Abstracts tagged "Atherosclerosis"

Abstract Number: 1210 • 2013 ACR/ARHP Annual Meeting
Epicardial Adipose Tissue and Atherosclerosis In Patients With Familial Mediterranean Fever
Adem Kucuk¹, Yalcin Solak², Hakan Akilli³, Oguzhan Yildirim³, Ibrahim Guler⁴, Ramazan Ucar⁵, Alpay Aribas³, Orhan Ozbek⁶, Mehmet Kayrak³ and Recep Tunc¹, ¹Necmettin Erbakan University, Meram Medical Faculty,Division of Rheumatology, Konya, Turkey, ²Karaman State Hospital, Division of Nephrology, Karaman, Turkey, ³Necmettin Erbakan University, Division of Cardiology, Konya, Turkey, ⁴Konya Research and Education Hospital, Division of Radiology, Konya, Turkey, ⁵Konya Education and Research Hospital, Department ofInternal Medicine, Konya, Turkey, ⁶Necmettin Erbakan University, Division of Radiology, Konya, Turkey
Background/Purpose : Familial Mediterranean Fever (FMF) is a chronic autosomal recessive hereditary disease characterized by episodic attacks of fever and inflammation of serosal and synovial…
Abstract Number: 1157 • 2013 ACR/ARHP Annual Meeting
Peptidylarginine Deiminase Inhibition Prevents Neutrophil Extracellular Trap Formation, Modulates Innate Immune Responses, and Reduces Vascular Damage In Mice
Jason S. Knight¹, Wei Luo², Alexander A. O'Dell¹, Wenpu Zhao³, Venkataraman Subramanian⁴, Chiao Guo², Robert C. Grenn³, Paul Ryan Thompson⁴, Daniel T. Eitzman² and Mariana J. Kaplan⁵, ¹Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan Cardiology, Ann Arbor, MI, ³University of Michigan Rheumatology, Ann Arbor, MI, ⁴The Scripps Research Institute, Jupiter, FL, ⁵Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Neutrophil extracellular trap (NET) formation promotes vascular damage, while stimulating interferon alpha (IFN-α) production in diseased arteries. Patients with rheumatoid arthritis and systemic…
Abstract Number: 887 • 2013 ACR/ARHP Annual Meeting
Atherosclerosis and Cardiovascular Disease In Systemic Lupus Eryhematosus Are Related To An Inflammatory/Oxidative Status Linked To The Autoimmune Condition and The Clinical Activity Of The Disease. Effect Of Statins Treatment
Chary Lopez-Pedrera¹, Patricia Ruiz-Limon¹, Carlos Perez-Sanchez¹, Mª Angeles Aguirre², Nuria Barbarroja¹, Tomás Cerdó-Ráez³, Maria Laura Bertolaccini⁴, Munther A. Khamashta⁵, Antonio Rodriguez-Ariza⁶, Yolanda Almaden⁷, Husam Khraiwesh⁸, Jose Antonio Gonzalez-Reyes⁹, Jose Manuel Villalba¹⁰, Eduardo Collantes¹¹ and Mª Jose Cuadrado¹², ¹Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, ²Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ³Imibic, Córdoba, Spain, ⁴Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom, ⁵Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, ⁶Oncology Service and Research Unit, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ⁷Imibic, Códoba, Spain, ⁸UCO, Córdoba, Spain, ⁹Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain, ¹⁰Cell Biology, Physiology and Immunology, University of Cordoba, Agrifood Campus of International Excelence (ciA3), Cordoba, Spain, ¹¹Rheumatology, Hospital Reina Sofia, Cordoba, Spain, ¹²Lupus Research Unit, The Rayne Institute, London, United Kingdom
Background/Purpose: Atherosclerosis (AT) and cardiovascular disease (CVD) are enhanced systemic lupus erythematosus (SLE). Although there is evidence that statins have anti-inflammatory properties, their mechanism of…
Abstract Number: 763 • 2013 ACR/ARHP Annual Meeting
The Risk Of Myocardial Infarction In Systemic Sclerosis: A Population-Based Cohort Study
Iman Hemmati¹, Hyon K. Choi^2,3, Kamran Shojania^3,4, Eric C. Sayre³ and J. Antonio Avina-Zubieta^3,5, ¹Deparment of Medicine and Rheumatology, University of British Columbia, Vancouver, BC, Canada, ²Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose: An increased risk of premature atherosclerosis has been well described in patients with rheumatoid arthritis and systemic lupus erythematosus. However, there is limited data…
Abstract Number: 559 • 2013 ACR/ARHP Annual Meeting
Effects Of In Vivo Treatment With Hydroxychloroquine On Endothelial Function In a Murine Model Of Systemic Lupus Erythematosus
Marta Mosca¹, Chiara Tani², Sabrina Vagnani³, Linda Carli^3,4, Rosaria Talarico⁵, Chiara Baldini⁵, Stefano Bombardieri³ and Agostino Virdis⁶, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ⁴GenOMeC PhD, University of Siena, Siena, Italy, ⁵University of Pisa, Rheumatology Unit, Pisa, Italy, ⁶Department of Clinical and Experimental Medicine. University of Pisa, Hypertension Unit, University of Pisa, Pisa, Italy
