Abstracts tagged "autoantibodies"

Abstract Number: 1600 • 2013 ACR/ARHP Annual Meeting
Anti-Ribosomal P Protein Antibodies Exacerbate Long-Term Prognosis In Patients With Diffuse Neuropsychiatric/Neuropsychological Syndromes In Systemic Lupus Erythematous
Yoshiyuki Arinuma¹, Hirotoshi Kikuchi², Eisuke Ogawa¹, Tatsuhiko Wada¹, Tatsuo Nagai³, Sumiaki Tanaka¹ and Shunsei Hirohata¹, ¹Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan, ²Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Systemic lupus erythematous (SLE) is a chronic inflammatory disease characterized by the expression of a variety of autoantibodies. Although the comprehensive survival from the…
Abstract Number: 560 • 2013 ACR/ARHP Annual Meeting
Purified IgG From Patients With Systemic Lupus Erythematosus Enhances Apoptosis In Neonatal Rat Cardiomyocytes Exposed To Simulated Myocardial Ischaemic/Reperfusion Injury
Lauren Bourke¹, James McCormick², Vera Ripoll³, Charis Pericleous⁴, Anna Radziszewska⁵, Anastasis Stephanou⁶ and Yiannis Ioannou⁷, ¹Centre for Rheumatology Research, University College London, London, United Kingdom, ²Clinical & Molecular Genetics Unit, University College London, London, United Kingdom, ³Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ⁴Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ⁵The Rayne Institute, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, ⁶Medical and Molecular Biology Unit (MMBU), University College London, London, United Kingdom, ⁷Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom
Background/Purpose: A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the reperfusion stage which is known as ischaemic reperfusion (I/R) injury…
Abstract Number: 2289 • 2013 ACR/ARHP Annual Meeting
Correlation Of Anti-Citrullinated Protein and Anti-Carp Antibodies With Disease Duration and Activity In Rheumatoid Arthritis
Michael Mahler¹, Gabriella Lakos¹, Tyler Webb¹, Alvin Yee¹, Leendert A. Trouw² and Pier-Luigi Meroni³, ¹Research, INOVA Diagnostics, San Diego, CA, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Int Medicine, University of Milan, Milano, Italy
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) are important serological markers in the diagnosis of rheumatoid arthritis (RA) and are part of the…
Abstract Number: 1602 • 2013 ACR/ARHP Annual Meeting
Autoantibodies, Cytokines and Chemokines In Serum and Cerebrospinal Fluid Of SLE Patients With Cognitive Dysfunction
Hilda Fragoso-Loyo¹, Alí Duarte-García², Sandra Juárez-Arellano³, Alba Cicero-Casarrubias⁴, Juanita Romero-Díaz⁵, Luis LLorente-Peters¹ and Jorge Sánchez-Guerrero⁶, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ²Department of Medicine, Tufts Medical Center, Boston, MA, ³Department of Neurology, Instituto Nacional de Ciencias Medicas y Nutricion S.Z., Mexico city, Mexico, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ⁶Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada
Background/Purpose: The nature and pathogenesis and cognitive dysfunction (CD) in patients with SLE is unkown.To determine the presence and levels of autoantibodies, cytokines and chemokines…
Abstract Number: 527 • 2013 ACR/ARHP Annual Meeting
Presence Of Gastrointestinal Symptoms and Autoantibodies In Patients With Spondyloarthritis In A Colombian Population
Consuelo Romero-Sanchez^1,2,3, Wilson Bautista-Molano^1,4, Diana M Munoz C¹, Viviana Parra I¹, Alejandro Escobar¹, Carlos Martínez⁵, Ferney Garcia⁵, Daniel Herrera⁶, Sebastían Segura¹, Juliette De Ávila³, Ana MAría Mesa¹, Haroldo Juliao⁷, John Londono¹ and Rafael Valle-Oñate^8,9, ¹Rheumatology, Spondyloarthropathy Group, Rheumatology Department, Hospital Militar Central/Universidad de La Sabana, Bogotá, Colombia, ²Rheumatology, Universidad Militar Nueva Granada, Bogotá, Colombia, ³School of Dentistry, UIBO Institute (Oral Basic Research Unit),School of Dentistry, Universidad El Bosque, Bogotá, Colombia, ⁴Universidad Militar Nueva Granada, Bogotá, Colombia, ⁵Coloproctology, Coloproctology Deparment, Hospital Militar Central, Bogotá, Colombia, ⁶Genetic, Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia, ⁷Gastroenterology, Gastroenterology Deparment, Hospital Militar Central, Bogotá, Colombia, ⁸Spondyloarthritis Group. Rheumatology Department. Hospital Militar Central/Universidad de La Sabana. Bogotá. Colombia, Bogotá, Colombia, ⁹Rheumatology, Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia
