ACR Meeting Abstracts

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Abstracts tagged "axial spondyloarthritis"

  • Abstract Number: 2778 • 2019 ACR/ARP Annual Meeting

    Alcohol Consumption as a Predictor of the Progression of Spinal Structural Damage in Axial Spondyloarthritis: Data from the Catholic Axial Spondyloarthritis COhort (CASCO)

    Hong Ki Min1, Seung-Ki Kwok 2 and Sang-Heon Lee 1, 1Konkuk university medical center, Seoul, Republic of Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

    Background/Purpose: The purpose of the present study was to demonstrate the predicting factors of spinal structural damage in axial spondyloarthritis (axSpA) in a prospective cohort…
  • Abstract Number: 573 • 2019 ACR/ARP Annual Meeting

    Identification of Factors Associated with Magnetic Resonance Images Changes Suggestive of Axial Spondyloarthritis in the Axial Skeleton of Individuals < 45 Years – Evaluation of Data from a Large Community Study

    Xenofon Baraliakos1, Adrian Richter 2, Daniel Feldmann 3, Anne Ott 3, Robin Buelow 4, Carsten Oliver Schmidt 5 and Jürgen Braun 6, 1Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, Herne, Germany, 2Institute for Community Medicine, University Greifswald, and German Rheumatism Research Center, Berlin, Berlin, Germany, 3Rheumazentrum Ruhrgebiet/Ruhr University Bochum, Herne, Germany, Herne, Germany, 4Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany, 5Institute for Community Medicine, University Greifswald, Greifswald, Germany, 6Rheumazentrum Ruhrgebiet/Ruhr University, Herne, Germany

    Background/Purpose: Active (bone marrow edema, BME) and structural (fatty lesions, FL) lesions in the spinal and the sacroiliac joints (SIJ), as assessed by magnetic resonance…
  • Abstract Number: 607 • 2019 ACR/ARP Annual Meeting

    Expansion of Peripheral Cytotoxic T Cells in Co-morbid Inflammatory Bowel Disease and Spondyloarthritis

    Adam Lefferts1, Emilie Regner 2, Andrew Stahly 3, Rebecca O'Rourke 1, Kenneth Jones 2 and Kristine Kuhn 1, 1University of Colorado, Anschutz Medical Campus, Aurora, CO, 2University of Colorado, Anschutz Medical Campus, Denver, CO, 3University of Colorado, Aurora, CO

    Background/Purpose: Background: The clinical overlap of axial spondyloarthritis (axSpA) and Crohn’s disease (CD) has given rise to the hypothesis that these conditions may share pathophysiologic…
  • Abstract Number: 854 • 2019 ACR/ARP Annual Meeting

    Do Smoking and Socio-economic Factors Independently Influence Imaging Outcomes in Axial Spondyloarthritis? Five-year Data from the DESIR Cohort

    Elena Nikiphorou1, Sofia Ramiro 2, Alexandre Sepriano 3, Adeline Ruyssen Witrand 4, Robert B.M. Landewé 5 and Désirée van der Heijde 3, 1King's College London, London, United Kingdom, 2Leiden University Medical Center and Zuyderland Medical Centre, Leiden, Netherlands, 3Leiden University Medical Center, Leiden, Netherlands, 4Rheumatology center, Pierre Paul Riquet Hospital, CHU of Toulouse, Paul Sabatier University, UMR 1027, Inserm, France, Toulouse, France, 5Amsterdam University Medical Center, Amsterdam, Netherlands

    Background/Purpose: Smoking and systemic inflammation have been shown to independently associate with radiographic spinal progression in patients with axSpA. Evidence suggests that certain socioeconomic (SE)…
  • Abstract Number: 1492 • 2019 ACR/ARP Annual Meeting

    Exposure-Response Analyses for Upadacitinib Efficacy and Safety in Ankylosing Spondylitis – Analyses of the SELECT-AXIS I Study

    Mohamed Ismail1, Ahmed Nader 1, Insa Winzenborg 2, In-Ho Song 3 and Ahmed Othman 1, 1AbbVie Inc., North Chicago, IL, 2AbbVie Deutschland GmbH & Co. KG, Ludwigshafen am Rhein, Germany, 3AbbVie Inc., North Chicago, IL, USA, North Chicago, IL

