Abstracts tagged "Bone"

Abstract Number: 2228 • 2017 ACR/ARHP Annual Meeting
Involvement of Receptor Tyrosine Kinase a Signaling in Rhumatoid Arthritis Using Trka/C Knock-in Mice: A Multimodal Approach
Lauriane Delay¹, Julie Barbier¹, Ludivine Boudieu¹, Denis Ardid¹, Arnaud Briat², Philippe Auzeloux², Elisabeth Moit-Noirault², Aziz Moqrich³ and Fabien Marchand¹, ¹Inserm U1107 NeuroDol, Université Clermont Auvergne, Clermont-Ferrand, France, ²4UMR 1240 Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne, Clermont-Ferrand, France, ³UMR 6216 CNRS-Université de la Méditerranée, Institut de Biologie du Développement de Marseille Luminy, Marseille, France
Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disease very commonly associated with chronic pain which is often resistant to currents analgesics. Targeting Nerve Growth Factor…
Abstract Number: 2941 • 2017 ACR/ARHP Annual Meeting
Effect of Achieving Sustained SDAI Remission on Erosion Repair in Patients with Early RA: A Prospective HR-pQCT Study
Jiang Yue¹, James F Griffith², Fan XIAO³, Ling Qin⁴ and Lai-Shan Tam⁵, ¹Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, HONGKONG, Hong Kong, ³Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁴Bone Quality and Health Centre of the Department of Orthopaedics and Traumatology, The Prince of Wales Hospital, The Chinese University of Hong Kong, hongkong, Hong Kong, ⁵Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: To assess whether achieving sustained SDAI remission in patients with early rheumatoid arthritis (ERA) facilitates repair of existing bone erosions as measured by high-resolution…
Abstract Number: 62 • 2017 ACR/ARHP Annual Meeting
Convergence of Joint Repair and Pain Pathways Via Nerve Growth Factor and p75 Expressing Mesenchymal Stem Cells in Established Osteoarthritis
Thomas Baboolal¹, Sumaiya Al Hinai², Elena Jones², Jill Reckless³, Martyn Foster⁴, Rachel Doyle⁵, Kerry af Forselles⁴, Simon Westbrook⁴ and Dennis McGonagle², ¹PhD, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³Rxcelerate Ltd, Cambridge, United Kingdom, ⁴Levicept Ltd, Ramsgate, United Kingdom, ⁵Tetrad Discovery Ltd, Ramsgate, United Kingdom
Background/Purpose: Nerve growth factor (NGF) is a key regulator of pain and anti-NGF therapy reduces osteoarthritis (OA) associated pain. However, anti-NGF therapy is associated with…
Abstract Number: 319 • 2017 ACR/ARHP Annual Meeting
The Placebo-Controlled Fracture Study in Postmenopausal Women with Osteoporosis: The Foundation Effect of Rebuilding Bone with One Year of Romosozumab Leads to Continued Lower Fracture Risk after Transition to Denosumab
Felicia Cosman¹, Daria B Crittenden², Serge Ferrari³, Aliya Khan⁴, Nancy E Lane⁵, Kurt Lippuner⁶, Toshio Matsumoto⁷, Cassandra E Milmont², Cesar Libanati⁸ and Andreas Grauer², ¹Helen Hayes Hospital, West Haverstraw, and Columbia University, New York, NY, ²Amgen Inc., Thousand Oaks, CA, ³Geneva University Hospital, Geneva, Switzerland, ⁴McMaster University, Hamilton, ON, Canada, ⁵UC Davis Medical Center, Sacramento, CA, ⁶Osteoporosis Policlinic, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland, ⁷University of Tokushima, Tokushima, Japan, ⁸UCB Pharma, Brussels, Belgium
Background/Purpose: Romosozumab (Romo), a sclerostin antibody, has a dual effect of increasing bone formation and decreasing bone resorption. In the FRAME study, one year of…
Abstract Number: 333 • 2017 ACR/ARHP Annual Meeting
Atypical Femoral Fracture in Patients of a Rheumatology Service: Clinical, Radiographic and Bone Histomorphometric Data
Mariana O Perez¹, Diogo S Domiciano¹, Vanda Jorgetti² and Rosa M R Pereira¹, ¹Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, ²Nephrology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
Background/Purpose: Atypical femoral fractures (AFF) are low energy femoral fractures with a specific radiographic pattern and subtrochanteric / diaphyseal localization that have been related to…
Abstract Number: 489 • 2017 ACR/ARHP Annual Meeting
