ACR Meeting Abstracts

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Abstracts tagged "Biologic agents"

  • Abstract Number: 598 • 2018 ACR/ARHP Annual Meeting

    Real-World Experience of Effectiveness and Safety of Certolizumab Pegol for Rheumatoid Arthritis in Japan: Single-Center Retrospective Study

    Naohiro Sugitani1,2, Eiichi Tanaka1, Eisuke Inoue1,3, Eri Sugano1, Kumiko Saka1, Moeko Ochiai1, Rei Yamaguchi1, Yoko Shimizu1, Naoki Sugimoto1, Katsunori Ikari1, Ayako Nakajima1,2, Atsuo Taniguchi1 and Hisashi Yamanaka4, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Center for Rheumatic Diseases, Mie University Hospital, Tsu city, Japan, 3Division of Medical Informatics, St. Marianna University School of Medicine, Kawasaki, Japan, 4Institute of Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: Certolizumab-pegol (CZP) is a sixth antitumor necrosis factor inhibitor for rheumatoid arthritis (RA) in Japan. Several clinical trials were conducted to evaluate the efficacy…
  • Abstract Number: 1887 • 2018 ACR/ARHP Annual Meeting

    Practice Variation in Prescriptions of Non-TNFi Biologics and Tofacitinib: Data from the Rheumatology Informatics System for Effectiveness (RISE) Registry

    Gabriela Schmajuk1,2, Michael Evans3, Julia Kay2, Megan E. B. Clowse4, Esi Morgan5, Andreas Reimold6, Tracy Johansson7, Lindsay Lewis8 and Jinoos Yazdany9, 1San Francisco VA Medical Center, San Francisco, CA, 2Medicine/Rheumatology, University of California - San Francisco, San Francisco, CA, 3University of California - San Francisco, San Francisco, CA, 4Department of Medicine, Division of Rheumatology and Immunology, Duke University, Durham, NC, 5University of Cincinnati, Cincinnati, OH, 6Rheumatology, University of TX Southwestern Medical Center, Dallas, TX, 7Practice, Advocacy & Quality, American College of Rheumatology, Atlanta, GA, 8American College of Rheumatology, Atlanta, GA, 9University of California, San Francisco, San Francisco, CA

    Background/Purpose:   Biologic DMARDs and tofacitinib account for a large proportion of drug spending in the U.S. Although TNFi drugs have dominated sales, use of…
  • Abstract Number: 2855 • 2018 ACR/ARHP Annual Meeting

    Expanding the Phenotype: New Variant in the IL1RN-Gene Associated with Late Onset and Atypical Presentation of Dira

    Jasmin B. Kuemmerle-Deschner1, Konstanze Hoertnagel2, Susanne Schlipf3, Sandra Hansmann4, Toni Hospach5, Ilias Tsiflikas6, Xiao Liu7, Susanne Benseler8 and Alexander Weber7, 1Department of Pediatrics, Division of Rheumatology, University Hospital Tuebingen, Germany, Tuebingen, Germany, 2Praxis für Humangenetik Tübingen,Tuebingen, Germany, Tuebingen, Germany, 3Kinderarztpraxis Dr. Lakner, Schwäbisch Gmünd, Germany, Schwäbisch Gmünd, Germany, 4Department of Pediatrics, Division of Pediatric Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, Tuebingen, Germany, 5Pediatrics, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany, 6Division of Pediatric Radiology, Department of Radiology, University Hospital Tuebingen, Germany, Tuebingen, Germany, 7Department of Immunology, University of Tübingen, Tübingen, Germany, Tuebingen, Germany, 8Rheumatology, Department of Paediatrics, Alberta Children's Hospital, University of Calgary, Alberta, Canada, Calgary, AB, Canada

    Background/Purpose: Deficiency of the Interleukin-1 receptor antagonist (DIRA) is an autoinflammatory disease of infancy characterized by severe systemic inflammation with bone and skin involvement. This…
  • Abstract Number: 611 • 2018 ACR/ARHP Annual Meeting

