Abstracts tagged "autoantibodies"

Abstract Number: 761 • 2014 ACR/ARHP Annual Meeting
Specific Autoantibody Profiles and Disease Subgroups Correlate with Circulating Micro-RNA in Systemic Sclerosis
Dirk Wuttge¹, Anting L. Carlsen², Gabriel Teku³, Samantha Steen⁴, Marie Wildt¹, Mauno Vihinen³, Roger Hesselstrand¹ and Niels H. H. Heegaard^4,5, ¹Rheumatology, Lund University, Lund, Sweden, ²Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ³Experimental Medical Science, Lund University, Lund, Sweden, ⁴Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ⁵Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, Odense C, Denmark
Background/Purpose: Systemic sclerosis (SSc) is a serious autoimmune disease with clinical phenotypes of different prognosis, progression rate, and different extent of involvement of internal organs.…
Abstract Number: 2698 • 2014 ACR/ARHP Annual Meeting
Survival in Systemic Sclerosis-Pulmonary Arterial Hypertension By Serum Autoantibody Status
Monique Hinchcliff^1,2, Saira Khanna³, Jungwha Lee^4,5, Orit Almagor⁶, Rowland W. Chang^2,7, Virginia D. Steen⁸ and Lorinda Chung⁹, ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Preventive Medicine, Northwestern University Medical School, Chicago, IL, ⁶Northwestern University, Chicago, IL, ⁷Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ⁹Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA
Background/Purpose: Previous studies have shown that anticentromere (AC) and isolated nucleolar (NUC) antibodies are the most common autoantibodies in patients with systemic sclerosis (SSc) and…
Abstract Number: 1262 • 2014 ACR/ARHP Annual Meeting
Mechanisms of Muscular Necrosis in Auto-Immune Myopathies Associated with Anti-Signal Recognition Particle and Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase Antibodies: Pathogenic Role of Auto-Antibodies
Yves Allenbach^1,2,3, Aude Rigolet³, Bruno Eymard⁴, Tanya Stojkovic⁴, Anthony. Behin⁴, Pascal Laforet⁴, Peter Hufnagl⁵, Norman Zerbe⁶, Thierry Maisonobe⁷, Kuberaka Mariampillai⁸, Serge Herson⁸, Olivier Benveniste^2,3 and Werner Stenzel⁹, ¹Neuropathology, Charite Hospital, Berlin, Germany, ²UMR 974, Sorbonne Universités, University Pierre et Marie-Curie-Paris 6, INSERM, Paris, France, ³Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France, ⁴Department of Neurology, Myology Institute, Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ⁵Pathology departmen, Charite Hospital, Berlin, Germany, ⁶Department of Pathology, Charite Hospital, Berlin, Germany, ⁷Neuropathology, Pitie-Salpetriere Hospital, Paris, France, ⁸Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ⁹Department of Neuropathology, Charite Hospital, Berlin, Germany
Background/Purpose: Necrotizing auto-immune myopathies (NAM) are a group of acquired idiopathic inflammatory myopathies characterized by severe muscle weakness and no or mild extra-muscular involvement. Definition of…
Abstract Number: 638 • 2014 ACR/ARHP Annual Meeting
Commensal Microbiota Influence Systemic Autoimmune Responses
Jens Van Praet¹, Erin Donovan², Michael Drennan¹, Fons Van de Loo³, Sylvie Rabot⁴, Jeroen Raes⁵, Tom Van De Wiele⁶, Carl Ware⁷ and Dirk Elewaut⁸, ¹Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ²department of Rheumatology, Ghent University Hospital, ghent, Belgium, ³Rheumatology, Raboud University Medical Center, Utrecht, Netherlands, ⁴AgroParisTech, Micalis,, Jouy-en-Josas, France, ⁵Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium, ⁶Laboratory of Microbial Ecology and Technology, Ghent University Hospital, Ghent, Belgium, ⁷Infectious and Inflammatory Disease Center,, Sanford-Burnham Medical Research Institute, La Jolla, CA, ⁸Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium
Background/Purpose Antinuclear antibodies are a hallmark feature of generalized autoimmune diseases, including systemic lupus erythematosus and systemic sclerosis. However, the processes underlying the loss of…
