ACR Meeting Abstracts

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Abstracts tagged "Atherosclerosis"

  • Abstract Number: 1509 • 2015 ACR/ARHP Annual Meeting

    Serum Nitrite Levels in Rheumatoid Arthritis and Relationship to Cardiovascular Risk Factors and Atherosclerosis Biomarkers

    Kimberly P. Liang1, Douglas P. Landsittel2, Bernadette B. Sendon3, Donald M. Jones4, Rachel Gartland3, Suresh R. Mulukutla5, Steven E. Reis6, Flordeliza S. Villanueva5, Ali Hakim Shoushtari7, Cameron Dezfulian8 and Larry W. Moreland4, 1Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 2Medicine, University of Pittsburgh, Pittsburgh, PA, 3Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 4Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 5Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, 6Division of Cardiology and Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, 7Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, 8Critical Care Medicine and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Nitric oxide (NO) has been implicated in immune regulation, inflammation, arthritis and atherosclerosis. Raised levels of nitrite (NO2) in serum and synovial fluid have…
  • Abstract Number: 1903 • 2015 ACR/ARHP Annual Meeting

    Assessment of Subclinical Atherosclerosis in Patients with Systemic Sclerosis: Results from a Multicentric Cohort

    Codrina Ancuta1,2, Codruta Belibou3, Cristina Pomirleanu1,4, Carina Mihai5, Ioan Ancuta5, Patricia E. Carreira6, Jose Luis Rosales Alexander7, Juan José Alegre8, Valeria Riccieri9, Maria J. Salvador10 and Rodica Chirieac4, 1Rheumatology, Gr.T.Popa University of Medicine and Pharmacy, Iasi, Romania, 2Rheumatology 2, Clinical Rehablitation Hospital, Iasi, Romania, 3Research Department, Clinical Rehabilitation Hospital, Iasi, Romania, 4Rheumatology 2, Clinical Rehabilitation Hospital, Iasi, Romania, 5Department of Internal Medicine and Rheumatology, Dr.I.Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, 6Multidisciplinary Pulmonary Hypertension Unit. Hospital Universitario 12 de Octubre, Madrid, Spain, 7Rheumatology, Hospiten Health Network, Tenerife, Spain, 8Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, 9Cattedra di Reumatologia, Dip Clinica e Terapia Medica, Sapienza Università di Roma, Roma, Italy, 10Rheumatology, Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra, EPE, Coimbra, Portugal

    Background/Purpose: Although numerous studies have reported different findings on subclinical and definite atherosclerosis (AS) in autoimmune rheumatic diseases, data in systemic sclerosis (SSc) are still…
  • Abstract Number: 1913 • 2014 ACR/ARHP Annual Meeting

    Rosuvastatin Induced Carotid Plaque Regression in Patients with Inflammatory Joint Diseases

    Silvia Rollefstad1, Eirik Ikdahl1, Jonny Hisdal2, Inge C. Olsen3, Ingar Holme4, Hilde Berner Hammer5, Knut T. Smerud6, G Kitas7, Terje R. Pedersen8, Tore K. Kvien9 and Anne Grete Semb1, 1Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Section of Vascular Investigations, Uslo University Hospital-Aker, Oslo, Norway, 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Department of biostatistics, epidemiology and health economics, Oslo University Hospital, Oslo, Norway, 5Postboks 23 Vinderen, Diakonhjemmet Hospital, Oslo, Norway, 6Smerud Medical Research International AS, Oslo, Norway, 7The Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, 8Faculty of Medicine, University of Oslo, Oslo, Norway, 9PsAID taskforce, EULAR, Zurich, Switzerland

    Background/Purpose Patients with rheumatoid arthritis (RA) and carotid artery plaques (CP) have increased risk of acute coronary syndromes. Statin treatment with low density lipoprotein cholesterol…
  • Abstract Number: 438 • 2014 ACR/ARHP Annual Meeting

    Distinct Profiles of Proinflammatory Macrophages in Rheumatoid Arthritis and Coronary Artery Disease

