Abstracts tagged "autoantibodies"

Abstract Number: 454 • 2014 ACR/ARHP Annual Meeting
The Specificity of Anti-Carbamylated Protein Antibodies for Rheumatoid Arthritis in a Setting of Early Arthritis
Jing Shi, H.W. van Steenbergen, J. a. B. van Nies, E.W.Nivine Levarht, Annette H. M. van der Helm- van Mil, Tom W. J. Huizinga, René E.M. Toes and Leendert A. Trouw, Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose Anti-carbamylated protein (anti-CarP) antibodies have been described in rheumatoid arthritis (RA) and arthralgia patients [1;2] and occur in subsets of the anti-CCP2 positive and…
Abstract Number: 2186 • 2014 ACR/ARHP Annual Meeting
Clinical and Immunologic Correlates in Cocaine Users with Serum Anti-Neutrophil Cytoplasmic Antibodies
Christian Lood and Grant C. Hughes, Medicine/Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Illicit cocaine use is associated with the development of serum anti-neutrophil cytoplasmic autoantibodies (ANCA) and a variety of clinical manifestations. However, the mechanisms linking…
Abstract Number: 1257 • 2014 ACR/ARHP Annual Meeting
A New Multianalyte Assay for Detection of Dermatomyositis-Specific Autoantibodies Undetectable By Commercially Available Immunoassays
Masataka Kuwana¹, Yuka Okazaki² and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: The disease expression of dermatomyositis (DM) is highly variable among patients, ranging form those with severe muscle weakness in the absence of internal organ…
Abstract Number: 387 • 2014 ACR/ARHP Annual Meeting
Levels of IgG Autoantibodies to Oxidation-Associated MDA Neo-Determinants Are a Biomarker for Systemic Inflammation and Disease Activity in SLE and RA
Caroline Grönwall¹, Lelise Getu², Jeffrey D. Greenberg³, Robert M. Clancy⁴ and Gregg J. Silverman¹, ¹Medicine, New York University School of Medicine, New York, NY, ²New York University School of Medicine, New York, NY, ³Rheumatology, New York University School of Medicine, New York, NY, ⁴Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose Monitoring disease activity in patients with autoimmune rheumatic disease is an essential part of clinical care. Highly reactive malondialdehyde (MDA) arise from reactive oxygen…
Abstract Number: 2016 • 2014 ACR/ARHP Annual Meeting
Occupation and Risk of Developing Rheumatoid Arthritis
Anna Ilar¹, Pernilla Wiebert¹, Lars Klareskog², Lars Alfredsson¹ and Camilla Bengtsson¹, ¹The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden
Background/Purpose The role of environmental factors in the etiology of rheumatoid arthritis (RA) is still fairly unknown. Finding occupations associated with the risk of disease…
Abstract Number: 1255 • 2014 ACR/ARHP Annual Meeting
Pathogenic Role of Tyrosyl–Transfer RNA Synthetase in Anti-Synthetase Syndrome
Yuko Okamoto¹, Yasuhiro Katsumata¹, Yasushi Kawaguchi¹, Manabu Kawamoto¹, Ken Iwaki², Miki Miyanokoshi², Keisuke Wakasugi², Koji Tahara³, Kaori Ito³, Hiroaki Hattori³, Takahisa Gono¹, Masanori Hanaoka¹, Tomoaki Higuchi¹, Hidenaga Kawasumi¹ and Hisashi Yamanaka⁴, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan, ³Advanced Medical Technology and Development, BML, Saitama, Japan, ⁴Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose : Autoantibodies directed against the aminoacyl transfer RNA (tRNA) synthetases are associated with myositis, arthritis, Raynaud’s phenomenon, mechanic’s hands, fever, and interstitial lung disease,…
Abstract Number: 359 • 2014 ACR/ARHP Annual Meeting
14-3-3η Cit:Arg Antibody Ratios: Are We Overlooking the Prognostic Utility of Citrullinated Antibodies By Only Looking at Titers?
