Abstracts tagged "Atherosclerosis"

Abstract Number: 1572 • 2015 ACR/ARHP Annual Meeting
Plasma Apolipoprotein B48 Levels in Patients with Rheumatoid Arthritis: Evaluating Novel Cardiovascular Risk Factors
Deborah van Breukelen-van der Stoep¹, Derkjen van Zeben¹, Marijke de Vries², Boudewijn Klop², Noelle van der Meulen², Gert Jan van de Geijn³, Hans Janssen³, Pedro Valdivielso⁴, José Rioja⁴, José Ramirez-Bollero⁴, Mieke Hazes⁵, Erwin Birnie^6,7 and Manuel Castro Cabezas⁸, ¹Department of Rheumatology, Sint Franciscus Gasthuis, Rotterdam, Netherlands, ²Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, Netherlands, ³Department of Clinical Chemistry, Sint Franciscus Gasthuis, Rotterdam, Netherlands, ⁴Department of Internal Medicine and Dermatology, Hospital Virgen de la Victoria, Malaga, Spain, ⁵Department of Rheumatology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands, ⁶Statistics and Education, Sint Franciscus Gasthuis, Rotterdam, Netherlands, ⁷Insitute of Health Policy and Management, Erasmus University, Rotterdam, Netherlands, ⁸Department of Internal Medicine, Sint Francicscus Gasthuis, Rotterdam, Netherlands
Background/Purpose: Chylomicrons, with apolipoprotein (apo) B48 as a structural protein, induce leukocyte and complement activation and contribute to atherosclerosis. ApoB48 is higher in conditions associated…
Abstract Number: 2630 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patients with Carotid Plaque: 10-Year Follow-up
Raymundo Vera-Pineda¹, Alberto Cardenas-de La Garza², Dionicio A. Galarza-Delgado², Jose Ramon Azpiri-Lopez³, Iris J. Colunga-Pedraza², Jorge Munoz De Hoyos², Griselda Serna-Peña⁴, Brenda B Tovar-Jasso², Mario Alberto Garza-Elizondo² and Gerardo Ornelas⁵, ¹Cardiology., Hospital Universitario, UANL., Monterrey, Mexico, ²Rheumatology, Hospital Universitario, UANL., Monterrey, Mexico, ³Cardiology, Hospital Universitario, UANL., Monterrey, Mexico, ⁴Internal Medicine, Hospital Universitario, UANL., Monterrey, Mexico, ⁵Radiology, Hospital Universitario, UANL., Monterrey, Mexico
Background/Purpose: The main cause of mortality in patients with rheumatoid arthritis (RA) is atherosclerotic cardiovascular disease (ASCVD). RA patients have a 10-year decrease in life…
Abstract Number: 1440 • 2014 ACR/ARHP Annual Meeting
Asymptomatic Carotid Plaques in RA Patients Are Associated with Increased HDL Function
Silvia Rollefstad¹, Bente Halvorsen², Tonje Skarpengland², Sella Provan³, Tore K. Kvien⁴ and Anne Grete Semb¹, ¹Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose Reverse cholesterol transport (RCT) is a major anti atherogenic function of high density lipoprotein cholesterol (HDL) and has been shown to be related to…
Abstract Number: 334 • 2014 ACR/ARHP Annual Meeting
Inflammatory Arthritis in K/BxN Mice Is Associated with Abnormal HDL Function
C. Charles-Schoeman¹, Ani Shahbazian¹, Yuen Yin Lee¹ and Srinivasa T. Reddy², ¹Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Medicine-Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality. Abnormal function of high density lipoprotein (HDL) has been implicated as…
Abstract Number: 1437 • 2014 ACR/ARHP Annual Meeting
Cholesterol Efflux Capacity of HDL and Coronary Atherosclerosis in Rheumatoid Arthritis
Michelle J. Ormseth¹, Patricia Yancey², Suguru Yamamoto², Annette M. Oeser¹, Tebeb Gebretsadik³, Ayumi Shintani¹, MacRae F. Linton¹, Sergio Fazio¹, Sean Davies¹, L Jackson Roberts II¹, Kasey C. Vickers¹, Paolo Raggi⁴, Valentina Kon¹ and C Michael Stein¹, ¹Vanderbilt University, Nashville, TN, ²Medicine, Vanderbilt University, Nashville, TN, ³Biostatistics, Vanderbilt University, Nashville, TN, ⁴Emory University, Atlanta, GA
Background/Purpose: Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL…
Abstract Number: 79 • 2014 ACR/ARHP Annual Meeting
PECAM-1 GENE Polymorphisms and Soluble PECAM-1 LEVEL in Rheumatoid Arthritis and Systemic LUPUS Erythematosus Patients Is There a Link with Clinical Atherosclerotic Events?
