Abstracts tagged "Atherosclerosis"

Abstract Number: 2763 • 2013 ACR/ARHP Annual Meeting
Carotid Atherosclerosis As a Predictor Of Mortality In Rheumatoid Arthritis
Inmaculada del Rincon¹, Roy W. Haas², Jose Felix Restrepo³, Daniel F. Battafarano⁴, Daniel H. O'Leary⁵, Emily Molina¹ and Agustin Escalante⁶, ¹Rheumatology, University of Texas Health Science Center, San Antonio, TX, ²Dept. of Medicine-Rheumatology, University of Texas Health Science Center, San Antonio, TX, ³Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, ⁴Medicine / MCHE-MDR, Brooke Army Medical Ctr, San Antonio, TX, ⁵Radiology, Tufts University-Boston Campus, Boston, MA, ⁶Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX
Background/Purpose: Patients with rheumatoid arthritis (RA) have higher mortality than do persons of the same age and sex without RA. This is due in part…
Abstract Number: 384 • 2013 ACR/ARHP Annual Meeting
Carotid Artery Plaques Are Associated With Coronary Atherosclerosis In Patients With Inflammatory Joint Diseases Independent Of Several Cardiovascular Risk Calculators
Silvia Rollefstad¹, Eirik Ikdahl², Inge C. Olsen³, Tore K. Kvien^4,5, Anne S. Eirheim², Terje R. Pedersen^4,6 and Anne G. Semb², ¹Rhuematology, Diakonhjemmet Hospital, Oslo, Norway, ²Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Faculty of Medicine, University of Oslo, Oslo, Norway, ⁵Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁶Centre of Preventive Medicine, Oslo University Hospital-Ullevaal, Oslo, Norway
Background/Purpose: Patients with rheumatoid arthritis (RA) and carotid plaque (CP) have been shown to have increased risk of future acute coronary syndrome. We have established…
Abstract Number: 2343 • 2013 ACR/ARHP Annual Meeting
Assessment Of Subclinical Atherosclerosis (Flow Mediated Dilatation and arterial stiffness) After 24 Weeks Of a Tocilizumab Therapy In 22 Patients With Rheumatoid Arthritis
Martin Soubrier¹, Thomas Frayssac², Bruno Pereira³, Marion Couderc Sr.⁴, Coline Daron², Jean Jacques Dubost⁵, Sandrine Malochet-Guinamand⁴, Anne Tournadre⁴ and Sylvain Mathieu⁴, ¹Rheumatology, CHU CLERMONT-FERRAND, Clermont-Ferrand, France, ²CHU CLERMONT-FERRAND, Clermont-ferrand, France, ³Clinical research department, Clermont-Ferrand, France, ⁴Rheumatology CHU Gabriel Montpied, Clermont-Ferrand, France, ⁵Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France
Background/Purpose: Increased incidence of cardiovascular diseases and sub-clinical atherosclerosis have been observed in rheumatoid arthritis (RA). Inflammation and traditional risk factors could be involved in…
Abstract Number: 386 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Is Associated With Systemic Inflammation In Coronary Vessels
Inge A.M. van den Oever¹, Alper M. van Sijl¹, Umit Baylan², Michael. T. Nurmohamed¹, Alexandre E. Voskuyl¹, Hans W. Niessen² and Suat Simsek³, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Pathology, VU University Medical Center, Amsterdam, Netherlands, ³Internal Medicine, Medical Center Alkmaar (MCA), Alkmaar, Netherlands
Background/Purpose: Patients with a chronic inflammatory disease (CID), particularly rheumatoid arthritis (RA), have an increased risk of fatal myocardial infarction (MI), as compared to the…
Abstract Number: 1975 • 2013 ACR/ARHP Annual Meeting
Cardiovascular Risk Stratification In Rheumatic Diseases : Carotid Ultrasound Is More Sensitive Than Coronary Artery Calcification Score To Detect Subclinical atherosclerosis In Patients With Rheumatoid Arthritis
Francisco Ortiz-Sanjuán¹, Alfonso Corrales², José Antonio Parra³, Carlos González-Juanatey⁴, Montserrat Santos⁵, Javier Rueda⁶, Ricardo Blanco⁷, Vanesa Calvo-Río⁸, Javier Loricera⁸, Javier Llorca⁹ and Miguel A González-Gay¹⁰, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ²Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ³Radiology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁴Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁵Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ⁶Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁷Hospital Marques de Valdecilla, Santander, Spain, ⁸Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁹Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, ¹⁰Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a disease associated to accelerated atherogenesis leading to increased incidence of cardiovascular (CV) mortality. Adequate stratification of the CV risk…
Abstract Number: 387 • 2013 ACR/ARHP Annual Meeting
Left Ventricular Myocardial Tissue In Rheumatoid Arthritis Shows Systemic Inflammation After Fatal Myocardial Infarction
Inge A.M. van Den Oever¹, Alper M. van Sijl¹, Umit Baylan², Michael. T. Nurmohamed¹, Alexandre E. Voskuyl¹, Hans W. Niessen² and Suat Simsek³, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Pathology, VU University Medical Center, Amsterdam, Netherlands, ³Internal Medicine, Medical Center Alkmaar (MCA), Alkmaar, Netherlands
