ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases"

  • Abstract Number: 2826 • 2017 ACR/ARHP Annual Meeting

    Fine-Mapping Identifies Causal Variants for RA and T1D in DNASE1L3, Sirpg, MEG3, TNFAIP3 and CD28/CTLA4 Loc

    Harm-Jan Westra1, Marta Martinez-Bonet2, Suna Onengut3, Annette Lee4, Yang Luo1, Nikola Teslovich1, Jane Worthington5, Javier Martín6, TWJ Huizinga7, Lars Klareskog8, Solbritt Rantapää Dahlqvist9, Wei-Min Chen3, Aaron Quinlan10, John Todd11, Stephen Eyre5, Peter Nigrovic2, Peter Gregersen4, Stephen Rich3 and Soumya Raychaudhuri12, 1Division of Genetics and Rheumatology, Department of Medicine, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Department of Public Health Sciences, University of Virginia, Charlottesville, VA, 4The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, 5Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 6Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, 7Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 8Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 9University of Umeå, Umeå, Sweden, 10Department of Human Genetics, University of Utah, Salt Lake City, UT, 11JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, 12Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: While genome-wide association studies have identified risk loci for rheumatoid arthritis and other autoimmune diseases, in very few instances have causal variants driving risk…
  • Abstract Number: 27 • 2017 ACR/ARHP Annual Meeting

    Effects of High Titers of Anti-Chimeric Antibodies Following Rituximab

    Roberta Fenoglio1, Laura Solfietti1, Savino Sciascia2 and Dario Roccatello1, 1Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, 2Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy

    Background/Purpose: Monoclonal antibodies (MoAbs) are highly successful in treating various immunological disorders. The development of anti-drug antibodies (ADA) against the therapeutic MoAb is relatively common.…
  • Abstract Number: 1466 • 2017 ACR/ARHP Annual Meeting

    The Effects of Rituximab and B-Cells Depletion on the Inflammatory and Pro-Thrombotic Profile of Leucocytes of Rheumatoid Arthritis Patients and on the Vascular Endothelium

    Irene Cecchi1, Carlos Perez-Sanchez2, Patricia Ruiz-Limon3, Ivan Arias de la Rosa3, Maria Carmen Abalos-Aguilera3, Yolanda Jiménez-Gómez2, Rafaela Ortega-Castro2, Eduardo Collantes-Estévez2, Alejandro Escudero-Contreras3, Massimo Radin4, Nuria Barbarroja2, Dario Roccatello5, Savino Sciascia6 and Chary Lopez-Pedrera7, 1Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 2Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 5Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 6Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, 7IMIBIC/Reina Sofia Hospital/ University of Cordoba, Cordoba, Spain

    Background/Purpose: Cardiovascular disease (CVD) constitutes a relevant cause of morbidity and mortality in Rheumatoid Arthritis (RA) patients. Rituximab (RTX) has been proved to be effective…
  • Abstract Number: 41 • 2017 ACR/ARHP Annual Meeting

    A Fine Bioinformatical Analysis of Lymphocyte Distribution Predicts the Diagnosis of Systemic Autoimmune Diseases

    Quentin Simon1, Bénédicte Rouvière1, Tifenn Martin1, Lucas Le Lann1, Alain Saraux1, Valérie Devauchelle-Pensec1, Concepcion Marañón2, Nieves Varela Hernández2, Aleksandra Dufour3, Carlo Chizzolini4, Ellen de Langhe5, Nuria Barbarroja6, Chary Lopez-Pedrera7, Velia Gerl8, Aurelie Degroof9, Julie Ducreux10, Elena Trombetta11, Tianlu Li12, Marta Alarcón-Riquelme13, Christophe Jamin1 and Jacques-Olivier Pers1, 1U1227, Université de Brest, Inserm, Labex IGO, CHU de Brest, Brest, France, 2GENYO, Centre for Genomics and Oncological Research Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain, 3Immunology & Allergy, University Hospital and School of Medicine, Geneva, Switzerland, 4University hospital of Geneva, Geneva, Switzerland, 5Rheumatology, University Hospital KU Leuven, Leuven, Belgium, 6Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 7IMIBIC/Reina Sofia Hospital/ University of Cordoba, Cordoba, Spain, 8Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, 9Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, 10Pôle de pathologies rhumatismales inflammatoires et systémiques, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, 11Laboratorio di Analisi Chimico Cliniche e Microbiologia - Servizio di Citofluorimetria, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy, 12Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, 13GENYO. Center for Genomics and Oncological Research, Granada, Spain