Omer Nuri Pamuk¹, Hilmi Tozkir², Mehmet Sevki Uyanik³, Hakan Gurkan⁴, Julide Duymaz⁴, Salim Donmez⁵, Metin Yazar² and Gulsum Pamuk³, ¹Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, ²Genetics, Trakya University Medical Faculty, EDIRNE, Turkey, ³Hematology, Trakya University Medical Faculty, Edirne, Turkey, ⁴Trakya University Medical Faculty, EDIRNE, Turkey, ⁵Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey
Background/Purpose: Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) which plays a role in the transmigration of leucocytes into tissues is a member of the immunoglobulin (Ig) superfamily.…
Abstract Number: 1218 • 2014 ACR/ARHP Annual Meeting
The Reduction of Serum Uric Acid Level Might Prevent Atherosclerosis in Mice
Yoshitaka Kimura^1,2, Tamiko Yanagida³, Akiko Onda⁴, Hajime Kono², Maki Takayama², Kurumi Asako², Akiko Okamoto², Hirotoshi Kikuchi² and Toshihiro Nanki⁵, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Depart ment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁵Department of Clinical Research Medicine, Teikyo University, Tokyo, Japan
Background/Purpose: Excess amount of uric acid in human body causes acute inflammation, gout. In addition, uric acid is identified as a danger signal and is…
Abstract Number: 1182 • 2014 ACR/ARHP Annual Meeting
Do Patients with Active RA Also Have Inflamed Atherosclerotic Plaques on PET-MRI?
Sarah Skeoch¹, Heather Williams², Penny Cristanacce³, Jacqueline James⁴, Paul Hockings⁵, Yvonne Alexander⁶, John Waterton^7,8 and Ian N. Bruce⁹, ¹University of Manchester, Manchester, United Kingdom, ²Centre for Imaging Sciences Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, ³Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, ⁴Department of Nuclear Medicine, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁵MedTech West, Chalmers University of Technology, Gottenburg, Sweden, ⁶Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁷R&D Personalised Healthcare & Biomarkers, Astra Zeneca, MACCLESFIELD, United Kingdom, ⁸Bioimaging Institute, University of Manchester, Manchester, United Kingdom, ⁹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Inflammation plays a key role in the progression and destabilisation of atherosclerotic plaque in the general population. In RA, inflammation is thought to accelerate…
Abstract Number: 840 • 2014 ACR/ARHP Annual Meeting
Vascular Calcifications on Hand and Wrist Radiographs Are Associated with Cardiovascular Risk Factors, Antigen-Specific Anti-Citrullinated Protein Antibodies, and Mortality in Rheumatoid Arthritis
E. Blair Solow¹, Fang Yu², Geoffrey M. Thiele³, Jeremy Sokolove^4,5, William H. Robinson^6,7, Zachary M. Pruhs³, Kaleb Michaud^8,9, Alan R. Erickson⁹, Harlan Sayles⁹, Gail S. Kerr¹⁰, Angelo L. Gaffo¹¹, Liron Caplan¹², Lisa A. Davis¹³, Grant W. Cannon¹⁴, Andreas M. Reimold¹⁵, Joshua Baker¹⁶, Pascale Schwab^17,18, Daniel Anderson⁹ and Ted R. Mikuls⁹, ¹Internal Medicine, Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX, ²University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁴VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ⁵Stanford University School of Medicine, Stanford, CA, ⁶VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁷Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁸National Data Bank for Rheumatic Diseases, Wichita, KS, ⁹Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ¹⁰Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, ¹¹Medicine, Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, AL, ¹²Div of Rheumatology, Denver VAMC and Univ of Colorado School of Medicine, Aurora, CO, ¹³Denver VAMC and Univ of Colorado School of Medicine, Aurora, CO, ¹⁴Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ¹⁵Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, ¹⁶Medicine/Rheumatology, University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA, ¹⁷Department of Internal Medicine, Division of Rheumatology, Portland VA Medical Center, Portland, OR, ¹⁸Internal Medicine, Division of Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR
Background/Purpose: Rheumatoid arthritis (RA) is associated with increased mortality due to cardiovascular disease (CVD). Select antigen-specific anti-citrullinated protein antibodies (ACPA) are associated with atherosclerotic…
Abstract Number: 829 • 2014 ACR/ARHP Annual Meeting
Asymptomatic Deposit of Monosodium Urate Crystals Associates to a More Severe Coronary Calcification in Hyperuricemic Patients with Acute Coronary Syndrome
