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Abstract Number: 2907

Comparison of the Joints Ultrasonography in the Patients with Rheumatoid Arthritis Treated By Biological Agents and the Corresponding Synovial Histological Findings

Asami Abe1, Hajime Ishikawa2 and Kunihiko Wakaki3, 1Rheumatology, Niigata Rheumatic Center, Shibata, Japan, 2Department of Rheumatology, Niigata Rheumatic Center, Shibata, Japan, 3Pathology, Niigata Prefectural Shibata Hospital, Shibata, Japan

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Biologic agents, histopathologic, rheumatoid arthritis (RA) and ultrasonography

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Session Information

Date: Wednesday, October 24, 2018

Session Title: 6W006 ACR Abstract: Imaging of Rheumatic Diseases II: Ultrasound (2904–2909)

Session Type: ACR Concurrent Abstract Session

Session Time: 9:00AM-10:30AM

Comparison of the joints ultrasonography in the patients with rheumatoid arthritis treated by biological agents and the corresponding synovial histological findings

Background/Purpose: In the treatment of Rheumatoid arthritis (RA), early diagnosis and early treatment with tight control have become increasingly important with the advent of biological therapy. Ultrasonography (US) of the various joints enables the real-time evaluation of synovial hypertrophy, effusion and bone erosion, Power Doppler (PD) ultrasound is able to identify both subclinical synovitis and early erosive disease. The objectives of this study were to investigate whether the image of US at the operated joint reflect synovium histopathology or clinical indicators, and to compare the results in the patient treated by non-biological agent (NonBio) and biological agent (Bio)..

Methods: RA related orthopaedic surgery was performed at 1191 joints including 17 shoulders, 144 knees, 92 elbows, 352 wrists, 333 fingers, 34 ankles and 218 toes during the period between January 2011 and May 2018 at our rheumatic center. Preoperatively, ultrasound evaluations were performed and grade of PD signal was determined at the part with the highest signal. PD signal consists 4 grades from grade 0 to 3. The operations were performed within one week after the ultrasound evaluations.  Rooney score of the synovium pathology, DAS28-ESR(4), MMP-3, CRP were investigated. Rooney score represents the histologic features in the synovium of RA.  It includes 6 features i.e. synoviocytes hyperplasia, fibrosis, proliferating blood vessels, perivascular infiltrates of lymphocytes, focal aggregates of lymphocytes, diffuse infiltrates of lymphocytes. They were scored separately on a scale of 1-10.The treatments that the patients received included: biological agents (Bio) (n=351 29%), etanercept (ETN) (n= 96), tocilizumab (TCZ) (n=99), infliximab (IFX) (n=25), adalimumab (ADA) (n=26), certlizumab pegol (CZP) (n=8), golimumab (GLM) (n=49), and abatacept (ABT) (n=47), tofacitinib (TOF) (n=1).

Results: PD signal (0.75}0.89), DAS28 (2.77}1.13), CRP(0.10}1.22 mg/dL), MMP-3 (104.6}108.4 ng/mL) and Rooney score (22.1}7.7) in the patients treated by Bio were significantly lower than those (1.41}0.96, 3.67}1.11, 0.79}1.32 mg/dL, 145.0}138.2 ng/dL, 28.5}9.24 ) in the patients using NonBio. Rooney score fibrosis (9.57}1.51) in patients using Bio was significantly higher than those (8.55}2.45) in patients treated by NonBio. Rooney score synoviocyte hyperplasia (0.91}1.27), three items of lymphocyte (1.59}2.91, 1.38}2.49, 0.86}2.27) in patients treated Bio were lower than those (1.73}1.30, 3.84}3.56, 3.70}3.48, 2.47}2.93) in patients treated by NonBio. TCZ, ADA, ABT and IFX had some significant differences for Rooney score and Rooney item score between the patients treated NonBio.

Conclusion: The activity of RA synovitis at operated site was suppressed in patients treated by Bio. There were some differences in clinical data, histopathological score, PD signal and DAS among Bio.


Disclosure: A. Abe, None; H. Ishikawa, None; K. Wakaki, None.

To cite this abstract in AMA style:

Abe A, Ishikawa H, Wakaki K. Comparison of the Joints Ultrasonography in the Patients with Rheumatoid Arthritis Treated By Biological Agents and the Corresponding Synovial Histological Findings [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/comparison-of-the-joints-ultrasonography-in-the-patients-with-rheumatoid-arthritis-treated-by-biological-agents-and-the-corresponding-synovial-histological-findings/. Accessed March 8, 2021.
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