Abstracts tagged "autoantibodies"

Abstract Number: 1328 • 2014 ACR/ARHP Annual Meeting
Modulation of Natural IgM-Autoantibodies to Oxidative Stress-Related Neo-Epitopes on Apoptotic Cells in Newborns of Mothers with Anti-Ro Autoimmunity
Caroline Grönwall¹, Robert M. Clancy², Lelise Getu³, Don L. Siegel⁴, Joanne Reed³, Jill P. Buyon² and Gregg J. Silverman¹, ¹Medicine, New York University School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³New York University School of Medicine, New York, NY, ⁴Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Background/Purpose At birth, the human immune system expresses substantial circulating levels of polymeric IgM that include autoantibodies to oxidation-associated epitopes on apoptotic cells. This study…
Abstract Number: 773 • 2014 ACR/ARHP Annual Meeting
Functional Autoantibodies from Patients with Systemic Sclerosis Reactive to Angiotensin II Type 1and Endothelin-1 Type a Receptor Induce Inflammatory Lymphocyte Infiltration into Lungs of Mice
Angela Kill¹, Clement Braesch¹, Anja Kühl², Jeannine Guenther³, Mike O. Becker⁴, Gerd Burmester⁵, Thomas Walther⁶ and Gabriela Riemekasten⁷, ¹Rheumatology and clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, ²Department of Internal Medicine, Charité University Hospital, Berlin, Germany, ³Rheumatology and Clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, ⁴Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, ⁵Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁶Pharmacology & Therapeutics, University College Cork, Cork, Ireland, ⁷Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany
Background/Purpose Functional autoantibodies reactive to the angiotensin II type 1 receptor (AT1R) and endothelin 1 type A receptor (ETAR) were found in elevated levels in…
Abstract Number: 2700 • 2014 ACR/ARHP Annual Meeting
Clinical Phenotype of Systemic Sclerosis Patients with Anti-RNA Polymerase III Antibodies: A New French Cohort, Systematic Review and Meta-Analysis
Vincent Sobanski^1,2, Luc Dauchet^3,4, Guillaume Lefèvre², Marc Lambert⁵, Sandrine Morell-Dubois⁶, Thierno Sy⁶, Eric Hachulla¹, Pierre-Yves Hatron⁷, Sylvain Dubucquoi^8,9 and David Launay^1,9, ¹Service de médecine interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, CHRU Lille, Lille, France, ²EA 2686, Lille, LILLE, France, ³Service d'Epidémiologie Régionale, CHRU Lille, LILLE, France, ⁴INSERM U744, LILLE, France, ⁵Faculté de Médecine Henri Warembourg, Université Lille Nord de France, Lille, France, ⁶Internal Medicine, CHRU Lille, LILLE, France, ⁷Internal Medicine, Lille, France, ⁸Institut d’Immunologie, Centre de Biologie-Pathologie-Génétique, CHRU Lille, Lille, France, ⁹EA 2686, Lille, Lille, France
Background/Purpose: Anti-RNA polymerase III antibodies (anti-RNAP III) are one of the most frequent antinuclear antibodies identified in systemic sclerosis (SSc), with an estimated prevalence of…
Abstract Number: 1317 • 2014 ACR/ARHP Annual Meeting
Anti-p155/140 Autoantibodies and Selected Features at Illness Onset Are Associated with a Chronic Course of Illness in the Juvenile Idiopathic Inflammatory Myopathies
G. Esther A. Habers¹, Adam M. Huber², Gulnara Mamyrova³, Ira Targoff⁴, Chantal Boonacker⁵, Marco van Brussel¹, Frederick W. Miller⁶, Lisa G. Rider⁶ and Annet van Royen-Kerkhof⁷, ¹Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands, ²IWK Health Centre, Halifax, NS, Canada, ³Rheumatology, George Washington University, Washington, DC, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁷Paediatric Immunology and Rheumatology, University Medical Centre Utrecht - Wilhelmina Children's Hospital, Utrecht, Netherlands
Background/Purpose : Three types of disease courses can be distinguished in patients with juvenile idiopathic inflammatory myopathies (JIIM), namely monocyclic (M), polycyclic (P), and chronic…
Abstract Number: 761 • 2014 ACR/ARHP Annual Meeting
Specific Autoantibody Profiles and Disease Subgroups Correlate with Circulating Micro-RNA in Systemic Sclerosis
Dirk Wuttge¹, Anting L. Carlsen², Gabriel Teku³, Samantha Steen⁴, Marie Wildt¹, Mauno Vihinen³, Roger Hesselstrand¹ and Niels H. H. Heegaard^4,5, ¹Rheumatology, Lund University, Lund, Sweden, ²Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ³Experimental Medical Science, Lund University, Lund, Sweden, ⁴Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ⁵Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, Odense C, Denmark