Mariano Andrés¹, María Amparo Quintanilla², Francisca Sivera¹, Paloma Vela^3,4 and Juan Miguel Ruiz-Nodar⁵, ¹Sección de Reumatología, Hospital General Universitario de Elda, Alicante, Spain, ²Sección de Cardiología, Hospital General Universitario de Elda, Alicante, Spain, ³Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain, ⁴Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ⁵Servicio de Cardiología, Hospital General Universitario de Alicante, Alicante, Spain
Background/Purpose: Increased cardiovascular (CV) risk in gout relates to crystal-driven inflammation. Monosodium urate (MSU) crystals are found in ~25% of patients with asymptomatic hyperuricemia (AH)…
Abstract Number: 799 • 2014 ACR/ARHP Annual Meeting
Peripheral Arterial Disease in Patients with Giant Cell Arteritis: A Systematic Review and Meta-Analysis
Patompong Ungprasert¹, Praveen Ratanasrimetha², Charat Thongprayoon³, Wisit Cheungpasitporn³ and Promporn Suksaranjit⁴, ¹Department of Internal medicine, Bassett medical center, Cooperstown, NY, ²Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ³Department of Medicine, Mayo clinic, Rochester, MN, ⁴Department of Cardiology, University of Utah School of Medicine, Salt Lake City, UT
Peripheral Arterial Disease in Patients with Giant Cell Arteritis: A Systematic Review and Meta-analysisBackground/Purpose: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus…
Abstract Number: 726 • 2014 ACR/ARHP Annual Meeting
Risk of Ischemic Stroke in Patients with Systemic Sclerosis: A Systematic Review and Meta-Analysis
Patompong Ungprasert¹, Praveen Ratanasrimetha², Charat Thongprayoon³, Wisit Cheungpasitporn³ and Promporn Suksaranjit⁴, ¹Department of Internal medicine, Bassett medical center, Cooperstown, NY, ²Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ³Department of Medicine, Mayo clinic, Rochester, MN, ⁴Department of Cardiology, University of Utah School of Medicine, Salt Lake City, UT
Risk of Ischemic Stroke in Patients with Systemic Sclerosis: A Systematic Review and Meta-analysisBackground/Purpose: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus…
Abstract Number: 2637 • 2014 ACR/ARHP Annual Meeting
Assessment of Plaque Thickness and Area in Patients with SLE As Measures of Atherosclerosis – Associations with Disease Activity
Sara Croca¹, Maura Griffin², David Isenberg³, Andrew Nicolaides⁴ and Anisur Rahman⁵, ¹5 University Street, University College London, London, United Kingdom, ²Vascular Screening and Diagnostic Centre, London, United Kingdom, ³Centre for Rheumatology Research, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, ⁴St Georges London/Nicosia Medical School, University of Nicosia, Cyprus, Nicosia, Cyprus, ⁵Centre for Rheumatology Research, University College London, London, United Kingdom
Background/Purpose SLE is an independent risk factor for cardiovascular disease (CVD). Traditional risk stratification tools underestimate CVD risk in patients with SLE. Previous vascular ultrasound…
Abstract Number: 628 • 2014 ACR/ARHP Annual Meeting
The Predictive Value of Cardiovascular and Metabolic Biomarkers for Progression of Atherosclerosis in Psoriatic Disease
Lihi Eder¹, Fatima Abji¹, Cheryl Rosen², Vinod Chandran¹ and Dafna D. Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose The pathophysiologic mechanisms underlying the accelerated atherosclerosis in patients with psoriatic disease (PsD) are unknown. We aimed to investigate candidate pathways involved in this…
Abstract Number: 2617 • 2014 ACR/ARHP Annual Meeting
No Evidence of Accelerated Atheromatosis, Increased Arterial Stiffness or Hypertrophy in Ankylosing Spondylitis: A Systematic Case-Control Study
Aikaterini I. Arida¹, Maria Konsta¹, Alexios Iliopoulos², Maria Tektonidou³, George Konstantonis¹, George D. Kitas⁴, Athanasios D. Protogerou¹ and Petros P. Sfikakis¹, ¹First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ²Department of Rheumatology, Veterans Administration Hospital, Athens, Greece, ³First Department of Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ⁴The Dudley Group of Hospitals NHS Foundation Trust, Dudley, and Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose: Chronic inflammatory arthritis is associated with increased cardiovascular disease (CVD) risk. The mechanisms behind this link include chronic inflammation, comorbidities and disease-related drugs. CV…

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