Abstracts tagged "Arthritis"

Abstract Number: 2902 • 2017 ACR/ARHP Annual Meeting
Inflammatory Arthritis Due to Immune Checkpoint Inhibitors: A Persistent Problem Requiring Immunosuppression
Laura Cappelli¹, Clifton O. Bingham III² and Ami A. Shah³, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University, Baltimore, MD, ³Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Immune checkpoint inhibitors (ICIs) have emerged as an important treatment for advanced malignancies. ICIs are a form of immunotherapy which block negative co-stimulation of…
Abstract Number: 314 • 2017 ACR/ARHP Annual Meeting
Effects of Exercise on Anxiety in Adults with Arthritis: A Systematic Review with Meta-Analysis
George Kelley¹, Kristi Kelley¹ and Leigh F. Callahan², ¹Biostatistics, West Virginia University, Morgantown, WV, ²Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Previous randomized controlled trials have led to conflicting findings regarding the effects of exercise on anxiety in adults with arthritis and other rheumatic diseases…
Abstract Number: 1742 • 2017 ACR/ARHP Annual Meeting
Involvement of T Helper 17 Cells in Inflammatory Arthritis Depends on the Host Intestinal Microbiota
Heather Evans-Marin¹, Rebecca Rogier², Jose U. Scher³, Debbie M. Roeleveld², Marije I. Koenders⁴ and Shahla Abdollahi-Roodsaz^5,6, ¹Division of Rheumatology, New York University School of Medicine, New York, NY, ²Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ³New York University School of Medicine, New York, NY, ⁴Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁵Department of Medicine, Division of Rheumatoogy, New York University School of Medicine, New York, NY, ⁶Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose: The intestinal microbiota has been associated with psoriatic and rheumatoid arthritis. One of the major effects of microbiota is the induction of mucosal T…
Abstract Number: 378 • 2017 ACR/ARHP Annual Meeting
Musculoskeletal Features in Copa Syndrome
William B. Lapin¹, Monica Marcus², Andrea A. Ramirez³, Marietta M. de Guzman³ and Levi B. Watkin^4,5, ¹Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ²Pediatric Immunology, Allergy and Rheumatology, Texas Children's Hospital, Houston, TX, ³Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ⁴Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, ⁵Texas Children's Hospital, Center for Human Immunobiology, Houston, TX
Background/Purpose: COPA syndrome is a newly discovered primary immunodeficiency resulting in immune dysregulation showing autosomal dominant inheritance with incomplete penetrance. Its name is derived from…
Abstract Number: 1865 • 2017 ACR/ARHP Annual Meeting
Novel Approach to Arthritis Surveillance Suggests a Much Higher Prevalence of Arthritis Among US Adults Than Previous Estimate
S. Reza Jafarzadeh and David T. Felson, Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Current national estimates of arthritis prevalence in the United States rely on a single survey question about doctor-diagnosed arthritis from the National Health Interview…
Abstract Number: 379 • 2017 ACR/ARHP Annual Meeting
H Syndrome: Five New Cases from the United States with Novel Features and Responses to Therapy
Jessica Bloom¹, Clara Lin², Lisa F. Imundo³, Stephen Guthery⁴, Shelly Stepenaskie⁵, Csaba Galambos⁶, Amy Lowichik⁷ and John F. Bohnsack⁸, ¹Pediatrics, Children's Hospital Colorado, Aurora, CO, ²Pediatric Rheumatology, Children's Hospital Colorado, Aurora, CO, ³Pediatrics, Columbia University Medical Center, New York, NY, ⁴Department of Pediatrics,, University of Utah, Salt Lake City, UT, ⁵Pathology and Dermatology, University of New Mexico, Albuquerque, NM, ⁶Pathology, Children's Hospital Colorado, Aurora, CO, ⁷Pathology, University of Utah, Salt Lake City, UT, ⁸Division of Allergy, Immunology and Pediatric Rheumatology, University of Utah, Salt Lake City, UT
Background/Purpose: H Syndrome is an autosomal recessive disorder characterized by cutaneous hyperpigmentation, hypertrichosis, and induration with numerous systemic manifestations. The syndrome is caused by mutations…
Abstract Number: 1913 • 2017 ACR/ARHP Annual Meeting
Inter-Omic Analysis Reveals Functional Relationship between Diverse Gut Microbiota and Dysregulated Host Immune Response in HLA-B27-Mediated Experimental Spondyloarthritis
Tejpal Gill¹, Stephen R. Brooks², Mark Asquith³, James T. Rosenbaum⁴ and Robert Colbert⁵, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Biodata Mining and Discovery Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, ³Oregon Health & Science University, Portland, OR, ⁴Ophthalmology, Oregon Health & Science University and Legacy Devers Eye Institute, Portland, OR, ⁵NIAMS/NIH, Bethesda, MD
Background/Purpose: HLA-B27 has been hypothesized to alter gut microbiota and host-microbe interactions to promote spondyloarthritis (SpA). In HLA-B27 transgenic (HLA-B27 Tg) rats with experimental SpA,…
Abstract Number: 380 • 2017 ACR/ARHP Annual Meeting
Treatment Outcomes of Down Syndrome Arthropathy
