ACR Meeting Abstracts

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Abstracts tagged "Bone"

  • Abstract Number: 1152 • 2015 ACR/ARHP Annual Meeting

    Comprehensive Novel Proteomic Analysis of RA Synovial Fluid Highlights the Distinct Protein Profiles of Bone and Cartilage Metabolism

    Yasushi Kondo1, Katsuya Suzuki1, Masaru Takeshita2, Yoshiaki Kassai3, Keiko Koga3, Yuumi Gotou4, Takahiro Miyazaki3, Rimpei Morita5, Yasuo Niki6, Atsuko Murota1, Ayumi Nishikawa1, Hironari Hanaoka1, Yuko Kaneko7, Hidekata Yasuoka7, Kunihiro Yamaoka1, Akihiko Yoshimura5 and Tsutomu Takeuchi8, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 3Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Kanagawa, Japan, 4Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Tokyo, Tokyo, Japan, 5Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan, 6Department of Orthopaedic Surgery, Keio University, Tokyo, Japan, 7Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, 8Dept. of Internal Medicine, School of Medicine Keio University, Tokyo, Japan

    Background/Purpose: Growing interest has arisen in the search for specific pathophysiology and biomarker for rheumatoid arthritis (RA) utilizing synovial fluid (SF) proteomic analysis. However the…
  • Abstract Number: 1307 • 2015 ACR/ARHP Annual Meeting

    Does Computerized Segmentation of Early Erosions on Magnetic Resonance Imaging Predict Functional Ability in Rheumatoid Arthritis?

    Matthew Jessome1, Michael Tomizza1, Karen A. Beattie2, William G. Bensen2, Raja Bobba2, Alfred Cividino2, Patrick D. Emond2, Chris Gordon2, Lawrence Hart2, George Ioannidis2, Maggie Larche2, Arthur Lau3, Ruben Tavares2, Stephen Tytus2 and Jonathan D. Adachi2, 1McMaster University, Hamilton, ON, Canada, 2St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 3Division of Rheumatology, McMaster University, Hamilton, ON, Canada

    Background/Purpose: Functional ability of rheumatoid arthritis (RA) patients is reduced by both acute (inflammatory) and chronic (joint damage) disease manifestations. However, the impact of early…
  • Abstract Number: 1315 • 2015 ACR/ARHP Annual Meeting

    Detecting Subtle Changes in Bone Structure Following Three-Month Anti-TNF Theraphy Using High-Resolution Peripheral Quantitative Computed Tomography

    Matthew Tanaka1, Favian Su2, Min Hee Lee3,4, Andrew J. Burghardt5, Thomas M. Link4, Jonathan D. Graf6, John Imboden7 and Xiaojuan Li8, 1University of California Berkeley, Berkeley, CA, 2Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, 3Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea, 4Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, 5Department of Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 6Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, 7Rheumatology, Rheumatology, University of California San Francisco, San Francisco, CA, 8Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA

    Background/Purpose: Radiographs have been traditionally used to detect bone erosions and joint space narrowing (JSN) in rheumatoid arthritis (RA), but they are not sensitive to…
  • Abstract Number: 1744 • 2015 ACR/ARHP Annual Meeting

    Free DKK-1 Serum Levels Are Unchanged in Spondyloarthritis Patients Treated By Etanercept

    Corinne Miceli-Richard1, Bernard Combe2, Francis Berenbaum3, Thierry Schaeverbeke4, Maria Dilleen5, Nandan Koppiker6, Isabelle Logeart7, Arnaud Dubanchet7 and Maxime Dougados8, 1Rhuematology, Cochin Hospital, Paris Descartes University, Paris, France, 2Rheumatology, Hopital Lapeyronie, Montpellier, France, 3Rheumatology and Paris VI University, Saint-Antoine Hospital, Paris, France, 4Rheumatology, CHU Bordeaux, Bordeaux, France, 5Pfizer GIPB, Sandwich, United Kingdom, 6Pfizer PGRD, Sandwich, United Kingdom, 7Pfizer, Paris, France, 8Paris-Descartes University, Paris, France

    Background/Purpose: DKK-1 and SOST are two inhibitory proteins of the Wnt signaling pathway that lead to decreased bone formation by osteoblasts and osteocytes, respectively. Functional…
  • Abstract Number: 2047 • 2015 ACR/ARHP Annual Meeting

    A Randomised Double-Blind Placebo-Controlled Trial of Vitamin D Supplementation in Juvenile-Onset Systemic Lupus Erythematosus: Effects on Microarchitecture Measured By HR-pQCT

    Glauce Lima1, Juliane Paupitz1, Nadia E Aikawa2, Jackeline Couto Alvarenga3, Eloisa Bonfá1 and Rosa M R Pereira4, 1Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 2Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 3Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 4Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Vitamin D has an important effect in bone quality and vitamin D deficiency in Juvenile-onset Systemic Lupus Erythematosus patients (JoSLE) may be associated with…
  • Abstract Number: 2087 • 2015 ACR/ARHP Annual Meeting

    Defective Circadian Control in Mesenchymal Cells Reduces Adult Bone Mass

    Julia F. Charles1 and Joerg Ermann2, 1Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Genetic disruption of the circadian molecular clock in mice is a powerful tool to dissect the role of circadian rhythms in health and disease.…
  • Abstract Number: 1172 • 2014 ACR/ARHP Annual Meeting

    Assessing the Validity and Reliability of a Novel MRI Semi-Automated Algorithm for Quantifying Bone Loss in the Hand

