Abstracts tagged "Biomarkers"

Abstract Number: 781 • 2018 ACR/ARHP Annual Meeting
Simultaneous Identification of Two Biomarkers in ACTIVE LUPUS Nephritis: Autophagy in Treg CELLS and Prolactin Receptors in B Lymphocytes
Luis J. Jara-Quezada¹, Emma Zurita², Ana Durán², Antonio Sanchez³, Reyna Bustamante³, Gabriela Medina⁴, Miguel A Saavedra⁵, María Pilar Cruz-Dominguez³, Olga Vera-Lastra⁶, María Pilar Jiménez-Arellano⁷, Michel Augusto Martínez-Bencomo³ and Azucena Rodriguez², ¹Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional,, Mexico, Mexico, ²Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional,, Mexico City, Mexico, ³Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional "La Raza", Mexico City, Mexico, ⁴Clinical Research Unit, Hospital de Especialidades Centro Medico La Raza,IMSS, Mexico City, Mexico, ⁵Novartis Farmaceutica, Calz de Tlaplan 1779, Mexico, Mexico, ⁶Rheumatology, Instituto Mexicano Seguro Social, Mexico City, Mexico, ⁷Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional "La Raza", Mexico CIty, Mexico
Background/Purpose: Recent studies suggest that autophagy defects contributes to systemic lupus erythematosus (SLE) pathogenesis. Prolactin (PRL) is associated with active SLE and stimulates the immune…
Abstract Number: 1255 • 2018 ACR/ARHP Annual Meeting
Elevated Serum Globulin Gap As a Reliable and Cost-Savings Marker of Inflammation in Patients with Systemic Rheumatic Diseases
William Stohl¹, Beatrice Kenol², Andrew Kelly², Aditi Ananth Correa² and Richard Panush³, ¹Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Keck School of Medicine of University of Southern California, Los Angeles, CA, ³Rheumatology, Keck School of Medicine of University of Southern California, Los Angeles, CA
Background/Purpose: In clinical practice, the two most commonly used markers of systemic inflammation are the serum CRP level and ESR. The economic costs of these…
Abstract Number: 1573 • 2018 ACR/ARHP Annual Meeting
Salivary Dysbiosis Correlates with Clinical Status of Anti-Ro Positive Mothers of Children with Neonatal Lupus
Robert M. Clancy¹, Carl Langefeld², Hannah C. Ainsworth³, Martin Blaser⁴, Peter M. Izmirly⁵, Corey Lacher¹, Miranda C Marion⁶, Mala Masson¹, Gregg Silverman⁷ and Jill P. Buyon¹, ¹NYU School of Medicine, New York, NY, ²Wake Forest School of Medicine, Winston-Salem, NC, ³Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁴Director of the NYU Human Microbiome Program, NYU School of Medicine, New York, NY, ⁵Rheumatology, NYU School of Medicine, New York, NY, ⁶Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC, ⁷Dept of Medicine, NYU School of Medicine, New York, NY
Background/Purpose: Neonatal lupus is linked to the presence of circulating anti-Ro antibodies in the mother. These antibodies are present in asymptomatic individuals, who in a…
Abstract Number: 2035 • 2018 ACR/ARHP Annual Meeting
Effect of Baricitinib on Joint-Related Biomarkers in Patients with Moderate-to-Severe Rheumatoid Arthritis
Christian S. Thudium¹, Anne C. Bay-Jensen¹, Suntara Cahya², Ernst R. Dow², Morten A. Karsdal¹, Alisa E. Koch², Wenling Zhang² and Robert J. Benschop², ¹Nordic Bioscience, Herlev, Denmark, ²Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Baricitinib (bari) is an oral selective inhibitor of Janus kinase (JAK) 1 and JAK2. In the phase 3 study RA-BUILD (NCT01721057), once-daily bari yielded…
Abstract Number: 2937 • 2018 ACR/ARHP Annual Meeting