    Influence of Dose Titration of Concomitant Steroid and Methotrexate during Biologic Therapy in Patients with Rheumatoid Arthritis in Daily Practice Based on the IORRA Cohort

    Yoko Shimizu1, Eiichi Tanaka1, Eisuke Inoue1,2, Kumiko Saka1, Eri Sugano1, Naohiro Sugitani1,3, Moeko Ochiai1, Rei Yamaguchi1, Naoki Sugimoto1, Ayako Nakajima1,3, Katsunori Ikari1, Atsuo Taniguchi1 and Hisashi Yamanaka4, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Division of Medical Informatics, St. Marianna University School of Medicine, Kawasaki, Japan, 3Center for Rheumatic Diseases, Mie University Hospital, Tsu city, Japan, 4Institute of Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: After the introduction of Biological Disease-Modifying Anti-Rheumatic-Drugs (bDMARDs) for the treatment of patients with active rheumatoid arthritis (RA), clinical remission has become an achievable…
  • Abstract Number: 2311 • 2018 ACR/ARHP Annual Meeting

    Effect of TNF Inhibitors on Bone Mineral Density in Rheumatoid Arthritis Patients Receiving Bisphosphonate

    Jung Sun Lee1, Seokchan Hong2, Doo-Ho Lim3, Jebum Won1, Oh Chan Kwon2, Ji Seon Oh2, Yong-Gil Kim2, Chang Keun Lee2 and Bin Yoo2, 1Division of Rheumatology, Department of Internal Medicine,, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of (South), 3Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of (South)

    Background/Purpose: . This study aimed to investigate whether tumor necrosis factor inhibitors (TNFi) have beneficial effects on bone mineral density (BMD) in rheumatoid arthritis (RA)…
  • Abstract Number: 2876 • 2018 ACR/ARHP Annual Meeting

    Torque Teno Virus Quantification for Functional Monitoring of Immunomodulation with Biological Compounds in the Treatment of Rheumatoid Arthritis

    Paul Studenic1, Gregor Bond2, Andreas Kerschbaumer3, Manuel Bécède3, Karel Pavelka4, Dmitry Karateev5, Jutta Stieger6, Rudolf Puchner7, Ruediger Mueller8, Elisabeth Puchhammer-Stöckl9, Martina Durechova10, Michaela Loiskandl10, Thomas Perkmann11, Marta Olejarova4, Elena Luchikhina12, Carl-Walter Steiner13, Michael Bonelli10, Josef S. Smolen14 and Daniel Aletaha10, 1Division of Rheumatology, Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Internal Medicine 3, Division of Nephrology, Medical University of Vienna, Vienna, Austria, 3Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 4Department of Experimental Rheumatology, 1st Faculty of Medicine, Institute of Rheumatology, Charles University in Prague, Prague, Czech Republic, 5Department of Rheumatology, Department of Rheumatology, Moscow Regional Research and Clinical Institute (MONIKI), Moscow, Russian Federation, 62nd Deparment of Medicine, 2nd Deparment of Medicine, Hitzing Hospital, Vienna, Austria, 7Private Office, Wels, Austria, 8Division of Rheumatology, Immunology and Rehabilitation, Division of Rheumatology, Immunology and Rehabilitation, Kantonsspital St Gallen, St. Gallen, Switzerland, 9Institute for Virology, Institute for Virology, Medical University of Vienna, Vienna, Austria, 10Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 11Department of Laboratory Medicine, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, 12Department of rheumatology, Moscow Regional Research and Clinical Institute (MONIKI), Moscow, Russian Federation, 13Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 14Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Rheumatoid arthritis (RA) patients who fail to respond to methotrexate (MTX) can be subjected to an addition of biologic disease-modifying antirheumatic drug (bDMARD). Currently…
  • Abstract Number: 619 • 2018 ACR/ARHP Annual Meeting

