Abstracts tagged "Bone"

Abstract Number: 2087 • 2015 ACR/ARHP Annual Meeting
Defective Circadian Control in Mesenchymal Cells Reduces Adult Bone Mass
Julia F. Charles¹ and Joerg Ermann², ¹Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Genetic disruption of the circadian molecular clock in mice is a powerful tool to dissect the role of circadian rhythms in health and disease.…
Abstract Number: 2210 • 2015 ACR/ARHP Annual Meeting
Immunological Dysregulation and Inadequate Hypoxia Adaptation – HIF-Stabilization As Possible Prevention of Fracture Healing Disorders in RA or Immune-Suppressed Patients
Annemarie Lang^1,2,3, Sarah Fuegener², Paula Hoff^1,2, Katharina Schmidt-Bleek⁴, Timo Gaber^1,2 and Frank Buttgereit², ¹German Rheumatism Research Center (DRFZ), Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ³Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany, ⁴Julius Wolff Institut, Charité University Medicine, Berlin, Germany
Background/Purpose: Patients suffering from rheumatoid arthritis (RA) are often affected by fracture-healing complications such as increased fracture healing time or non-unions. There is not much…
Abstract Number: 2211 • 2015 ACR/ARHP Annual Meeting
Extracellular Vesicles from Cow Milk Accelerate Osteoblast Differentiation into Osteocytes, However, Type I Collagen Synthesis Is Reduced and Bone Matrix Organization Is Impaired
Marina C. Oliveira¹, Onno J. Arntz¹, Esmeralda Blaney Davidson¹, Wim van den Berg¹, Adaliene V.M. Ferreira² and Fons A.J. van de Loo¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Nutrition, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Background/Purpose: Milk consumption during childhood stimulates bone growth but the claimed beneficial effect of milk on bone at adulthood is a matter of debate. Recently…
Abstract Number: 2571 • 2015 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Antibody Prevents Loss of Bone Strength in a Mouse Model of Collagen-Induced Arthritis
Hiroto Yoshida, Yuanyuan Bi, Miho Suzuki, Keisuke Tanaka and Yoshihiro Matsumoto, Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a disease that typically induces secondary osteoporosis, which increases the risk of bone fractures and, consequently, mortality. Bone fracture is…
Abstract Number: 202 • 2015 ACR/ARHP Annual Meeting
Bone Accrual in the Dnase II-Deficient Model of Autoimmunity Requires Sting, As Well As Hematopoietic and Stromal Elements
Rebecca Baum¹, Shruti Sharma¹, Ann Marshak-Rothstein¹, Katherine A. Fitzgerald¹ and Ellen M. Gravallese², ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: We have previously identified a role for cytosolic DNA sensors in bone by analyzing mice that develop inflammatory polyarthritis and trabecular bone accrual in…
Abstract Number: 2700 • 2015 ACR/ARHP Annual Meeting
Trabecular Thinning in Metacarpophalangeal Joints of Anticitrullinated Peptide Antibody Positive Patients with Arthralgia
Kresten Krarup Keller¹, Jesper Skovhus Thomsen², Kristian Stengaard-Pedersen¹, Andreas Wiggers Nielsen¹, Berit Schiøtz-Christensen³, Lone Svendsen⁴, Merete Graakjær⁵, Peter Mosborg Pedersen⁶, Barbara Unger⁷, Bente Langdahl⁸ and Ellen-Margrethe Hauge¹, ¹Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ²Aarhus University, Aarhus, Denmark, ³Spine Centre of Southern Denmark, Middelfart, Denmark, ⁴Private Practice in Rheumatology, Skanderborg, Denmark, ⁵Clinic of Rheumatology Aarhus, Aarhus, Denmark, ⁶Randers Hospital, Randers, Denmark, ⁷Horsens Hospital, Horsens, Denmark, ⁸Endocrinology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: Rheumatoid arthritis (RA) is characterized by synovitis leading to bone erosions and joint destruction, but little is known about bone structure in the joints…
Abstract Number: 2792 • 2014 ACR/ARHP Annual Meeting
Methotrexate Prevents Inflammatory Osteolysis By Activation of the Adenosine a_2A Receptor (A2AR)
Aranzazu Mediero¹, Tuere Wilder² and Bruce N. Cronstein³, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Medicine, division of Translational Medicine, NYU School of Medicine, New York, NY, ³NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Prior studies demonstrate that adenosine, acting at A2AR, mediates the anti-inflammatory effects of methotrexate (MTX) in models of both acute and chronic inflammation. We…
Abstract Number: 2345 • 2014 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Antibody Prevents Deterioration in Bone Structure in a Mouse Model of Collagen-Induced Arthritis
Hiroto Yoshida, Mika Yagoto, Miho Suzuki, Keisuke Tanaka, Misato Hashizume and Yoshihiro Matsumoto, Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a disease that typically induces secondary osteoporosis, which increases the risk of bone fractures and, consequently, mortality. Bone fracture is…
