Abstracts tagged "Atherosclerosis"

Abstract Number: 365 • 2013 ACR/ARHP Annual Meeting
Oral Calcium Supplementation Is Associated With Subclinical Atherosclerosis In Rheumatoid Arthritis
Shanthi Dhaduvai¹, Laura Geraldino-Pardilla², Jon T. Giles³ and Joan M. Bathon⁴, ¹Division of Rheumatology, Columbia University Medical Center, New York, NY, ²Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, NY, ³Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁴Columbia University, New York, NY
Background/Purpose: Recent studies in the general population highlight possible adverse cardiovascular effects with calcium supplementation; however, the association between calcium intake and subclinical markers of…
Abstract Number: 1724 • 2013 ACR/ARHP Annual Meeting
The Role Of Low-Grade Inflammation In The Association Between Uric Acid and Atherosclerosis: The Codam Study
José M.A. Wijnands¹, Annelies Boonen², Pieter C. Dagnelie³, Marleen M.J. van Greevenbroek⁴, Carla J.H, van der Kallen⁵, Isabel Ferreira⁴, Casper G. Schalkwijk⁴, Edith J.M. Feskens⁶, Sjef van der Linden², Coen D.A. Stehouwer⁷ and Ilja C.W. Arts³, ¹Department of Internal Medicine, Division of Rheumatology, Maastricht University, Maastricht, Netherlands, ²Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Epidemiology, Maastricht University, Maastricht, Netherlands, ⁴Department of Internal Medicine, Maastricht University, Maastricht, Netherlands, ⁵Department of Internal Medicine, Maastricht University, Maastricht, Netherlands, ⁶Division of Human Nutrition, Wageningen University, Wageningen, Netherlands, ⁷Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Netherlands
Background/Purpose: Uric acid may be involved in the atherosclerotic process by increasing the level of low-grade inflammation. The aims of this study were: 1) to…
Abstract Number: 358 • 2013 ACR/ARHP Annual Meeting
Inflammatory Burden Predicts Carotid Plaque Progression and Subsequent Cardiovascular Events In Rheumatoid Arthritis: The 2-Year Prospective Cohort Study
Churl Hyun Im¹, Sang Hoon Kwon², Jeong Soo Eun¹, Na Ri Kim¹, Eon Jeong Nam¹ and Young Mo Kang³, ¹Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, ²Internal medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea, ³Department of Internal Medicine (Rheumatology), Kyungpook National University School of Medicine, Daegu, South Korea
Background/Purpose: Rheumatoid arthritis (RA) patients have increased prevalence of carotid atherosclerosis, especially plaque formation, which has been associated with inflammatory burden in a previous study.…
Abstract Number: 1381 • 2013 ACR/ARHP Annual Meeting
The ZC3HC1 rs11556924 Polymorphism Is Associated With Increased Carotid Intima-Media Thickness In Patients With Rheumatoid Arthritis
Raquel lopez Mejias¹, Fernanda Genre², Mercedes García-Bermúdez³, Alfonso Corrales⁴, Carlos González-Juanatey⁵, J. Llorca⁶, Encarnación Amigo⁷, Jose A. Miranda-Filloy⁸, Javier Rueda-Gotor¹, Ricardo Blanco¹, Santos Castañeda⁹, Javier Martin¹⁰ and Miguel A. Gonzalez-Gay¹¹, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain., Santander, Spain, ²Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ³Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁴Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁵Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁶Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁷Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, ⁸Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ⁹Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, ¹⁰Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ¹¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a complex polygenic disease associated with chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. A recent meta-analysis has described…
Abstract Number: 285 • 2013 ACR/ARHP Annual Meeting
Juvenile Idiopathic Arthritis Patients Demonstrate Alterations In HDL Functionality Without Accelerated Subclinical Atherosclerosis
Preethi Mani¹, Kiyoko Uno², Katherine Wolski³, Steven J. Spalding⁴, Stephen J. Nicholls⁵ and M. Elaine Husni⁶, ¹Cleveland Clinic Lerner College of Medicine, Cleveland, OH, ²Cardiovascular medicine, Cleveland Clinic Foundation, Cleveland, OH, ³Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, ⁴Pediatric Institute, Department of Pediatric Rheumatology, The Cleveland Clinic, Cleveland, OH, ⁵Clinical Research Heart & Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH, ⁶Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Previous literature supports an increase in cardiovascular (CV) morbidity and mortality in adults with inflammatory joint disease, however it is not known whether children with…
Abstract Number: 1382 • 2013 ACR/ARHP Annual Meeting
The 11q23.3 Genomic Region – rs964184- Is Associated With Cardiovascular Disease In Patients With Rheumatoid Arthritis