Background/Purpose: Patients with a chronic inflammatory disease (CID), particularly rheumatoid arthritis (RA), have an increased risk of fatal myocardial infarction (MI) and a diminished survival…
Abstract Number: 1941 • 2013 ACR/ARHP Annual Meeting
Imaging Atherosclerotic Plaque Inflammation In RA: Methodology and Initial Findings In a Single Centre Cohort
Sarah Skeoch¹, Penny Hubbard², Heather Williams^3,4, Dongxiang Xu⁵, Sun Jie⁵, Niranjan Balu⁵, Wei Zhang⁵, Jacqueline James³, Thomas Hatsukami⁵, Chun Yuan⁵, M. Yvonne Alexander⁶, Paul Hockings⁷, John Waterton^4,8 and Ian N. Bruce⁹, ¹Arthritis Research UK Centre for Epidemiology and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²Centre for Imaging Sciences Biomedical Imaging Institute Oxford Road Manchester, M13 9PT United Kingdom, University of Manchester, Manchester, United Kingdom, ³Department of Nuclear Medicine, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴Centre for Imaging Sciences Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, ⁵Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, ⁶Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁷Drug Safety and Metabolism, Astra Zeneca, Mölndal, Sweden, ⁸R&D Personalised Healthcare & Biomarkers, Astra Zeneca, MACCLESFIELD, United Kingdom, ⁹Kellgren Centre for Rheumatology, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Chronic inflammation in RA may contribute to an unstable atherosclerotic plaque phenotype. Dynamic contrast enhanced MRI (DCE MRI) can be used to image carotid…
Abstract Number: 391 • 2013 ACR/ARHP Annual Meeting
Insulin Resistance As A Risk Factor For Subclinical Atherosclerosis In Rheumatoid Arthritis
Adel M. Elsayed¹, Samah A. El Bakry¹, S. A. M. Hassan¹, Rehab A. Rahman², Rania A. Abo-Shady³ and Nouran Abaza⁴, ¹Rheumatology Division of Internal medicine department, Ain Shams University, Cairo, Egypt, ²Radiology department, Ain Shams University, Cairo, Egypt, ³clinical pathology, Ain Shams University, Cairo, Egypt, ⁴Physical medicine, Rheumatology and Rehabilitation, Lecturer of Physical medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Background/Purpose: Insulin resistance (IR) is a state in which a high insulin concentration is associated with an inadequate response to glucose with normal or high…
Abstract Number: 1724 • 2013 ACR/ARHP Annual Meeting
The Role Of Low-Grade Inflammation In The Association Between Uric Acid and Atherosclerosis: The Codam Study
José M.A. Wijnands¹, Annelies Boonen², Pieter C. Dagnelie³, Marleen M.J. van Greevenbroek⁴, Carla J.H, van der Kallen⁵, Isabel Ferreira⁴, Casper G. Schalkwijk⁴, Edith J.M. Feskens⁶, Sjef van der Linden², Coen D.A. Stehouwer⁷ and Ilja C.W. Arts³, ¹Department of Internal Medicine, Division of Rheumatology, Maastricht University, Maastricht, Netherlands, ²Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Epidemiology, Maastricht University, Maastricht, Netherlands, ⁴Department of Internal Medicine, Maastricht University, Maastricht, Netherlands, ⁵Department of Internal Medicine, Maastricht University, Maastricht, Netherlands, ⁶Division of Human Nutrition, Wageningen University, Wageningen, Netherlands, ⁷Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands
Background/Purpose: Uric acid may be involved in the atherosclerotic process by increasing the level of low-grade inflammation. The aims of this study were: 1) to…
Abstract Number: 365 • 2013 ACR/ARHP Annual Meeting
Oral Calcium Supplementation Is Associated With Subclinical Atherosclerosis In Rheumatoid Arthritis
Shanthi Dhaduvai¹, Laura Geraldino-Pardilla², Jon T. Giles³ and Joan M. Bathon⁴, ¹Division of Rheumatology, Columbia University Medical Center, New York, NY, ²Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, NY, ³Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁴Columbia University, New York, NY
Background/Purpose: Recent studies in the general population highlight possible adverse cardiovascular effects with calcium supplementation; however, the association between calcium intake and subclinical markers of…
Abstract Number: 1381 • 2013 ACR/ARHP Annual Meeting
The ZC3HC1 rs11556924 Polymorphism Is Associated With Increased Carotid Intima-Media Thickness In Patients With Rheumatoid Arthritis
Raquel lopez Mejias¹, Fernanda Genre², Mercedes García-Bermúdez³, Alfonso Corrales⁴, Carlos González-Juanatey⁵, J. Llorca⁶, Encarnación Amigo⁷, Jose A. Miranda-Filloy⁸, Javier Rueda-Gotor¹, Ricardo Blanco¹, Santos Castañeda⁹, Javier Martin¹⁰ and Miguel A. Gonzalez-Gay¹¹, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain., Santander, Spain, ²Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ³Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁴Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁵Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁶Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁷Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, ⁸Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ⁹Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, ¹⁰Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ¹¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a complex polygenic disease associated with chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. A recent meta-analysis has described…