    Tsuyoshi Shirai1, Eric L. Matteson2, David G. Harrison3, Barbara B. Wallis4, Themistocles L. Assimes5, Jorg J. Goronzy6 and Cornelia M. Weyand1, 1Medicine, Stanford University School of Medicine, Stanford, CA, 2Rheumatology, Mayo Clinic, Rochester, MN, 3Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, 4Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, 5Stanford University School of Medicine, Stanford, CA, 6Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Patients with RA have an increased risk of developing coronary artery disease (CAD) compared to the general population. The underlying pathological process of CAD…
  • Abstract Number: 1633 • 2014 ACR/ARHP Annual Meeting

    Galectin-3-Binding Protein Is Associated with Disease Activity, but Not with Atherosclerosis in SLE Patients

    Susan Kay1, Niels Heegaard2 and Anne Voss3, 1Rheumatolog, Rheumatology, Odense, Denmark, 2Cinical Biochemistry and Pharmacology, Cinical Biochemistry and Pharmacology, Odense, Denmark, 3Reumatology, Reumatology, Odense, Denmark

    Background/Purpose . Patients with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular disease (CVD), which may be due to an increased prevalence of atherosclerosis.…
  • Abstract Number: 398 • 2014 ACR/ARHP Annual Meeting

    Anti-Rheumatic Therapy Decreases Syndecan-1 Shedding in Rheumatoid Arthritis (RA)

    Ivana Hollan1, Gunnbjørg Hjeltnes2, Torstein Lyberg3, Stefan Agewall3, Allan Wiik4, Knut Mikkelsen5, Øystein T. Førre6, Tram T. Vuong3 and Svein O. Kolset3, 1Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 2Medicine, Innlandet Hospital Trust, Lillehammer, Norway, 3University of Oslo, Oslo, Norway, 4Clinical Biochem/Immunology, Statens Serum Institute, Copenhagen S, Denmark, 5Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 6Oslo University Hospital, Oslo, Norway

    Background/Purpose Intact glycocalyx is of importance for healthy endothelial function. Changes in the endothelial glycocalyx, characterized by increased levels of circulating syndecan-1, might be related…
  • Abstract Number: 1591 • 2014 ACR/ARHP Annual Meeting

    Exploring the Association of Serum Paraoxonase and Arylesterase Activities with Cardiovascular Risk in Psoriasis and Psoriatic Arthritis

    M. Elaine Husni1, Danielle Brennan2, WH Wilson Tang3 and Stanley Hazen3, 1Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH, 2Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, 3Cardiology, CCF, Cleveland, OH

    Background/Purpose Psoriatic diseases are systemic inflammatory joint and skin disorders associated with increased cardiovascular (CV) morbidity.  Paraoxonase (PON) and Arylesterase (ARYL) are antioxidant enzymatic proteins…
  • Abstract Number: 374 • 2014 ACR/ARHP Annual Meeting

    IL-33 and Soluble ST2 Levels As Novel Predictors for Remission and Progression of Carotid Plaque in Early Rheumatoid Arthritis: A Prospective Study

    Jiayun Shen1, Qing Shang1, Ying Ying Leung2, Shui Lian Yu1, Chun-Kwok Wong3, Edmund Li1, Tracy Y. Zhu1 and Lai-Shan Tam1, 1Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, 3Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose Clinical remission is achievable for patients with early rheumatoid arthritis (ERA). Identification of predictors for response of treatment may provide risk estimation and help…
  • Abstract Number: 1443 • 2014 ACR/ARHP Annual Meeting

    Increased Occurence of Carotid and Femoral Plaques, but Not Increased Arterial Stiffness of Hypertrophy, in Classical Risk Factor-Free Patients with Rheumatoid Arthritis

    Aikaterini I. Arida1, Evaggelia Zampeli1, George Konstantonis1, Kalliopi Fragkiadaki1, George D. Kitas2, Athanasios D. Protogerou1 and Petros P. Sfikakis1, 1First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, 2The Dudley Group of Hospitals NHS Foundation Trust, Dudley, and Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom

    Background/Purpose  Several lines of evidence indicate that classical cardiovascular disease (CVD) risk factors, such as arterial hypertension, diabetes mellitus, smoking and dyslipidemia, are significantly increased…
  • Abstract Number: 373 • 2014 ACR/ARHP Annual Meeting