Abstract Number: 2530 • 2014 ACR/ARHP Annual Meeting
PRE.MARK-TNF Test Based on Iga-Specific Autoantigens Predicts Therapy Response in Rheumatoid Arthritis Patients Treated with TNFα Inhibitors
Karl Skriner¹, Jörg Hollidt², Gerd Burmester³ and Zoltan Konthur⁴, ¹Department of Rheumatology and Clinical Immunology, Germany, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Drug Response DX GmbH, Berlin, Germany, ³Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Drug Response DX GmbH, Hennigsdorf, Germany
Background/Purpose One third of rheumatoid arthritis patients treated with biologicals targeting TNFα are therapy non-responders. We have earlier investigated the difference in seroreactivity of patients…
Abstract Number: 1272 • 2014 ACR/ARHP Annual Meeting
Myositis-Specific and Myositis Associated Autoantibodies in Indian Patients with Inflammatory Myositis
Puja Srivastava, Ramnath Misra, Able Lawrence, Amita Aggarwal and Vikas Agarwal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose Recently, idiopathic inflammatory myositis (IIM) has been categorised into distinct subsets based on myositis specific autoantibodies (MSA) and myositis associated autoantibodies (MAA). However, there is…
Abstract Number: 442 • 2014 ACR/ARHP Annual Meeting
Anti-Carbamylated Protein Antibody Levels Are Elevated in Seropositive Rheumatoid Arthritis and Correlate with Anti-Sa/Citrullinated Vimentin Antibody Levels
Gregory J. Challener¹, Jonathan D. Jones², B. JoNell Hamilton¹, Gilles Boire³, Artur José de Brum-Fernandes⁴, Pierre Cossette⁵, Patrick Liang³, Ariel Masetto⁶, Nathalie Carrier⁷, Henri A. Ménard⁸ and William F.C. Rigby⁹, ¹Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, ²Rheumatology, Geisel School of Medicine at Dartmouth College, Lebanon, NH, ³Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁴Médecine, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Internal Medicine Departement, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶Rheumatology, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁷Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁸Rheumatology, Research Institute of the McGill University Health Center, Montreal, QC, Canada, ⁹Rheumatology; Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Lebanon, NH
Background/Purpose: Recent studies indicate that the breach of immune tolerance that occurs in rheumatoid arthritis (RA) extends beyond the citrullination of arginines (as recognized by…
Abstract Number: 2457 • 2014 ACR/ARHP Annual Meeting
Anti-Major Histocompatibility Complex Class I-Related Chain a (MICA) Antibodies in Rheumatoid Arthritis Patients with Interstitial Lung Disease
Hiroshi Furukawa¹, Shomi Oka¹, Kota Shimada², Akiko Komiya¹, Naoshi Fukui¹, Naoyuki Tsuchiya³ and Shigeto Tohma¹, ¹Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ²Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ³Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Interstitial lung disease (ILD) is frequently associated with rheumatoid arthritis (RA), and is designated RA-associated ILD (RA-ILD) that influences the prognosis of the disease.…
Abstract Number: 1264 • 2014 ACR/ARHP Annual Meeting
Analysis of Clinical Manifestations and Myositis-Specific Autoantibodies Associated with Severity of Physical Dysfunction after Treatment for Polymyositis and Dermatomyositis
Hidenaga Kawasumi¹, Takahisa Gono¹, Yasushi Kawaguchi¹, Yasuhiro Katsumata¹, Hisae Ichida¹, Akiko Tochimoto¹, Masanori Hanaoka¹, Yuko Okamoto¹, Sayuri Kataoka¹ and Hisashi Yamanaka², ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: Half of all polymyositis (PM)/dermatomyositis (DM) patients suffer from muscle weakness after initial treatment. Therefore, many patients with PM/DM have trouble with daily living…