    Background/Purpose : We investigated 194 individuals with SADs (38 primary Sjögren’s syndrome (pSS), 47 rheumatoid arthritis (RA), 46 systemic lupus erythematosus (SLE), 42 systemic sclerosis…
  • Abstract Number: 1479 • 2017 ACR/ARHP Annual Meeting

    Difference in Clinical Presentation between Female and Male Patients with Primary Sjogren’s Syndrome at Diagnosis and in Long-Term Follow-up

    Jorge Ramírez1, Marika Kvarnstrom2, Susanna Brauner3, Chiara Baldini4, Per Eriksson5, Thomas Mandl6, Katrine Brække Norheim7, Svein Joar Johnsen8, Daniel S. Hammenfors9,10, Malin V. Jonsson11, Kathrine Skarstein12,13, Johan G. Brun9,10, Lars Rönnblom14, Helena Forsblad D’Elia15, Sara Magnusson Bucher16, Elke Theander17, Roald Omdal8, Roland Jonsson9,10, Gunnel Nordmark18 and Marie Wahren-Herlenius19, 1Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Solna, Sweden, 2Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 3Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 4Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 5Division of Rheumatology, Department of Clinical Experimental Medicine, Linköping University, Linköping, Sweden, Linköping, Sweden, 6Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, Lund, Sweden, 7Department of Internal Medicine, Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, Stavanger, Norway, 8Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, Stavanger, Norway, 9Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, Bergen, Norway, 10Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, Bergen, Norway, 11Section for Oral and Maxillofacial Radiology, Department of Clinical Dentistry, University of Bergen, Bergen, Norway, Bergen, Norway, 12Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, 13Department of Pathology, Haukeland University Hospital, Bergen, Bergen, Norway, 14Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, 15Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden., Umeå, Sweden, 16Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden, Örebro, Sweden, 17Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, Malmö, Sweden, 18Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, 19Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune…
  • Abstract Number: 164 • 2017 ACR/ARHP Annual Meeting

    Association of Natural Killer Cell Ligand Polymorphism, HLA-C Asn80Lys, with the Development of Anti-SSA/Ro Associated Congenital Heart Block

    Hannah C. Ainsworth1, Miranda C Marion1, Antonio Brucato2, Nathalie Costedoat-Chalumeau3, Tiziana Bertero4, Rolando Cimaz5, Micaela Fredi6, Patrick M. Gaffney7, Jennifer A. Kelly7, Kateri Levesque8, Alice Maltret8, Nathalie Morel8, Véronique Ramoni9, Amelia Ruffatti10, Carl D Langefeld1, Jill P. Buyon11 and Robert M Clancy11, 1Wake Forest University, Winston Salem, NC, 2Ospedale Papa Giovanni XXIII, Bergamo, Italy, 3Service de médecine interne Pôle médecine, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares de l’île de France, Paris, France, 4Ospedale Mauriziano, Torino, Italy, 5Department of Paediatrics, University of Florence and Anna Meyer Children's Hospital, Florence, Italy, Florence, Italy, 6Department of Rheumatology and Clinical Immunology, Rheumatology and Clinical Immunology, Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, 7Oklahoma Medical Research Foundation, Oklahoma City, OK, 8Université Paris Descartes-Sorbonne Paris Cité, Paris, France, 9Ospedale Papa Giovanni XXIII of Bergamo, Policlinico San Matteo of Pavia, Bergamo, Pavia, Italy, 10Unità di Reumatologia, Dipartimento di Medicina-DIMED, Università di Padova., Padova, Italy, 11NYU Langone Medical Center, New York, NY

    Background/Purpose: Fetal exposure to maternal anti-SSA/Ro antibodies is necessary but insufficient for the development of congenital heart block (CHB), suggesting the potential of a fetal…
  • Abstract Number: 1741 • 2017 ACR/ARHP Annual Meeting

    Tolerance and Efficiency of Anti-Programmed Death 1 Antibodies in Patients with Cancer and Preexisting Autoimmune or Inflammatory Diseases

