ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1608

Protective Role of the Vitamin D Receptor Apai (rs7975232) Polymorphism Against Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis from Northern Spain

Raquel López-Mejías1, Fernanda Genre1, Sara Remuzgo-Martínez1, Gema Robledo2, Begoña Ubilla1, Veronica Mijares1, Javier Llorca3, Montserrat Robustillo-Villarino4, Alfonso Corrales1, Carlos González-Juanatey5, Jose A. Miranda-Filloy6, Trinitario Pina7, Ricardo Blanco7, Esther Vicente8, Juan José Alegre9, Cesar Magro10, Enrique Raya11, Beatriz Tejera12, Marco A Ramírez Huaranga13, Ivan Ferraz-Amaro12, Santos Castañeda14, Javier Martín2 and Miguel A. Gonzalez-Gay1,15, 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, 2Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, 3Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, 4Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, 5Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, 6Rheumatology Division, Hospital Lucus Augusti, Lugo, Spain, 7Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 8Rheumatology Department, Hospital Universitario la Princesa, IIS-Princesa, Madrid, Spain, 9Rheumatology, Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, 10Rheumatology Department, Hospital Clínico San Cecilio, Granada, Spain, 11Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, 12Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 13Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, 14Rheumatology, H.U. La Princesa, Madrid, Spain, 15Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: , , ,

Session Information

Date: Monday, November 9, 2015

Title: Rheumatoid Arthritis - Human Etiology and Pathogenesis Poster II

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Several vitamin D receptor (VDR) polymorphisms have been associated with cardiovascular (CV) and autoimmune diseases. Carotid plaques are surrogate markers of severe atherosclerotic disease. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease associated with an increased risk of CV death, mainly due to a process of accelerated atherogenesis. Patients with RA have increased frequency of carotid plaques when compared with the general population. The aim of the present study was to determine the potential association of TaqI (rs731236), ApaI (rs7975232), BsmI (rs1544410) and Fokl (rs2228570) VDR polymorphisms with carotid plaques in patients with RA.

Methods: A total of 591 RA patients from Northern Spain who met the 1987 American College of Rheumatology (ACR) and the 2010 ACR/European League Against Rheumatism criteria for RA were genotyped for rs731236, rs7975232, rs1544410 and rs2228570 VDR polymorphisms by TaqMan genotyping assays. In addition, the presence of carotid plaques was evaluated in these patients by carotid ultrasound technology.

Results: RA patients carrying VDR rs7975232 CC genotype had a decreased risk of carotid plaques, after adjustment for sex, age and traditional CV risk factors (p=0.014, OR=0.46, 95% CI: [0.24-0.85]). This effect was also found in patients who carried the mutant VDR rs7975232 C allele, after adjustment for potential confounder factors (p=0.018, OR=0.70, 95% CI: [0.52-0.94]). Although no association between rs731236, rs1544410 and rs2228570 VDR polymorphisms and presence of carotid plaques was observed, RA patients who carried the GATG haplotype (which harbors the A allele of rs7975232) had an increased risk of carotid plaques, after adjustment for sex, age and traditional CV risk factors (p=0.003, OR=2.20, 95% CI: [1.30-3.73]).

Conclusion: Our results show a protective effect of the VDR rs7975232 allele C on the risk of severe atherosclerosis in patients with RA.

This study was supported by European Union FEDER funds and “Fondo de Investigación Sanitaria” (grant PI12/00060) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain). It was also partially supported by RETICS Programs RD12/0009 (RIER) from ‘Instituto de Salud Carlos III’ (ISCIII, Health Ministry, Spain), and in part by grants from the European IMI BTCure Program. RLM is a recipient of a Sara Borrell postdoctoral fellowship from the Instituto Carlos III de Salud at the Spanish Ministry of Health (Spain) (CD12/00425). FG and BU are supported by funds from the RETICS Program (RIER) (RD12/0009/0013).

Disclosure: R. López-Mejías, None; F. Genre, None; S. Remuzgo-Martínez, None; G. Robledo, None; B. Ubilla, None; V. Mijares, None; J. Llorca, None; M. Robustillo-Villarino, None; A. Corrales, None; C. González-Juanatey, None; J. A. Miranda-Filloy, None; T. Pina, None; R. Blanco, None; E. Vicente, None; J. J. Alegre, None; C. Magro, None; E. Raya, None; B. Tejera, None; M. A. Ramírez Huaranga, None; I. Ferraz-Amaro, None; S. Castañeda, None; J. Martín, None; M. A. Gonzalez-Gay, None.

To cite this abstract in AMA style:

López-Mejías R, Genre F, Remuzgo-Martínez S, Robledo G, Ubilla B, Mijares V, Llorca J, Robustillo-Villarino M, Corrales A, González-Juanatey C, Miranda-Filloy JA, Pina T, Blanco R, Vicente E, Alegre JJ, Magro C, Raya E, Tejera B, Ramírez Huaranga MA, Ferraz-Amaro I, Castañeda S, Martín J, Gonzalez-Gay MA. Protective Role of the Vitamin D Receptor Apai (rs7975232) Polymorphism Against Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis from Northern Spain [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/protective-role-of-the-vitamin-d-receptor-apai-rs7975232-polymorphism-against-subclinical-atherosclerosis-in-patients-with-rheumatoid-arthritis-from-northern-spain/. Accessed .

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