Abstracts tagged "Bone"

Abstract Number: 1128 • 2016 ACR/ARHP Annual Meeting
Anti-Fractalkine Monoclonal Antibody Inhibits Cartilage Destruction and Bone Erosion in Collagen-Induced Arthritis Model
Kana Hoshino¹, Masayoshi Ohkuro², Wataru Ikeda¹, Tomoya Nakatani¹, Yoshikazu Kuboi³, Naoto Ishii¹, Toshihiko Yamauchi¹, Nobuyuki Yasuda¹ and Toshio Imai¹, ¹KAN Research Institute Inc., Chuo-ku, Kobe-shi, Japan, ²Research Project Promotion Group, EA Pharma Co., Ltd., Kawasaki-ku, Kawasaki-shi, Japan, ³Medicine Creation. Neuro Business Group, Eisai Co., Ltd., Tsukuba-shi, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. In the previous Phase 1/2 clinical study, E6011, a novel humanized anti-fractalkine (FKN)…
Abstract Number: 1307 • 2016 ACR/ARHP Annual Meeting
Anatomical Patterns Suggest the Involvement of Biomechanical Stress in the Pathogenesis of Erosions in Rheumatoid Arthritis
Matthew A. Jessome¹, Michael A. Tomizza¹, Karen A. Beattie², William G. Bensen², Raja S. Bobba², Alfred Cividino², Patrick D. Emond², Chris Gordon², Lawrence Hart², Maggie Larche², Arthur Lau³, Ruben Tavares², Stephen Tytus² and Jonathan D. Adachi², ¹Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³50 Charlton Avenue East, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Background/Purpose: There is limited data outlining the anatomic characteristics of bone erosions of the small joints in rheumatoid arthritis (RA). In particular, there is minimal…
Abstract Number: 1512 • 2016 ACR/ARHP Annual Meeting
Bone Structural Deficits in Rheumatoid Arthritis: Impact of Muscle Mass and Density
Joshua Baker¹, Jin Long², Babette S. Zemel³, Janet E. Dinnella⁴, Prerna Sharma⁵, Said Ibrahim⁶ and Mary B. Leonard⁷, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Stanford University, Palo Alto, CA, ³Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁴Arthritis/Immun Center, U Penn & VA Med Ctr, Philadelphia, PA, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Medicine, University of Pennsylvania, Philadelphia, PA, ⁷Pediatrics, Division of Nephrology, Stanford School of Medicine, Stanford University, Palo Alto, CA
Background/Purpose: Rheumatoid arthritis (RA) is associated with muscle loss, obesity, and osteoporotic fractures. Body composition and muscle quality are important regulators of bone strength among…
Abstract Number: 1671 • 2016 ACR/ARHP Annual Meeting
Pirfenidone Might Inhibit New Bone Formation in Spondyloarthritis: Proof of Concept Study Using Cell Culture Models
Julie Laustsen¹, Søren Lomholt¹, Pernille Andersen², Jens Kelsen³ and Tue Wenzel Kragstrup^1,4, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark, ³Department of Gastroenterology, Aarhus University Hospital, Aarhus, Denmark, ⁴Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized…
Abstract Number: 2134 • 2016 ACR/ARHP Annual Meeting
Bone Replaces Cartilage in Non-Weight Bearing Regions of Immobilized Knees
T Mark Campbell¹, Katherine Reilly², Odette Laneuville³, Hans Uhthoff⁴ and Guy Trudel⁵, ¹Physical Medicine and Rehabilitation, Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa, ON, Canada, ³Biology, University of Ottawa, Ottawa, ON, Canada, ⁴Surgery, The Ottawa Hospital, Ottawa, ON, Canada, ⁵Medicine, The Ottawa Hospital Rehabilitation Centre, Ottawa, ON, Canada
Bone Replaces Cartilage In Non-Weight Bearing Regions Of Immobilized KneesBackground/Purpose: Osteoarthritis causes pain, restricts joint range of motion, reduces function, is highly prevalent worldwide and…
Abstract Number: 2280 • 2016 ACR/ARHP Annual Meeting
Monosodium Urate Crystal-Induced Inflammation Promotes Osteocyte Expression of Pro-Resorptive and Inflammatory Mediators: Implications for Erosive Gout