    Francois-Xavier Danlos1, Anne-Laure Voisin2, Valérie Dyevre3, Jean-Marie Michot1, Emilie Routier4, Laurent Taillade5, Stéphane Champiat1, Sandrine Aspeslagh1, Julien Haroche6, Laurence Albiges7, Christophe Massard1, Nicolas Girard8, Stéphane Dalle9, Benjamin Besse7, Salim Laghouati2, Jean-Charles Soria1, Christine Mateus4, Caroline Robert4, Emilie Lanoy3, Aurélien Marabelle1,10 and Olivier Lambotte11, 1Drug Development Department, Gustave Roussy Institut, Villejuif, France, 2Unité Fonctionnelle de Pharmacovigilance, Gustave Roussy Institut, Villejuif, France, 3Service de biostatistique et d’épidémiologie, Gustave Roussy Institut, Villejuif, France, 4Department of dermatology, Gustave Roussy Institut, Villejuif, France, 5Department of medical oncology, Pitié Salpétrière Hospital, Paris, France, 6Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, 7Department of medical oncology, Gustave Roussy Institut, Villejuif, France, 88. Department of Respiratory Medicine, National Expert Centre for Thymic Malignancies, Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, France, 9Department of dermatology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France, 10Immunotherapy program, Gustave Roussy Institut, Villejuif, France, 11Internal Medicine, Hopital Kremlin Bicêtre, Kremlin Bicêtre, France

    Background/Purpose: Patients with auto-immune or inflammatory diseases (AID) treated by immune check-points inhibitors (ICI) are intrinsically susceptible to develop immune related adverse events (irAE). We…
  • Abstract Number: 183 • 2017 ACR/ARHP Annual Meeting

    Allele-Dependent Binding of a Viral Protein to Autoimmune Disease-Associated Genetic Variants

    Matthew Weirauch1, Daniel Miller2, Leah C. Kottyan3, Ignacio Ibarra4, Arthur Lynch2, Sayeed Syed5, Xiaoting Chen2, Erin Zoller2, Connor Schroeder2, Josh Lee2, Albert Magnusen6, Ally Yang7, Timothy R. Hughes7, Joo-Seop Park8, Charles Vinson5 and John B. Harley2,9, 1Center for Autoimmune Genomics and Etiology (CAGE) and Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany, 5NCI, Bethesda, MD, 6Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 7University of Toronto, Toronto, ON, Canada, 8Divisions of Urology and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 9US Department of Veterans Affairs Medical Center, Cincinnati, OH

    Background/Purpose: Risk factors are known for many diseases, but the etiologies of most autoimmune diseases remain unknown and are idiopathic. Pathogenesis of disease likely involves…
  • Abstract Number: 1747 • 2017 ACR/ARHP Annual Meeting

    Human C-C Chemokine Receptor-6 (CCR6)+ Th Memory Cells, Including Th17 and Th17.1 Cells, Change into Anti-Inflammatory Cells with Regulatory Capacity upon Exposure to Vitamin D

    Wendy Dankers1, Nadine Davelaar2, Jan Piet van Hamburg3, Patrick Asmawidjaja2, Hoyan Wen2, Johannes van Leeuwen4, Edgar Colin5 and Erik Lubberts2, 1Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 2Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 3Rheumatology, Erasmus MC, Rotterdam, Netherlands, 4Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 5ZGT Almelo, Deventer, Netherlands

    Background/Purpose: Autoimmune diseases such as RA are driven by an aberrantly activated immune system and an imbalance between pro- and anti-inflammatory cells, resulting in tissue…
  • Abstract Number: 184 • 2017 ACR/ARHP Annual Meeting

    An Epigenome-Guided Approach to Causal Variant Discovery in Autoimmune Disease

    Richard C. Pelikan1, Jennifer A. Kelly2, Yao Fu2, Caleb Lareau3, Graham B. Wiley1, Stuart Glenn1, Martin Aryee3,4, Courtney Montgomery5 and Patrick Gaffney2, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Charlestown, MA, 4Department of Pathology, Harvard Medical School, Boston, MA, 5Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Genome-wide association studies have identified thousands of genetic associations with complex human diseases and traits. However, establishing the truly causal regions of risk haplotypes…
  • Abstract Number: 1786 • 2017 ACR/ARHP Annual Meeting

    Lupus Nephritis Is Linked to Immunity to an Intestinal Commensal Lachnospiracaea Species

    Gregg J. Silverman1, Doua F. Azzouz2, Hanane El Bannoudi2, Aidana Omarbekova3, Brad H. Rovin4, Roberto Caricchio5, Alexander Alekseyenko6 and Jill P. Buyon2, 1Department of Medicine, New York University School of Medicine, New York, NY, 2Medicine, New York University School of Medicine, New York, NY, 3New York University School of Medicine, New York, NY, 4Ohio State University Medical Center, Columbus, OH, 5Medicine/Rheumatology, Temple University, Philadelphia, PA, 6Medical University of South Carolina, Charleston, SC