Abstract Number: 358 • 2013 ACR/ARHP Annual Meeting
Inflammatory Burden Predicts Carotid Plaque Progression and Subsequent Cardiovascular Events In Rheumatoid Arthritis: The 2-Year Prospective Cohort Study
Churl Hyun Im¹, Sang Hoon Kwon², Jeong Soo Eun¹, Na Ri Kim¹, Eon Jeong Nam¹ and Young Mo Kang³, ¹Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, ²Internal medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, ³Department of Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea
Background/Purpose: Rheumatoid arthritis (RA) patients have increased prevalence of carotid atherosclerosis, especially plaque formation, which has been associated with inflammatory burden in a previous study.…
Abstract Number: 1382 • 2013 ACR/ARHP Annual Meeting
The 11q23.3 Genomic Region – rs964184- Is Associated With Cardiovascular Disease In Patients With Rheumatoid Arthritis
Raquel lopez Mejias¹, Fernanda Genre², Mercedes García-Bermúdez³, Santos Castañeda⁴, Carlos González-Juanatey⁵, J. Llorca⁶, Encarnación Amigo⁷, Alfonso Corrales⁸, Jose A. Miranda-Filloy⁹, Javier Rueda-Gotor¹, Carmen Gomez vaquero¹⁰, Luis Rodriguez Rodriguez¹¹, Benjamin Fernandez Gutierrez¹¹, Alejandro Balsa¹², Dora Pascual-Salcedo¹³, Francisco Javier López-Longo¹⁴, Patricia Carreira¹⁵, Ricardo Blanco¹, Isidoro González-Alvaro¹⁶, Javier Martin¹⁷ and Miguel A. Gonzalez-Gay¹⁸, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain., Santander, Spain, ²Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ³Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁴Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, ⁵Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁶Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁷Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, ⁸Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁹Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ¹⁰Department of Rheumatology, Hospital Universitario Bellvitge, Barcelona, Spain, ¹¹Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹²Rheumatology unit, La Paz University Hospital, Rheumatology, Madrid, Spain, ¹³La Paz University Hospital, Rheumatology, Madrid, Spain, ¹⁴Hospital General Universitario Gregorio Marañón, Department of Rheumatology, Madrid, Spain, ¹⁵Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁶Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ¹⁷Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ¹⁸Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and high risk of cardiovascular (CV) disease. A recent meta-analysis has…
Abstract Number: 285 • 2013 ACR/ARHP Annual Meeting
Juvenile Idiopathic Arthritis Patients Demonstrate Alterations In HDL Functionality Without Accelerated Subclinical Atherosclerosis
Preethi Mani¹, Kiyoko Uno², Katherine Wolski³, Steven J. Spalding⁴, Stephen J. Nicholls⁵ and M. Elaine Husni⁶, ¹Cleveland Clinic Lerner College of Medicine, Cleveland, OH, ²Cardiovascular medicine, Cleveland Clinic Foundation, Cleveland, OH, ³Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, ⁴Pediatric Institute, Department of Pediatric Rheumatology, The Cleveland Clinic, Cleveland, OH, ⁵Clinical Research Heart & Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH, ⁶Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Previous literature supports an increase in cardiovascular (CV) morbidity and mortality in adults with inflammatory joint disease, however it is not known whether children with…
Abstract Number: 1277 • 2013 ACR/ARHP Annual Meeting
A Pilot Study Of Young Adults With Juvenile Dermatomyositis With Decreased Nailfold Capillary End Row Loops: Brachial Artery Reactivity and Oxidized Lipids
Lauren M. Pachman^1,2, Maureen A. McMahon³, Tamar Polonsky⁴, Gabrielle A. Morgan¹, Maria Amoruso⁵ and Chiang-Ching Huang⁶, ¹Cure JM Myositis Center, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Chicago, IL, ²Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁴Cardiology, University of Chicago Medicine, Chicago, IL, ⁵Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Cure JM Myositis Center, Chicago, IL, ⁶Zilber School of Public Health, University of Wisconsin at Milwaukee, Milwaukee, WI
Background/Purpose: Our center previously reported increased carotid intima media thickness, and lower high-density lipoprotein (HDL) levels in young or middle-age adults with a history of…

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