Ashika Chhana¹, Mei-Lin Tay², Bregina Pool³, Karen E. Callon², David Musson², Dorit Naot¹, Gregory Gamble³, Jillian Cornish³ and Nicola Dalbeth², ¹Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Bone erosion in gout is strongly associated with tophi; lesions comprising of inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are…
Abstract Number: 2998 • 2016 ACR/ARHP Annual Meeting
Gut Microbiota Induce IGF-1 and Promote Bone Formation and Growth
Jing Yan¹, Jeremy Herzog², Kelly Tsang¹, R. Balfour Sartor², Antonios Aliprantis³ and Julia F. Charles¹, ¹Medicine/Rheumatology, Brigham and Women's Hospital, Boston, MA, ²National Gnotobiotic Rodent Resource Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Appreciation of the role of the gut microbiome in regulating vertebrate metabolism has exploded recently. However, the effects of gut microbiota on skeletal growth…
Abstract Number: 156 • 2016 ACR/ARHP Annual Meeting
Detection of Finger Joint Osteophytes and Bone Erosions By Ultrasound; A Comparison to Computed Tomography and Histology
Martin Stradner¹, Stephanie Finzel², Rusmir Husic¹, Manuel Dreu³, Alexander Hofmeister⁴, christine Beham-Schmid⁵, Winfried Graninger¹ and Christian Dejaco¹, ¹Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ²Department of Rheumatology and Clinical Immunology, Medical Faculty, University Medical Center, University of Freiburg, Freiburg, Germany, ³Department of Anatomy, Medical University of Graz, Graz, Austria, ⁴Core Facility Alternative Biomodels & Preclinical Imaging, Medical University of Graz, Graz, Austria, ⁵5Institute of Pathology, Medical University of Graz, Graz, Austria
Background/Purpose: Ultrasound (US) is an emerging technique for the examination of osteoarthritis of the hands (HOA).Bone erosions and osteophytes are hallmarks of advanced HOA. We…
Abstract Number: 326 • 2016 ACR/ARHP Annual Meeting
Cortical Bone Changes in Pre- and Postmenopausal Healthy Women Measured with HR-pQCT
Jackeline Couto Alvarenga¹ and Rosa M R Pereira², ¹Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da USP, São Paulo, Brazil
Background/Purpose: Increased fracture rates are well-recognized in adults with trabecular and cortical bone deficits, but cortical evaluation has been poorly studied. The aim of this…
Abstract Number: 468 • 2016 ACR/ARHP Annual Meeting
Angiotensin II Exacerbates Bone Destruction in TNF-Transgenic Arthritis Mice
Takafumi Mito¹, Tomoyuki Mukai², Shunichi Fujita², Akiko Nagasu², Hiroyasu Hirano², Teruki Sone³ and Yoshitaka Morita², ¹rheumatology, Kawasaki medical school, Okayama, Japan, ²Rheumatology, Kawasaki medical school, Okayama, Japan, ³Nuclear Medicine, Kawasaki medical school, Okayama, Japan
Background/Purpose: Angiotensin II (Ang II) is known to function on various organs including kidneys, adrenal glands as well as the nervous and cardiovascular systems. In…
Abstract Number: 528 • 2016 ACR/ARHP Annual Meeting
Assessment of Metacarpal Head Bone Microarchitecture According to Presence or Not of Inflammation in Rheumatoid Arthritis Patients with Low Disease Activity
Shuing Kong¹, Hervé Locrelle¹, Adamah Amouzougan¹, Delphine Denarie¹, Philippe Collet¹, Béatrice Pallot Prades¹, Thierry Thomas^1,2 and Hubert Marotte^1,2, ¹Rheumatology Department, University Hospital of Saint-Etienne, Saint-Etienne, France, ²INSERM U1059/LBTO, Université de Lyon - Université Jean Monnet, Saint-Etienne, France
Background/Purpose: Bone alteration at the metacarpeal head during rheumatoid arthritis (RA) disease remained under investigated. High‐resolution peripheral quantitative computed tomography (HRpQCT) allows exploration of microarchitecture…
Abstract Number: 538 • 2016 ACR/ARHP Annual Meeting
What Is the Relationship Between Early Metacarpophalangeal Erosions on MRI and Joint Pain in Rheumatoid Arthritis?
