Session Type: ACR Concurrent Abstract Session
Session Time: 11:00AM-12:30PM
To assess whether achieving sustained SDAI remission in patients with early rheumatoid arthritis (ERA) facilitates repair of existing bone erosions as measured by high-resolution peripheral quantitative computed tomography (HR-pQCT).
In this prospective study, 63 ERA patients were treated with a tight-control protocol aiming at remission using csDMARDs. HR-pQCT examinations were performed at baseline and one-year post-baseline. Changes in erosion size (maximal width, depth, volume) and density of the surrounding bone (marginal osteosclerosis) of erosion near the second metacarpal-phalangeal joint (MCP2) were quantified using HR-pQCT at baseline, 6 months and 12 months. Patients were sub-grouped according to whether or not they achieved sustained simplified disease activity score (SDAI) remission (SDAI< 3.3) at month 6, 9 and 12.
19 (31%) patients achieved (Group 1) and 44 (69%) patients did not achieve (Group 2) sustained SDAI remission. At baseline, no significant differences in erosion size and marginal osteosclerosis were present between the two groups. In group 1, significant reduction in erosion volume and increase in marginal osteosclerosis was observed between baseline and 12 months (Table 1). In contrast, erosion width significantly increased in group 2 at 6 and 12 months compared to baseline. At 12 months, change in erosion volume was significantly different between the two groups.
In ERA patients who achieved sustained SDAI remission, HR-pQCT revealed a reduction in erosion volume and an increase in marginal osteosclerosis, indicating that partial erosion repair seems to be possible as long as effective reduction of inflammation is achieved.
We would like to acknowledge the Health and Medical Research Fund (HMRF) for funding support (HMRF Project No. 10110071).
To cite this abstract in AMA style:Yue J, Griffith JF, XIAO F, Qin L, Tam LS. Effect of Achieving Sustained SDAI Remission on Erosion Repair in Patients with Early RA: A Prospective HR-pQCT Study [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/effect-of-achieving-sustained-sdai-remission-on-erosion-repair-in-patients-with-early-ra-a-prospective-hr-pqct-study/. Accessed May 27, 2020.
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