ACR Meeting Abstracts

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Abstracts tagged "Atherosclerosis"

  • Abstract Number: 559 • 2013 ACR/ARHP Annual Meeting

    Effects Of In Vivo Treatment With Hydroxychloroquine On Endothelial Function In a Murine Model Of Systemic Lupus Erythematosus

    Marta Mosca1, Chiara Tani2, Sabrina Vagnani3, Linda Carli3,4, Rosaria Talarico5, Chiara Baldini5, Stefano Bombardieri3 and Agostino Virdis6, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 3Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 4GenOMeC PhD, University of Siena, Siena, Italy, 5University of Pisa, Rheumatology Unit, Pisa, Italy, 6Department of Clinical and Experimental Medicine. University of Pisa, Hypertension Unit, University of Pisa, Pisa, Italy

    Background/Purpose: Antimalarial drugs are a cornerstone of treatment of systemic lupus erythematosus (SLE). It has been suggested that antimalarial drugs may have a protective effect…
  • Abstract Number: 2898 • 2013 ACR/ARHP Annual Meeting

    Atherosclerosis In Systemic Lupus Erythematosus (SLE) and Controls, -An Analysis Of SLE Subgroups

    Johanna Gustafsson1, Kerstin Jensen-Urstad2, Marie Herlitz-Lindberg2, Sonia Möller1, Susanne Pettersson1, Iva Gunnarsson1, Anders Larsson3 and Elisabet Svenungsson4, 1Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 2Department of Clinical Physiology, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden, 3Department of Clinical Chemistry and Pharmacology, Akademiska Hospital, Uppsala, Sweden, 4Department of Medicine, Unit of Rheumatology, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Atherosclerosis is often assumed to be the main underlying cause of premature vascular events (VE) among patients with systemic lupus erythematosus (SLE) and accelerated…
  • Abstract Number: 469 • 2013 ACR/ARHP Annual Meeting

    Anti-TNF Therapy Induces Positive Changes In The Lipoprotein Profile Of RA Patientes. Results Of a Prospective Study

    Jaime Calvo-Alén1, Carmela Baamonde2, Ignacio Villa1, Víctor Martínez-Taboada3, Mario Agudo4 and Juan Gómez-Gerique5, 1Rheumatology, Hospital Universitario Sierrallana, Torrelavega, Spain, 2Biochemistry, Hospital Universitario Sierrallana, Torrelavega, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 4Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, 5Biochemistry, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain

    Background/Purpose: Anti-TNF therapy induces elevations in total cholesterol levels although does not seem to modify the atherogenic index. Otherwise, it appears to have a cardiovascular…
  • Abstract Number: 2780 • 2013 ACR/ARHP Annual Meeting

    Cumulative Exposure To Elevated Inflammatory Markers Is Associated With Increased Burden Of Atherosclerosis In Psoriatic Arthritis Patients: A Cohort Study

    Lihi Eder1, Arane Thavaneswaran2, Vinod Chandran3, Richard J. Cook4 and Dafna D. Gladman3, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 4Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada

    Background/Purpose: Cardiovascular morbidity is increased in patients with psoriatic arthritis (PsA). Traditional cardiovascular risk factors do not fully explain this excessive risk. It is unclear…
  • Abstract Number: 402 • 2013 ACR/ARHP Annual Meeting

    Can Modulators Of Inflammation Serve As Biomarkers For Subclinical Atherosclerosis In Rheumatoid Arthritis?

    Kimberly P. Liang1, Douglas P. Landsittel2, Suresh R. Mulukutla3, Steven E. Reis4, Marc C. Levesque5, Donald M. Jones6, Rachel Gartland7, Ali Shoushtari8, Flordeliza S. Villanueva3, Hunter C. Champion8 and Larry W. Moreland5, 1Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 2Medicine, Biostatistics and Clinical and Translational Science, University of Pittsburgh, Center for Health Care Research Data Center, Pittsburgh, PA, 3Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, 4Division of Cardiology and Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, 5Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 6Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 7Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 8Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Rheumatoid arthritis (RA) is independently associated with a higher risk of cardiovascular disease (CVD) and premature atherosclerosis. Mechanisms of atherosclerosis include (1) Endothelial dysfunction/activation mediated…
  • Abstract Number: 2763 • 2013 ACR/ARHP Annual Meeting