Jordan T. Jones¹, Leena Danawala², Nasreen Talib³ and Mara L Becker⁴, ¹Rheumatology Division, Children's Mercy Kansas City, Kansas City, MO, ²University of Missouri-Kansas City School of Medicine, Kansas City, MO, ³General Pediatrics, Children's Mercy Kansas City, Kansas City, MO, ⁴Rheumatology, Children's Mercy Kansas City, Kansas City, MO
Background/Purpose: Crude prevalence estimates indicate Down syndrome arthropathy (DA) is 3-8 times more common than juvenile idiopathic arthritis (JIA), however, DA is still largely under…
Abstract Number: 1994 • 2017 ACR/ARHP Annual Meeting
Erosion Depth Predicts Erosion Progression in Patients with Early RA: A Longitudinal Analysis Using HR-pQCT
Jiang YUE¹, James F Griffith², Fan XIAO³, Jiankun XU⁴, Ling Qin⁵ and Lai-Shan Tam⁶, ¹Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, HONGKONG, Hong Kong, ³Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁴Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁵Bone Quality and Health Centre of the Department of Orthopaedics and Traumatology, The Prince of Wales Hospital, The Chinese University of Hong Kong, hongkong, Hong Kong, ⁶Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Background/Purpose: To ascertain the predictors of erosion progression in patients with early RA using high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods: In this prospective study,…
Abstract Number: 381 • 2017 ACR/ARHP Annual Meeting
Down’s Arthritis (DA) – Clinical and Radiological Features of Arthritis in Children with Trisomy 21
Charlene Foley, Emma Jane Mac Dermott and Orla Killeen, National Centre for Paediatric Rheumatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland
Background/Purpose: Down's Arthritis (DA) was first reported in the literature in 1984. Crude estimates suggest higher incidence and prevalence rates of DA compared with Juvenile…
Abstract Number: 2069 • 2017 ACR/ARHP Annual Meeting
Gout Is More Frequent in Sickle Cell Disease Than the General Population
Richard Akintayo¹, Olufemi Adelowo², Adindu Chijioke¹, Timothy Olanrewaju¹, Kehinde Olufemi-Aworinde³ and Foluke Akintayo⁴, ¹Internal Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria, ²Arthrimed Specialist Clinic:The Arthritis Centre, Lagos, Nigeria, ³Haematology, Bowen University Teaching Hospital, Ogbomosho, Nigeria, ⁴Family Medicine, Ladoke Akintola University of Technology Teaching Hospital, Ogbomosho, Nigeria
Background/Purpose: Despite the well known risk of hyperuricaemia in Sickle Cell Disease (SCD), it has not been determined if these patients are more prone to…
Abstract Number: 143 • 2017 Pediatric Rheumatology Symposium
Influence of Age and Sex on Collagen-Induced Arthritis
Tracy Wilson-Gerwing¹, Arash Panahifar², David M.L. Cooper² and Alan Rosenberg¹, ¹Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ²Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada
Background/Purpose: Age and sex differences are found in certain subsets of juvenile idiopathic arthritis (JIA). Collagen Induced Arthritis (CIA) in rodents has utility in assessing…
Abstract Number: 146 • 2017 Pediatric Rheumatology Symposium
Age-Related Differences in Neuronal High Mobility Group Box-1 and Resolvin D1 Receptors in Collagen-Induced Arthritis
Tracy Wilson-Gerwing and Alan Rosenberg, Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada
Background/Purpose: More thorough understanding of age-related molecular interactions that drive inflammation and inflammatory pain is required to help guide evidenced-based, age appropriate treatment strategies that…
Abstract Number: 153 • 2017 Pediatric Rheumatology Symposium
Training pediatric rheumatology fellows intra-articular injection techniques and skills using a cadaver based musculoskeletal curriculum
Baruch Goldberg¹, Amanda Brown² and Monica Marcus³, ¹Pediatric Rheumatology, Texas Children's Hospital, Houston, TX, ²Allergy, Immunology and Rheumatology, Texas Children's Hospital, houston, TX, ³Pediatric Immunology, Allergy and Rheumatology, Texas Children's Hospital, Houston, TX
Background/Purpose: Intra-articular injections are important to treat children with arthritis. Practice differences, comfort levels, and reimbursement can decrease fellow exposure to this skill. The purpose…
Abstract Number: 144 • 2017 Pediatric Rheumatology Symposium
Linear Discriminant Analysis of Cultured Fibroblast-like Synoviocytes Identifies 6 Candidate Genes Which Predict Extended Course in Juvenile Idiopathic Arthritis
AnneMarie Brescia¹, Megan Simonds², Suzanne M. McCahan³, Timothy Bunnell³, Kathleen E. Sullivan⁴ and Carlos D. Rosé⁵, ¹Pediatric Rheumatology, Nemours A.I. duPont Hospital for Children, Wilmington, DE, ²Nemours, Nemours Biomedical Research, Wilmington, DE, ³Nemours Biomedical Research, Wilmington, DE, ⁴Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁵Pediatric Rheumatology, Nemours/Thomas Jefferson University, Wilmington, DE
Background/Purpose: The goal of this project is the identification of informative synovial biomarkers to predict which children with oligoarticular juvenile idiopathic arthritis (JIA) will have…

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