Abstracts tagged "Atherosclerosis"

Abstract Number: 502 • 2018 ACR/ARHP Annual Meeting
Implications of Coronary Artery Calcium Score and Its Change over Time As Markers of Coronary Plaque Vulnerability and Patient Risk in Rheumatoid Arthritis
George Karpouzas¹, Sarah Ormseth², Elizabeth Hernandez² and Matthew Budoff³, ¹Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, ²Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, ³Cardiology, Harbor-UCLA Medical Center, Torrance, CA
Background/Purpose: Atherosclerotic plaque calcification is considered a stabilizing physiologic process; calcified coronary plaques (CP) are less prone to rupture and yield lower risk of cardiovascular…
Abstract Number: 517 • 2018 ACR/ARHP Annual Meeting
Effects of Statin-Treatment on Coronary Plaques in Patients with Inflammatory Joint Diseases
Silvia Rollefstad¹, Mona Svanteson², Nils Einar Kløw^2,3, Jonny Hisdal⁴, Eirik Ikdahl⁵, Joseph Sexton⁶, Ylva Haig² and Anne Grete Semb¹, ¹Preventive Cardio-Rheuma clinic, Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Division of Radiology and Nuclear Medicine, Oslo University Hospital, Ullevål, Oslo, Norway, ³Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway, ⁴Department of Vascular investigations, Oslo University Hospital, Aker, Oslo, Norway, ⁵Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁶Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Effects of Statin-treatment on Coronary Plaques in Patients with Inflammatory Joint DiseasesBackground/Purpose: Statins have an established preventive effect on coronary artery disease in the general…
Abstract Number: 1071 • 2018 ACR/ARHP Annual Meeting
Protective Role of the Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Rs2495477 Polymorphism in Patients with Rheumatoid Arthritis
Sara Remuzgo-Martínez¹, Fernanda Genre¹, Verónica Pulito-Cueto¹, Alfonso Corrales¹, Javier Llorca², Verónica Mijares¹, Leticia Lera-Gómez¹, Virginia Portilla¹, Iván Ferraz-Amaro³, Santos Castañeda⁴, Oreste Gualillo⁵, Javier Martín⁶, Ricardo Blanco¹, Raquel Lopez-Mejías¹ and Miguel Angel González-Gay⁷, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, Santander, Spain, ³Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain, Tenerife, Spain, ⁴Rheumatology Department, Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain, Madrid, Spain, ⁵SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), The NEIRID Group (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Santiago University Clinical Hospital, Santiago de Compostela, Spain, Santiago de Compostela, Spain, ⁶Instituto de Parasitología y Biomedicina "López-Neyra", CSIC, PTS Granada, Granada, Spain, Granada, Spain, ⁷Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain
Background/Purpose: RA is associated with the development of cardiovascular (CV) disease and subclinical atherosclerosis, which leads to an increased risk of CV mortality in RA…
Abstract Number: 1155 • 2018 ACR/ARHP Annual Meeting
A Collaborative Cardio-Rheumatology Clinic for Primary Prevention of Cardiovascular Diseases – a Descriptive Study
Shadi Akhtari¹, Paula Harvey¹, Micaela Jacobson², Shani Nagler³, Keith Colaco⁴ and Lihi Eder⁵, ¹Cardiology, Women's College Hospital, University of Toronto, Toronto, ON, Canada, ²Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada, ³Women's College Hospital, Toronto, ON, Canada, ⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ⁵Women's College Research Institute, University of Toronto, Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Patients with inflammatory arthritis are at increased risk for atherosclerotic cardiovascular (CV) disease. This has been under-recognized in clinical practice. Additionally, the current risk…
Abstract Number: 2357 • 2017 ACR/ARHP Annual Meeting
Retinal Vessel Morphological Associations with Systemic Inflammation and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis
Panagiota Anyfanti¹, Areti Triantafyllou¹, Eugenia Gkaliagkousi¹, Xenophon Zabulis², Stella Douma¹ and Spyros Aslanidis³, ¹3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, Thessaloniki, Greece, ²Institute of Computer Science, Foundation for Research and Technology-Hellas (FORTH), Heraklion, Greece, Heraklion, Greece, ³Rheumatology Department-2nd Propedeutic Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece, Thessaloniki, Greece