    Background/Purpose: Upadacitinib, a selective inhibitor of Janus kinase 1 (JAK1), is currently being evaluated for the treatment of several autoimmune disorders, including axial spondyloarthritis (axial…
  • Abstract Number: 1551 • 2019 ACR/ARP Annual Meeting

    Does Retention and Remission Rates to 2nd and 3rd TNF Inhibitors in Patients with Axial Spondyloarthritis Depend on the Reason from Withdrawal to the Previous Treatment? – Real World Data from 12 European Countries in the EuroSpA Research Collaboration

    Lykke Midtbøll Ørnbjerg 1, Cecilie Heegaard Brahe1, Anne Gitte Loft 2, Johan Askling 3, Adrian Ciurea 4, Herman Mann 5, Servet Akar 6, Eirik Kristianslund 7, Dan Nordström 8, Maria José Santos 9, Catalin Codreanu 10, Manuel Pombo-Suarez 11, Ziga Rotar 12, Bjorn Gudbjornsson 13, Daniela DiGuiseppe 14, Michael J. Nissen 15, Karel Pavelka 5, Soner Senel 16, Joe Sexton 17, Kari K. Eklund 18, Anabela Barcelos 19, Ruxandra IONESCU 20, Carlos Sánchez-Piedra 21, Matija Tomsic 22, Arni Jon Geirsson 23, Irene van der Horst-Bruinsma 24, Gary Macfarlane 25, Florenzo Iannone 26, Brigitte Michelsen 1, Lise Hyldstrup 27, Niels Steen Krogh 28, Merete Lund Hetland 29 and Mikkel Østergaard 30, 1EuroSpA Coordinating Center, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Glostrup, Denmark, 2Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, Århus, Denmark, 3Karolinska Institutet, Stockholm, Sweden, 4University Hospital Zürich, Zürich, Switzerland, 5Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic, 6Izmir Katip Celebi University, Faculty of Medicine, Division of Rheumatology, İzmir, Turkey, 7Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway., Oslo, Norway, 8Department of Medicine, ROB-FIN, Helsinki University Hospital and Helsinki University, Helsinki, Finland., Helsinki, Finland, 9Rheumatology department, Hospital Garcia de Orta, Almada, Portugal, 10Center of Rheumatic Diseases, University of Medicine and Pharmacy, Bucharest, Romania., Bucharest, Romania, 11Rheumatology Unit, Clinical University Hospital of Santiago de Compostela,, Santiago, Spain, 12UMC LJUBLJANA, DPT. OF RHEUMATOLOGY, LJUBLJANA, Slovenia, 13Centre for Rheumatology Research, Landspitali and Faculty of Medicine, University of Iceland, Reykjavik, Iceland, 14Clinical Epidemiology Division, Dept of Medicine Solna, Karolinska Institutet,, Stockholm, Sweden, 15University Hospital Geneva, Geneva, Switzerland, 16Division of Rheumatology, Erciyes University School of Medicine, Kayseri, Turkey, Kayseri, Turkey, 17Diakonhjemmet Hospital, Dept. of Rheumatology, Oslo, Norway, 18ROB-FIN registry, Department of Medicine, Helsinki University and University Hospital, Helsinki, Finland, 19Centro Hospitalar Baixo Vouga | iBemed, University of Aveiro, Aveiro, Portugal, 20SPITALUL CLINIC SFANTA MARIA, Bucharest, 21Research Unit, Spanish Society of Rheumatology, Madrid, Spain, 22Department of Rheumatology, University Medical Center Ljubljana, Slovenia, Ljubljana, Slovenia, 23Centre for Rheumatology Research, University Hospital and Faculty of Medicine, Reykjavik, Iceland, 24Amsterdam University Medical Center, Amsterdam, Netherlands, 25University of Aberdeen, Aberdeen, United Kingdom, 26Department of Emergency and Transplantation , Rheumatology Unit, University Hospital of Bari, Bari, Italy., Bari, Italy, 27Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Denmark, Copenhagen, Denmark, 28Zitelab / DANBIO, Copenhagen, Denmark, 29DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark, 30Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark

    Background/Purpose: Tumour necrosis factor inhibitors (TNFi) are efficacious in patients with axial spondyloarthritis (axSpA), but still some patients switch to a different TNFi because of…
  • Abstract Number: 2779 • 2019 ACR/ARP Annual Meeting

