Abstract Number: 2087 • 2015 ACR/ARHP Annual Meeting
Defective Circadian Control in Mesenchymal Cells Reduces Adult Bone Mass
Background/Purpose: Genetic disruption of the circadian molecular clock in mice is a powerful tool to dissect the role of circadian rhythms in health and disease.…Abstract Number: 2210 • 2015 ACR/ARHP Annual Meeting
Immunological Dysregulation and Inadequate Hypoxia Adaptation – HIF-Stabilization As Possible Prevention of Fracture Healing Disorders in RA or Immune-Suppressed Patients
Background/Purpose: Patients suffering from rheumatoid arthritis (RA) are often affected by fracture-healing complications such as increased fracture healing time or non-unions. There is not much…Abstract Number: 2211 • 2015 ACR/ARHP Annual Meeting
Extracellular Vesicles from Cow Milk Accelerate Osteoblast Differentiation into Osteocytes, However, Type I Collagen Synthesis Is Reduced and Bone Matrix Organization Is Impaired
Background/Purpose: Milk consumption during childhood stimulates bone growth but the claimed beneficial effect of milk on bone at adulthood is a matter of debate. Recently…Abstract Number: 2571 • 2015 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Antibody Prevents Loss of Bone Strength in a Mouse Model of Collagen-Induced Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a disease that typically induces secondary osteoporosis, which increases the risk of bone fractures and, consequently, mortality. Bone fracture is…Abstract Number: 202 • 2015 ACR/ARHP Annual Meeting
Bone Accrual in the Dnase II-Deficient Model of Autoimmunity Requires Sting, As Well As Hematopoietic and Stromal Elements
Background/Purpose: We have previously identified a role for cytosolic DNA sensors in bone by analyzing mice that develop inflammatory polyarthritis and trabecular bone accrual in…Abstract Number: 2700 • 2015 ACR/ARHP Annual Meeting
Trabecular Thinning in Metacarpophalangeal Joints of Anticitrullinated Peptide Antibody Positive Patients with Arthralgia
Background/Purpose: Rheumatoid arthritis (RA) is characterized by synovitis leading to bone erosions and joint destruction, but little is known about bone structure in the joints…Abstract Number: 2792 • 2014 ACR/ARHP Annual Meeting
Methotrexate Prevents Inflammatory Osteolysis By Activation of the Adenosine a2A Receptor (A2AR)
Background/Purpose Prior studies demonstrate that adenosine, acting at A2AR, mediates the anti-inflammatory effects of methotrexate (MTX) in models of both acute and chronic inflammation. We…Abstract Number: 2345 • 2014 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Antibody Prevents Deterioration in Bone Structure in a Mouse Model of Collagen-Induced Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a disease that typically induces secondary osteoporosis, which increases the risk of bone fractures and, consequently, mortality. Bone fracture is…Abstract Number: 2130 • 2014 ACR/ARHP Annual Meeting
Bone Microstructure in Patients with Cutaneous Psoriasis and No History of Psoriatic Arthritis Shows Bone Anabolic Changes at a Greater Extent Than in Healthy Controls
Background/Purpose Psoriasis (PSO) is a frequent disease which affects about 1-2% of the population and can be associated to arthritis (PsA). Skin disease often predates…Abstract Number: 2143 • 2014 ACR/ARHP Annual Meeting
Cortical Breaks and Bone Erosions in the Hand Joints: A Cadaver Study Comparing Conventional Radiography with High-Resolution and Micro-Computed Tomography
Background/Purpose . Conventional radiography (CR) is considered the gold standard for diagnosing bone erosions in rheumatic diseases. However, High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) and…Abstract Number: 1914 • 2014 ACR/ARHP Annual Meeting
IL-17A Deficiency Promotes Periosteal Bone Formation in a Model of Inflammatory Arthritis
Background/Purpose: Enthesial and periosteal bone formation in spondyloarthropathies (SpAs) are important sequelae of disease that contribute to patient morbidity. Anti-TNF therapies do not significantly alter…Abstract Number: 1892 • 2014 ACR/ARHP Annual Meeting
In Vivo Visualization of Cortical Microchannels in Metacarpal Bones in Patients with Cutaneous Psoriasis By High Resolution Peripheral Computed tomography – Detecting Cortical Pathologies before the Clinical Onset of Psoriatic-Arthritis
Background/Purpose Normal bones present cortical micro-channels (CMC), which carry micro-vessels and ensure communication between the bone marrow and the synovial compartment. Only recently these structures…Abstract Number: 1794 • 2014 ACR/ARHP Annual Meeting
The Sting Pathway Regulates Bone Remodeling in a Model of Autoimmune Disease
Background/Purpose: Cytosolic DNA sensors detect viral and bacterial DNA, inducing inflammatory cytokines and type I IFNs via the adaptor stimulator of interferon genes (STING) to…Abstract Number: 1424 • 2014 ACR/ARHP Annual Meeting
Bone Erosions in Patients with RA: Exploring the Impact of the Anatomy of Interest on the Relationship Between MRI and X-Ray Erosion Detection
Background/Purpose: Detection of bone erosions in patients with RA is critical in clinical practice, with treatment initiation and effectiveness largely based on limiting erosive progression.…Abstract Number: 1301 • 2014 ACR/ARHP Annual Meeting
Trabecular Bone Impairment Assessed By HR-pQCT in Juvenile-Onset Systemic Lupus Erythematous with Vertebral Fractures
Background/Purpose The three-dimensional evaluation of bone by HR-pQCT has the advantage to provide assessment to not only bone density, but also to a noninvasive evaluation…
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