Background/Purpose: Rheumatoid arthritis (RA) is associated with a chronic inflammatory state, accelerated atherosclerosis and excess cardiovascular risk. Quantification of morphological changes in the retinal microvasculature…
Abstract Number: 2369 • 2017 ACR/ARHP Annual Meeting
Relationship of Bone Mineral Density and Inflammatory Burden with Carotid Plaque Formation in Rheumatoid Arthritis: A 5-Year Prospective Study
Na Ri Kim, Jong Wan Kang, Jung Su Eun, Ji Hun Kim, Jin Young Kang, Gi Bum Bae, Sang Jin Lee, Eon Jeong Nam and Young Mo Kang, Division of Rheumatology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea, Republic of (South)
Background/Purpose: Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease. The incidence of the cardiovascular (CV) disease is significantly increased in patients with RA…
Abstract Number: 2401 • 2017 ACR/ARHP Annual Meeting
Rheumatoid Arthritis with Kidney Dysfunction Contributes to Higher Risk of Cardiovascular Disease Development
Suad Hannawi¹ and Issa Al Salmi², ¹Rheumatology, Asst.Prof, Dubai, United Arab Emirates, ²Prof, Muscat, Oman
Background/Purpose: Reduced kidney function render patients with RA rheumatoid arthritis (RA), have an increased risk of cardtiovascular disease (CVD), particulary ischemic heart disease (IHD). This…
Abstract Number: 2527 • 2017 ACR/ARHP Annual Meeting
Increased Prevalence of Subclinical Atherosclerosis in Moderate-Severe Plaque Psoriasis Patients
Nuria Vegas-Revenga¹, José Luis Martín-Varillas¹, Susana Armesto², Marcos A González- López³, Virginia Portilla², Patricia Fuentevilla¹, Javier Rueda-Gotor², Carlos Fernández-Díaz¹, Lucia C. Domínguez-Casas¹, Belén Atienza-Mateo¹, Jose L. Hernández⁴, Ricardo Blanco¹, Miguel Angel González-Gay¹ and Alfonso Corrales¹, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ²Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ³Dermatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ⁴Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain
Background/Purpose: Surrogate markers of subclinical atherosclerosis and cardiovascular (CV) mortality such as carotid plaques (CP), arterial stiffness (AS) and carotid intima-media thickness (c-IMT), have been…
Abstract Number: 2546 • 2017 ACR/ARHP Annual Meeting
Secukinumab Decreases Arterial Wall Inflammation in Patients with Peripheral Spondyloarthritis
Leonieke van Mens¹, Simone Verweij², Arno van Kuijk³, Erik Stroes² and Dominique Baeten¹, ¹AMC, Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands, ²Vascular Medicine, Academisch Medisch Centrum, Amsterdam, Netherlands, ³Reade, Amsterdam Immunology and Rheumatology Center, Amsterdam, Netherlands
Background/Purpose: Patients with spondyloarthritis (SpA), a chronic inflammatory disease, have an increased cardiovascular risk, which is partly due to increased inflammatory activity in the arterial…
Abstract Number: 2656 • 2017 ACR/ARHP Annual Meeting
Alterations of the Splicing Machinery Components in Leukocytes from Systemic Lupus Erythematosus Patients Influences Its Development and Atherothrombotic Profile and Drives the Therapeutic Response
Carlos Perez-Sanchez¹, Maria Ángeles Aguirre Zamorano¹, Sergio Pedraza-Arévalo², Mercedes del Río-Moreno², Irene Cecchi³, Patricia Ruiz-Limon⁴, Nuria Barbarroja¹, Yolanda Jiménez-Gómez¹, Ivan Arias de la Rosa⁴, Maria Carmen Abalos-Aguilera⁴, Pedro Segui⁵, Eduardo Collantes-Estévez¹, Justo P Castaño², Raul M Luque⁶, Maria Jose Cuadrado⁷ and Chary Lopez-Pedrera¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Department of Cell Biology, Physiology and Immunology. University of Cordoba, Reina Sofia Hospital, IMIBIC, CIBERobn, and ceiA3, Córdoba, Spain, ³Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁴Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁵Radiology, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁶Department of Cell Biology, Physiology and Immunology. University of Cordoba, Hospital Universitario Reina Sofia (HURS), Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), CIBERobn, and ceiA3, Córdoba, Spain, ⁷St Thomas Hospital, Lupus Research Unit, London, United Kingdom
