Abstracts tagged "Bone"

Abstract Number: 326 • 2016 ACR/ARHP Annual Meeting
Cortical Bone Changes in Pre- and Postmenopausal Healthy Women Measured with HR-pQCT
Jackeline Couto Alvarenga¹ and Rosa M R Pereira², ¹Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da USP, São Paulo, Brazil
Background/Purpose: Increased fracture rates are well-recognized in adults with trabecular and cortical bone deficits, but cortical evaluation has been poorly studied. The aim of this…
Abstract Number: 468 • 2016 ACR/ARHP Annual Meeting
Angiotensin II Exacerbates Bone Destruction in TNF-Transgenic Arthritis Mice
Takafumi Mito¹, Tomoyuki Mukai², Shunichi Fujita², Akiko Nagasu², Hiroyasu Hirano², Teruki Sone³ and Yoshitaka Morita², ¹rheumatology, Kawasaki medical school, Okayama, Japan, ²Rheumatology, Kawasaki medical school, Okayama, Japan, ³Nuclear Medicine, Kawasaki medical school, Okayama, Japan
Background/Purpose: Angiotensin II (Ang II) is known to function on various organs including kidneys, adrenal glands as well as the nervous and cardiovascular systems. In…
Abstract Number: 528 • 2016 ACR/ARHP Annual Meeting
Assessment of Metacarpal Head Bone Microarchitecture According to Presence or Not of Inflammation in Rheumatoid Arthritis Patients with Low Disease Activity
Shuing Kong¹, Hervé Locrelle¹, Adamah Amouzougan¹, Delphine Denarie¹, Philippe Collet¹, Béatrice Pallot Prades¹, Thierry Thomas^1,2 and Hubert Marotte^1,2, ¹Rheumatology Department, University Hospital of Saint-Etienne, Saint-Etienne, France, ²INSERM U1059/LBTO, Université de Lyon - Université Jean Monnet, Saint-Etienne, France
Background/Purpose: Bone alteration at the metacarpeal head during rheumatoid arthritis (RA) disease remained under investigated. High‐resolution peripheral quantitative computed tomography (HRpQCT) allows exploration of microarchitecture…
Abstract Number: 538 • 2016 ACR/ARHP Annual Meeting
What Is the Relationship Between Early Metacarpophalangeal Erosions on MRI and Joint Pain in Rheumatoid Arthritis?
Matthew A. Jessome¹, Karen A. Beattie², William G. Bensen², Raja S. Bobba², Alfred Cividino², Patrick D. Emond², Chris Gordon², Lawrence Hart², George Ioannidis², Maggie Larche², Arthur Lau³, Ruben Tavares², Stephen Tytus² and Jonathan D. Adachi², ¹Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³50 Charlton Avenue East, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Background/Purpose: Erosive damage to small joints is a hallmark feature of rheumatoid arthritis (RA). The degree to which early erosive damage contributes to joint pain…
Abstract Number: 935 • 2016 ACR/ARHP Annual Meeting
Pretreatment Plasma IL-6 Levels Are Responsible for Bone Erosion Progression on Magnetic Resonance Imaging in Patients with Rheumatoid Arthritis
Yasushi Kondo¹, Yuko Kaneko^2,3, Hiroaki Sugiura⁴, Shunsuke Matsumoto⁴, Naoshi Nishina³, Masahiro Jinzaki⁴ and Tsutomu Takeuchi¹, ¹Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, ²Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, ³Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ⁴Department of Radiology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Plasma cytokines include tumour necrosis factor (TNF)-ƒ¿, interleukin (IL)-1 and IL-6 play important roles in the pathogenesis of rheumatoid arthritis (RA) causing not only…
Abstract Number: 937 • 2016 ACR/ARHP Annual Meeting
Distal Interphalangeal Joint Erosions Assessed By HR-pQCT in Patients with Psoriatic Onycholysis
