Abstracts tagged "Atherosclerosis"

Abstract Number: 2463 • 2016 ACR/ARHP Annual Meeting
Association Between High Sodium Intake and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis
Gulsen Ozen¹, Ali Ugur Unal², Simge Saydam³, Murat Sunbul⁴, Kursat Tigen⁴, Haner Direskeneli⁵ and Nevsun Inanc¹, ¹Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ²Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, ³Marmara University Faculty of Medicine, Istanbul, Turkey, ⁴Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁵Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey
Background/Purpose: High sodium intake has been reported to be associated with increased ACPA positivity in smoker RA patients. However, apart from this, the associations with…
Abstract Number: 1465 • 2016 ACR/ARHP Annual Meeting
Utility of Relative Cardiovascular Risk Score Scales in Patients UNDER the Age of 50 and Its Association with the Presence of Carotid Atherosclerosis in the Ultrasound
Andrea Zacarias¹, Carmen Gomez Vaquero², Francisco Javier Narváez³, Miguel Angel González-Gay⁴, Alfonso Corrales⁵, Carlos González-Juanatey⁶, Javier Llorca⁷ and Joan Miquel Nolla⁸, ¹Hospital Universitari de Bellvitge, Barcelona, Spain, ²Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ³Rheumatology, Hospital Universitario de Bellvitge-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain, ⁴Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain, ⁵Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ⁶Cardiology Division, Hospital Xeral-Calde, Lugo, Spain, ⁷Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁸Rheumatology, Bellvitge University Hospital, Barcelona, Spain
Background/Purpose: Rheumatoid Arthritis (RA) is associated with a greater cardiovascular mortality than the general population of the same age and gender. Cardiovascular events prediction scales,…
Abstract Number: 2781 • 2016 ACR/ARHP Annual Meeting
Immunization with ApoB100 Peptide Vaccine Reduces Atherosclerosis Development in a Mouse Model of Systemic Lupus Erythematosus
Ingrid Yao-Mattisson, Maria Wigren, Gunilla Nordin Fredrikson and Jan Nilsson, Lund University, Malmö, Sweden
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by impaired self-tolerance causing damage to multiple organs including the cardiovascular system. Current therapies do…
Abstract Number: 1466 • 2016 ACR/ARHP Annual Meeting
Cardiovascular Risk Assessment in Persons with Rheumatoid Arthritis: A Correlative Study of Non-Invasive Arterial Health Testing with the Inflammatory Burden of Disease
Erin Scanlon¹, Rekha Mankad², Cynthia S. Crowson³, Iftikhar Kullo⁴, Sharon Mulvagh², Eric L. Matteson¹, Zoran Kvrgic¹ and John M. Davis III⁵, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Cardiovascular Diseases, Mayo Clinic, Rochester, MN, ³Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, ⁵Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Persons with rheumatoid arthritis (RA) have increased morbidity and mortality attributable to atherosclerotic cardiovascular disease (ASCVD) events. It is unknown how presence of subclinical…
Abstract Number: 2876 • 2016 ACR/ARHP Annual Meeting
SLE Serum Impairs NO Production in Huvecs through Induction of eNOS Uncoupling
Jim Oates^1,2, Diane L. Kamen³ and Joy N Jones Buie⁴, ¹Medical Service, Ralph H. Johnson VAMC, Charleston, SC, ²Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ³Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ⁴Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) induces endothelial cell dysfunction (ECD) that can manifest as glomerulonephritis or atherosclerosis. Lupus-prone mice lacking endothelial nitric oxide synthase (eNOS,…
Abstract Number: 1467 • 2016 ACR/ARHP Annual Meeting
Cardiovascular Risk Assessment in Persons with Rheumatoid Arthritis: Non-Invasive Arterial Health Testing to Assess Subclinical Risk of Cardiovascular Disease
Erin Scanlon¹, Rekha Mankad², Cynthia S. Crowson³, Iftikhar Kullo⁴, Sharon Mulvagh², Eric L. Matteson¹, Zoran Kvrgic¹ and John M. Davis III⁵, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Cardiovascular Diseases, Mayo Clinic, Rochester, MN, ³Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, ⁵Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Measures of arterial health may be useful in assessing the risk of atherosclerotic cardiovascular disease (ASCVD) in patients with rheumatoid arthritis (RA). The…
Abstract Number: 2880 • 2016 ACR/ARHP Annual Meeting