Anti-Vinculin Antibodies in Systemic Sclerosis (SSc): A Potential Biomarker Linking Vascular and Gastrointestinal System Involvement in Two Phenotypically Distinctive SSc Groups
Yossra A Suliman¹, Suzanne Kafaja², Gianluca Bagnato³, Mohamed Alemam⁴, Isela Valera⁵, Walter Morales⁶, Mark Pimentel⁷, Francesco Del Galdo⁸ and Daniel E. Furst⁹, ¹Rheumatology and Rehabilitation dept., Rheumatology and Rehabilitation dept. Assiut university hospital, Assiut Egypt, Assiut, Egypt, ²Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ³Leeds Musculoskeletal Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁴Clinical Pathology and Laboratory Medicine Department, Lecturer, Qena, Egypt, ⁵Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, ⁶GI Motility Program, Research associate, Los Angeles, CA, ⁷Gastrointestinal, Cedar Sinai Medical Center, Los Angeles, CA, ⁸Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁹Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Vinculin is a cytoskeletal protein that plays a major role in cell-cell and cell-extracellular matrix adhesion thus regulating cell growth, migration and function of…
Abstract Number: 783 • 2018 ACR/ARHP Annual Meeting
Procalcitonin and CXCL9 As Potential Biomarkers for Pneumonia in Patients with Systemic Lupus Erythematosus
Hilda Fragoso-Loyo¹, Andrea Hinojosa-Azaola¹, Ricardo Ríos-Corzo², John Hernandez-Flores³, Mariana Lopez-Lopez¹, Ariadna Díaz-Mora¹, Alma Lilia Pulido-Ramírez², Jose Sifuentes-Osornio³, María de Lourdes Guerrero-Almeida⁴, Luis Alfredo Ponce de León-Garduño⁴, Eduardo Carrillo-Maravilla⁵, Luis Llorente¹ and Yemil Atisha-Fregoso^6,7, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Medicine Division, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ³Internal Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁴Infectious Diseases Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁵Medicina Interna, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, Mexico, ⁶Instituto Tecnológico de Estudios Superiores de Monterrey, Mexico City, Mexico, ⁷Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
Background/Purpose: Pneumonia is an important cause of death in patients with SLE. In general population, recommendations encourage the use of procalcitonin for management of pneumonia,…
Abstract Number: 1332 • 2018 ACR/ARHP Annual Meeting
Proteomic Discovery Analysis Identifies Unique Proteins and Pathways Correlating with Different Clinical Activity and Damage Measures in Juvenile Dermatomyositis (JDM)
Hanna Kim¹, Angelique Biancotto², Foo Cheung², Terrance P. O'Hanlon³, Yan Huang⁴, Frederick W. Miller³, Raphaela Goldbach-Mansky⁴ and Lisa G. Rider⁵, ¹Pediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD, ²Center for Human Immunology Autoimmunity and Inflammation (CHI), NIAID, NIH, Bethesda, MD, ³Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁴Translational Autoinflammatory Disease Section (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, ⁵Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD
Background/Purpose: JDM is a complex heterogeneous autoimmune disease. To define biomarkers and better understand JDM pathogenesis, aptamer-based proteomic technology was used to mine the serum…
Abstract Number: 1589 • 2018 ACR/ARHP Annual Meeting
Cardiac Biomarkers and Carotid Atherosclerosis and Its Progression in Psoriatic Disease