Background/Purpose: Antimalarial drugs are a cornerstone of treatment of systemic lupus erythematosus (SLE). It has been suggested that antimalarial drugs may have a protective effect…
Abstract Number: 2898 • 2013 ACR/ARHP Annual Meeting
Atherosclerosis In Systemic Lupus Erythematosus (SLE) and Controls, -An Analysis Of SLE Subgroups
Johanna Gustafsson¹, Kerstin Jensen-Urstad², Marie Herlitz-Lindberg², Sonia Möller¹, Susanne Pettersson¹, Iva Gunnarsson¹, Anders Larsson³ and Elisabet Svenungsson⁴, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical Physiology, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden, ³Department of Clinical Chemistry and Pharmacology, Akademiska Hospital, Uppsala, Sweden, ⁴Department of Medicine, Unit of Rheumatology, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Atherosclerosis is often assumed to be the main underlying cause of premature vascular events (VE) among patients with systemic lupus erythematosus (SLE) and accelerated…
Abstract Number: 469 • 2013 ACR/ARHP Annual Meeting
Anti-TNF Therapy Induces Positive Changes In The Lipoprotein Profile Of RA Patientes. Results Of a Prospective Study
Jaime Calvo-Alén¹, Carmela Baamonde², Ignacio Villa¹, Víctor Martínez-Taboada³, Mario Agudo⁴ and Juan Gómez-Gerique⁵, ¹Rheumatology, Hospital Universitario Sierrallana, Torrelavega, Spain, ²Biochemistry, Hospital Universitario Sierrallana, Torrelavega, Spain, ³Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁴Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁵Biochemistry, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain
Background/Purpose: Anti-TNF therapy induces elevations in total cholesterol levels although does not seem to modify the atherogenic index. Otherwise, it appears to have a cardiovascular…
Abstract Number: 2780 • 2013 ACR/ARHP Annual Meeting
Cumulative Exposure To Elevated Inflammatory Markers Is Associated With Increased Burden Of Atherosclerosis In Psoriatic Arthritis Patients: A Cohort Study
Lihi Eder¹, Arane Thavaneswaran², Vinod Chandran³, Richard J. Cook⁴ and Dafna D. Gladman³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
Background/Purpose: Cardiovascular morbidity is increased in patients with psoriatic arthritis (PsA). Traditional cardiovascular risk factors do not fully explain this excessive risk. It is unclear…
Abstract Number: 402 • 2013 ACR/ARHP Annual Meeting
Can Modulators Of Inflammation Serve As Biomarkers For Subclinical Atherosclerosis In Rheumatoid Arthritis?
Kimberly P. Liang¹, Douglas P. Landsittel², Suresh R. Mulukutla³, Steven E. Reis⁴, Marc C. Levesque⁵, Donald M. Jones⁶, Rachel Gartland⁷, Ali Shoushtari⁸, Flordeliza S. Villanueva³, Hunter C. Champion⁸ and Larry W. Moreland⁵, ¹Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Medicine, Biostatistics and Clinical and Translational Science, University of Pittsburgh, Center for Health Care Research Data Center, Pittsburgh, PA, ³Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, ⁴Division of Cardiology and Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Rheumatoid arthritis (RA) is independently associated with a higher risk of cardiovascular disease (CVD) and premature atherosclerosis. Mechanisms of atherosclerosis include (1) Endothelial dysfunction/activation mediated…
Abstract Number: 2763 • 2013 ACR/ARHP Annual Meeting
Carotid Atherosclerosis As a Predictor Of Mortality In Rheumatoid Arthritis
Inmaculada del Rincon¹, Roy W. Haas², Jose Felix Restrepo³, Daniel F. Battafarano⁴, Daniel H. O'Leary⁵, Emily Molina¹ and Agustin Escalante⁶, ¹Rheumatology, University of Texas Health Science Center, San Antonio, TX, ²Dept. of Medicine-Rheumatology, University of Texas Health Science Center, San Antonio, TX, ³Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, ⁴Medicine / MCHE-MDR, Brooke Army Medical Ctr, San Antonio, TX, ⁵Radiology, Tufts University-Boston Campus, Boston, MA, ⁶Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX
Background/Purpose: Patients with rheumatoid arthritis (RA) have higher mortality than do persons of the same age and sex without RA. This is due in part…
