concerning bone metabolism.Methods: We conducted a retrospective and descriptive study of patients…
  • Abstract Number: 0460 • ACR Convergence 2024

    Cartilage Damage or (sub)luxation of Finger Joints: Impact on Physical Function in Patients with Rheumatoid Arthritis

    Takehisa Ogura1, Yasuto Minegishi2, Chihiro Imaizumi1, Reina Maezawa1, Takaharu Katagiri1 and Hideto Kameda1, 1Toho university, Tokyo, Japan, 2Toho University, Tokyo

    Background/Purpose: It has been reported that radiographic joint space narrowing (JSN) score affects the health assessment questionnaire-disability index (HAQ-DI) score in rheumatoid arthritis (RA) patients.…
  • Abstract Number: 1210 • ACR Convergence 2024

    Optimal Definitions of Worsening Cartilage Using Sequential MRI OsteoArthritis Knee Scores (MOAKS)

    Kathryn Bacon1, mike LaValley2, Tuhina Neogi3, Ali Guermazi3, Frank Roemer3, Neil Segal4, Cora Lewis5, Michael Nevitt6, David Felson7 and John Lynch8, 1Boston University, Webster, NH, 2Boston University School of Public Health, Arlington, MA, 3Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 4University of Kansas, Kansas City, KS, 5University of Alabama at Birmingham, Birmingham, AL, 6University of California, San Francisco, San Francisco, CA, 7Boston University, Boston, MA, 8UCSF, San Francisco, CA

    Background/Purpose: The MRI OsteoArthritis Knee Score (MOAKS) is increasingly used in studies of knee osteoarthritis.  Our aim was to evaluate methods using MOAKS scores to…
  • Abstract Number: 0822 • ACR Convergence 2023

    From Biomarkers to Endotypes: Data-driven Identification of Knee Osteoarthritis Patients Subtypes

    Monica Hannani1, Zofia Lisowska-Petersen2, Morten Karsdal2, Cecilie Bager2, Anne-Christine Bay-Jensen2 and Christian Thudium2, 1University of Copenhagen, Herlev, Denmark, 2Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Osteoarthritis (OA) is a diverse and multifaceted condition. Despite its widespread incidence, the core mechanisms of the disease remain elusive, and therapeutic interventions are…
  • Abstract Number: 0874 • ACR Convergence 2023

    RNA-Binding Proteins That Are Highly Expressed and Enriched in Healthy Cartilage but Suppressed in Osteoarthritis

    Hannah Swahn, Merissa Olmer and Martin K Lotz, Scripps Research Institute, La Jolla, CA

    Background/Purpose: RNA-binding proteins (RBPs) have diverse and essential biological functions, but their role in cartilage health and disease is largely unknown. The objectives of this…
  • Abstract Number: 0877 • ACR Convergence 2023

    Loss of Transient Receptor Potential Channel 1 (TRPC1) Links Regulation of Intracellular Calcium to Cellular Senescence and Leads to Development of Osteoarthritis

    Meike Sambale1, starlee lively2, Osvaldo Espin-Garcia2, Pratibha Potla2, Chiara Pastrello3, Alexandra Schaefer1, Jessica Bertrand4, Mohit Kapoor5, Thomas Pap1 and Joanna Sherwood1, 1University Hospital Münster, Münster, Germany, 2University Health Network, Toronto, ON, Canada, 3Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, 4Department of Orthopaedic Surgery, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany, 5Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, Toronto, ON, Canada

    Background/Purpose: Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane. It is crucial for the…
  • Abstract Number: 0882 • ACR Convergence 2023

    Activation of Ovarian Cancer G-Protein Coupled Receptor (OGR1) Attenuates Chondrocytes Inflammation via ERK1/2 Signaling Pathways in an in Vitro Model of Osteoarthritis

    Omar Syed, Bhakti Patel, William Martin, Martha Diaz-Hernandez, Hicham Drissi and Mohd Nazir Khan, Emory University, Atlanta, GA

    Background/Purpose: Osteoarthritis (OA) is the most prevalent joint disease, accounting for 50% of the musculoskeletal burden. Inflammation plays a crucial role in the development of…
  • Abstract Number: 0883 • ACR Convergence 2023

    The Role of Plasmin and Fibrinolysis Pathways in Osteoarthritis

    Qian Wang, heidi Wong, Audrey Bai, Zelda Love, Constance Chu and William Robinson, Stanford School of Medicine, Stanford, CA

    Background/Purpose: Osteoarthritis (OA) is the major cause of joint failure. Increasing evidence suggests that activation of fibrinolysis is involved in the pathogenesis of OA. Here…
  • Abstract Number: 0884 • ACR Convergence 2023

    Identification of a Mast Cell-high Synovial Pathotype of Osteoarthritis

    Shady Younis, Audrey Bai, heidi Wong, Zelda Love, Qian Wang and William Robinson, Stanford School of Medicine, Stanford, CA

    Background/Purpose: Mast cells in the osteoarthritis (OA) synovium correlate with disease severity. This study aimed to further elucidate the role of mast cells in OA…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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