Anthony Marotta¹, Samina Turk², Mairead Murphy³, Walter P. Maksymowych⁴ and Dirkjan van Schaardenburg⁵, ¹1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada, ²Reade, Amsterdam, Netherlands, ³Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Dr Jan van Breemenstraat 2, Reade, Amsterdam, Netherlands
Background/Purpose Citrullination is a post-translational modification whereby arginine (Arg) is deiminated by PAD enzymes to form citrulline (Cit). In RA, there are auto-antibodies (AAb) to…
Abstract Number: 1939 • 2014 ACR/ARHP Annual Meeting
Development of Cell–Based Enzyme–Linked Immunosorbent Assay for the Quantification of Anti–M–type phospholipase–a–receptor Antibodies and Its Clinical Usefulness in Patients with Membranous Nephropathy
Yasuhiro Katsumata¹, Yuko Okamoto¹, Takahito Moriyama², Manabu Kawamoto¹, Hirotaka Kaneko¹, Yasushi Kawaguchi¹, Takahisa Gono¹, Masanori Hanaoka¹, Tomoaki Higuchi¹, Hidenaga Kawasumi¹, Keiko Uchida², Kosaku Nitta² and Hisashi Yamanaka³, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan, ³Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose : Better risk prediction is needed to identify patients who will benefit from immunosuppressive therapy with idiopathic membranous nephropathy (MN) due to the variable…
Abstract Number: 1169 • 2014 ACR/ARHP Annual Meeting
Hippocampal Atrophy Is Associated with Anti-NR2 Antibodies in Patients with Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome
Maria B Lauvsnes¹, Mona K Beyer², Jan T Kvaløy^3,4, Ole J Greve⁵, Simone Appenzeller⁶, Erna Harboe⁷, Anne B Tjensvoll⁸, Lasse G Gøransson⁷ and Roald Omdal⁹, ¹Department of Internal Medicine, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway, ²Department of Radiology and Nuclear medicine, Oslo University Hospital, National Hospital, Oslo, Norway, ³Research Department, Stavanger University Hospital, Stavanger, Norway, ⁴Department of Mathematics and Natural Sciences, University of Stavanger, Stavanger, Norway, ⁵Department of Radiology, Stavanger University Hospital, Stavanger, Norway, ⁶Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil, ⁷Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ⁸Department of Neurology, Stavanger University Hospital, Stavanger, Norway, ⁹Department of Internal Medicin, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway
Background/Purpose: Antibodies against the NR2 subtype of the NMDA-receptor (anti-NR2 antibodies) are detected in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (SS).…
Abstract Number: 1907 • 2014 ACR/ARHP Annual Meeting
Clinical Evaluation of Anti-Aminoacyl tRNA Synthase Antibodies in Rheumatoid Arthritis Patients
Masakazu Matsushita¹, Ken Yamaji¹, Naoto Tamura² and Yoshinari Takasaki³, ¹Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Anti-Jo-1 is an autoantibody that is specifically detected in the blood sera of patients with polymyositis/dermatomyositis (PM/DM). The corresponding antigen is known to be…
Abstract Number: 1037 • 2014 ACR/ARHP Annual Meeting
Anti-MDA5 Antibody Associated Myositis Compared to DM Patient: A Distinct Muscular Pattern Associated with a shared IFN Signature
Yves Allenbach^1,2,3, Gaelle Leroux⁴, Aude Rigolet², Baptiste Hervier⁵, Nicolas Limal⁶, Peter Hufnagl⁷, Norman Zerbe⁸, Thierry Maisonobe⁹, Alain Meyer¹⁰, Yurdagul Uzunhan¹¹, Kuberaka Mariampillai¹², Romain Gherardi¹³, Serge Herson¹², Olivier Benveniste^2,3 and Werner Stenzel¹⁴, ¹Neuropathology, Charite Hospital, Berlin, Germany, ²Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France, ³UMR 974, Sorbonne Universités, University Pierre et Marie-Curie-Paris 6, INSERM, Paris, France, ⁴Department of Internal Medicine and Clinical Immunology, Hospital University Department: inflammation, immunopathology