Lihi Eder¹, Vinod Chandran², Iain B. McInnes³, Richard J. Cook⁴, Dafna D Gladman⁵, Paul Welsh⁶, Naveed Sattar⁷ and Paula Harvey⁸, ¹Women's College Research Institute, University of Toronto, Women's College Hospital, Toronto, ON, Canada, ²Krembil Research Institute & University of Toronto, Toronto, ON, Canada, ³University of Glasgow, Glasgow, United Kingdom, ⁴Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁵Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁶nstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, ⁷Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, ⁸Cardiology, Women's College Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Laboratory biomarkers indicative of cardiac ischemia or dysfunction improve cardiovascular (CV) risk stratification in the general population. Their utility in patients with psoriatic disease…
Abstract Number: 2036 • 2018 ACR/ARHP Annual Meeting
Adenosine Receptors Expression As Predictor of Response to Methotrexate Therapy in Patients with Rheumatoid Arthritis
Ankita Singh¹, Ramnath Misra² and Amita Aggarwal², ¹Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Methotrexate (MTX) is first line of therapy to treat Rheumatoid Arthritis (RA) patients and one third of patients do not respond to this drug.…
Abstract Number: 877 • 2018 ACR/ARHP Annual Meeting
Serum Krebs Von Den Lungen-6 Is a Useful Biomarker for Assessing Activity of Myositis-Associated Interstitial Lung Disease
Satoshi Takanashi¹, Naoshi Nishina², Maho Nakazawa², Yuko Kaneko² and Tsutomu Takeuchi², ¹Division of Rheumatoloy, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Interstitial lung disease (ILD) is one of serious organ involvements in idiopathic inflammatory myositis. Krebs von den Lungen-6 (KL-6) is an antigen produced primarily…
Abstract Number: 1356 • 2018 ACR/ARHP Annual Meeting
Increasing Oral Doses of GLPG1972 Administered Daily for 29 Days Show a Strong Target Engagement in Patients with Knee and/or Hip OA
Henri Deckx¹, Simon Hatch², Martine Robberechts¹, Sonia Dupont³, Julie Desrivot³, Hugh Coleman⁴, Staffan Larsson⁵, André Struglics⁵, Ellen van der Aar¹ and Ann Fieuw¹, ¹Galapagos NV, Mechelen, Belgium, ²Galapagos NV, Boston, MA, ³Galapagos SASU, Romainville, France, ⁴CRU, Covance, Daytona Beach, FL, ⁵Clinical Sciences, Lund University, Lund, Sweden
Background/Purpose: Osteoarthritis (OA) is characterized by structural changes of the joint, of which degradation of articular cartilage is one of the major signs1. The main…
Abstract Number: 1669 • 2018 ACR/ARHP Annual Meeting
iC3b/C3 Ratios More Strongly Correlate with SLE Disease Activity in African-Americans Compared to Whites
Deepali Sen¹, Vibeke Strand², Nancy Mathis³, Qiang Fu⁴ and Alfred Kim⁵, ¹Rheumatology, Washington University School of Medicine, St. Louis, MO, ²Stanford University School of Medicine, Palo Alto, CA, ³Rheumatology, Washington University School of Medicine, Saint Louis, MO, ⁴Epidemiology and Biostatistics, Saint Louis University College for Public Health and Social Justice, Saint Louis, MO, ⁵Medicine/Rheumatology, Washington University School of Medicine, St. Louis, MO
iC3b/C3 Ratios More Strongly Correlate with SLE Disease Activity in African-Americans Compared with WhitesBackground/Purpose: Complement activation is a hallmark of systemic lupus erythematosus (SLE) pathophysiology.…
Abstract Number: 2047 • 2018 ACR/ARHP Annual Meeting
Synovial Fluid Cytokines /Chemokines and Proteins from the Knees of Symptomatic RA and OA Patients Which Correlate with the Magnitude of the Inflammatory Response As Measured By Synovial Fluid WBC Levels