Background/Purpose: Systemic sclerosis (SSc) is a serious autoimmune disease with clinical phenotypes of different prognosis, progression rate, and different extent of involvement of internal organs.…
Abstract Number: 2407 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis-Related Autoantibodies In The Lung Evolve Over Time In Subjects At Elevated Risk For Future Rheumatoid Arthritis
M. Kristen Demoruelle¹, Patrick R. Wood², Michael H. Weisman³, Mark C. Parish¹, Isabel F. Pedraza⁴, Jill M. Norris⁵, V. Michael Holers⁶ and Kevin D. Deane¹, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Internal Medicine, University of Colorado School of Medicine, Aurora, CO, ³Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Division of Pulmonary and Critical Care Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Epidemiology, Colorado School of Public Health, Aurora, CO, ⁶Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Recent data from our group have demonstrated that RA-related autoantibodies (Abs), including anti-CCP and RF, are detectable in sputum from subjects with early Classified…
Abstract Number: 1600 • 2013 ACR/ARHP Annual Meeting
Anti-Ribosomal P Protein Antibodies Exacerbate Long-Term Prognosis In Patients With Diffuse Neuropsychiatric/Neuropsychological Syndromes In Systemic Lupus Erythematous
Yoshiyuki Arinuma¹, Hirotoshi Kikuchi², Eisuke Ogawa¹, Tatsuhiko Wada¹, Tatsuo Nagai³, Sumiaki Tanaka¹ and Shunsei Hirohata¹, ¹Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan, ²Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Systemic lupus erythematous (SLE) is a chronic inflammatory disease characterized by the expression of a variety of autoantibodies. Although the comprehensive survival from the…
Abstract Number: 560 • 2013 ACR/ARHP Annual Meeting
Purified IgG From Patients With Systemic Lupus Erythematosus Enhances Apoptosis In Neonatal Rat Cardiomyocytes Exposed To Simulated Myocardial Ischaemic/Reperfusion Injury
Lauren Bourke¹, James McCormick², Vera Ripoll³, Charis Pericleous⁴, Anna Radziszewska⁵, Anastasis Stephanou⁶ and Yiannis Ioannou⁷, ¹Centre for Rheumatology Research, University College London, London, United Kingdom, ²Clinical & Molecular Genetics Unit, University College London, London, United Kingdom, ³Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ⁴Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ⁵The Rayne Institute, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, ⁶Medical and Molecular Biology Unit (MMBU), University College London, London, United Kingdom, ⁷Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom
Background/Purpose: A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the reperfusion stage which is known as ischaemic reperfusion (I/R) injury…
Abstract Number: 2289 • 2013 ACR/ARHP Annual Meeting
Correlation Of Anti-Citrullinated Protein and Anti-Carp Antibodies With Disease Duration and Activity In Rheumatoid Arthritis
Michael Mahler¹, Gabriella Lakos¹, Tyler Webb¹, Alvin Yee¹, Leendert A. Trouw² and Pier-Luigi Meroni³, ¹Research, INOVA Diagnostics, San Diego, CA, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Int Medicine, University of Milan, Milano, Italy
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) are important serological markers in the diagnosis of rheumatoid arthritis (RA) and are part of the…
Abstract Number: 1602 • 2013 ACR/ARHP Annual Meeting
Autoantibodies, Cytokines and Chemokines In Serum and Cerebrospinal Fluid Of SLE Patients With Cognitive Dysfunction
Hilda Fragoso-Loyo¹, Alí Duarte-García², Sandra Juárez-Arellano³, Alba Cicero-Casarrubias⁴, Juanita Romero-Díaz⁵, Luis LLorente-Peters¹ and Jorge Sánchez-Guerrero⁶, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ²Department of Medicine, Tufts Medical Center, Boston, MA, ³Department of Neurology, Instituto Nacional de Ciencias Medicas y Nutricion S.Z., Mexico city, Mexico, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ⁶Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada
Background/Purpose: The nature and pathogenesis and cognitive dysfunction (CD) in patients with SLE is unkown.To determine the presence and levels of autoantibodies, cytokines and chemokines…