Background/Purpose: The frequency of gastrointestinal (GI) involvement in spondyloarthritis (SpA) ranges from 21% to 30% and 5% to 10% are associated with inflammatory bowel disease…
Abstract Number: 2217 • 2013 ACR/ARHP Annual Meeting
Experimental Arthritis Exacerbates Periodontal Disease But Periodontal Infection Does Not Exacerbated Experimental Arthritis
John Butcher¹, Jessica Oliver-Bell¹, Robert Benson¹, James Brewer², Paul Garside¹, Iain B. McInnes¹ and Shauna Culshaw³, ¹Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ²Immunology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ³Dental School, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: There is a proposed link between periodontal disease (PD) and rheumatoid arthritis (RA). A substantial, although not unanimous, body of epidemiological evidence indicates a…
Abstract Number: 1575 • 2013 ACR/ARHP Annual Meeting
Identification Of Novel Distinct Autoantigen Clusters Reflecting The Heterogeneity Of Systemic Lupus Erythematosus
Petra Budde¹, Angelika Lueking¹, Stefan Vordenbäumen², Heike Göhler¹, Martin Gamer¹, Klaus Marquardt¹, Anna Telaar¹, Daniel Chamrad¹, Carmen Theek¹, Peter Schulz-Knappe¹ and Matthias Schneider², ¹Protagen AG, Dortmund, Germany, ²Department of Endocrinology, Diabetes and Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
Background/Purpose: Diagnosis of systemic lupus erythematosus (SLE) is based on a combination of clinical findings and laboratory evidence such as anti-nuclear autoantibodies (ANA), anti-Smith and…
Abstract Number: 541 • 2013 ACR/ARHP Annual Meeting
An Essential Role For Caspase-1 In The Induction Of Murine Lupus and Its Associated Vascular Damage
J. Michelle Kahlenberg¹, Srilakshmi Yalavarthi², Wenpu Zhao², Jeffrey Hodgin³, Tamra J. Reed⁴, Noriko M. Tsuji⁵ and Mariana J. Kaplan⁶, ¹Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan Rheumatology, Ann Arbor, MI, ³Department of Pathology, University of Michigan, Ann Arbor, MI, ⁴Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ⁵3Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan, ⁶Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune syndrome associated with organ damage and an elevated risk of cardiovascular disease (CVD) resulting from activation…
Abstract Number: 2070 • 2013 ACR/ARHP Annual Meeting
Cytokine Profiles In Polymyositis and Dermatomyositis Complicated With Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Associated Interstitial Lung Disease Or Anti-Aminoacyl tRNA Synthetase Antibody-Associated Interstitial Lung Disease
Takahisa Gono, Yasushi Kawaguchi, Hirotaka Kaneko, Yasuhiro Katsumata, Masanori Hanaoka, Sayuri Kataoka, Hidenaga Kawasumi, Kae Takagi, Hisae Ichida, Sayumi Baba, Yuko Okamoto, Yuko Ota and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Polymyositis (PM) / dermatomyositis (DM) are often complicated with interstitial lung disease (ILD). In PM/DM, complication with ILD is associated with anti-aminoacyl-tRNA synthetase (ARS),…
Abstract Number: 1399 • 2013 ACR/ARHP Annual Meeting
Citrullinated Proteoglycan (Aggrecan) Present In Human Cartilage Is Recognized By Serum Antibodies From Rheumatoid Arthritis Patients
Timea Ocsko¹, Beata Tryniszewska¹, Andras Vida¹, Janos Gal², Gyorgyi Soos², Zoltan Szekanecz³, Tibor A. Rauch¹, Joshua Jacobs¹, Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, Bacs-Kiskun County Hospital, Kecskemet, Hungary, ³Rheumatology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
