ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases"

  • Abstract Number: 843 • 2018 ACR/ARHP Annual Meeting

    Localization of the Voltage-Gated Sodium Channel 1.7 in Peripheral Monocytes Contributes to Activation of BAFF Signaling in Monocytes of Patients with Primary Sjögren’s Syndrome

    Keiko Yoshimoto, Yumi Ikeda, Katsuya Suzuki and Tsutomu Takeuchi, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: In our previous study, we have reported that IL-6 production was robustly increased in BAFF-stimulated peripheral monocytes of patients with primary Sjögren’s syndrome (pSS)…
  • Abstract Number: 1182 • 2018 ACR/ARHP Annual Meeting

    The Disproportionate High Risk of Re-Fracture after Osteoporotic Treatment in Patients with Autoimmune Diseases

    Wen-Nan Huang1, Yi-Ming Chen1, Wei-Ting Hung2, Yu-Wan Liao3 and Yi-Hsing Chen1, 1Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan, 2Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, 3Taichung Veterans General Hospital, Taichung, Taiwan

    Background/Purpose: Patients with autoimmune diseases are associated with an increased risk of osteoporotic fracture. Anti-osteoporotic treatment could diminish re-fracture rates in post-menopause women. However, treatment…
  • Abstract Number: 1584 • 2018 ACR/ARHP Annual Meeting

    Evaluation of the Performance of the 2016 American College of Rheumatology-European League Against Rheumatism (Acr-Eular) Classification Criteria for Primary Sjogren`S Syndrome in Different Centers of Argentina

    Hugo Najera1, Marta Mamani2, Anastasia Secco1, Fernando Melo3, Cristian Troitiño4, Felix Romanini Sr.2, Emmanuel Guerra2, Antonio Catalan Pellet5, Silvia Beatriz Papasidero6, Rodrigo Aguila Maldonado7, Mercedes Garcia7, Mariano Rivero8, Juan Carlos Barreira9, ivan remolina10, A. perdomo11, quevedo mayorga10, M.J. santacruz12 and j demarchi10, 1Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, 2Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 3Rheumatology Department, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 4Reumatologia, Hospital Bernardino Rivadavia, CAPITAL FEDERAL, Argentina, 5Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 6Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, Buenos Aires, Argentina, 7Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, 8Rheumatology, Consultorios Externos Vacarezza,Alberdi,Pcia Buenos Aires, Pcia Buenos Aires, Argentina, 9Rheumatology Unit, Hospital Británico, Buenos Aires, Buenos Aires, Argentina, 10hospital britanico, Buenos Aires, Argentina, 11hospital nuestra señora de la merced, alberti, Argentina, 12hospital tornu, Buenos Aires, Argentina

    Background/Purpose: Primary Sjögren`s Syndrome (pSS) is a multisystemic, autoimmunity disease, characterized mainly by the hypofunction of the salivary and lacrimal glands, however the clinical spectrum…
  • Abstract Number: 1771 • 2018 ACR/ARHP Annual Meeting

    Long-Term Survival of Renal Transplantation in Rapidly Progressive Glomerulonephritis (RPGN). Study of 43 Cases from a Single Center

    Belén Atienza-Mateo1, Lara Sánchez-Bilbao1, José Luis Martín-Varillas1, Marina de Cos-Gómez2, Íñigo González-Mazón1, Diana Prieto Peña3, Monica Calderón Goercke3, Emilio Rodrigo Calabia2, Juan Carlos Ruiz San Millán2, Miguel Angel González-Gay1 and Ricardo Blanco4, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Nephrology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 3Rheumatology, Rheumatology. Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 4Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain

    Background/Purpose: Rapidly Progressive Glomerulonephritis (RPGN) is characterized histology by presence of crescents and clinically by rapid and severe decline in kidney function. Thus, it may…
  • Abstract Number: 1915 • 2018 ACR/ARHP Annual Meeting

    Big Data Analysis of Autoimmune Diseases Induced By Cancer Immunotherapies: Identifying Pharmacological Patterns of Organ-Specific Involvement