    Patterns of Change of a Second Biological Dmard in a Cohort of Patients with Rheumatoid Arthritis

    Roger Rolon Campuzano1, Andrea Lujan Coronel Ale2, Osvaldo Cerda3,4,5, Fernando Dal Pra6, Emilce E Schneeberger7, María de los Angeles Correa3, Marcos G. Rosemffet8, Emilio Buschiazzo9, Rodrigo García Salinas10, Silvia Beatriz Papasidero11, Belén Barrios12, Hernán Maldonado Ficco13 and Gustavo Citera2, 1Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, Buenos Aires, Argentina, 2Rheumatology Section, Instituto de Rehabilitación Psicofísica, CABA, Argentina, 3Rheumatology Section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 4Staff, Buenos Aires, Argentina, 5Sociedad Argentina de Reumatologia, CABA, Argentina, 6Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 7Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 8Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 9Rheumatology Section, Hospital Señor del Milagro, Salta, Argentina, 10Rheumatology Section, Hospital Italiano de La Plata, La Plata, Argentina, 11Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, Buenos Aires, Argentina, 12Rheumatology section, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, 13Rheumatology Section, Hospital San Antonio de Padua, Río Cuarto- Córdoba, Argentina

    Background/Purpose: Evaluate the survival of the 2nd biological disease modifying drug (bDMARD)and to determine the causes of suspension of the 2nd bDMARD. Methods: Patients ≥…
  • Abstract Number: 2394 • 2018 ACR/ARHP Annual Meeting

    Anti-Adalimumab Antibodies Kinetics: An Early Guide for Juvenile Idiopathic Arthritis (JIA) Switching

    Juliana Brunelli1, Clovis A Silva1, Sandra G Pasoto2, Carla GS Saad2, Katia T. Kozu1, Elaine P Leon2, Margarete B Vendramini2, Nicole Fontoura2, Eloisa Bonfa3 and Nadia E Aikawa2, 1Pediatric Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil, 2Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil, 3Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Anti-adalimumab antibody (AAA) production may lead to reduced adalimumab (ADA) serum levels and therapy failure. There are, however, scarce and conflicting data regarding ADA…
  • Abstract Number: 2907 • 2018 ACR/ARHP Annual Meeting

    Comparison of the Joints Ultrasonography in the Patients with Rheumatoid Arthritis Treated By Biological Agents and the Corresponding Synovial Histological Findings

    Asami Abe1, Hajime Ishikawa2 and Kunihiko Wakaki3, 1Rheumatology, Niigata Rheumatic Center, Shibata, Japan, 2Department of Rheumatology, Niigata Rheumatic Center, Shibata, Japan, 3Pathology, Niigata Prefectural Shibata Hospital, Shibata, Japan

    Comparison of the joints ultrasonography in the patients with rheumatoid arthritis treated by biological agents and the corresponding synovial histological findings Background/Purpose: In the treatment…
  • Abstract Number: 688 • 2018 ACR/ARHP Annual Meeting

    Real Life Analysis of a Latin America Tertiary Spondyloarthritis Single-Center: High Frequency of Peripheral Involvement and Use of Synthetic Dmard

    Andrea Shimabuco1, Julio CB Moraes1, Percival Sampaio-Barros2, Cláudia Goldenstein-Schainberg1, Celio R. Gonçalves1, Ana CM Ribeiro1 and Carla GS Saad1, 1Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 2Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., São Paulo, Brazil

    Background/Purpose: The use of synthetic DMARDS (sDMARDs) in spondyloarthritis (SpA) has been increasingly questioned and restricted to peripheral disease, on the other hand, the use…
  • Abstract Number: 2449 • 2018 ACR/ARHP Annual Meeting

    Prevalence and Risk Factors of Serious Infections in Rheumatoid Arthritis Patients Receiving the Biologic/Targeted Synthetic Dmards: A Propensity Score Analysis from the Hong Kong Biologics Registry