    Carotid Atherosclerosis As a Predictor Of Mortality In Rheumatoid Arthritis

    Inmaculada del Rincon1, Roy W. Haas2, Jose Felix Restrepo3, Daniel F. Battafarano4, Daniel H. O'Leary5, Emily Molina1 and Agustin Escalante6, 1Rheumatology, University of Texas Health Science Center, San Antonio, TX, 2Dept. of Medicine-Rheumatology, University of Texas Health Science Center, San Antonio, TX, 3Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 4Medicine / MCHE-MDR, Brooke Army Medical Ctr, San Antonio, TX, 5Radiology, Tufts University-Boston Campus, Boston, MA, 6Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX

    Background/Purpose: Patients with rheumatoid arthritis (RA) have higher mortality than do persons of the same age and sex without RA. This is due in part…
  • Abstract Number: 384 • 2013 ACR/ARHP Annual Meeting

    Carotid Artery Plaques Are Associated With Coronary Atherosclerosis In Patients With Inflammatory Joint Diseases Independent Of Several Cardiovascular Risk Calculators

    Silvia Rollefstad1, Eirik Ikdahl2, Inge C. Olsen3, Tore K. Kvien4,5, Anne S. Eirheim2, Terje R. Pedersen4,6 and Anne G. Semb2, 1Rhuematology, Diakonhjemmet Hospital, Oslo, Norway, 2Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Faculty of Medicine, University of Oslo, Oslo, Norway, 5Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 6Centre of Preventive Medicine, Oslo University Hospital-Ullevaal, Oslo, Norway

    Background/Purpose: Patients with rheumatoid arthritis (RA) and carotid plaque (CP) have been shown to have increased risk of future acute coronary syndrome. We have established…
  • Abstract Number: 2343 • 2013 ACR/ARHP Annual Meeting

    Assessment Of Subclinical Atherosclerosis (Flow Mediated Dilatation and arterial stiffness) After 24 Weeks Of a Tocilizumab Therapy In 22 Patients With Rheumatoid Arthritis

    Martin Soubrier1, Thomas Frayssac2, Bruno Pereira3, Marion Couderc Sr.4, Coline Daron2, Jean Jacques Dubost5, Sandrine Malochet-Guinamand4, Anne Tournadre4 and Sylvain Mathieu4, 1Rheumatology, CHU CLERMONT-FERRAND, Clermont-Ferrand, France, 2CHU CLERMONT-FERRAND, Clermont-ferrand, France, 3Clinical research department, Clermont-Ferrand, France, 4Rheumatology CHU Gabriel Montpied, Clermont-Ferrand, France, 5Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France

    Background/Purpose:  Increased incidence of cardiovascular diseases and sub-clinical atherosclerosis have been observed in rheumatoid arthritis (RA). Inflammation and  traditional risk factors could be involved in…
  • Abstract Number: 386 • 2013 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis Is Associated With Systemic Inflammation In Coronary Vessels

    Inge A.M. van den Oever1, Alper M. van Sijl1, Umit Baylan2, Michael. T. Nurmohamed1, Alexandre E. Voskuyl1, Hans W. Niessen2 and Suat Simsek3, 1Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 2Pathology, VU University Medical Center, Amsterdam, Netherlands, 3Internal Medicine, Medical Center Alkmaar (MCA), Alkmaar, Netherlands

    Background/Purpose: Patients with a chronic inflammatory disease (CID), particularly rheumatoid arthritis (RA), have an increased risk of fatal myocardial infarction (MI), as compared to the…
  • Abstract Number: 1975 • 2013 ACR/ARHP Annual Meeting

    Cardiovascular Risk Stratification In Rheumatic Diseases : Carotid Ultrasound Is More Sensitive Than Coronary Artery Calcification Score To Detect Subclinical atherosclerosis In Patients With Rheumatoid Arthritis

    Francisco Ortiz-Sanjuán1, Alfonso Corrales2, José Antonio Parra3, Carlos González-Juanatey4, Montserrat Santos5, Javier Rueda6, Ricardo Blanco7, Vanesa Calvo-Río8, Javier Loricera8, Javier Llorca9 and Miguel A González-Gay10, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 3Radiology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 4Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, 5Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 6Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, 7Hospital Marques de Valdecilla, Santander, Spain, 8Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 9Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, 10Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is a disease associated to accelerated atherogenesis leading to increased incidence of cardiovascular (CV) mortality. Adequate stratification of the CV risk…
  • Abstract Number: 387 • 2013 ACR/ARHP Annual Meeting

    Left Ventricular Myocardial Tissue In Rheumatoid Arthritis Shows Systemic Inflammation After Fatal Myocardial Infarction 