Abstract Number: 2130 • 2014 ACR/ARHP Annual Meeting
Bone Microstructure in Patients with Cutaneous Psoriasis and No History of Psoriatic Arthritis Shows Bone Anabolic Changes at a Greater Extent Than in Healthy Controls
David Simon¹, Francesca Faustini¹, Matthias Englbrecht¹, Arnd Kleyer¹, Roland Kocijan², Judith Haschka³, Stephanie Finzel¹, Sebastian Kraus³, Axel J. Hueber¹, Michael Sticherling⁴, Georg Schett¹ and Jürgen Rech³, ¹Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Medical Department II, St. Vincent Hospital, Vienna, Austria, ³Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose Psoriasis (PSO) is a frequent disease which affects about 1-2% of the population and can be associated to arthritis (PsA). Skin disease often predates…
Abstract Number: 2143 • 2014 ACR/ARHP Annual Meeting
Cortical Breaks and Bone Erosions in the Hand Joints: A Cadaver Study Comparing Conventional Radiography with High-Resolution and Micro-Computed Tomography
A. Scharmga¹, A. van Tubergen¹, J. van den Bergh¹, J. de Jong¹, M. Peters¹, B. van Rietbergen² and P. Geusens¹, ¹Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ²Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
Background/Purpose . Conventional radiography (CR) is considered the gold standard for diagnosing bone erosions in rheumatic diseases. However, High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) and…
Abstract Number: 1914 • 2014 ACR/ARHP Annual Meeting
IL-17A Deficiency Promotes Periosteal Bone Formation in a Model of Inflammatory Arthritis
Anita T. Shaw¹, Yukiko Maeda¹, Catherine Manning¹ and Ellen M. Gravallese^1,2, ¹Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ²Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Enthesial and periosteal bone formation in spondyloarthropathies (SpAs) are important sequelae of disease that contribute to patient morbidity. Anti-TNF therapies do not significantly alter…
Abstract Number: 1892 • 2014 ACR/ARHP Annual Meeting
In Vivo Visualization of Cortical Microchannels in Metacarpal Bones in Patients with Cutaneous Psoriasis By High Resolution Peripheral Computed tomography – Detecting Cortical Pathologies before the Clinical Onset of Psoriatic-Arthritis
David Simon¹, Francesca Faustini¹, Arnd Kleyer¹, Judith Haschka¹, David Werner¹, Axel J. Hueber¹, Michael Sticherling², Georg Schett¹ and Juergen Rech¹, ¹Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose Normal bones present cortical micro-channels (CMC), which carry micro-vessels and ensure communication between the bone marrow and the synovial compartment. Only recently these structures…
Abstract Number: 1794 • 2014 ACR/ARHP Annual Meeting
The Sting Pathway Regulates Bone Remodeling in a Model of Autoimmune Disease
Rebecca Baum¹, Jason M. Organ², David B. Burr³, Ann Marshak-Rothstein⁴, Katherine A. Fitzgerald⁵ and Ellen M. Gravallese⁶, ¹Cell Biology, University of Massachusetts Medical School, Worcester, MA, ²Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, ³Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, ⁴Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ⁵Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, ⁶Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Cytosolic DNA sensors detect viral and bacterial DNA, inducing inflammatory cytokines and type I IFNs via the adaptor stimulator of interferon genes (STING) to…
Abstract Number: 1424 • 2014 ACR/ARHP Annual Meeting
Bone Erosions in Patients with RA: Exploring the Impact of the Anatomy of Interest on the Relationship Between MRI and X-Ray Erosion Detection
Michael Tomizza¹, Isabel Rodrigues¹, Matthew Jessome¹, Joshua Barbosa¹, Karen Beattie², William G. Bensen², Raja Bobba², Alfred Cividino², Patrick D. Emond², Karen Finlay³, Chris Gordon², Lawrence Hart², George Ioannidis², Erik Jurriaans³, Melissa Koh¹, Maggie Larche², Arthur Lau², Naveen Parasu³, Ruben Tavares², Stephen Tytus², Hao Wu¹ and Jonathan D. Adachi^1,2, ¹McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³Radiology, Hamilton Health Sciences, Hamilton, ON, Canada
Background/Purpose: Detection of bone erosions in patients with RA is critical in clinical practice, with treatment initiation and effectiveness largely based on limiting erosive progression.…
Abstract Number: 1301 • 2014 ACR/ARHP Annual Meeting
Trabecular Bone Impairment Assessed By HR-pQCT in Juvenile-Onset Systemic Lupus Erythematous with Vertebral Fractures
Juliane Paupitz, Glauce Lima, Valéria Caparbo, Henrique Fuller, Eloisa Bonfa and Rosa M R Pereira, Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose The three-dimensional evaluation of bone by HR-pQCT has the advantage to provide assessment to not only bone density, but also to a noninvasive evaluation…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].