Richard Meehan¹, Eric Hoffman², Mary Wolf³, Elizabeth Regan⁴, Prashant Parmar⁵, Karin Pacheco⁶, Jim Crooks⁷ and Vijaya Knight⁸, ¹MEDICINE, National Jewish Health, Denver, CO, ²Medicine/Rheumatology, National Jewish Health, Denver, CO, ³Pathology Department, National Jewish Health, Denver, CO, ⁴Medicine, National Jewish Health, Denver, CO, ⁵Internal Medicine, St Joseph Hospital, Denver, CO, ⁶MEDICINE/ Occupational Medince, National Jewish Health, Denver, CO, ⁷Biostatistics, National Jewish Health, Denver, CO, ⁸Pathology, ADX laboratory, National Jewish Health, Denver, CO
Background/Purpose: Synovial fluid (SF) provides nutritional support for cartilage and contains numerous catabolic and anabolic cytokines, chemokines and proteins. The precise role of these proteins…
Abstract Number: 419 • 2018 ACR/ARHP Annual Meeting
Effect of Changes in Physical Activity on Cartilage Degradation in Knee Osteoarthritis
Gustavo J. Almeida¹, Charity Moore-Patterson¹, Clair N. Smith¹, Prakash Jayabalan² and Sara R. Piva¹, ¹Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ²Shirley Ryan AbilityLab, Northwestern Feinberg School of Medicine, Chicago, IL
Background/Purpose: Guidelines recommend 150 minutes a week in moderate-intensity physical activity (PA) to improve health in knee osteoarthritis (KOA). Despite that, individuals with KOA do…
Abstract Number: 878 • 2018 ACR/ARHP Annual Meeting
IFN Level Assessed By Ultrasensitive Detection Technology in Myositis Patient: A Promising Biomarker of Disease Activity in Dermatomyositis and Anti-Synthetase Syndrome
Loïs BOLKO^1,2, Ségolène Toquet³, Océane Landon-Cardinal⁴, Karim DORGHAM⁵, Celine Anquetil⁶, Darragh Duffy⁷, Nadège WESNER⁸, Damien Amelin⁹, Gaëlle DZANGUE TCHOUPOU², Perrine Guillaume¹⁰, Aude Rigolet¹¹, Baptiste Hervier¹¹, Mathieu Vautier¹¹, Nicolas Champtiaux¹¹, Guy Gorochov¹², Jean-Hugues Salmon¹³, Olivier Benveniste¹¹ and Yves Allenbach¹⁴, ¹Rheumatology, CHU Reims, Hôpital Maison Blanche, Reims, France, ²INSERM UMRS974, Pitié-Salpêtrière University Hospital, Paris, France, ³Médecine interne, CHU Reims, Robert debré, Reims, France, ⁴Rhumatologie, Hopital Notre-Dame Montréal, Montreal, QC, Canada, ⁵CIMI, INSERM, Paris, France, ⁶CDR en myologie UMR974,, Institut National de la Santé et de la Recherche Médicale, Association Institut de Myologie, PARIS, France, ⁷Institut Pasteur, Paris, Paris, France, ⁸INSERM UMRS974, Pitié-Salpêtrière University Hospital, paris, France, ⁹Sorbonne Universités UPMC Univ Paris 06, Myology research center, INSERM UMRS974, CNRS FRE3617, Pitié-Salpêtrière University Hospital, Paris, France, Paris, France, ¹⁰Assistance Publique – Hôpitaux de Paris (AP-HP), Hôpital Universitaire Pitié Salpêtrière, paris, France, ¹¹Department of Internal Medicine and Clinical Immunology and Inflammation-Immunopathology-Biotherapy Department (I2B), Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, East Paris Neuromuscular Diseases Reference Center, Paris, France, ¹²CIMI, INSERM, paris, France, ¹³Service de Rhumatologie, CHU Reims, Hôpital Maison Blanche, Reims, France, ¹⁴Internal Medicine and Clinical Immunology, Sorbonne University - Assistance Public - Hopitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France
Background/Purpose: Inflammatory idiopathic myopathies (IIM) is a heterogeneous group of disorders ranging from muscle specific auto-immune diseases to systemic ones (dermatomyositis (DM), anti-synthetase syndrome (ASS),…

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