Raquel lopez Mejias¹, Fernanda Genre², Mercedes García-Bermúdez³, Santos Castañeda⁴, Carlos González-Juanatey⁵, J. Llorca⁶, Encarnación Amigo⁷, Alfonso Corrales⁸, Jose A. Miranda-Filloy⁹, Javier Rueda-Gotor¹, Carmen Gomez vaquero¹⁰, Luis Rodriguez Rodriguez¹¹, Benjamin Fernandez Gutierrez¹¹, Alejandro Balsa¹², Dora Pascual-Salcedo¹³, Francisco Javier López-Longo¹⁴, Patricia Carreira¹⁵, Ricardo Blanco¹, Isidoro González-Alvaro¹⁶, Javier Martin¹⁷ and Miguel A. Gonzalez-Gay¹⁸, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain., Santander, Spain, ²Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ³Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁴Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, ⁵Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, ⁶Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁷Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, ⁸Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁹Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ¹⁰Department of Rheumatology, Hospital Universitario Bellvitge, Barcelona, Spain, ¹¹Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹²Rheumatology unit, La Paz University Hospital, Rheumatology, Madrid, Spain, ¹³La Paz University Hospital, Rheumatology, Madrid, Spain, ¹⁴Hospital General Universitario Gregorio Marañón, Department of Rheumatology, Madrid, Spain, ¹⁵Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁶Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ¹⁷Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ¹⁸Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain
Background/Purpose: Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and high risk of cardiovascular (CV) disease. A recent meta-analysis has…
Abstract Number: 1277 • 2013 ACR/ARHP Annual Meeting
A Pilot Study Of Young Adults With Juvenile Dermatomyositis With Decreased Nailfold Capillary End Row Loops: Brachial Artery Reactivity and Oxidized Lipids
Lauren M. Pachman^1,2, Maureen A. McMahon³, Tamar Polonsky⁴, Gabrielle A. Morgan¹, Maria Amoruso⁵ and Chiang-Ching Huang⁶, ¹Cure JM Myositis Center, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Chicago, IL, ²Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁴Cardiology, University of Chicago Medicine, Chicago, IL, ⁵Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Cure JM Myositis Center, Chicago, IL, ⁶Zilber School of Public Health, University of Wisconsin at Milwaukee, Milwaukee, WI
Background/Purpose: Our center previously reported increased carotid intima media thickness, and lower high-density lipoprotein (HDL) levels in young or middle-age adults with a history of…
Abstract Number: 1267 • 2013 ACR/ARHP Annual Meeting
Impact Of Disease Duration On Vascular Surrogates Of Early Atherosclerosis In Childhood-Onset Systemic Lupus Erythematosus
Julie Barsalou¹, Timothy J. Bradley², Cameron Slorach², Lawrence W.K. Ng³, Deborah M. Levy⁴ and Earl D. Silverman¹, ¹Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ²Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ³Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
Background/Purpose: Cardiovascular disease is a leading cause of morbidity and mortality in adults with systemic lupus erythematosus. Exposure to atherogenic risk factors in childhood-onset SLE…
Abstract Number: 1210 • 2013 ACR/ARHP Annual Meeting
Epicardial Adipose Tissue and Atherosclerosis In Patients With Familial Mediterranean Fever
Adem Kucuk¹, Yalcin Solak², Hakan Akilli³, Oguzhan Yildirim³, Ibrahim Guler⁴, Ramazan Ucar⁵, Alpay Aribas³, Orhan Ozbek⁶, Mehmet Kayrak³ and Recep Tunc¹, ¹Necmettin Erbakan University, Meram Medical Faculty,Division of Rheumatology, Konya, Turkey, ²Karaman State Hospital, Division of Nephrology, Karaman, Turkey, ³Necmettin Erbakan University, Division of Cardiology, Konya, Turkey, ⁴Konya Research and Education Hospital, Division of Radiology, Konya, Turkey, ⁵Konya Education and Research Hospital, Department ofInternal Medicine, Konya, Turkey, ⁶Necmettin Erbakan University, Division of Radiology, Konya, Turkey
Background/Purpose : Familial Mediterranean Fever (FMF) is a chronic autosomal recessive hereditary disease characterized by episodic attacks of fever and inflammation of serosal and synovial…
Abstract Number: 1157 • 2013 ACR/ARHP Annual Meeting
Peptidylarginine Deiminase Inhibition Prevents Neutrophil Extracellular Trap Formation, Modulates Innate Immune Responses, and Reduces Vascular Damage In Mice
Jason S. Knight¹, Wei Luo², Alexander A. O'Dell¹, Wenpu Zhao³, Venkataraman Subramanian⁴, Chiao Guo², Robert C. Grenn³, Paul Ryan Thompson⁴, Daniel T. Eitzman² and Mariana J. Kaplan⁵, ¹Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²University of Michigan Cardiology, Ann Arbor, MI, ³University of Michigan Rheumatology, Ann Arbor, MI, ⁴The Scripps Research Institute, Jupiter, FL, ⁵Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD
Background/Purpose: Neutrophil extracellular trap (NET) formation promotes vascular damage, while stimulating interferon alpha (IFN-α) production in diseased arteries. Patients with rheumatoid arthritis and systemic…
Abstract Number: 887 • 2013 ACR/ARHP Annual Meeting
Atherosclerosis and Cardiovascular Disease In Systemic Lupus Eryhematosus Are Related To An Inflammatory/Oxidative Status Linked To The Autoimmune Condition and The Clinical Activity Of The Disease. Effect Of Statins Treatment
Chary Lopez-Pedrera¹, Patricia Ruiz-Limon¹, Carlos Perez-Sanchez¹, Mª Angeles Aguirre², Nuria Barbarroja¹, Tomás Cerdó-Ráez³, Maria Laura Bertolaccini⁴, Munther A. Khamashta⁵, Antonio Rodriguez-Ariza⁶, Yolanda Almaden⁷, Husam Khraiwesh⁸, Jose Antonio Gonzalez-Reyes⁹, Jose Manuel Villalba¹⁰, Eduardo Collantes¹¹ and Mª Jose Cuadrado¹², ¹Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, ²Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ³Imibic, Córdoba, Spain, ⁴Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom, ⁵Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, ⁶Oncology Service and Research Unit, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ⁷Imibic, Códoba, Spain, ⁸UCO, Córdoba, Spain, ⁹Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain, ¹⁰Cell Biology, Physiology and Immunology, University of Cordoba, Agrifood Campus of International Excelence (ciA3), Cordoba, Spain, ¹¹Rheumatology, Hospital Reina Sofia, Cordoba, Spain, ¹²Lupus Research Unit, The Rayne Institute, London, United Kingdom
Background/Purpose: Atherosclerosis (AT) and cardiovascular disease (CVD) are enhanced systemic lupus erythematosus (SLE). Although there is evidence that statins have anti-inflammatory properties, their mechanism of…
Abstract Number: 763 • 2013 ACR/ARHP Annual Meeting
The Risk Of Myocardial Infarction In Systemic Sclerosis: A Population-Based Cohort Study
Iman Hemmati¹, Hyon K. Choi^2,3, Kamran Shojania^3,4, Eric C. Sayre³ and J. Antonio Avina-Zubieta^3,5, ¹Deparment of Medicine and Rheumatology, University of British Columbia, Vancouver, BC, Canada, ²Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose: An increased risk of premature atherosclerosis has been well described in patients with rheumatoid arthritis and systemic lupus erythematosus. However, there is limited data…
Abstract Number: 559 • 2013 ACR/ARHP Annual Meeting
Effects Of In Vivo Treatment With Hydroxychloroquine On Endothelial Function In a Murine Model Of Systemic Lupus Erythematosus
Marta Mosca¹, Chiara Tani², Sabrina Vagnani³, Linda Carli^3,4, Rosaria Talarico⁵, Chiara Baldini⁵, Stefano Bombardieri³ and Agostino Virdis⁶, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ⁴GenOMeC PhD, University of Siena, Siena, Italy, ⁵University of Pisa, Rheumatology Unit, Pisa, Italy, ⁶Department of Clinical and Experimental Medicine. University of Pisa, Hypertension Unit, University of Pisa, Pisa, Italy
Background/Purpose: Antimalarial drugs are a cornerstone of treatment of systemic lupus erythematosus (SLE). It has been suggested that antimalarial drugs may have a protective effect…
Abstract Number: 2898 • 2013 ACR/ARHP Annual Meeting
Atherosclerosis In Systemic Lupus Erythematosus (SLE) and Controls, -An Analysis Of SLE Subgroups
Johanna Gustafsson¹, Kerstin Jensen-Urstad², Marie Herlitz-Lindberg², Sonia Möller¹, Susanne Pettersson¹, Iva Gunnarsson¹, Anders Larsson³ and Elisabet Svenungsson⁴, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical Physiology, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden, ³Department of Clinical Chemistry and Pharmacology, Akademiska Hospital, Uppsala, Sweden, ⁴Department of Medicine, Unit of Rheumatology, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Atherosclerosis is often assumed to be the main underlying cause of premature vascular events (VE) among patients with systemic lupus erythematosus (SLE) and accelerated…
Abstract Number: 469 • 2013 ACR/ARHP Annual Meeting
Anti-TNF Therapy Induces Positive Changes In The Lipoprotein Profile Of RA Patientes. Results Of a Prospective Study
Jaime Calvo-Alén¹, Carmela Baamonde², Ignacio Villa¹, Víctor Martínez-Taboada³, Mario Agudo⁴ and Juan Gómez-Gerique⁵, ¹Rheumatology, Hospital Universitario Sierrallana, Torrelavega, Spain, ²Biochemistry, Hospital Universitario Sierrallana, Torrelavega, Spain, ³Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁴Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁵Biochemistry, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain
Background/Purpose: Anti-TNF therapy induces elevations in total cholesterol levels although does not seem to modify the atherogenic index. Otherwise, it appears to have a cardiovascular…

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