    Soledad Retamozo1,2,3, Alejandra Flores-Chavez4,5,6, Belchin Kostov7, Antoni Sisó-Almirall8, Marta Pérez-de-Lis9, Roberto Pérez-Alvarez10, Pilar Brito-Zerón11,12, Munther A Khamashta13 and Manuel Ramos-Casals14, 1Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, 2Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, 3Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, 4Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Spain., Barcelona, Spain, 5Unidad de Investigación Biomédica 02 (Unidad de Investigación en Epidemiología Clínica), UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Jalisco, Mexico, 6Programa de Doctorado en Ciencias Médicas, Centro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, Mexico, Mexico, Mexico, 7ABS Les Corts, CAPSE, Research Group in Primary Care, IDIBAPS, ABS Les Corts, CAPSE, Barcelona, Spain, 8Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC, Barcelona, Barcelona, Spain, 9Department of Anesthesia, Complexo Hospitalario Universitario A Coruña (CHUAC), A Coruña, Spain, 10Department of Internal Medicine, Hospital Alvaro Cunqueiro, Vigo, Vigo, Spain, 11Autoimmune Diseases Unit, Department of Internal Medicine, Hospital CIMA-Sanitas, Barcelona, Barcelona, Spain, 12Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona, Barcelona, Spain, 13Lupus Research Unit, The Rayne Institute, Lupus Research Unit, The Rayne Institute, Kings' College London School of Medicine, St Thomas' Hospital, London, United Kingdom, 14Department of Autoimmune Diseases, ICMiD, Hospital Clínic Barcelona., Barcelona, Spain

    Background/Purpose: The scenario of biological-triggered autoimmune diseases has dramatically changed in recent years due to the increasing use of biologics in patients with solid cancers. Methods:…
  • Abstract Number: 2167 • 2018 ACR/ARHP Annual Meeting

    Incidence and Baseline Characteristics of Exacerbation in Patients with Interstitial Pneumonia with Autoimmune Features: A Single Center Large-Scale Cross-Sectional Cohort Study

    Okinori Murata, Nobuhito Sasaki and Makoto Maemondo, Division of Pulmonary medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan

    Background/Purpose: Patients with idiopathic interstitial pneumonia (IIP) may have features of connective tissue diseases (CTDs). The term interstitial pneumonia with autoimmune features (IPAF) has been…
  • Abstract Number: 2256 • 2018 ACR/ARHP Annual Meeting

    Rheumatic Diseases Associated with Neuromyelitis Optica Spectrum Disorders (NMOSD): Prevalence, Clinical, Laboratory and Imaging Characteristics

    Milena Rodriguez Alvarez1, Su Zhaz Leon1, Fernando Cuascut2, Naureen Kabani3, Joshy Pathiparampil3, Kristaq Koci4, Manjeet Bhamra5, Latoya Freeman4, Alexandra Kreps6, Justin Levinson6, Sophia Francis6, Vinodkumar Velayndhan6, Steve Xie7, Abhimanyu Amarnani6, Helen Valsamis8, Yaacov Anziska6, Ellen M. Ginzler9 and Isabel M. McFarlane9, 1Rheumatology, SUNY Downstate, Brooklyn, NY, 2Neurology, SUNY Downstate, Brooklyn, NY, 3Internal Medicine, SUNY Downstate Medical Center, Brooklyn, NY, 4Medicine, SUNY Downstate Medical Center, Brooklyn, NY, 5Medicine, SUNY Downstate, Brooklyn, NY, 6SUNY Downstate, Brooklyn, NY, 7NYC Health + Hospitals Kings County, Brooklyn, NY, 8Neurology, NYC Health + Hospitals Kings County, Brooklyn, NY, 9Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY

     Background/Purpose: NMOSD are autoimmune disorders characterized by optic neuritis (ON), longitudinal extensive transverse myelitis (LETM), and other clinical features. Aquaporin 4 antibodies (AQP4 Ab) have…
  • Abstract Number: 2257 • 2018 ACR/ARHP Annual Meeting

    Prevalence and Distinct Clinical Phenotype of Concomitant Sarcoidosis in Other Autoimmune Rheumatic Diseases

