ACR Meeting Abstracts

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Abstracts tagged "Atherosclerosis"

  • Abstract Number: 257 • 2015 ACR/ARHP Annual Meeting

    Investigation of the Arterial Stiffness and Associated Factors in Patients with Familial Mediterranean Fever

    Mustafa Cakar1, Muharrem Akhan2, Tolga Doğan2, Gurhan Taskin3, Kadir Ozturk4, Muhammet Cinar1, Erol Arslan2 and Sedat Yılmaz1, 1Rheumatology, Gulhane Medical Faculty, Ankara, Turkey, 2Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey, 3Internal Medicine Intensive Care, Gulhane Medical Faculty, Ankara, Turkey, 4Gastroenterology, Gulhane Medical Faculty, Ankara, Turkey

    Background/Purpose: Arterial stiffness represents the viscoelastic properties of the vessel wall. It occurs as a result of known atherosclerotic risk factors such as hypertension, diabetes…
  • Abstract Number: 1608 • 2015 ACR/ARHP Annual Meeting

    Protective Role of the Vitamin D Receptor Apai (rs7975232) Polymorphism Against Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis from Northern Spain

    Raquel López-Mejías1, Fernanda Genre1, Sara Remuzgo-Martínez1, Gema Robledo2, Begoña Ubilla1, Veronica Mijares1, Javier Llorca3, Montserrat Robustillo-Villarino4, Alfonso Corrales1, Carlos González-Juanatey5, Jose A. Miranda-Filloy6, Trinitario Pina7, Ricardo Blanco7, Esther Vicente8, Juan José Alegre9, Cesar Magro10, Enrique Raya11, Beatriz Tejera12, Marco A Ramírez Huaranga13, Ivan Ferraz-Amaro12, Santos Castañeda14, Javier Martín2 and Miguel A. Gonzalez-Gay1,15, 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, 2Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, 3Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, 4Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, 5Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, 6Rheumatology Division, Hospital Lucus Augusti, Lugo, Spain, 7Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 8Rheumatology Department, Hospital Universitario la Princesa, IIS-Princesa, Madrid, Spain, 9Rheumatology, Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, 10Rheumatology Department, Hospital Clínico San Cecilio, Granada, Spain, 11Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, 12Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 13Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, 14Rheumatology, H.U. La Princesa, Madrid, Spain, 15Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: Several vitamin D receptor (VDR) polymorphisms have been associated with cardiovascular (CV) and autoimmune diseases. Carotid plaques are surrogate markers of severe atherosclerotic disease.…
  • Abstract Number: 840 • 2014 ACR/ARHP Annual Meeting

    Vascular Calcifications on Hand and Wrist Radiographs Are Associated with Cardiovascular Risk Factors, Antigen-Specific Anti-Citrullinated Protein Antibodies, and Mortality in Rheumatoid Arthritis

    E. Blair Solow1, Fang Yu2, Geoffrey M. Thiele3, Jeremy Sokolove4,5, William H. Robinson6,7, Zachary M. Pruhs3, Kaleb Michaud8,9, Alan R. Erickson9, Harlan Sayles9, Gail S. Kerr10, Angelo L. Gaffo11, Liron Caplan12, Lisa A. Davis13, Grant W. Cannon14, Andreas M. Reimold15, Joshua Baker16, Pascale Schwab17,18, Daniel Anderson9 and Ted R. Mikuls9, 1Internal Medicine, Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX, 2University of Nebraska Medical Center, Omaha, NE, 3Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 4VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 5Stanford University School of Medicine, Stanford, CA, 6VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 7Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 8National Data Bank for Rheumatic Diseases, Wichita, KS, 9Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 10Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, 11Medicine, Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, AL, 12Div of Rheumatology, Denver VAMC and Univ of Colorado School of Medicine, Aurora, CO, 13Denver VAMC and Univ of Colorado School of Medicine, Aurora, CO, 14Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 15Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, 16Medicine/Rheumatology, University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA, 17Department of Internal Medicine, Division of Rheumatology, Portland VA Medical Center, Portland, OR, 18Internal Medicine, Division of Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR

    Background/Purpose:   Rheumatoid arthritis (RA) is associated with increased mortality due to cardiovascular disease (CVD).  Select antigen-specific anti-citrullinated protein antibodies (ACPA) are associated with atherosclerotic…
  • Abstract Number: 829 • 2014 ACR/ARHP Annual Meeting

    Asymptomatic Deposit of Monosodium Urate Crystals Associates to a More Severe Coronary Calcification in Hyperuricemic Patients with Acute Coronary Syndrome