Abstract Number: 455 • 2014 ACR/ARHP Annual Meeting
Clinical and Tissue Specificity of Antibodies Against Carbamylated Proteins in Patients with Rheumatoid Arthritis
Antonio Gonzalez¹, Ariana Montes¹, Eva Perez-Pampin¹, Maria Dolores Boveda² and Juan J. Gomez-Reino^1,3, ¹Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria- Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ²Laboratorio Metabolopatias, Insitituto Investigacion Sanitaria- Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ³Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
Background/Purpose Antibodies against carbamylated proteins (CarP) are a new type of autoantibodies specific of patients with rheumatoid arthritis (RA) relative to healthy controls, but their…
Abstract Number: 2392 • 2014 ACR/ARHP Annual Meeting
Anti-Carbamylated Antibodies (anti-CarPA) Are Associated with Long Term Disability and Increased Disease Activity in Patients with Early Inflammatory Arthritis: Results from the Norfolk Arthritis Register (NOAR)
Jenny H. Humphreys¹, Marije K Verheul², Anne Barton^3,4, Tarnya Marshall⁵, Bo Fu⁶, René E.M. Toes⁷, Deborah PM Symmons^1,4, Leendert A. Trouw⁷ and Suzanne MM Verstappen¹, ¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, United Kingdom, ⁴NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁵Rheumatology, Norfolk and Norwich University Hospitals Trust, Norwich, United Kingdom, ⁶Centre for Biostatistics, Institute of Population Health, The University of Manchester, Manchester, United Kingdom, ⁷Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Anti-CarPA have been shown to predict development of rheumatoid arthritis (RA) in patients with arthralgia. However, little is known about their association with disease…
Abstract Number: 1260 • 2014 ACR/ARHP Annual Meeting
The Early Use of Cyclosporine Is Beneficial for Long-Term Prognosis in Patients of Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease with Anti- Synthetase Antibodies
Yuji Hosono¹, Ran Nakashima², Yoshitaka Imura³, Naoichiro Yukawa², Hajime Yoshifuji², Takaki Nojima⁴, Koichiro Ohmura² and Tsuneyo Mimori², ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁴Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: Interstitial lung disesases (ILD) is the most common cause of mortality in polymyosotis (PM) and dermatomyositis (DM). Cyclosporine had been reported to improve clinical…
Abstract Number: 454 • 2014 ACR/ARHP Annual Meeting
The Specificity of Anti-Carbamylated Protein Antibodies for Rheumatoid Arthritis in a Setting of Early Arthritis
Jing Shi, H.W. van Steenbergen, J. a. B. van Nies, E.W.Nivine Levarht, Annette H. M. van der Helm- van Mil, Tom W. J. Huizinga, René E.M. Toes and Leendert A. Trouw, Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose Anti-carbamylated protein (anti-CarP) antibodies have been described in rheumatoid arthritis (RA) and arthralgia patients [1;2] and occur in subsets of the anti-CCP2 positive and…
Abstract Number: 2186 • 2014 ACR/ARHP Annual Meeting
Clinical and Immunologic Correlates in Cocaine Users with Serum Anti-Neutrophil Cytoplasmic Antibodies
Christian Lood and Grant C. Hughes, Medicine/Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Illicit cocaine use is associated with the development of serum anti-neutrophil cytoplasmic autoantibodies (ANCA) and a variety of clinical manifestations. However, the mechanisms linking…
Abstract Number: 1257 • 2014 ACR/ARHP Annual Meeting
A New Multianalyte Assay for Detection of Dermatomyositis-Specific Autoantibodies Undetectable By Commercially Available Immunoassays
Masataka Kuwana¹, Yuka Okazaki² and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: The disease expression of dermatomyositis (DM) is highly variable among patients, ranging form those with severe muscle weakness in the absence of internal organ…

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