Abstract Number: 527 • 2013 ACR/ARHP Annual Meeting
Presence Of Gastrointestinal Symptoms and Autoantibodies In Patients With Spondyloarthritis In A Colombian Population
Consuelo Romero-Sanchez^1,2,3, Wilson Bautista-Molano^1,4, Diana M Munoz C¹, Viviana Parra I¹, Alejandro Escobar¹, Carlos Martínez⁵, Ferney Garcia⁵, Daniel Herrera⁶, Sebastían Segura¹, Juliette De Ávila³, Ana MAría Mesa¹, Haroldo Juliao⁷, John Londono¹ and Rafael Valle-Oñate^8,9, ¹Rheumatology, Spondyloarthropathy Group, Rheumatology Department, Hospital Militar Central/Universidad de La Sabana, Bogotá, Colombia, ²Rheumatology, Universidad Militar Nueva Granada, Bogotá, Colombia, ³School of Dentistry, UIBO Institute (Oral Basic Research Unit),School of Dentistry, Universidad El Bosque, Bogotá, Colombia, ⁴Universidad Militar Nueva Granada, Bogotá, Colombia, ⁵Coloproctology, Coloproctology Deparment, Hospital Militar Central, Bogotá, Colombia, ⁶Genetic, Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia, ⁷Gastroenterology, Gastroenterology Deparment, Hospital Militar Central, Bogotá, Colombia, ⁸Spondyloarthritis Group. Rheumatology Department. Hospital Militar Central/Universidad de La Sabana. Bogotá. Colombia, Bogotá, Colombia, ⁹Rheumatology, Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia
Background/Purpose: The frequency of gastrointestinal (GI) involvement in spondyloarthritis (SpA) ranges from 21% to 30% and 5% to 10% are associated with inflammatory bowel disease…
Abstract Number: 2217 • 2013 ACR/ARHP Annual Meeting
Experimental Arthritis Exacerbates Periodontal Disease But Periodontal Infection Does Not Exacerbated Experimental Arthritis
John Butcher¹, Jessica Oliver-Bell¹, Robert Benson¹, James Brewer², Paul Garside¹, Iain B. McInnes¹ and Shauna Culshaw³, ¹Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ²Immunology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ³Dental School, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: There is a proposed link between periodontal disease (PD) and rheumatoid arthritis (RA). A substantial, although not unanimous, body of epidemiological evidence indicates a…
Abstract Number: 1575 • 2013 ACR/ARHP Annual Meeting
Identification Of Novel Distinct Autoantigen Clusters Reflecting The Heterogeneity Of Systemic Lupus Erythematosus
Petra Budde¹, Angelika Lueking¹, Stefan Vordenbäumen², Heike Göhler¹, Martin Gamer¹, Klaus Marquardt¹, Anna Telaar¹, Daniel Chamrad¹, Carmen Theek¹, Peter Schulz-Knappe¹ and Matthias Schneider², ¹Protagen AG, Dortmund, Germany, ²Department of Endocrinology, Diabetes and Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
Background/Purpose: Diagnosis of systemic lupus erythematosus (SLE) is based on a combination of clinical findings and laboratory evidence such as anti-nuclear autoantibodies (ANA), anti-Smith and…
Abstract Number: 541 • 2013 ACR/ARHP Annual Meeting
An Essential Role For Caspase-1 In The Induction Of Murine Lupus and Its Associated Vascular Damage
J. Michelle Kahlenberg¹, Srilakshmi Yalavarthi², Wenpu Zhao², Jeffrey Hodgin³, Tamra J. Reed⁴, Noriko M. Tsuji⁵ and Mariana J. Kaplan⁶, ¹Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan Rheumatology, Ann Arbor, MI, ³Department of Pathology, University of Michigan, Ann Arbor, MI, ⁴Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ⁵3Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan, ⁶Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune syndrome associated with organ damage and an elevated risk of cardiovascular disease (CVD) resulting from activation…
Abstract Number: 2070 • 2013 ACR/ARHP Annual Meeting
Cytokine Profiles In Polymyositis and Dermatomyositis Complicated With Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Associated Interstitial Lung Disease Or Anti-Aminoacyl tRNA Synthetase Antibody-Associated Interstitial Lung Disease
Takahisa Gono, Yasushi Kawaguchi, Hirotaka Kaneko, Yasuhiro Katsumata, Masanori Hanaoka, Sayuri Kataoka, Hidenaga Kawasumi, Kae Takagi, Hisae Ichida, Sayumi Baba, Yuko Okamoto, Yuko Ota and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Polymyositis (PM) / dermatomyositis (DM) are often complicated with interstitial lung disease (ILD). In PM/DM, complication with ILD is associated with anti-aminoacyl-tRNA synthetase (ARS),…

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