    Mariano Andrés1, María Amparo Quintanilla2, Francisca Sivera1, Paloma Vela3,4 and Juan Miguel Ruiz-Nodar5, 1Sección de Reumatología, Hospital General Universitario de Elda, Alicante, Spain, 2Sección de Cardiología, Hospital General Universitario de Elda, Alicante, Spain, 3Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain, 4Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, 5Servicio de Cardiología, Hospital General Universitario de Alicante, Alicante, Spain

    Background/Purpose: Increased cardiovascular (CV) risk in gout relates to crystal-driven inflammation. Monosodium urate (MSU) crystals are found in ~25% of patients with asymptomatic hyperuricemia (AH)…
  • Abstract Number: 799 • 2014 ACR/ARHP Annual Meeting

    Peripheral Arterial Disease in Patients with Giant Cell Arteritis: A Systematic Review and Meta-Analysis

    Patompong Ungprasert1, Praveen Ratanasrimetha2, Charat Thongprayoon3, Wisit Cheungpasitporn3 and Promporn Suksaranjit4, 1Department of Internal medicine, Bassett medical center, Cooperstown, NY, 2Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, 3Department of Medicine, Mayo clinic, Rochester, MN, 4Department of Cardiology, University of Utah School of Medicine, Salt Lake City, UT

    Peripheral Arterial Disease in Patients with Giant Cell Arteritis: A Systematic Review and Meta-analysisBackground/Purpose: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus…
  • Abstract Number: 726 • 2014 ACR/ARHP Annual Meeting

    Risk of Ischemic Stroke in Patients with Systemic Sclerosis: A Systematic Review and Meta-Analysis

    Patompong Ungprasert1, Praveen Ratanasrimetha2, Charat Thongprayoon3, Wisit Cheungpasitporn3 and Promporn Suksaranjit4, 1Department of Internal medicine, Bassett medical center, Cooperstown, NY, 2Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, 3Department of Medicine, Mayo clinic, Rochester, MN, 4Department of Cardiology, University of Utah School of Medicine, Salt Lake City, UT

    Risk of Ischemic Stroke in Patients with Systemic Sclerosis: A Systematic Review and Meta-analysisBackground/Purpose: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus…
  • Abstract Number: 2637 • 2014 ACR/ARHP Annual Meeting

    Assessment of Plaque Thickness and Area in Patients with SLE As Measures of Atherosclerosis – Associations with Disease Activity

    Sara Croca1, Maura Griffin2, David Isenberg3, Andrew Nicolaides4 and Anisur Rahman5, 15 University Street, University College London, London, United Kingdom, 2Vascular Screening and Diagnostic Centre, London, United Kingdom, 3Centre for Rheumatology Research, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, 4St Georges London/Nicosia Medical School, University of Nicosia, Cyprus, Nicosia, Cyprus, 5Centre for Rheumatology Research, University College London, London, United Kingdom

    Background/Purpose SLE is an independent risk factor for cardiovascular disease (CVD). Traditional risk stratification tools underestimate CVD risk in patients with SLE. Previous vascular ultrasound…
  • Abstract Number: 628 • 2014 ACR/ARHP Annual Meeting

    The Predictive Value of Cardiovascular and Metabolic Biomarkers for Progression of Atherosclerosis in Psoriatic Disease

    Lihi Eder1, Fatima Abji1, Cheryl Rosen2, Vinod Chandran1 and Dafna D. Gladman1, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose The pathophysiologic mechanisms underlying the accelerated atherosclerosis in patients with psoriatic disease (PsD) are unknown. We aimed to investigate candidate pathways involved in this…
  • Abstract Number: 2617 • 2014 ACR/ARHP Annual Meeting

    No Evidence of Accelerated Atheromatosis, Increased Arterial Stiffness or Hypertrophy in Ankylosing Spondylitis: A Systematic Case-Control Study

    Aikaterini I. Arida1, Maria Konsta1, Alexios Iliopoulos2, Maria Tektonidou3, George Konstantonis1, George D. Kitas4, Athanasios D. Protogerou1 and Petros P. Sfikakis1, 1First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, 2Department of Rheumatology, Veterans Administration Hospital, Athens, Greece, 3First Department of Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, 4The Dudley Group of Hospitals NHS Foundation Trust, Dudley, and Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom

    Background/Purpose: Chronic inflammatory arthritis is associated with increased cardiovascular disease (CVD) risk. The mechanisms behind this link include chronic inflammation, comorbidities and disease-related drugs. CV…
  • Abstract Number: 627 • 2014 ACR/ARHP Annual Meeting

    HLA Markers for Disease Severity Are Associated with a Higher Burden of Atherosclerosis in Patients with Psoriatic Disease