Distinct Metabolic Pathways Regulate Lipid Antigen Presentation By Monocytes and B Cells: Implications for SLE Patients with Pre-Clinical Atherosclerotic Plaque
Kirsty Waddington¹, Edward Smith², Sara Croca³, David A. Isenberg⁴, Anisur Rahman⁵, Ines Pineda Torra⁶ and Elizabeth Jury⁷, ¹Clinical Pharmacology and Rheumatology, University College London, London, United Kingdom, ²Centre for Rheumatology Research, University College London, London, United Kingdom, ³Rheumatology, University College London, London, United Kingdom, ⁴Centre for Rheumatology Research, University College Hospital London, UK, London, United Kingdom, ⁵Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, ⁶Clinical Pharmacology, University College London, London, United Kingdom, ⁷Division of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) patients have an increased risk of developing clinically apparent cardiovascular disease (CVD) and subclinical atherosclerotic plaque, detectable by vascular ultrasound…
Abstract Number: 1473 • 2016 ACR/ARHP Annual Meeting
Expression of Vitamin D Receptor Associated Genes in the Aorta of Coronary Artery Disease Patients with and without Rheumatoid Arthritis
Ingvild Oma¹, Sverre Holm^2,3, Jacqueline Kirsti Andersen⁴, Ole K. Olstad⁵, Ida G. Fostad⁶, Torstein Lyberg⁵, Sven Martin Almdahl⁷, Øyvind Molberg⁸ and Ivana Hollan^9,10,11, ¹Innlandet Hospital Trust, Lillehammer, Norway, ²Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ³Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁴Norwegian University of Science and Technology, Gjøvik, Norway, ⁵Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway, ⁶Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway, ⁷Department of Cardiothoracic Surgery, University Hospital of North Norway, Tromsø, Norway, ⁸Oslo University Hospital, Oslo, Norway, ⁹Brigham and Women’s Hospital, Boston, MA, ¹⁰Harvard Medical School, Boston, MA, ¹¹Lillehammer Hospital for Rheumatic Diseases, Lillahammer, Norway
Background/Purpose: Vitamin D has an important role in the immune system, and has been linked to inflammation, rheumatoid arthritis (RA) and coronary artery disease (CAD)[1,…
Abstract Number: 3099 • 2016 ACR/ARHP Annual Meeting
Higher Prevalence and Severity of Coronary Atherosclerosis in Psa Patients
Lydia Ho Pui TAM^1,2, Tsz Ho CHENG¹, Ho Man LAM¹, Ka Tat WONG³, Qing SHANG⁴, Edmund LI¹, Wang Kit LI⁵, Man Fei CHEUNG⁵, Uen-Lam MING¹, Tin-Long LUI⁵, Wing-Lam TAO¹, SY TSANG¹ and Lai-Shan TAM⁶, ¹Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, Hong Kong, ³Prince of Wales Hospital, Hong Kong, Hong Kong, ⁴Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁵The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁶Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Background/Purpose: Patients with psoriatic arthritis (PsA) have increased risk in cardiovascular diseases (CVD) including subclinical atherosclerosis. However, previous knowledge was limited to carotid atherosclerosis. The…
Abstract Number: 1474 • 2016 ACR/ARHP Annual Meeting
Increased Levels of Lipoprotein(a) in RA Patients with Cardiovascular Disease
Sverre Holm^1,2, Ingvild Oma³, Tor-Arne Hagve⁴, Kjell Saatvedt⁵, Knut Mikkelsen⁶, Hans Rydningen⁷, Sven Martin Almdahl⁸, Pål Aukrust^9,10, Bente Halvorsen^9,11 and Ivana Hollan^6,12,13,14, ¹Hospital For Rheumatic Diseases, Lillehammer, Norway, ²Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ³Innlandet Hospital Trust, Lillehammer, Norway, ⁴Oslo University Hospital, Rikshospitalet, Oslo, Norway, ⁵Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway, ⁶Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁷Feiring Heart Clinic, Feiring, Norway, ⁸Department of Cardiothoracic Surgery, University Hospital of North Norway, Tromsø, Norway, ⁹Institute of Clinical Medicine, University of Oslo, Oslo, Norway, ¹⁰Research Intitute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ¹¹Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ¹²Department of Medicine, Brigham and Women’s Hospital, Boston, MA, ¹³Harvard Medical School, Boston, MA, ¹⁴Department of Medicine, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Patients with various inflammatory rheumatic diseases (IRD) have increased cardiovascular morbidity caused by atherosclerosis. The aetiology of the accelerated atherosclerosis in IRD is still…
Abstract Number: 3100 • 2016 ACR/ARHP Annual Meeting
Can Achieving Sustained Minimal Disease Activity (MDA) Prevent Progression of Subclinical Atherosclerosis? a Prospective Cohort Study in Psoriatic Arthritis