    Chi Chiu Mok, Ting Hung Wan and Lai Shan Fong, Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong

    Background/Purpose: To study the prevalence and risk factors for serious infections (SIs) in rheumatoid arthritis (RA) patients receiving the biologic / target synthetic (b/ts) DMARDs.…
  • Abstract Number: 827 • 2018 ACR/ARHP Annual Meeting

    Rituximab Therapy for Systemic Rheumatoid Vasculitis: Indications, Outcomes and Adverse Events

    Caitrin Coffey1, Michael Richter1, Cynthia S. Crowson2, Matthew J. Koster3, Kenneth J. Warrington4 and Ashima Makol3, 1Internal Medicine, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, 3Rheumatology, Mayo Clinic, Rochester, MN, 4Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN

    Background/Purpose: Rheumatoid vasculitis (RV) is a rare systemic inflammatory process affecting small to medium sized blood vessels in patients with rheumatoid arthritis (RA). RV confers…
  • Abstract Number: 2456 • 2018 ACR/ARHP Annual Meeting

    Risk of Venous Thromboembolism in Rheumatoid Arthritis Patients in Truven Marketscan Data (Jan 2010–Sept 2015) Treated with Biologic or Conventional Dmards

    Claudia A. Salinas1, Lucy Mitchell2, Jon T. Giles3, Thomas Dörner4 and Stephen P. Motsko1, 1Eli Lilly and Company, Indianapolis, IN, 2Eli Lilly and Company, Indianapols, IN, 3Columbia University, College of Physicians and Surgeons, New York, NY, 4Charité Universitätsmedizin Berlin and Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany

    Background/Purpose: Patients with RA have an increased risk of venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT) compared to non-RA populations1. …
  • Abstract Number: 1226 • 2018 ACR/ARHP Annual Meeting

    Effect of New Method for Pre-Administration Assessment of Intravenous Biologics on Infections in Patients with Rheumatoid Arthritis

    Sho Fukui1, Masei Suda2, Haruki Sawada3, Yukihiko Ikeda1, Mitsuru Watanabe4, Ayako Koido4, Rui Kawato5, Yasuhiro Suyama6, Hisanori Shimizu7, Haruyuki Yanaoka7, Ryo Rokutanda1, Hiromichi Tamaki1, Tokutaro Tsuda1, Ken-ichi Yamaguchi8, Mitsumasa Kishimoto1 and Masato Okada9, 1Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 2Immuno-Rheumatology Center, St luke's International hospital, Tokyo, Japan, 3Immuno-rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 4Immune-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 5Immuno rheumatology center, St. Luke's International Hospital, Tokyo, Japan, 6Division of Rheumatology, JR Tokyo General Hospital, Tokyo, Japan, 7St. Luke's International Hospital, Tokyo, Japan, 8Allergy and Rheumatology, St. Luke's International Hospital, Tokyo, Japan, 9Immuno-Rheumatology Center, St. Luke’s International Hospital, Tokyo, Japan

    Background/Purpose: Biologics are widely used and effective treatments for rheumatoid arthritis (RA), but generally biologics are avoided when patients have active infections on the day…
  • Abstract Number: 2461 • 2018 ACR/ARHP Annual Meeting

    Analysis of Severe Adverse Drug Reactions to Disease Modifying Drugs in an Inception Rheumatoid Arthritis Cohort

    Zulema Rosales Rosado1,2, Judit Font Urgelles1, Pia Mercedes Lois1, Cristina Vadillo Font1, Dalifer Freites Núñez2, Isabel Hernández-Rodríguez1, Juan A Jover Jover1 and Lydia A Alcazar2, 1Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 2Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain

    Background/Purpose: There is a well-known risk of developing adverse drug reactions (ADR) in rheumatic patients due, mainly, to the Disease Modifying Drugs (DMARD) widely used.…
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