    Higher Disease Activity Is Associated with More Spinal Radiographic Progression in Patients with Axial Spondyloarthritis Independently of Prior Exposure to TNF Inhibitors

    Alexandre Sepriano1, Sofia Ramiro 2, Stephanie Wichuk 3, Praveena Chiowchanwisawakit 4, Terrie MacCosham 3, Joel Paschke 5, Désirée van der Heijde 1, Robert B.M. Landewé 6 and Walter Maksymowych 7, 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center and Zuyderland Medical Centre, Leiden, Netherlands, 3University of Alberta, Edmonton, Canada, 4Mahidol University, Bangkok, Thailand, 5CARE Arthritis, Edmonton, Canada, 6Amsterdam University Medical Center, Amsterdam, Netherlands, 7University of Alberta and CARE Arthritis, Edmonton, Canada

    Background/Purpose: The association between disease activity and spinal radiographic progression in radiographic axial spondyloarthritis (r-axSpA) has been previously shown in a cohort of patients (pts)…
  • Abstract Number: 577 • 2019 ACR/ARP Annual Meeting

    Gender Contrasts in Patient Reported Outcomes Don’t Alter the Disease Activity Score in Axial Spondyloarthritis Patients

    Ann-Sophie De Craemer1, Thomas Renson 1, Liselotte Deroo 1, Manouk de Hooge 1, Philippe Carron 1, Filip Van den Bosch 1 and Dirk Elewaut 1, 1Ghent University Hospital, Ghent, Belgium

    Background/Purpose: Disease activity in axial spondyloarthritis (axSpA) is often quantified by the Ankylosing Spondylitis Disease Activity Score (ASDAS), a composite index which combines 4 patient…
  • Abstract Number: 608 • 2019 ACR/ARP Annual Meeting

    Prevalence of Radiographic Entheseal Lesions at the Hip and Pelvic Region in Patients with Ankylosing Spondylitis versus Controls

    Freke Wink1, Thomas Diemel 2, Suzanne Arends 2 and Anneke Spoorenberg 2, 1Medical Center Leeuwarden, Leeuwarden, Netherlands, 2University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Enthesitis is one of the features of ankylosing spondylitis (AS). High prevalence of structural and inflammatory ultrasound lesions of peripheral entheses are found in…
  • Abstract Number: 856 • 2019 ACR/ARP Annual Meeting

    MRI of the Sacroiliac Joints in Athletes: Do Semi-axial Slices Added to Standard Semi-coronal Scans Facilitate Recognition of Non-specific Bone Marrow Edema?

    Ulrich Weber1, Anne Grethe Jurik 2, Anna Zejden 2, Ejnar Larsen 3, Steen Hylgaard Jørgensen 4, Kaspar Rufibach 5, Christian Schioldan 6 and Søren Schmidt-Olsen 7, 1Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sonderborg, Denmark, 2Department of Radiology, Aarhus University Hospital, Aarhus, Denmark, 3Department of Radiology, North Denmark Regional Hospital, Hjørring, Denmark, 4Center for Clinical Research, North Denmark Regional Hospital, Hjørring, Denmark, 5Division of Biostatistics, F. Hoffmann-La Roche, Basel, Switzerland, 6Department of Physiotherapy, Clinic Benefit, Frederikshavn, Denmark, 7Department of Rheumatology and Sports Medicine, North Denmark Regional Hospital, Hjørring, Denmark

    Background/Purpose: Low grade bone marrow edema (BME) on magnetic resonance imaging (MRI) of the sacroiliac joints (SIJ) is challenging the discrimination between patients with early…
  • Abstract Number: 1499 • 2019 ACR/ARP Annual Meeting

    Golimumab Persistence in Biologic Naive and Non-Naive Patients with Axial Spondyloarthritis: Results of the GO PRACTICE Study

    René-Marc Flipo 1, Florence Tubach 2, Jean Ouaniche 3, Philippe Goupille4, Eric Lespessailles 5, Najat Gouyette 6, Naoual Harid 7, Jean-Marie Fayette 8, Philippe Bertin 9 and Bruno Fautrel 10, 1Roger Salengro University-Hospital, Lille , France, Lille, France, 2Pitié Salpétrière University-Hospital, Paris, Ile-de-France, France, 3Private Practice , Toulon, France, Toulon, France, 4Tours University-Hospital, Tours, France, Tours, France, 5Orléans Regional Hospitals, Orléans ,France, Orléans, France, 6MSD France, Courbevoie ,France, Courbevoie, Ile-de-France, France, 7MSD France, Courbevoie, France, Courbevoie, Ile-de-France, France, 8ClinSearch, Malakoff, France, Malakoff, Ile-de-France, France, 9Limoges University-Hospital , Limoges, France, Limoges, France, 10Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France