    Background/Purpose: A transmissible agent has long been suspected in the pathogenesis of SLE, yet the potential contribution of members of the intestinal microbiome to the…
  • Abstract Number: 210 • 2017 ACR/ARHP Annual Meeting

    Pharmacovigilance Surveillance of Autoimmune Diseases Induced By Biological Agents: A Review of 12013 Cases (aeBIOGEAS-SEMI Registry)

    Soledad Retamozo1,2,3, Manuel Ramos-Casals4,5, Marta Pérez de Lis6, Alejandra Flores-Chavez7,8,9, Sofia Arteaga10,11, Celeste Galcerán-Chaves12, Belchin Kostov13, Roberto Pérez-Alvarez6 and Pilar Brito-Zerón2,14, 1Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, 2Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, 3Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, 4Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 5Department of Medicine, University of Barcelona, Barcelona, Spain., Barcelona, Spain, 6Department of Internal Medicine, Hospital Alvaro Cunqueiro, Vigo, Vigo, Spain, 7Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Spain., Barcelona, Spain, 8Unidad de Investigación Biomédica 02 (Unidad de Investigación en Epidemiología Clínica), UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Jalisco, Mexico, 9Programa de Doctorado en Ciencias Médicas, Centro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, Mexico, Mexico, Mexico, 10Residente de Reumatologia II año, Universidad de Antioquia, Medellin, Colombia, Medellin, Colombia, 11d) Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Spain., Barcelona, Spain, 12Neuroscience Clinical Institute, Hospital Clínic, Barcelona, Spain, Barcelona, Spain, 13Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, CAPSE, Barcelona, Barcelona, Spain, 14Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona., Bacelona, Spain

    Background/Purpose: The increasing use of biological agents has been linked with the paradoxical development of autoimmune processes. The scenario has dramatically change in recent years…
  • Abstract Number: 1792 • 2017 ACR/ARHP Annual Meeting

    Distinct and Overlapping Activities of IL-17A and TNF on the Expression of Proinflammatory Cytokines and MMPs in Psoriatic Arthritis: Rationale for Anti-IL-17A/Anti-Tnfalpha Combination Therapy?

    Xiaofei Xu1, Nadine Davelaar2, Anne-Marie Otten-Mus3, Patrick Asmawidjaja2, J.M.W. Hazes4, Dominique Baeten5, Marijn Vis6, Radjesh Bisoendial1 and Erik Lubberts2, 1Rheumatology, Erasmus MC, Rotterdam, Netherlands, 2Rheumatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 3Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 4Department of Rheumatology, Erasmus University Medical Centre, Rotterdam, Netherlands, 5Clinical Immunology and Rheumatology/Experimental immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 6Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands

    Background/Purpose: TNF and IL-17A are proinflammatory cytokines critically involved in the pathogenesis of psoriatic arthritis (PsA). Currently, targeting TNF is the first choice of a…
  • Abstract Number: 284 • 2017 ACR/ARHP Annual Meeting

    Metabolic Activity Sustains Macrophage Cytokine Production in Rheumatoid Arthritis and Coronary Artery Disease

    Cornelia M. Weyand1, Markus Zeisbrich1, Lukas Brosig2, Barbara Wallis1, Niall Roche3, Janice Lin1 and Jorg Goronzy4, 1Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, 2Medicine: Immunology and Rheumatology, Stanford University, Stanfod, CA, 3The Arthritis Center, Pleasanton, CA, 4Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Accelerated atherosclerosis has become increasingly recognized as a complication of chronic inflammatory disease, such as in patients with rheumatoid arthritis (RA). RA patients have…
  • Abstract Number: 1999 • 2017 ACR/ARHP Annual Meeting

    Magnetic Resonance Imaging of Skeletal Muscles in Patients with Dermatomyositis and Polymyositis: Novel and Distinctive Characteristic Findings

    Taro Ukichi1, Ken Yoshida1, Satoshi Matsushima2, Go Kawakami2, Kentaro Noda1, Kazuhiro Furuya1 and Daitaro Kurosaka1, 1Division of Rheumatology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan, 2Department of Radiology, Jikei University School of Medicine, Tokyo, Japan

    Background/Purpose: Radiological studies to distinguish between dermatomyositis (DM) and polymyositis (PM) are few. We predicted that the magnetic resonance imaging (MRI) findings of skeletal muscle…
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