Tsz Ho CHENG¹, Qing SHANG², PW Alex LEE¹, Priscilla WONG¹, Tracy Y. ZHU³, Chun-Kwok WONG⁴, JW Jack LEE⁵, M Mimi CHANG⁶, Edmund LI¹ and Lai-Shan TAM⁷, ¹Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ³Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China, ⁴Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁵Biostatistics Division, School of Public and Primary Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁶Department of Medicine & Therapeutics, Prince of Wales Hospital, Hong Kong, Hong Kong, ⁷Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Background/Purpose: Patients with PsA were reported to have a higher incidence of cardiovascular disease (CVD) and subclinical carotid atherosclerosis due to underlying inflammation. Minimal disease…
Abstract Number: 1485 • 2016 ACR/ARHP Annual Meeting
Generation of New Carotid Plaque Is Determined By the Prexisting Carotid Atherosclerosis and Ongoning Disease Activity of Rheumatoid Arthritis
Jong Wan Kang¹, Eun Song Lee², Jung Su Eun¹, Na Ri Kim¹, Ji Hun Kim³, Jin Young Kang⁴, Eon Jeong Nam¹ and Young Mo Kang⁵, ¹Division of Rheumatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea, ²Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, Kyungpook National University Hospital, Daegu, South Korea, ⁴Dept of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea, Republic of
Background/Purpose: This study shows that carotid plaque at year 5 is predicted by IMT and dyslipidemia at baseline, whereas formation of new plaques after…
Abstract Number: 3101 • 2016 ACR/ARHP Annual Meeting
Lipoprotein Profile and Serum Glycoprotein Acetylation As Markers of Cardiovascular Risk in Systemic Lupus Erythematosus
Simantini Sakhardande¹, Monica Purmalek¹, Yenealem Temesgen-Oyelakin², Maureen Sampson³, Aditya Joshi⁴, Alice Fike⁵, Michael Davis⁶, Taufiq Salahuddin⁷, Balaji Natarajan⁷, Joseph Lerman⁷, Zerai G. Manna⁸, Amit Dey⁹, Marcus Chen⁷, Sarfaraz Hasni⁸, Nehal N. Mehta⁷, Alan Remaley⁷ and Mariana Kaplan¹⁰, ¹Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases,, National Institutes of Health, Bethesda, MD, ³Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, ⁴National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, ⁵National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶NIH, Bethesda, MD, ⁷NHLBI, National Institutes of Health, Bethesda, MD, ⁸National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁹National Institutes of Health, Bethesda, MD, ¹⁰NIAMS/NIH, Bethesda, MD
Background/Purpose: The risk of atherosclerotic cardiovascular disease (CVD) is significantly increased in systemic SLE compared to age and gender matched controls. The implementation of nuclear…
Abstract Number: 1653 • 2016 ACR/ARHP Annual Meeting
Delineating the Effects of Rheumatoid Arthritis Pharmacotherapies on Vascular Inflammation: Rationale and Design of a Clinical Trial
Jon T. Giles¹, Katherine Liao², Nina Paynter³, Alyssa Wohlfahrt⁴, Afshin Zartoshti⁵, Rachel Broderick⁶, Daniel H. Solomon⁷ and Joan Bathon⁶, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ³Medicine, Harvard University, Boston, MA, ⁴Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Rheumatology, Columbia University, College of Physicians & Surgeons, New York city, NY, ⁶Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁷Division of Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Rheumatoid arthritis is associated with an excess cardiovascular disease (CVD) burden. Fewer CVD events associated with specific DMARD therapies have been reported; however, causal…
Abstract Number: 3102 • 2016 ACR/ARHP Annual Meeting
Neutrophil Subsets, Arterial Inflammation, and Vascular Stiffness in Patients with Systemic Lupus Erythematosus
Monica Purmalek¹, Simantini Sakhardande¹, Yenealem Temesgen-Oyelakin², Aditya Joshi³, Joseph Lerman⁴, Michael Davis³, Alice Fike⁵, Amit Dey⁶, Taufiq Salahuddin⁷, Balaji Natarajan³, Martin P. Playford⁷, Heather Teague³, Zerai G. Manna⁵, Marcus Chen³, Sarfaraz Hasni⁵, Nehal N. Mehta⁷ and Mariana Kaplan¹, ¹Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases,, National Institutes of Health, Bethesda, MD, ³NIH, Bethesda, MD, ⁴Clinical Center, NIH, Bethesda, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶National Institutes of Health, Bethesda, MD, ⁷NHLBI, National Institutes of Health, Bethesda, MD
Background/Purpose: Patients with systemic lupus erythematosus (SLE) show a striking increase in risk of atherosclerotic cardiovascular disease (CVD) not explained by Framingham risk, when compared…

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