    Kristina E.N. Clark1, Huw Beynon2, Christopher P. Denton3 and Voon H. Ong4, 1Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 2Department of Rheumatology, Royal Free Hospital, London, United Kingdom, 3UCL Division of Medicine, Royal Free Campus, London, United Kingdom, 4Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: Lung involvement is common in both sarcoidosis (up to 90%) and autoimmune rheumatic diseases (ARDs). Case reports have suggested distinct clinical manifestations when sarcoidosis…
  • Abstract Number: 1171 • 2017 ACR/ARHP Annual Meeting

    Mycophenolate Mofetil May Improve Interstitial Pneumonia with Autoimmune Features

    Sara S. McCoy1, Zubin Mukadam2, Keith C. Meyer3, Emmanuel Sampene4, Jeffrey P. Kanne5, Christopher A. Meyer5, Maria D. Martin5, Scott W. Aesif6, Laurie Rice7 and Christie M. Bartels8, 1Department of Medicine, Rheumatology Division, University of Wisconsin School of Medicine and Public Health, Madison, WI, 2PULMONARY & CRITICAL CARE, University of Wisconsin School of Medicine and Public Health, madison, WI, 3PULMONARY & CRITICAL CARE, University of Wisconsin School of Medicine and Public Health, Madison, WI, 4Biostatistics, University of Wisconsin School of Medicine and Public Health, Madison, WI, 5Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 6Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, madison, WI, 7Critical Care Medicine, SSM Health Dean Medical Group, madison, WI, 8Rheumatology/Medicine, University of Wisconsin - Madison, Madison, WI

    Background/Purpose: To assess the efficacy of mycophenolate mofetil (MMF) in treatment of adult patients with interstitial pneumonia with autoimmune features (IPAF). Methods: A retrospective medical…
  • Abstract Number: 2601 • 2017 ACR/ARHP Annual Meeting

    Novel Anti-Malarial Drug Derivative Inhibited Type I Interferon Production and Autoimmune Inflammation in SLE Patient PBMC and in Trex1-/- Mouse Spleen and Heart

    Jie An1, Weinan Lai2,3, Joshua Woodward4, Xizhang Sun1, Lena Tanaka1, Tomikazu Sasaki5 and Keith B. Elkon6, 1Division of Rheumatology, University of Washington, Seattle, WA, 2Department of Medicine/Division of Rheumatology, University of Washington, Seattle, WA, 3Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China, 4Department of Microbiology, University of Washington, Seattle, WA, 5Department of Chemistry, University of Washington, Seattle, WA, 6Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA

    Background/Purpose: Type I interferon (IFN-I) is strongly implicated in the pathogenesis of Systemic Lupus Erythematosus (SLE) as well as rare monogenic ‘interferonopathies’ such as Aicardi-Goutieres…
  • Abstract Number: 1290 • 2017 ACR/ARHP Annual Meeting

    Preterm Birth Phenotypes in Women with Autoimmune Diseases

    Kathleen D. Kolstad1, Jonathan A. Mayo2, Lorinda Chung3, Yashaar Chaichian4, Victoria M. Kelly5, Maurice Druzin6, David K. Stevenson7, Gary M. Shaw8 and Julia F Simard9, 1Rheumatology, Stanford University Medical Center, Stanford, CA, 2Stanford University Medical Center, Stanford, CA, 3Rheumatology, Stanford University Medical Center, Palo Alto, CA, 4Medicine, Immunology & Rheumatology Division, Stanford School of Medicine, Stanford, CA, 5Palo Alto Medical Foundation, Palo Alto, CA, 6Obstetrics & Gynecology, Stanford School of Medicine, Stanford, CA, 7Pediatrics - Neonatology, Stanford University, Stanford, CA, 8Pediatrics, Division of Neonatology and Developmental Medicine, Stanford School of Medicine, Stanford, CA, 9Division of Epidemiology, Health Research and Policy Department, Stanford School of Medicine, Stanford, CA

    Background/Purpose: Systemic autoimmune diseases expose patients to chronic inflammation, immune dysregulation, and vascular abnormalities; complications that can impact obstetric outcomes. The goal of this study…
  • Abstract Number: 2634 • 2017 ACR/ARHP Annual Meeting