    Matthew Jessome1, Isabel Rodrigues2, Michael Tomizza2, Joshua Barbosa2, Melissa XP. Koh1, Karen Beattie3, William G. Bensen3, Raja Bobba3, Alfred Cividino3, Patrick D. Emond3, Karen Finlay4, Chris Gordon3, Lawrence Hart3, George Ioannidis3, Erik Jurriaans4, Maggie Larche3, Arthur Lau3, Naveen Parasu4, Ruben Tavares3, Stephen Tytus3, Hao Wu2 and Jonathan D. Adachi2,3, 1Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada, 2McMaster University, Hamilton, ON, Canada, 3St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 4Radiology, Hamilton Health Sciences, Hamilton, ON, Canada

    Background/Purpose Efficient and accurate evaluation of erosive damage to the MCP joints in RA patients is desirable in both clinical trials and clinical practice. The…
  • Abstract Number: 1019 • 2014 ACR/ARHP Annual Meeting

    Targeting the Bone-Driven Metabolic OA Phenotype By a Novel Dual Amylin Calcitonin Receptor Agonist, KBP-056

    Ditte Reker, Sara Toftegaard Hjuler, Kim Andreassen, Morten Asser Karsdal, Kim Henriksen and Anne C. Bay-Jensen, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark

    Background/Purpose: Osteoarthritis (OA) may be segregated into different disease phenotypes based on disease drivers; cartilage damage, joint inflammation or subchondral bone remodelling. Each phenotype may…
  • Abstract Number: 330 • 2014 ACR/ARHP Annual Meeting

    Prolactin Reduces Bone Erosion in Adjuvant-Induced Arthritis

    Maria G. Ledesma-Colunga, Norma Adan, Ana L. Reyes-Lopez, Fernando Lopez-Barrera, Gonzalo Martinez de la Escalera and Carmen Clapp, Institute of Neurobiology, National University of Mexico (UNAM), Queretaro, Mexico

    Background/Purpose Bone erosion is an important feature of rheumatoid arthritis (RA) that frequently results in lifelong crippling. The receptor activator of NFkB ligand (RANKL)/osteoprotegerin (OPG)/RANK…
  • Abstract Number: 2792 • 2014 ACR/ARHP Annual Meeting

    Methotrexate Prevents Inflammatory Osteolysis By Activation of the Adenosine a2A Receptor (A2AR)

    Aranzazu Mediero1, Tuere Wilder2 and Bruce N. Cronstein3, 1Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, 2Medicine, division of Translational Medicine, NYU School of Medicine, New York, NY, 3NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose Prior studies demonstrate that adenosine, acting at A2AR, mediates the anti-inflammatory effects of methotrexate (MTX) in models of both acute and chronic inflammation. We…
  • Abstract Number: 2345 • 2014 ACR/ARHP Annual Meeting

    Anti-IL-6 Receptor Antibody Prevents Deterioration in Bone Structure in a Mouse Model of Collagen-Induced Arthritis

    Hiroto Yoshida, Mika Yagoto, Miho Suzuki, Keisuke Tanaka, Misato Hashizume and Yoshihiro Matsumoto, Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a disease that typically induces secondary osteoporosis, which increases the risk of bone fractures and, consequently, mortality. Bone fracture is…
  • Abstract Number: 2130 • 2014 ACR/ARHP Annual Meeting

    Bone Microstructure in Patients with Cutaneous Psoriasis and No History of Psoriatic Arthritis Shows Bone Anabolic Changes at a Greater Extent Than in Healthy Controls

    David Simon1, Francesca Faustini1, Matthias Englbrecht1, Arnd Kleyer1, Roland Kocijan2, Judith Haschka3, Stephanie Finzel1, Sebastian Kraus3, Axel J. Hueber1, Michael Sticherling4, Georg Schett1 and Jürgen Rech3, 1Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, 2Medical Department II, St. Vincent Hospital, Vienna, Austria, 3Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 4Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose Psoriasis (PSO) is a frequent disease which affects about 1-2% of the population and can be associated to arthritis (PsA). Skin disease often predates…
  • Abstract Number: 2143 • 2014 ACR/ARHP Annual Meeting

    Cortical Breaks and Bone Erosions in the Hand Joints: A Cadaver Study Comparing Conventional Radiography with High-Resolution and Micro-Computed Tomography

    A. Scharmga1, A. van Tubergen1, J. van den Bergh1, J. de Jong1, M. Peters1, B. van Rietbergen2 and P. Geusens1, 1Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 2Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

    Background/Purpose . Conventional radiography (CR) is considered the gold standard for diagnosing bone erosions in rheumatic diseases. However, High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) and…
  • Abstract Number: 1914 • 2014 ACR/ARHP Annual Meeting

    IL-17A Deficiency Promotes Periosteal Bone Formation in a Model of Inflammatory Arthritis

    Anita T. Shaw1, Yukiko Maeda1, Catherine Manning1 and Ellen M. Gravallese1,2, 1Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, 2Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA

    Background/Purpose: Enthesial and periosteal bone formation in spondyloarthropathies (SpAs) are important sequelae of disease that contribute to patient morbidity. Anti-TNF therapies do not significantly alter…
  • Abstract Number: 1892 • 2014 ACR/ARHP Annual Meeting

    In Vivo Visualization of Cortical Microchannels in Metacarpal Bones in Patients with Cutaneous Psoriasis By High Resolution Peripheral Computed tomography – Detecting Cortical Pathologies before the Clinical Onset of Psoriatic-Arthritis

    David Simon1, Francesca Faustini1, Arnd Kleyer1, Judith Haschka1, David Werner1, Axel J. Hueber1, Michael Sticherling2, Georg Schett1 and Juergen Rech1, 1Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose Normal bones present cortical micro-channels (CMC), which carry micro-vessels and ensure communication between the bone marrow and the synovial compartment. Only recently these structures…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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