ACR Meeting Abstracts

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Abstracts tagged "autoantigens"

  • Abstract Number: 713 • 2012 ACR/ARHP Annual Meeting

    Rpp25 Is a Major Target of Autoantibodies to the Th/to Complex As Measured by ELISA and a New Chemilumiscence Assay

    Michael Mahler1, Cristina Gascon2, Sima Patel2, Angela Ceribelli3, Edward K.L. Chan3 and Minoru Satoh4, 1Research, INOVA Diagnostics, San Diego, CA, 2Research, INOVA Diagnostics, Inc., San Diego, CA, 3Oral Biology, University of Florida, Gainesville, FL, 4Medicine, University of Florida, Gainesville, FL

    Background/Purpose: Anti-nuclear antibodies (ANA) play an important role in the diagnosis of systemic autoimmune diseases including systemic sclerosis (SSc). A significant portion of ANA in…
  • Abstract Number: 889 • 2012 ACR/ARHP Annual Meeting

    Modeling Environmental and Genetic Determinants to Identify the Association of Risk Genes in Anti-Ro60-Mediated Injury: Relaxin Receptor I and Tumor Necrosis Factor

    Joanne H. Reed1, Paula S. Ramos2, Jiri Zavadil3, Jill P. Buyon4 and Robert M. Clancy1, 1Medicine, New York University School of Medicine, New York, NY, 2Department of Medicine, Medical University of South Carolina, Charleston, SC, 3Pathology and Center for Health Informatics and Bioinformtics, New York University School of Medicine, New York, NY, 4Department of Medicine, New York University School of Medicine, New York, NY

    Background/Purpose: Fetuses exposed to maternal anti-Ro60 antibodies can develop cardiac conduction abnormalities and life threatening cardiomyopathy; manifestations of neonatal lupus (NL). Recent data support an injury…
  • Abstract Number: 1081 • 2012 ACR/ARHP Annual Meeting

    Toll-Like Receptor 7, 8 and 9 Activation of Primary Human Cells by Lupus Immune Complexes Is Dependent On Interleukin 1 Receptor Associated Kinase 4 Activity

    Aaron Winkler1, Weiyong Sun1, Ken Dower2, Elizabeth A. Murphy1, Julia Shin1, Michael Luong1, Michael J. Primiano1, Varenka A. Rodriguez2, Tatyana Souza1, Lih-Ling Lin3, J. Perry Hall1, Katherine Lee4, Vikram R. Rao1 and Margaret Fleming1, 1Inflammation & Remodeling, Pfizer, Cambridge, MA, 2Inflammation and Remodeling, Pfizer, Cambridge, MA, 3Inflammation and Remodeling Research Unit, Pfizer, Cambridge, MA, 4Worldwide Medicinal Chemistry, Pfizer, Cambridge, MA

    Background/Purpose: Genetic, in vitro and in vivo evidence strongly implicate the activation of nucleic acid sensing toll like receptors (TLR) 7, 8, and 9 in…
  • Abstract Number: 1391 • 2012 ACR/ARHP Annual Meeting

    Anti-Ku Autoantibodies in Systemic Lupus Erythematosus Versus Autoimmune Myositis As Measured by a Novel Chemiluminescence Assay

    Michael Mahler1, Jason Wu2, Magdalena Szmyrka-Kaczmarek3, Andreas Swart4, Marvin J. Fritzler5, Jean-Luc Senécal6 and John G. Hanly7, 1Research, INOVA Diagnostics, San Diego, CA, 2Research, INOVA Diagnostics, San Diego, 3Rheumatology, Wroclaw Medical University, Wroclaw, Poland, 4Rheumatology clinic Neuss, Neuss, Germany, 5Medicine, University of Calgary, Calgary, AB, Canada, 6Rheumatology, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, 7Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada

    Background/Purpose: Autoantibodies targeting Ku, an abundant nuclear protein with DNA helicase activity, have been reported in patients with systemic autoimmune rheumatic diseases. Little is known…
  • Abstract Number: 2577 • 2012 ACR/ARHP Annual Meeting

    Characterization of Circulating Human B Cells That Bind Cyclic Citrullinated Peptide Antigens in Clinically Active Rheumatoid Arthritis

    Gregg J. Silverman1, John Jung2, Jeffrey D. Greenberg3, Adam J. Pelzek4, Caroline Gronwall5 and Jaya Vas5, 1Medical and Pathology, NYU School of Medicine, New York, NY, 2School of Medicine, NYU, New York, NY, 3New York Hospital for Joint Disease, New York, NY, 4School of Medicine, NYU School of Medicine, New York, NY, 5Rheumatology, NYU School of Medicine, New York, NY

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) were first identified based on their high specificity for RA and now are commonly used as a diagnostic tool. Yet,…
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ACR Pediatric Rheumatology Symposium 2020

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