    Background/Purpose: The pivotal GO AFTER study [1] and the ongoing observational GO BEYOND study investigate GLM efficacy in rheumatoid arthritis (RA) patients who previously received…
  • Abstract Number: 1778 • 2019 ACR/ARP Annual Meeting

    Entheseal CD90+ SOX9+ Cartilage-like Cells Initiate Spinal Ankylosis in Ankylosing Spondylitis

    Sungsin Jo1, Young Lim Lee 1, Tae-Han Lee 1, Ye-Soo Park 2 and Tae-Hwan Kim 1, 1Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 2Department of Orthopedic Surgery, Hanyang University Medical Center, Guri Hospital,, Guri, Republic of Korea

    Background/Purpose: Enthesitis is characterized by inflammation at the interface where tendon or ligament attaches to the bone and is a representative symptom of ankylosing spondylitis(AS).…
  • Abstract Number: 579 • 2019 ACR/ARP Annual Meeting

    Is There an Impact of Uveitis, Psoriasis and Inflammatory Bowel Disease on Musculoskeletal Disease Activity and Function in Axial Spondyloarthritis?

    Imke Redeker1, Johanna Callhoff 2, Falk Hoffmann 3, Hildrun Haibel 4, Joachim Sieper 4, Angela Zink 5 and Denis Poddubnyy 6, 1Charité – Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, 2German Rheumatism Research Centre, Berlin, Germany, 3Carl von Ossietzky University, Oldenburg, Germany, 4Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, 5German Rheumatism Research Centre and Charité University medicine, Berlin, Germany, 6Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany

    Background/Purpose: Uveitis, psoriasis and inflammatory bowel disease (IBD) are common in axial spondyloarthritis (axSpA) but data on their impact on activity of musculoskeletal manifestations and…
  • Abstract Number: 609 • 2019 ACR/ARP Annual Meeting

    Baseline Characteristics and Natural History of Radiographic versus Non-radiographic Axial Spondyloarthritis: 5 Years Follow-up of the Desir Cohort

    Clementina López-Medina1, Anna Moltó 2, Pascal Claudepierre 3 and Maxime Dougados 4, 1Cochin Hospital, Rheumatology Department, Paris, France, 2Paris Descartes University, Cochin Hospital, Rheumatology department, Paris, France, 3Rheumatology, CHU Henri Mondor Créteil, Paris, France, 4Cochin Hospital, Paris, France

    Background/Purpose: There is still a debate concerning the concept of non-radiographic (nr-axSpA) axial Spondyloarthritis (e.g. to consider it as a distinct entity from r-axSpA (Ankylosing…
  • Abstract Number: 935 • 2019 ACR/ARP Annual Meeting

    Reduction of Anterior Uveitis Flares in Patients with Axial Spondyloarthritis Following 1 Year of Treatment with Certolizumab Pegol: 48-Week Interim Results from a 96-Week Open-Label Study

    Irene van der Horst-Bruinsma1, Rianne van Bentum 1, Frank D. Verbraak 1, Thomas Rath 2, James T. Rosenbaum 3, Maria Misterska-Skóra 4, Bengt Hoepken 5, Oscar Irvin-Sellers 6, Brenda VanLunen 7, Lars Bauer 5 and Martin Rudwaleit 8, 1Amsterdam University Medical Center, Amsterdam, Netherlands, 2St Franziskus-Hospital, Münster, Germany, 3Devers Eye Institute and Oregon Health & Science University, Portland, OR, 4Wrocław Medical University, Wrocław, Poland, 5UCB Pharma, Monheim am Rhein, Germany, 6UCB Pharma, Slough, UK, Slough, United Kingdom, 7UCB Pharma, Raleigh, NC, 8Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany

    Background/Purpose: Acute anterior uveitis (AAU), inflammation of the anterior uveal tract, is the most common extraarticular manifestation in patients (pts) with axial spondyloarthritis (axSpA), reported…
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