Endotypic Clustering of Rheumatoid Arthritis Patients through the Use of Tissue Specific Serum Biomarkers Identifies Structural Progressors
Joseph Patrick Michele Blair¹, Cecilie Liv Bager¹, Line Mærsk Staunstrup¹, Henning Bay Nielsen¹, Morten Karsdal² and Anne-C. Bay-Jensen³, ¹ProScion, Herlev, Denmark, ²Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ³Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Treatment of RA patients is guided by measures of disease activity such as DAS28, best practice recommendation, and less often by a treat-to-target approach.…
Abstract Number: 656 • 2017 ACR/ARHP Annual Meeting
Prostaglandin E2 and Its Receptor Subtype EP4 Are Involved in Ankylosing Spondylitis Disease Progression
Archita Srinath^1,2,3, Giuliana Guggino⁴, Ismail Sari⁵, Fanxing Zeng⁶, Francesco Ciccia⁴ and Nigil Haroon⁵, ¹Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, ²Genes and Development, University Health Network, Toronto, ON, Canada, ³Krembil Discovery Tower, Toronto, ON, Canada, ⁴Rheumatology Unit, University of Palermo, Palermo, Italy, ⁵Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada, ⁶University Health Network, Toronto, ON, Canada
Background/Purpose: Single Nucleotide Polymorphisms (SNPs) in PTGER4 were found to be associated with Ankylosing spondylitis (AS) in GWAS. PTGER4 codes for the prostaglandin-E2 receptor EP4.…
Abstract Number: 1074 • 2017 ACR/ARHP Annual Meeting
High Cholesterol Levels By ApoE Defenciency Reduce Bone Destruction in Murine Antigen-Induced Arthritis Via Inhibition of Osteoclastogenesis
Giuliana Ascone¹, Irene Di Ceglie¹, Arjen B. Blom¹, Birgitte Walgreen², Annet W. Sloetjes¹, Peter M. van der Kraan¹, Ernst Lindhout³, Mike Martens³ and Peter L. van Lent⁴, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental, Radboud university medical center, Nijmegen, Netherlands, ³Future Diagnostics Solutions (FDs), Wijchen, Netherlands, ⁴Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by immune complex- deposition in the synovium, leading to increased bone destruction. In RA, joint…
Abstract Number: 1219 • 2017 ACR/ARHP Annual Meeting
Associations between Muscle Mass and Function with Bone Microarchitecture and Bone Strength in Postmenopausal Women
Daniel Lobo¹, Jackeline C Alvarenga¹, Diogo S Domiciano², Fabiana Benatti¹, Bruno Gualano¹ and Rosa M R Pereira², ¹Rheumatology Division, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil, ²Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
Background/Purpose: Most studies on sarcopenia and osteoporosis involve elderly populations. However, because postmenopausal hypoestrogenism is able to negatively modulate bone and muscle mass, it is…
Abstract Number: 1225 • 2017 ACR/ARHP Annual Meeting
BONE Mineral Density and Vertebral Fractures in Gaucher Disease Patients Treated with Imiglucerase
Maria Silvia Larroude¹, Gabriel Aguilar¹, Ignacio Rossi¹, Lucas Ricardo Brun² and Guillermo Drelichman³, ¹Centro de Diagnostico Rossi, Buenos Aires, Argentina, ²School of Medicine. Rosario National University, Bone Biology Laboratory, Rosario, Argentina, ³Hospital Ricardo Gutierrez, Buenos Aires, Argentina
Background/Purpose: Osteopenia and osteoporosis (OP) have been described in patients with Gaucher disease (GD) but there are very few reports about bone mass in GD…
Abstract Number: 1899 • 2017 ACR/ARHP Annual Meeting
Osteopontin and Leptin Are Associated with Erosive Disease in an Inception Cohort of Rheumatoid Arthritis Treated-to-Target with Combination Conventional DMARD Therapy
Mihir D. Wechalekar^1,2,3, Susan Lester⁴, Sunil Nagpal⁵, Suzanne Cole⁶, Jessica Peters⁷, Anuk Das⁸, Pravin Hissaria⁹, Tania Crotti¹⁰, Catherine Hill^1,11,12, Sudha Raghunath¹³, Llew Spargo¹⁴, Jennifer G Walker^13,14,15, Malcolm D. Smith² and Susanna Proudman^1,10, ¹Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, ²Flinders University, Adelaide, Australia, ³Rheumatology Unit, Repatriation General Hospital, Adelaide, Australia, ⁴Queen Elizabeth Hospital, Adelaide, Australia, ⁵Immunology, Janssen Research & Development, Spring House, PA, ⁶Immunology, Janssen Research and Development, Spring House, PA, ⁷Janssen Research & Development, Spring House, PA, ⁸Janssen R&D, Berwyn, PA, ⁹Immunology, SA Pathology, Adelaide, Australia, ¹⁰University of Adelaide, Adelaide, Australia, ¹¹Medicine, The University of Adelaide, Adelaide, Australia, ¹²The Queen Elizabeth Hospital, Adelaide, Australia, ¹³Repatriation General Hospital, Adelaide, Australia, ¹⁴Rheumatology Unit, Royal Adelaide Hospital, South Australia, Adelaide, Australia, ¹⁵Flinders University of South Australia, Adelaide, Australia
