Abstracts tagged "Apoptosis"

Abstract Number: 418 • 2012 ACR/ARHP Annual Meeting
Immediate Early Response Gene X-1 Is Over-Expressed and Regulates Apoptosis and Cytokine Production in Rheumatoid Arthritis Synovial Fibroblasts
Akio Morinobu¹, Masaaki Fujita², Shino Tanaka³, Jun Saegusa⁴ and Shunichi Kumagai⁵, ¹Department of clinical pathology and immunology, Kobe university graduate school of medicine, Kobe 650-0017, Japan, ²Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Clinical Pathology and Immunology, Rheumatology and Clinical Immunology, Kobe, Japan, ⁴Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Center of rheumatic diseases, Shinko hospital, Kobe, Japan
Background/Purpose: Histone deacetylase inhibitors (HDACi) are potential therapeutic drugs for the treatment of rheumatoid arthritis (RA). We found that an HDACi up-regulates the gene expression…
Abstract Number: 429 • 2012 ACR/ARHP Annual Meeting
The Significance of the Apoptosis Level and the Apoptosis Related Signal Proteins of CD4⁺t�ACD4⁺Foxp3⁺t Cell in Patients with Rheumatoid Arthritis
Ning Li¹, Tianrui Ma², Jie Han¹, Jieru Zhou¹ and Songguo Zheng³, ¹Rheumatology, Shanghai East Hospital, Shanghai, China, ²Rheumatology, Ningbo Pediatric Hospital, Ningbo, China, ³Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA
Background/Purpose: To investigate the apoptosis of CD4+T cell and Tregs in the pathogenesis and disease activity of rheumatoid arthritis patients. Methods: Isolated lymphocytes from human…
Abstract Number: 2679 • 2012 ACR/ARHP Annual Meeting
Loss of Caspase 8 in Dendritic Cells Induces a Systemic Lupus Erythematosus-Like Disease That Is Independent of the Necroptosome
Carla M. Cuda¹, Alexander V. Misharin², Rana Saber², G. Kenneth Haines III³, Jack Hutcheson⁴, Chandra Mohan⁵ and Harris R. Perlman⁶, ¹Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University, Chicago, IL, ³Department of Pathology, Yale University, New Haven, CT, ⁴Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX, ⁵Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, ⁶Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-organ, destructive autoimmune disease characterized by pathogenic autoantibodies. Though it is accepted that dendritic cells (DCs) play an…
Abstract Number: 2325 • 2012 ACR/ARHP Annual Meeting
PD-1 Signaling Promotes Suppressive Function of CD4⁺ Regulatory T Cells in (New Zealand Black x New Zealand White )F₁ Lupus-Prone Mice in a Dose-Dependent Manner
Maida Wong¹, Antonio La Cava² and Bevra H. Hahn³, ¹Internal Medicine/Rheumatology, University of California, Los Angeles, Los Angeles, CA, ²Internal Medicine/Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ³Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Programmed death-1 (PD-1) has been regarded as a negative regulatory signal in T cells. Our laboratory has shown that PD-1 is important in T…
Abstract Number: 2296 • 2012 ACR/ARHP Annual Meeting
Platelet Release Products Mediate Endothelial Apoptosis: A Possible Role for Thrombospondin 1- CD36 Pathway in SSc-Endothelial Apoptosis
Bashar Kahaleh¹ and Yongqing Wang², ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²Medicine, University of Toledo, Toledo, OH
Background/Purpose: Sequential pathologic observations in the early stages of SSc demonstrated evidence for platelet aggregation and binding to blood vessels that is generally followed by…
Abstract Number: 2083 • 2012 ACR/ARHP Annual Meeting
New Treatment Approach of Rheumatoid Arthritis Based On Inhibition of Cyclin Dependent Kinase-9
Annelie Hellvard¹, Lutz Zeitlmann², Ulrich Heiser³, André Niestroj³, Hans-Ulrich Demuth³, Jan Potempa⁴ and Piotr Mydel¹, ¹Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway, ²Ingenium Pharmaceuticals GmbH, Martinsried, Germany, ³Probiodrug AG, Halle/Saale, Germany, ⁴Microbiology Department, Jagiellonian University, Krakow, Poland
Background/Purpose: Cyclin dependent kinase-9 (cdk-9) is transcription regulator of the carboxyterminal domain of RNA polymerase II. The usage of pan-cdk inhibitors such as flavopiridol has…
Abstract Number: 1782 • 2012 ACR/ARHP Annual Meeting
Dual Effects of Soluble FasL and Membrane Bound FasL On Fibroblast-Like Synoviocytes Cells (FLS) From Rheumatoid Arthritis (RA) Patients
Rachel Audo¹, Flavia Calmon-Hamaty¹, Bernard Combe², Michael Hahne¹ and Jacques Morel³, ¹IGMM, CNRS UMR5535, Montpellier, Montpellier, France, ²Rheumatology, Hopital Lapeyronie, Montpellier, France, ³Dpartment of Rheumatology, Lapeyronie Hospital, Montpellier, France
Background/Purpose: Membrane bound FasL (mFasL) is able to induce fibroblast-like synoviocytes (FLS) cell death. In experimental arthritis mouse models, injection of agonistic antibody (Ab) anti-Fas…
Abstract Number: 1776 • 2012 ACR/ARHP Annual Meeting
Anti-SSA/Ro Mediated Injury to the Endothelium Via Urokinase Plasminogen Activator Receptor/Tgfbeta Activation: Implications in the Pathogenesis of Congenital Heart Block
Paraskevi Briasouli¹, Mark Halushka², Jill P. Buyon³ and Robert M. Clancy⁴, ¹Rheumatology, New York University Medical Center, New York, NY, ²Division of Cardiovascular Pathology, John Hopkins Pathology, Baltimore, MD, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Medicine, New York University School of Medicine, New York, NY
Background/Purpose: One mechanism by which anti-Ro antibodies are linked to the pathogenesis of (cardiac-NL) neonatal lupus is the increased urokinase plasminogen activator (uPA)/urokinase-type plasminogen activator receptor…
Abstract Number: 1743 • 2012 ACR/ARHP Annual Meeting
IL-5-Induced FasL⁺ Regulatory B Cells Are Inhibited by IL-4 and Cyclosporine
Matthew W. Klinker¹, Brian R. Alzua¹, Tamra J. Reed², David A. Fox³ and Steven K. Lundy⁴, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ³Rheumatology/Int Medicine, Univ of Michigan Med Ctr, Ann Arbor, MI, ⁴Internal Medicine-Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: We previously identified a subset of regulatory B cells that express the apoptosis-inducing molecule Fas ligand (FasL), and reported that these B cells were…
Abstract Number: 1635 • 2012 ACR/ARHP Annual Meeting
Polyarthritis Caused by TIARP (TNFAIP9) Deficiency Critically Dependent On Dysregulated STAT3, NF-κB Signaling and Cell Death in Macrophage
Asuka Inoue¹, Isao Matsumoto¹, Naoto Umeda¹, Yuki Tanaka¹, Satoru Takahashi² and Takayuki Sumida¹, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan, ²Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan
Background/Purpose: TNFα-induced adipose-related protein (TIARP) is a six-transmembrane protein induced by TNFα and IL-6 in adipose tissue. Recently, we found that TIARP is dominantly expressed…

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