and biotherapy (DHU i2B), DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, ⁵Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, PARIS, France, ⁶Department of Internal Medicine, Hôpital Henri Mondor, APHP, Creteil, France, ⁷Pathology departmen, Charite Hospital, Berlin, Germany, ⁸Department of Pathology, Charite Hospital, Berlin, Germany, ⁹Neuropathology, Pitie-Salpetriere Hospital, Paris, France, ¹⁰Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ¹¹Pneumology, APHP Avicenne Hospital, Bobigny, France, ¹²Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ¹³Pathology, APHP Henri Mondor Hospital, Creteil, France, ¹⁴Department of Neuropathology, Charite Hospital, Berlin, Germany
Background/Purpose Anti-MDA5 auto-antibodies are thought to be specifically associated with dermatomyositis (DM). Nevertheless anti-MDA5 auto-antibody positive patients (MDA5+ DM) predominantly suffer from extra-muscular involvement with severe…
Abstract Number: 3000 • 2014 ACR/ARHP Annual Meeting
Comparison of Systemic Sclerosis Subsets As Predictors of Mortality and Morbidity
Hebah Alhajeri¹, Marie Hudson^2,3, Canadian Scleroderma Research Group CSRG⁴ and Murray Baron⁵, ¹Rheumatology, McGill University, Montreal, QC, Canada, ²Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³Division of Rheumatology, McGill University, Montreal, QC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada
Background/Purpose: Identifying systemic sclerosis (SSc) subsets that predict mortality and morbidity could provide useful prognostic information. We undertook this study to compare the predictive ability…
Abstract Number: 1730 • 2014 ACR/ARHP Annual Meeting
Identification of Novel Scleroderma –associated Antigens and Development of an Autoantibody Assay Panel Enabling Their Subsequent Validation
Hans-Dieter Zucht¹, Petra Budde¹, Peter Schulz-Knappe¹, Nicolas Hunzelmann², Karsten Conrad³ and Prof. Dr. Matthias Schneider⁴, ¹Protagen AG, Dortmund, Germany, ²Department of Dermatology, University of Cologne, Cologne, Germany, ³Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, ⁴Department of Rheumatology, Univ. Duesseldorf, Duesseldorf, Germany
Background/Purpose: Scleroderma (systemic sclerosis or SSc) has a highly variable clinical presentation and course resulting in difficulties for disease management. When SSc is suspected, autoantibodies…
Abstract Number: 984 • 2014 ACR/ARHP Annual Meeting
Apolipoprotein B Is a Target of T and B Cell Responses in a Subgroup of Patients with Lyme Disease
Jameson T. Crowley¹, Elise E. Drouin², Qi Wang³, Gail McHugh⁴, Catherine E. Costello³ and Allen C. Steere⁵, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, ⁴Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ⁵Medicine, Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose Borrelia burgdorferi-induced autoimmunity in affected joints has been hypothesized to be a contributing factor to antibiotic-refractory Lyme arthritis (ARLA). Our prior study, which combined…
Abstract Number: 2985 • 2014 ACR/ARHP Annual Meeting
Autoantibodies to 14-3-3η Are Novel Biomarkers Associated with Inflammation and Radiographic Progression in Ankylosing Spondylitis
Walter P. Maksymowych¹, Stephanie Wichuk¹, RG Lambert², Mairead Murphy³ and Anthony Marotta⁴, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Radiology, University of Alberta, Edmonton, AB, Canada, ³Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁴1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada
Background/Purpose 14-3-3η is a ubiquitous intracellular chaperone protein that is expressed extracellularly in rheumatoid arthritis and mediates inflammatory cascades that result in expression of inflammatory…

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