Background/Purpose: We sought to identify biomarkers associated with erosive disease and bone loss in an inception rheumatoid arthritis (RA) cohort receiving treat-to-target combination DMARD therapy…
Abstract Number: 1946 • 2017 ACR/ARHP Annual Meeting
Development of a Multi-Component 3D Arthritic Joint Model
Alexandra Damerau^1,2, Lisa Ehlers^1,2, Moritz Pfeiffenberger^1,2, Igor Ponomarev³, Frank Buttgereit^2,4, Timo Gaber^4,5 and Annemarie Lang^1,2, ¹Rheumatologie und klinische Immunologie, Charité-Universitätsmedizin Berlin, Berlin, Germany, ²Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, ³Research Center of Medical Technology and Biotechnology, Bad Langensalza, Germany, ⁴Rheumatologie und klinische Immunologie, Charité Universitätsmedizin Berlin, Berlin, Germany, ⁵German Rheumatism Research Center (DRFZ) Berlin, Berlin, Germany
Background/Purpose: Our goal is to develop an in vitro 3D joint model to simulate the immune mediated pathogenesis of arthritides in order to present an…
Abstract Number: 1994 • 2017 ACR/ARHP Annual Meeting
Erosion Depth Predicts Erosion Progression in Patients with Early RA: A Longitudinal Analysis Using HR-pQCT
Jiang YUE¹, James F Griffith², Fan XIAO³, Jiankun XU⁴, Ling Qin⁵ and Lai-Shan Tam⁶, ¹Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, HONGKONG, Hong Kong, ³Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁴Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁵Bone Quality and Health Centre of the Department of Orthopaedics and Traumatology, The Prince of Wales Hospital, The Chinese University of Hong Kong, hongkong, Hong Kong, ⁶Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Background/Purpose: To ascertain the predictors of erosion progression in patients with early RA using high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods: In this prospective study,…
Abstract Number: 1997 • 2017 ACR/ARHP Annual Meeting
Detection of Progression of Radiographic Damage Despite Early and Targeted Therapy in Inflammatory Arthritis Using High-Resolution Peripheral Quantitative Computed Tomography
Sarah Manske^1,2, Stephanie Finzel³, Steven K. Boyd⁴ and Cheryl Barnabe⁵, ¹Department of Radiology, University of Calgary, Calgary, AB, Canada, ²McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, Canada, ³Department of Rheumatology and Clinical Immunology, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ⁴Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁵Division of Rheumatology, University of Calgary, Calgary, AB, Canada
Background/Purpose: Early initiation of DMARDs and targeted therapy to achieve remission are said to offer the best opportunity to prevent radiographic damage in early inflammatory…
Abstract Number: 2207 • 2017 ACR/ARHP Annual Meeting
Urine CTX-II, CTX-I, Osteocalcin, and Radiographic Severity of Multiple OA Knee Joints: Does CTX-II Originate from Bone or Cartilage?
Asger R. Bihlet¹, Inger Byrjalsen², Anne C. Bay-Jensen³, Jeppe Andersen⁴, Claus Christiansen¹, Bente J. Riis¹ and Morten Asser Karsdal³, ¹Nordic Bioscience, Clinical Development, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Rheumatology, Nordic Bioscience, Herlev, Denmark, ⁴Clinical Development, Nordic Bioscience, Herlev, Denmark
Background/Purpose: Excessive cartilage degradation is a known characteristic of osteoarthritis (OA), and several methods of quantification of cartilage degradation exist. Biomarkers such as urinary C-telopeptide…

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