    Lihi Eder1, Fatima Abji1, Cheryl Rosen2, Vinod Chandran1 and Dafna D. Gladman1, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose Recent evidence supports the link between the extent of inflammation and cardiovascular risk in patients with psoriatic disease (PsD). We aimed to investigate the…
  • Abstract Number: 2452 • 2014 ACR/ARHP Annual Meeting

    Protective Effect of the IL33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis

    Raquel López-Mejías1, Fernanda Genre1, Mercedes García-Bermúdez2, Alfonso Corrales1, Carlos González-Juanatey3, Begoña Ubilla1, J. Llorca4, Encarnación Amigo5, Jose A. Miranda-Filloy6, Trinitario Pina Murcia1, Ricardo Blanco7, Santos Castañeda8, Javier Martin9 and Miguel A González-Gay1, 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, 2Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, 3Hospital Universitario Lucus Augusti. Cardiology Division, Lugo, Spain, 4Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, 5Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, 6Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, 7Hospital Marques de Valdecilla, Santander, Spain, 8Rheumatology, Hospital Universitario de La Princesa, IISP, Madrid, Spain, 9Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain

    Background/Purpose: Rheumatoid arthritis (RA) is a complex inflammatory disease characterized by chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. Interleukin 33 (IL-33) is a…
  • Abstract Number: 542 • 2014 ACR/ARHP Annual Meeting

    Predictors for Cardiovascular Events in Patients with Psoriatic Arthritis – a Cohort Study

    Lihi Eder1, Arane Thavaneswaran1, Vinod Chandran1, Hua Shen2, Richard J. Cook2 and Dafna D. Gladman1, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada

    Background/Purpose The prevalence of cardiovascular (CV) morbidity is increased in patients with psoriatic arthritis (PsA). CV risk is only partially explained by traditional CV risk…
  • Abstract Number: 1978 • 2014 ACR/ARHP Annual Meeting

    Role of Monocytes Subsets in the Pathology of Rheumatoid Arthritis: Involvement in Endothelial Dysfunction and Proinflammatory Profile

    Chary Lopez-Pedrera, Patricia Ruiz-Limon, Carlos Perez-Sanchez, Rosario Carretero, Yolanda Jiménez Gómez, Ángeles Aguirre Zamorano, Jerusalem calvo-Gutierrez, Eduardo Collantes-Estevez, Alejandro Escudero-Contreras and Nuria Barbarroja, Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain

    Background/Purpose Different frequency of monocytes subsets has been reported in rheumatoid arthritis (RA).Human monocytes are divided into three main subpopulations according to expression of the…
  • Abstract Number: 489 • 2014 ACR/ARHP Annual Meeting

    Rosuvastatin Improves Arterial Stiffness in Patients with Inflammatory Joint Diseases

    Eirik Ikdahl1, Silvia Rollefstad1, Jonny Hisdal2, Inge C. Olsen3, Ingar Holme4, Terje R. Pedersen5, Tore Kvien6 and Anne Grete Semb1, 1Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Section of Vascular Investigations, Oslo University Hospital Aker, Oslo, Norway, 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Department of biostatistics, epidemiology and health economics, Oslo University Hospital, Oslo, Norway, 5Faculty of Medicine, University of Oslo, Oslo, Norway, 6Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose Arterial stiffness, as pulse wave velocity (PWV) and augmentation index (AIx) has emerged as early risk markers of cardiovascular disease (CVD) in patients with…
  • Abstract Number: 1913 • 2014 ACR/ARHP Annual Meeting

    Rosuvastatin Induced Carotid Plaque Regression in Patients with Inflammatory Joint Diseases

    Silvia Rollefstad1, Eirik Ikdahl1, Jonny Hisdal2, Inge C. Olsen3, Ingar Holme4, Hilde Berner Hammer5, Knut T. Smerud6, G Kitas7, Terje R. Pedersen8, Tore K. Kvien9 and Anne Grete Semb1, 1Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Section of Vascular Investigations, Uslo University Hospital-Aker, Oslo, Norway, 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Department of biostatistics, epidemiology and health economics, Oslo University Hospital, Oslo, Norway, 5Postboks 23 Vinderen, Diakonhjemmet Hospital, Oslo, Norway, 6Smerud Medical Research International AS, Oslo, Norway, 7The Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, 8Faculty of Medicine, University of Oslo, Oslo, Norway, 9PsAID taskforce, EULAR, Zurich, Switzerland

    Background/Purpose Patients with rheumatoid arthritis (RA) and carotid artery plaques (CP) have increased risk of acute coronary syndromes. Statin treatment with low density lipoprotein cholesterol…
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