Abstract Number: 384 • 2013 ACR/ARHP Annual Meeting
Carotid Artery Plaques Are Associated With Coronary Atherosclerosis In Patients With Inflammatory Joint Diseases Independent Of Several Cardiovascular Risk Calculators
Silvia Rollefstad¹, Eirik Ikdahl², Inge C. Olsen³, Tore K. Kvien^4,5, Anne S. Eirheim², Terje R. Pedersen^4,6 and Anne G. Semb², ¹Rhuematology, Diakonhjemmet Hospital, Oslo, Norway, ²Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Faculty of Medicine, University of Oslo, Oslo, Norway, ⁵Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁶Centre of Preventive Medicine, Oslo University Hospital-Ullevaal, Oslo, Norway
Background/Purpose: Patients with rheumatoid arthritis (RA) and carotid plaque (CP) have been shown to have increased risk of future acute coronary syndrome. We have established…
Abstract Number: 2343 • 2013 ACR/ARHP Annual Meeting
Assessment Of Subclinical Atherosclerosis (Flow Mediated Dilatation and arterial stiffness) After 24 Weeks Of a Tocilizumab Therapy In 22 Patients With Rheumatoid Arthritis
Martin Soubrier¹, Thomas Frayssac², Bruno Pereira³, Marion Couderc Sr.⁴, Coline Daron², Jean Jacques Dubost⁵, Sandrine Malochet-Guinamand⁴, Anne Tournadre⁴ and Sylvain Mathieu⁴, ¹Rheumatology, CHU CLERMONT-FERRAND, Clermont-Ferrand, France, ²CHU CLERMONT-FERRAND, Clermont-ferrand, France, ³Clinical research department, Clermont-Ferrand, France, ⁴Rheumatology CHU Gabriel Montpied, Clermont-Ferrand, France, ⁵Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France
Background/Purpose: Increased incidence of cardiovascular diseases and sub-clinical atherosclerosis have been observed in rheumatoid arthritis (RA). Inflammation and traditional risk factors could be involved in…
Abstract Number: 386 • 2013 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Is Associated With Systemic Inflammation In Coronary Vessels
Inge A.M. van den Oever¹, Alper M. van Sijl¹, Umit Baylan², Michael. T. Nurmohamed¹, Alexandre E. Voskuyl¹, Hans W. Niessen² and Suat Simsek³, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Pathology, VU University Medical Center, Amsterdam, Netherlands, ³Internal Medicine, Medical Center Alkmaar (MCA), Alkmaar, Netherlands
Background/Purpose: Patients with a chronic inflammatory disease (CID), particularly rheumatoid arthritis (RA), have an increased risk of fatal myocardial infarction (MI), as compared to the…
Abstract Number: 1975 • 2013 ACR/ARHP Annual Meeting
Cardiovascular Risk Stratification In Rheumatic Diseases : Carotid Ultrasound Is More Sensitive Than Coronary Artery Calcification Score To Detect Subclinical atherosclerosis In Patients With Rheumatoid Arthritis
Francisco Ortiz-Sanjuán¹, Alfonso Corrales², José Antonio Parra³, Carlos González-Juanatey⁴, Montserrat Santos⁵, Javier Rueda⁶, Ricardo Blanco⁷, Vanesa Calvo-Río⁸, Javier Loricera⁸, Javier Llorca⁹ and Miguel A González-Gay¹⁰, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ²Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ³Radiology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁴Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁵Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, ⁶Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁷Hospital Marques de Valdecilla, Santander, Spain, ⁸Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁹Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, ¹⁰Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a disease associated to accelerated atherogenesis leading to increased incidence of cardiovascular (CV) mortality. Adequate stratification of the CV risk…
Abstract Number: 387 • 2013 ACR/ARHP Annual Meeting
Left Ventricular Myocardial Tissue In Rheumatoid Arthritis Shows Systemic Inflammation After Fatal Myocardial Infarction
Inge A.M. van Den Oever¹, Alper M. van Sijl¹, Umit Baylan², Michael. T. Nurmohamed¹, Alexandre E. Voskuyl¹, Hans W. Niessen² and Suat Simsek³, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Pathology, VU University Medical Center, Amsterdam, Netherlands, ³Internal Medicine, Medical Center Alkmaar (MCA), Alkmaar, Netherlands
Background/Purpose: Patients with a chronic inflammatory disease (CID), particularly rheumatoid arthritis (RA), have an increased risk of fatal myocardial infarction (MI) and a diminished survival…

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