Background/Purpose: Recent studies emphasize the relevance of alternative splicing in the development of genetic and autoimmune diseases. The aim of this study was to identify…
Abstract Number: 2965 • 2017 ACR/ARHP Annual Meeting
Non-Invasive Imaging Methods for Evaluating the Cardiovascular Involvement in Patients with Rheumatoid Arthritis before and after 18 Months of Treatment with Anti-TNF Drugs
Fabiola Atzeni¹, Luigi Gianturco², Laura Boccassini³, Piercarlo Sarzi-Puttini³ and Maurizio Turiel⁴, ¹Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milano, Italy, ²Beato Matteo” Hospital, GSD Foundation, Vigevano, Italy, Vigevano, Italy, ³Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milan, Italy, ⁴IRCCS, Galeazzi Orthopedic Institute, Dept. Biomedical Sciences for Health, University of Milan, Milan, Italy
Background/Purpose: The aim of this study was to evaluate left ventricular myocardial function with two- dimensional speckle tracking echocardiography (STE), in addition to conventional Doppler…
Abstract Number: 644 • 2017 ACR/ARHP Annual Meeting
Association of Osteonectin, Osteopontin and Osteocalcin with Inflammation and Cardiovascular Risk in Patients with Axial Spondyloarthritis
Fernanda Genre¹, Javier Rueda-Gotor², Juan Irure-Ventura³, Sara Remuzgo-Martínez¹, Alfonso Corrales¹, Begoña Ubilla¹, Veronica Mijares¹, Carlos Fernández-Díaz¹, Virginia Portilla¹, Ricardo Blanco¹, Javier Llorca⁴, J. Gonzalo Ocejo-Vinyals³, Raquel López-Mejías¹ and Miguel Angel González-Gay⁵, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ²Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ³Immunology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁴Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, ⁵Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain
Background/Purpose: A higher incidence of cardiovascular (CV) risk factors and atherosclerosis has been reported in axial spondyloarthritis (axSpA) patients1. Since axSpA (particularly AS) is an…
Abstract Number: 899 • 2017 ACR/ARHP Annual Meeting
Neutrophil Gene Signature and Low Density Granulocyte Subsets Associate with Coronary Plaque Burden and Vascular Inflammation in Systemic Lupus Erythematosus
Philip Carlucci¹, Monica Purmalek¹, Simantini Sakhardande¹, Yenealem Temesgen-Oyelakin¹, Amit K. Dey², Aditya A. Joshi², Joseph B. Lerman³, Alice Fike¹, Michael Davis⁴, Hong-Wei Sun¹, Jonathan H. Chung², Martin P. Playford², Pragnesh Mistry¹, Gustavo Gutierrez-Cruz¹, Stefania Dell'Orso¹, Faiza Naz¹, Heather Teague², Zerai G. Manna⁵, Peter C. Grayson¹, Mohammad Naqi¹, Marcus Chen², Sarfaraz A. Hasni¹, Nehal N. Mehta² and Mariana J. Kaplan¹, ¹NIH/NIAMS, Bethesda, MD, ²NIH/NHLBI, Bethesda, MD, ³NIH/CC, Bethesda, MD, ⁴NIH/NIAMS, Bethesda, IA, ⁵NIH/NIAMS, Bethesda, MD, Afghanistan
Background/Purpose: Systemic lupus erythematosus (SLE) increases a young woman’s risk of myocardial infarction by up to 50-fold. This marked increase in cardiovascular disease (CVD) risk…
Abstract Number: 964 • 2017 ACR/ARHP Annual Meeting
Atherogenic Potency of Plasma from Persons with Autoimmune Rheumatic Disorders: Comparative Effects on Cholesterol Flux in Human Macrophages
Andrew Maidhof¹, Allison B. Reiss^1,2, Lora J. Kasselman², Elise Belilos¹, Kristina Belostocki¹, Gary Rosenblum¹, Lois Bonnetti¹, Melissa Fazzari², Joshua DeLeon¹ and Steven E. Carsons^1,2, ¹NYU Winthrop University Hospital, Department of Medicine, Mineola, NY, ²NYU Winthrop University Hospital, Winthrop Research Institute, Mineola, NY
Background/Purpose: Although the risk of atherosclerotic cardiovascular disease and abnormalities in cholesterol transport have been demonstrated in rheumatoid arthritis (RA), lupus (SLE) and, to a…
Abstract Number: 1484 • 2017 ACR/ARHP Annual Meeting
Association between Primary Sjogren’s Syndrome, Arterial Stiffness and Subclinical Atherosclerosis: A Systematic Review and Meta-Analysis
Wai Chung Yong, Anawin Sanguankeo and Sikarin Upala, Bassett Medical Center, Cooperstown, NY
AbstractBackground/Purpose: In rheumatoid arthritis and systemic lupus erythematosus, cardiovascular disease is frequently a major cause of mortality or morbidity. Studies have shown that acute systemic…

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