ACR Meeting Abstracts

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Abstracts tagged "autoantigens"

  • Abstract Number: 1607 • ACR Convergence 2023

    Autoantibodies to Transcription Factor a Mitochondria Link Mitochondrial Damage and Thrombosis in Systemic Lupus Erythematosus

    Eduardo Gomez-Banuelos1, Alessandra Ida Celia2, Maria Isabel Trejo Zambrano3, Merlin Paz3, Erika Darrah3, Daniel Goldman4, Michelle Petri4 and Felipe Andrade3, 1The Johns Hopkins University, Baltimore, MD, 2John Hopkins University of Medicine, Rome, Italy, 3Johns Hopkins University, Baltimore, MD, 4Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Upon activation with interferon (IFN) and RNP-immune complexes, defective mitophagy in neutrophils results in the release of mtDNA in complex with transcription factor A…
  • Abstract Number: 1734 • ACR Convergence 2023

    Serum PDGF-BB Levels Correlate with Lung Fibrosis in Mice Injected with Malondialdehyde-Acetaldehyde and/or Citrulline Modified Vimentin

    Nozima Aripova1, Michael Duryee1, Carlos Hunter1, Amy Nelson1, Breanna Butler1, Jill Poole1, Bryant England1, Geoffrey Thiele1 and Ted R Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Pulmonary manifestations of rheumatoid arthritis (RA), such as interstitial lung disease (RA-ILD), are a major contributor to morbidity and mortality. The mechanism of pulmonary…
  • Abstract Number: 1741 • ACR Convergence 2023

    The Occurrence and Phenotype of Autoreactive T Cells in the At-Risk Phase of Rheumatoid Arthritis

    Sara Turcinov1, Charlotte de Vries2, Ravi Kumar Sharma2, Christina Gerstner2, Bruno Raposo2, Anatoly Dubnovitsky2, William Kwok3, Karine Chemin2, Vivianne Malmström4 and Aase Hensvold5, 1Division of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet. Theme of Inflammation and Ageing, Medical Unit Gastro, Derma, Rheuma, Karolinska University Hospital, Stockholm, Sweden, 2Division of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 3Benaroya Research Institute at Virginia Mason, Seattle, WA, 4Karolinska Institutet, Stockholm, Sweden, 5Division of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet. Center for Rheumatology, Academic Specialist Center, Stockholm, Sweden

    Background/Purpose: CD4+ T cells recognizing citrullinated epitopes are present in peripheral blood of anti-citrulline protein antibody (ACPA) positive rheumatoid arthritis (RA) patients at time of…
  • Abstract Number: 1762 • ACR Convergence 2023

    Single-cell RNA Sequencing Analysis and Immune Profiling of Antigen-specific T Cells in Patients with Rheumatoid Arthritis and Healthy Controls

    JING SONG1, Cliff Rims1, Matthew Dufort1, Peter Linsley1, Eddie James2 and Jane Buckner2, 1Benaroya Research Institute, Seattle, WA, 2Benaroya Research Institute at Virginia Mason, Seattle, WA

    Background/Purpose: Single-cell analysis has emerged as a powerful tool for investigating the transcriptomics and T-cell receptor (TCR) diversity in patients with rheumatoid arthritis (RA). However,…
  • Abstract Number: 0008 • ACR Convergence 2023

    Differential Induction of Anti-Muscarinic Type-3-Receptor Antibodies by Immunization with 4-Hydroxy-2-nonenal-Modified Ro60 in BALB/c Mice

    Biji T Kurien1, Devavrat Dave1, Martha Tsaliki1, Valerie Lewis1 and R Hal Scofield2, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma City Veterans Affairs Medical Center, Oklahoma City, OK

    Background/Purpose: Sjögren's Disease is an autoimmune condition in which patients exhibit decreased salivary/lacrimal gland function and express autoantibodies that target the 60k molecular weight Ro…
  • Abstract Number: 0017 • ACR Convergence 2023

    Xist Ribonucleoproteins Promote Female Sex-biased Autoimmunity

    Diana Dou1, Yanding Zhao1, Julia Belk1, Yang Zhao1, Kerriann Casey2, Derek Chen1, Rui Li1, Bingfei Yu1, Suhas Srinivasan1, Brian Abe1, Katerina Kraft1, Ceke Hellström3, Ronald Sjöberg4, Sarah Chang5, Allan Feng5, Daniel Goldman6, Ami Shah7, Michelle Petri6, Lorinda Chung8, David Fiorentino9, Emma Lundberg10, Anton Wutz11, Paul Utz5 and Howard Chang1, 1Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, Stanford, CA, 2Department of Comparative Medicine, Stanford University, Stanford, CA, 3Autoimmunity and Serology Profiling, Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden, 4Department of Protein Science, SciLifelab, KTH Royal Institute of Technology, Stockholm, Sweden, 5Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 6Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 7Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Ellicott City, MD, 8Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Woodside, CA, 9Department of Dermatology, Stanford University School of Medicine, Menlo Park, CA, 10Departments of Bioengineering and Pathology, Stanford University, Stanford, CA, 11Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Hönggerberg, Zurich, Switzerland

    Background/Purpose: Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long noncoding RNA…
  • Abstract Number: 0081 • ACR Convergence 2023

    RA Disease Activity Influence the Frequency and Phenotype of Citrulline Reactive CD4 T Cells in DRB1*04:04 ACPA+ RA Patients