Matthew A. Jessome¹, Karen A. Beattie², William G. Bensen², Raja S. Bobba², Alfred Cividino², Patrick D. Emond², Chris Gordon², Lawrence Hart², George Ioannidis², Maggie Larche², Arthur Lau³, Ruben Tavares², Stephen Tytus² and Jonathan D. Adachi², ¹Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³50 Charlton Avenue East, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Background/Purpose: Erosive damage to small joints is a hallmark feature of rheumatoid arthritis (RA). The degree to which early erosive damage contributes to joint pain…
Abstract Number: 935 • 2016 ACR/ARHP Annual Meeting
Pretreatment Plasma IL-6 Levels Are Responsible for Bone Erosion Progression on Magnetic Resonance Imaging in Patients with Rheumatoid Arthritis
Yasushi Kondo¹, Yuko Kaneko^2,3, Hiroaki Sugiura⁴, Shunsuke Matsumoto⁴, Naoshi Nishina³, Masahiro Jinzaki⁴ and Tsutomu Takeuchi¹, ¹Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, ²Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, ³Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ⁴Department of Radiology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Plasma cytokines include tumour necrosis factor (TNF)-ƒ¿, interleukin (IL)-1 and IL-6 play important roles in the pathogenesis of rheumatoid arthritis (RA) causing not only…
Abstract Number: 937 • 2016 ACR/ARHP Annual Meeting
Distal Interphalangeal Joint Erosions Assessed By HR-pQCT in Patients with Psoriatic Onycholysis
Axel Patrice VILLANI¹, Stéphanie Boutroy², Hubert Marotte Sr.³, Loïs Barets⁴, Marie-Christine Carlier⁵, Roland Chapurlat⁶, Denis Jullien¹ and Cyrille B Confavreux⁷, ¹Dermatology, Hôpital Edouard Herriot, Dermatology department, Lyon I University, Lyon, France, ²Lyon I University, Inserm UMR1033, Lyon, France, ³CHU de St Etienne, Service de rhumatologie, St Etienne, France, ⁴Rheumatology, Hôpital Edouard Herriot, Lyon, France, ⁵Biochemistry, Hôpital Edouard Herriot, Lyon, France, ⁶Rheumatology, Hôpital Edouard Herriot, Hospices Civils de Lyon, University of Lyon, Lyon, France, ⁷Hôpital Edouard Herriot, Hospices Civils de Lyon, University of Lyon, Lyon, France
Background/Purpose: A third of cases of skin psoriasis are complicated by potentially incapacitating psoriatic arthritis (PsA). Nail psoriasis, especially onycholysis, is present in more than…
Abstract Number: 1103 • 2016 ACR/ARHP Annual Meeting
Gingival Tissue-Derived MSC Cells (GMSC) Suppress Osteoclastogenesis and Bone Erosion in Collagen-Induced Arthritis Thought CD73 Signal Pathway
Yongjiang Zheng^1,2, Julie Wang³, Nancy J. Olsen⁴, Limin Rong¹ and Song Guo Zheng^4,5, ¹Center for Clinic Immunology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangzhou, China, ²Medicine, Penn State University Hershey Medical Center, Hershey, PA, ³Medicine, Penn State Hershey Medical Center, Hershey, PA, ⁴Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA, ⁵Medicine/Rheumatology, Penn State University Milton S. Hershey Medical Center, Hershey, PA
Background/Purpose: Rheumatoid arthritis (RA) is characterized by chronic inflammatory synovitis leading to joint destruction and systemic bone loss. Osteoclasts are responsible for bone destruction in…

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