    Inge A.M. van Den Oever1, Alper M. van Sijl1, Umit Baylan2, Michael. T. Nurmohamed1, Alexandre E. Voskuyl1, Hans W. Niessen2 and Suat Simsek3, 1Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 2Pathology, VU University Medical Center, Amsterdam, Netherlands, 3Internal Medicine, Medical Center Alkmaar (MCA), Alkmaar, Netherlands

    Background/Purpose: Patients with a chronic inflammatory disease (CID), particularly rheumatoid arthritis (RA), have an increased risk of fatal myocardial infarction (MI) and a diminished survival…
  • Abstract Number: 1941 • 2013 ACR/ARHP Annual Meeting

    Imaging Atherosclerotic Plaque Inflammation In RA: Methodology and Initial Findings In a Single Centre Cohort

    Sarah Skeoch1, Penny Hubbard2, Heather Williams3,4, Dongxiang Xu5, Sun Jie5, Niranjan Balu5, Wei Zhang5, Jacqueline James3, Thomas Hatsukami5, Chun Yuan5, M. Yvonne Alexander6, Paul Hockings7, John Waterton4,8 and Ian N. Bruce9, 1Arthritis Research UK Centre for Epidemiology and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 2Centre for Imaging Sciences Biomedical Imaging Institute Oxford Road Manchester, M13 9PT United Kingdom, University of Manchester, Manchester, United Kingdom, 3Department of Nuclear Medicine, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 4Centre for Imaging Sciences Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, 5Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, 6Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, 7Drug Safety and Metabolism, Astra Zeneca, Mölndal, Sweden, 8R&D Personalised Healthcare & Biomarkers, Astra Zeneca, MACCLESFIELD, United Kingdom, 9Kellgren Centre for Rheumatology, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose: Chronic inflammation in RA may contribute to an unstable atherosclerotic plaque phenotype. Dynamic contrast enhanced MRI (DCE MRI) can be used to image carotid…
  • Abstract Number: 391 • 2013 ACR/ARHP Annual Meeting

    Insulin Resistance As A Risk Factor For Subclinical Atherosclerosis In Rheumatoid Arthritis

    Adel M. Elsayed1, Samah A. El Bakry1, S. A. M. Hassan1, Rehab A. Rahman2, Rania A. Abo-Shady3 and Nouran Abaza4, 1Rheumatology Division of Internal medicine department, Ain Shams University, Cairo, Egypt, 2Radiology department, Ain Shams University, Cairo, Egypt, 3clinical pathology, Ain Shams University, Cairo, Egypt, 4Physical medicine, Rheumatology and Rehabilitation, Lecturer of Physical medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    Background/Purpose: Insulin resistance (IR) is a state in which a high insulin concentration is associated with an inadequate response to glucose with normal or high…
  • Abstract Number: 1724 • 2013 ACR/ARHP Annual Meeting

    The Role Of Low-Grade Inflammation In The Association Between Uric Acid and Atherosclerosis: The Codam Study

    José M.A. Wijnands1, Annelies Boonen2, Pieter C. Dagnelie3, Marleen M.J. van Greevenbroek4, Carla J.H, van der Kallen5, Isabel Ferreira4, Casper G. Schalkwijk4, Edith J.M. Feskens6, Sjef van der Linden2, Coen D.A. Stehouwer7 and Ilja C.W. Arts3, 1Department of Internal Medicine, Division of Rheumatology, Maastricht University, Maastricht, Netherlands, 2Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 3Department of Epidemiology, Maastricht University, Maastricht, Netherlands, 4Department of Internal Medicine, Maastricht University, Maastricht, Netherlands, 5Department of Internal Medicine, Maastricht University, Maastricht, Netherlands, 6Division of Human Nutrition, Wageningen University, Wageningen, Netherlands, 7Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands

    Background/Purpose: Uric acid may be involved in the atherosclerotic process by increasing the level of low-grade inflammation. The aims of this study were: 1) to…
  • Abstract Number: 365 • 2013 ACR/ARHP Annual Meeting

    Oral Calcium Supplementation Is Associated With Subclinical Atherosclerosis In Rheumatoid Arthritis

    Shanthi Dhaduvai1, Laura Geraldino-Pardilla2, Jon T. Giles3 and Joan M. Bathon4, 1Division of Rheumatology, Columbia University Medical Center, New York, NY, 2Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, NY, 3Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, 4Columbia University, New York, NY

    Background/Purpose: Recent studies in the general population highlight possible adverse cardiovascular effects with calcium supplementation; however, the association between calcium intake and subclinical markers of…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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