    Cliff Rims1, Anne Hocking1, Sylvia Posso1, Bernard Ng2, Jeffrey Carlin3, Jane Buckner4 and Eddie James4, 1Benaroya Research Institute, Seattle, WA, 2Veteran Affairs, Seattle, WA, 3Virginia Mason Medical Center, Seattle, WA, 4Benaroya Research Institute at Virginia Mason, Seattle, WA

    Background/Purpose: The presence of ACPA in RA signifies an immune response toward citrullinated auto-antigens in disease pathogenesis and persistence. RA is a T cell mediated…
  • Abstract Number: 0609 • ACR Convergence 2022

    Macrophage Response to MAA Modified Fibrinogen in the Presence of Peptidyl Arginine Deiminase Inhibitor

    nozima Aripova1, Michael Duryee1, carlos hunter1, Geoffrey Thiele1 and Ted Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The formation of citrullinated (CIT) proteins is catalyzed by a calcium-dependent peptidyl arginine deiminase (PAD). In rheumatoid arthritis (RA), synovial macrophages are main contributors…
  • Abstract Number: 0631 • ACR Convergence 2022

    Perfluoroalkyl Substances and Community Vulnerability: Associations with Lupus-Related Autoantibodies and Disease

    Emily Vara, Dulaney Wilson, John Pearce, Jim Oates and Diane Kamen, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Perfluoroalkyl substances (PFAS) are a class of persistent organic pollutants found in nonstick products, water repellant fabrics, fire-retardant foams, and food packaging. Highly stable,…
  • Abstract Number: 1681 • ACR Convergence 2022

    Supernatants from Activated Macrophages Contain Citrullinated Vimentin and Induce Extracellular Matrix Deposition from Fibroblasts

    nozima Aripova1, Michael Duryee1, Eric Daubach1, carlos hunter1, Bryant England1, James O'Dell1, Ted Mikuls2 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Studies have shown that activated macrophages secrete several factors that promote human fibroblast-like synoviocyte (HFLS) activation, resulting in an invasive phenotype, that contributes to…
  • Abstract Number: 1682 • ACR Convergence 2022

    Peptidyl Arginine Deiminase Expression and Macrophage Polarization Following Stimulation with Citrullinated and Malondialdehyde-acetaldehyde Modified Fibrinogen

    nozima Aripova1, Michael Duryee1, carlos hunter1, Bryant England1, Debra Romberger1, James O'Dell1, Geoffrey Thiele1 and Ted Mikuls2, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Post-translational modifications (PTM) of extracellular matrix proteins, such as fibrinogen, have been implicated in the pathogenesis of rheumatoid arthritis (RA). Citrullination, a type of…
  • Abstract Number: 1686 • ACR Convergence 2022

    Post-translational Modification of Matrix-gla Protein with Malondialdehyde-Acetaldehyde Alters Cellular Responses by Human Fibroblasts

    Austin Ragland1, Michael Duryee1, nozima Aripova1, Spencer Jones1, Ted Mikuls2 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Post-translational modifications with malondialdehyde-acetaldehyde (MAA) alter protein structure and function, inducing pro-inflammatory and pro-fibrotic responses characteristic of rheumatoid arthritis (RA). Matrix-gla protein (MGP) chelates…
  • Abstract Number: 1734 • ACR Convergence 2022

    Identification of Sjögren’s Disease-Associated T Cell Receptors Through Deep Sequencing and Single-Cell Transcriptomics

    Ananth Aditya Jupudi1, Michelle Joachims1, Christina Lawrence1, Charmaine Lopez-Davis1, Bhuwan Khatri1, Astrid Rasmussen1, Lida Radfar2, Kiely Grundahl1, R. Hal Scofield2, Judith James1, Joel Guthridge1, Christopher Lessard1, Linda F. Thompson1 and A. Darise Farris1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjögren's disease (SjD) is a chronic rheumatic autoimmune disorder that primarily targets the lacrimal and salivary glands (SG) resulting in dry eyes and dry…
  • Abstract Number: 1735 • ACR Convergence 2022

    Clonally Expanded Cytotoxic CD8+ T Cells Recognize Citrullinated Antigens in ACPA+ Rheumatoid Arthritis

    Jae-Seung Moon1, Shady Younis2, Orr Sharpe2, Navin Rao3, Julie Carman3, Eddie James4, Jane Buckner4, Kevin D Deane5, Michael Holers6, Laura Donlin7, Mark Davis2 and William Robinson8, 1Stanford University, Palo Alto, CA, 2Stanford University, Stanford, CA, 3Janssen Research and Development, LLC, Spring House, PA, 4Benaroya Research Institute at Virginia Mason, Seattle, WA, 5University of Colorado Denver Anschutz Medical Campus, Denver, CO, 6Department of Medicine Division of Rheumatology, Aurora, CO, 7Hospital for Special Surgery, New York, NY, 8Stanford University School of Medicine, Palo Alto, CA

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease associated with MHC polymorphisms. The shared epitope polymorphism in MHC class II genes is by far…
  • Abstract Number: 1741 • ACR Convergence 2022

    Mutated Nod2 Controls T Cell Function and Promotes Uveitis in a Blau Syndrome Mouse Model

    Leah Huey1, Kylie Koney1, Emily Vance1, Chia-Feng Tsai2, Rosalie K. Chu2, Marina A. Gritsenko2, Ellen Lee1, Holly Rosenzweig1 and Ruth Napier1, 1Oregon Health & Science University and VA Portland Health Care System, Portland, OR, 2Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA

    Background/Purpose: Mutations in the microbial signaling molecule NOD2 cause granulomatous uveitis, arthritis, and dermatitis in Blau Syndrome. We previously showed a novel role for Nod2…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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