Background/Purpose: Citrullination is a post-translational protein modification, where arginine (Arg) is converted to citrulline (Cit) by peptidyl arginine deiminases (PADI). The presence of anti-citrullinated protein…
Abstract Number: 494 • 2013 ACR/ARHP Annual Meeting
Autoantibody Profiles Predict Responsiveness To Methotrexate and Anti-TNF Therapy In Early Rheumatoid Arthritis
Petra Budde¹, Angelika Lueking¹, Carmen Theek¹, Peter Schulz-Knappe¹, Jacqueline Detert², Gerd Burmester³ and Matthias Schneider⁴, ¹Protagen AG, Dortmund, Germany, ²Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ³Department of Rheumatology & Clinical Immunology, Charité-Universitätsmedizin Berlin, Free University and Humboldt University of Berlin, Berlin, Germany, ⁴Department of Endocrinology, Diabetes and Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany
Background/Purpose: Novel therapeutic concepts in early rheumatoid arthritis (ERA) are aiming for an early intervention and effective control of disease activity reaching remission. Most current…
Abstract Number: 2085 • 2013 ACR/ARHP Annual Meeting
Identification Of Clinical Features and Risk Factors Associated With Calcinosis In Adult Patients With Dermatomyositis
Antonia Valenzuela¹, Lorinda Chung², Livia Casciola-Rosen³, Antony Rosen³ and David Fiorentino⁴, ¹Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ²Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ³Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁴Dermatology, Stanford University School of Medicine, Redwood City, CA
Background/Purpose: Prior studies have estimated that 20% of adult dermatomyositis (DM) patients suffer from calcinosis. Although calcinosis is related to persistent disease activity, poor treatment…
Abstract Number: 1304 • 2013 ACR/ARHP Annual Meeting
Anti-Carbamylated Antibody Positivity Is Associated With More Severe Radiological Progression In Patients With Recent Onset ACPA Negative Rheumatoid Arthritis: Results From The Norfolk Arthritis Register (NOAR)
Jenny H. Humphreys¹, Suzanne M. Verstappen¹, Kimme L. Hyrich², Tarnya Marshall³, Anne Barton^4,5, René E.M. Toes⁶, Leendert A. Trouw⁶ and Deborah P. Symmons^4,7, ¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ³Rheumatology, Norfolk and Norwich University Hospitals Trust, Norwich, United Kingdom, ⁴Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁵NIHR Manchester Musculoskeletal BRU, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁶Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁷NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Autoantibodies against carbamylated proteins (anti-CarP) have been associated with more severe radiological damage in patients with rheumatoid arthritis (RA), including in a small subgroup…
Abstract Number: 28 • 2013 ACR/ARHP Annual Meeting
Differentiation, Activation, and Autoreactivity Of CD11c+ B Cells (ABCs)
Alice E. Wiedeman¹, Natalia V. Giltiay², Lena Tanaka³ and Keith B. Elkon³, ¹Immunology, University of Washington, Seattle, WA, ²Department of Immunology, Division of Rheumatology, University of Washington, Seattle, WA, ³Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Recently, a population of CD11c+ age-associated B cells (ABCs) was identified in normal aged female mice. These cells could be expanded following activation by…
Abstract Number: 2062 • 2013 ACR/ARHP Annual Meeting
Clinical Features and Outcome In Polymyositis Vs. Dermatomyositis Patients With The Anti-Jo-1 Autoantibody
Rohit Aggarwal¹, Diane Koontz², Zengbiao Qi³ and Chester V. Oddis⁴, ¹Medicine / Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Department of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: The clinical characteristics of dermatomyositis (DM) patients possessing the anti-Jo-1 autoantibody (autoAb) are not well known. We analyzed the clinical features and prognosis of…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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