    The Prevalence of Autoimmune Disease in Families of Patients with Systemic Lupus Erythematosus (SLE). a Single Centre Study

    Oseme Etomi1, Andrea Cove-Smith2, Ravindra Rajakariar3, Myles J. Lewis2,4,5,6, Angela Pakozdi2 and Debasish Pyne2, 1heumatology Department, Barth Health NHS foundation trust, London, United Kingdom, 2Barts Lupus Centre, Barts Health NHS Trust, London, United Kingdom, 3Bart's Lupus Center, Barts Health NHS Foundation Trust, London, United Kingdom, 4Experimental Medicine & Rheumatology, Queen Mary University of London, London, United Kingdom, 5Myles Lewis ([email protected]), London, United Kingdom, 6Rheumatology, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    Background/Purpose: Studies to date have reported that up to 30% of lupus patient have a first degree relative with an autoimmune disorder (AD). The most…
  • Abstract Number: 1328 • 2017 ACR/ARHP Annual Meeting

    A Dual ICOS/CD28 Antagonist ICOSL Variant Ig Domain (vIgDTM) Potently Suppresses Mouse Collagen-Induced Arthritis and Human Xenograft Graft Vs. Host Disease (GvHD)

    Stacey Dillon1, Katherine Lewis1, Ryan Swanson2, Lawrence Evans2, Michael Kornacker3, Steve Levin2, Martin Wolfson4, Erika Rickel2, Susan Bort2, Sherri Mudri1, Aaron Moss1, Michelle Seaberg1, Janhavi Bhandari4, Sean MacNeil4, Joe Hoover4, Mark Rixon4 and Stanford Peng5, 1Translational Sciences, Alpine Immune Sciences, Seattle, WA, 2Immunology, Alpine Immune Sciences, Seattle, WA, 3Protein Engineering, Alpine Immune Sciences, Seattle, WA, 4Protein Therapeutics, Alpine Immune Sciences, Seattle, WA, 5Clinical, R&D, Alpine Immune Sciences, Seattle, WA

    Background/Purpose:   Our proprietary variant Ig domain (vIgD) platform creates novel, therapeutically-applicable protein domains with tailored specificity and affinity. These vIgDs are created through directed…
  • Abstract Number: 2740 • 2017 ACR/ARHP Annual Meeting

    Cyclophosphamide Treatment Modulates Circulating Cell Populations in Patients with Vasculitis and Autoimmune Systemic Diseases

    Martina Skácelová1, Gabriela Gabčová2, Pavel Horak3, Zuzana Mikulková2, František Mrázek4, Eva Kriegová5 and Andrea Smržová6, 1III. Department of Internal Medicine, Faculty of Medicine and Dentistry, Palacký University of Olomouc, Olomouc, Czech Republic, 2Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic, 3III. Department of internal medicine, III. Department of Internal Medicine, Faculty of Medicine and Dentistry, Palacký University of Olomouc, Olomouc, Czech Republic, 4Department of Immunology, Faculty of Medicine and Dentistry, Palacky University of Olomouc, Olomouc, Czech Republic, 5Department of Immunology, Department of Immunology, Faculty of Medicine and Dentistry, Palacky University of Olomouc, Olomouc, Czech Republic, 6III. Department of Internal Medicine, III. Department of Internal Medicine, Faculty of Medicine and Dentistry, Palacký University of Olomouc, Olomouc, Czech Republic

    Background/Purpose: Although cyclophosphamide (CFA) remain the cornerstone for treatment of patients with severe manifestations of systemic autoimmune diseases, the knowledge about the effect of CFA…
  • Abstract Number: 1407 • 2017 ACR/ARHP Annual Meeting

    Huntingtin Interactin Protein 1 (HIP1) Regulates Invasiveness, Actin Filament and Lamellipodia Formation in Rheumatoid Arthritis Fibroblast-like Synoviocytes (FLS)

    Teresina Laragione, Carolyn Harris, Erjing Gao and Percio S. Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Huntingtin-interacting protein 1 (Hip1) is an arthritis severity and joint damage gene recently discovered in rodent models of arthritis. Hip1 regulates fibroblast-like synoviocytes (FLS)…
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