Axel Patrice VILLANI¹, Stéphanie Boutroy², Hubert Marotte Sr.³, Loïs Barets⁴, Marie-Christine Carlier⁵, Roland Chapurlat⁶, Denis Jullien¹ and Cyrille B Confavreux⁷, ¹Dermatology, Hôpital Edouard Herriot, Dermatology department, Lyon I University, Lyon, France, ²Lyon I University, Inserm UMR1033, Lyon, France, ³CHU de St Etienne, Service de rhumatologie, St Etienne, France, ⁴Rheumatology, Hôpital Edouard Herriot, Lyon, France, ⁵Biochemistry, Hôpital Edouard Herriot, Lyon, France, ⁶Rheumatology, Hôpital Edouard Herriot, Hospices Civils de Lyon, University of Lyon, Lyon, France, ⁷Hôpital Edouard Herriot, Hospices Civils de Lyon, University of Lyon, Lyon, France
Background/Purpose: A third of cases of skin psoriasis are complicated by potentially incapacitating psoriatic arthritis (PsA). Nail psoriasis, especially onycholysis, is present in more than…
Abstract Number: 1103 • 2016 ACR/ARHP Annual Meeting
Gingival Tissue-Derived MSC Cells (GMSC) Suppress Osteoclastogenesis and Bone Erosion in Collagen-Induced Arthritis Thought CD73 Signal Pathway
Yongjiang Zheng^1,2, Julie Wang³, Nancy J. Olsen⁴, Limin Rong¹ and Song Guo Zheng^4,5, ¹Center for Clinic Immunology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangzhou, China, ²Medicine, Penn State University Hershey Medical Center, Hershey, PA, ³Medicine, Penn State Hershey Medical Center, Hershey, PA, ⁴Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA, ⁵Medicine/Rheumatology, Penn State University Milton S. Hershey Medical Center, Hershey, PA
Background/Purpose: Rheumatoid arthritis (RA) is characterized by chronic inflammatory synovitis leading to joint destruction and systemic bone loss. Osteoclasts are responsible for bone destruction in…
Abstract Number: 1105 • 2016 ACR/ARHP Annual Meeting
Bone Metabolism in Rheumatic Diseases May be Affected By Free Fatty Acids
Klaus W. Frommer¹, Andreas Schäffler², Uwe Lange³, Stefan Rehart⁴, Jürgen Steinmeyer⁵, Markus Rickert⁶, Ulf Müller-Ladner⁷ and Elena Neumann¹, ¹Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Department of Internal Medicine III, Endocrinology, Diabetes, Metabolism, Justus-Liebig-University of Giessen, Bad Nauheim, Germany, ³Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁴Orthopedic & Trauma Surgery, Agaplesion Markus-Hospital, Frankfurt, Frankfurt, Germany, ⁵Dept Orthopedics and Experimental Orthopedics, University Hospital of Giessen and Marburg, Giessen, Germany, ⁶Dept of Orthopedics and Orthopedic Surgery, University Hospital of Giessen and Marburg, Gießen, Germany, ⁷Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Obesity is associated with an increased risk of osteoarthritis also in non-weight bearing joints and increased amounts of visceral fat are associated with lower…
Abstract Number: 1128 • 2016 ACR/ARHP Annual Meeting
Anti-Fractalkine Monoclonal Antibody Inhibits Cartilage Destruction and Bone Erosion in Collagen-Induced Arthritis Model
Kana Hoshino¹, Masayoshi Ohkuro², Wataru Ikeda¹, Tomoya Nakatani¹, Yoshikazu Kuboi³, Naoto Ishii¹, Toshihiko Yamauchi¹, Nobuyuki Yasuda¹ and Toshio Imai¹, ¹KAN Research Institute Inc., Chuo-ku, Kobe-shi, Japan, ²Research Project Promotion Group, EA Pharma Co., Ltd., Kawasaki-ku, Kawasaki-shi, Japan, ³Medicine Creation. Neuro Business Group, Eisai Co., Ltd., Tsukuba-shi, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. In the previous Phase 1/2 clinical study, E6011, a novel humanized anti-fractalkine (FKN)…
Abstract Number: 1307 • 2016 ACR/ARHP Annual Meeting
Anatomical Patterns Suggest the Involvement of Biomechanical Stress in the Pathogenesis of Erosions in Rheumatoid Arthritis