    Biomarkers of Cardiac Dysfunction and Inflammation in Plasma Predict Occult Coronary Plaque Burden and Composition in Rheumatoid Arthritis

    George A. Karpouzas1, Joel Estis2, John Todd2 and Matthew Budoff3, 1Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, 2Singulex, Alameda, California, Alameda, CA, 3Cardiology, Harbor-UCLA Medical Center, Torrance, CA

    Background/Purpose Rheumatoid arthritis (RA) is associated with accelerated coronary atherogenesis, myocardial infarction, and mortality. We previously reported a higher prevalence, severity, and different composition of…
  • Abstract Number: 1440 • 2014 ACR/ARHP Annual Meeting

    Asymptomatic Carotid Plaques in RA Patients Are Associated with Increased HDL Function

    Silvia Rollefstad1, Bente Halvorsen2, Tonje Skarpengland2, Sella Provan3, Tore K. Kvien4 and Anne Grete Semb1, 1Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway, 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4PsAID taskforce, EULAR, Zurich, Switzerland

    Background/Purpose  Reverse cholesterol transport (RCT) is a major anti atherogenic function of high density lipoprotein cholesterol (HDL) and has been shown to be related to…
  • Abstract Number: 334 • 2014 ACR/ARHP Annual Meeting

    Inflammatory Arthritis in K/BxN Mice Is Associated with Abnormal HDL Function

    C. Charles-Schoeman1, Ani Shahbazian1, Yuen Yin Lee1 and Srinivasa T. Reddy2, 1Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 2Medicine-Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality.  Abnormal function of high density lipoprotein (HDL) has been implicated as…
  • Abstract Number: 1437 • 2014 ACR/ARHP Annual Meeting

    Cholesterol Efflux Capacity of HDL and Coronary Atherosclerosis in Rheumatoid Arthritis

    Michelle J. Ormseth1, Patricia Yancey2, Suguru Yamamoto2, Annette M. Oeser1, Tebeb Gebretsadik3, Ayumi Shintani1, MacRae F. Linton1, Sergio Fazio1, Sean Davies1, L Jackson Roberts II1, Kasey C. Vickers1, Paolo Raggi4, Valentina Kon1 and C Michael Stein1, 1Vanderbilt University, Nashville, TN, 2Medicine, Vanderbilt University, Nashville, TN, 3Biostatistics, Vanderbilt University, Nashville, TN, 4Emory University, Atlanta, GA

    Background/Purpose: Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL…
  • Abstract Number: 79 • 2014 ACR/ARHP Annual Meeting

    PECAM-1 GENE Polymorphisms and Soluble PECAM-1 LEVEL in Rheumatoid Arthritis and Systemic LUPUS Erythematosus Patients Is There a Link with Clinical Atherosclerotic Events?

    Omer Nuri Pamuk1, Hilmi Tozkir2, Mehmet Sevki Uyanik3, Hakan Gurkan4, Julide Duymaz4, Salim Donmez5, Metin Yazar2 and Gulsum Pamuk3, 1Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, 2Genetics, Trakya University Medical Faculty, EDIRNE, Turkey, 3Hematology, Trakya University Medical Faculty, Edirne, Turkey, 4Trakya University Medical Faculty, EDIRNE, Turkey, 5Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey

    Background/Purpose: Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) which plays a role in the transmigration of leucocytes into tissues is a member of the immunoglobulin (Ig) superfamily.…
  • Abstract Number: 1218 • 2014 ACR/ARHP Annual Meeting

    The Reduction of Serum Uric Acid Level Might Prevent Atherosclerosis in Mice

    Yoshitaka Kimura1,2, Tamiko Yanagida3, Akiko Onda4, Hajime Kono2, Maki Takayama2, Kurumi Asako2, Akiko Okamoto2, Hirotoshi Kikuchi2 and Toshihiro Nanki5, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 3Depart ment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 4Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 5Department of Clinical Research Medicine, Teikyo University, Tokyo, Japan

    Background/Purpose: Excess amount of uric acid in human body causes acute inflammation, gout. In addition, uric acid is identified as a danger signal and is…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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