Matthew A. Jessome¹, Michael A. Tomizza¹, Karen A. Beattie², William G. Bensen², Raja S. Bobba², Alfred Cividino², Patrick D. Emond², Chris Gordon², Lawrence Hart², Maggie Larche², Arthur Lau³, Ruben Tavares², Stephen Tytus² and Jonathan D. Adachi², ¹Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³50 Charlton Avenue East, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Background/Purpose: There is limited data outlining the anatomic characteristics of bone erosions of the small joints in rheumatoid arthritis (RA). In particular, there is minimal…
Abstract Number: 1512 • 2016 ACR/ARHP Annual Meeting
Bone Structural Deficits in Rheumatoid Arthritis: Impact of Muscle Mass and Density
Joshua Baker¹, Jin Long², Babette S. Zemel³, Janet E. Dinnella⁴, Prerna Sharma⁵, Said Ibrahim⁶ and Mary B. Leonard⁷, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Stanford University, Palo Alto, CA, ³Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁴Arthritis/Immun Center, U Penn & VA Med Ctr, Philadelphia, PA, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Medicine, University of Pennsylvania, Philadelphia, PA, ⁷Pediatrics, Division of Nephrology, Stanford School of Medicine, Stanford University, Palo Alto, CA
Background/Purpose: Rheumatoid arthritis (RA) is associated with muscle loss, obesity, and osteoporotic fractures. Body composition and muscle quality are important regulators of bone strength among…
Abstract Number: 1671 • 2016 ACR/ARHP Annual Meeting
Pirfenidone Might Inhibit New Bone Formation in Spondyloarthritis: Proof of Concept Study Using Cell Culture Models
Julie Laustsen¹, Søren Lomholt¹, Pernille Andersen², Jens Kelsen³ and Tue Wenzel Kragstrup^1,4, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark, ³Department of Gastroenterology, Aarhus University Hospital, Aarhus, Denmark, ⁴Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized…
Abstract Number: 2134 • 2016 ACR/ARHP Annual Meeting
Bone Replaces Cartilage in Non-Weight Bearing Regions of Immobilized Knees
T Mark Campbell¹, Katherine Reilly², Odette Laneuville³, Hans Uhthoff⁴ and Guy Trudel⁵, ¹Physical Medicine and Rehabilitation, Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa, ON, Canada, ³Biology, University of Ottawa, Ottawa, ON, Canada, ⁴Surgery, The Ottawa Hospital, Ottawa, ON, Canada, ⁵Medicine, The Ottawa Hospital Rehabilitation Centre, Ottawa, ON, Canada
Bone Replaces Cartilage In Non-Weight Bearing Regions Of Immobilized KneesBackground/Purpose: Osteoarthritis causes pain, restricts joint range of motion, reduces function, is highly prevalent worldwide and…
Abstract Number: 2280 • 2016 ACR/ARHP Annual Meeting
Monosodium Urate Crystal-Induced Inflammation Promotes Osteocyte Expression of Pro-Resorptive and Inflammatory Mediators: Implications for Erosive Gout
Ashika Chhana¹, Mei-Lin Tay², Bregina Pool³, Karen E. Callon², David Musson², Dorit Naot¹, Gregory Gamble³, Jillian Cornish³ and Nicola Dalbeth², ¹Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Bone erosion in gout is strongly associated with tophi; lesions comprising of inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are…
Abstract Number: 2998 • 2016 ACR/ARHP Annual Meeting
Gut Microbiota Induce IGF-1 and Promote Bone Formation and Growth
Jing Yan¹, Jeremy Herzog², Kelly Tsang¹, R. Balfour Sartor², Antonios Aliprantis³ and Julia F. Charles¹, ¹Medicine/Rheumatology, Brigham and Women's Hospital, Boston, MA, ²National Gnotobiotic Rodent Resource Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Appreciation of the role of the gut microbiome in regulating vertebrate metabolism has exploded recently. However, the effects of gut microbiota on skeletal growth…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].