ACR Meeting Abstracts

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Abstracts tagged "Apoptosis"

  • Abstract Number: 0882 • ACR Convergence 2024

    Brepocitinib, a Selective TYK2/JAK1 Inhibitor Under Evaluation for the Treatment of Dermatomyositis, Reduces Inflammatory Cytokine Signaling and Interferon-induced Apoptosis in Primary Human Epidermal Keratinocytes

    Jiří Vencovský1, Alexandra Goriounova2, Lisa McConnachie2 and Brendan Johnson2, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 2Priovant Therapeutics, Durham, NC

    Background/Purpose: Dermatomyositis (DM) is characterized by inflammatory and degenerative changes of skin and muscle and upregulation of Type I IFN-regulated gene and protein levels in…
  • Abstract Number: 0875 • ACR Convergence 2023

    INV-1498, a Promising Caspase Inhibitor, Exhibits Dose-dependent Therapeutic Efficacy in a Canine Model of Osteoarthritis

    Jung Gyu Park1, Yurim Lee1, Joonghoon Park2 and myungjin Kim3, 1Innovo Therapeutics Inc., Daejeon, South Korea, 2Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang, South Korea, 3HLB bioStep Co. Ltd, Incheon, South Korea

    Background/Purpose: Osteoarthritis poses a substantial medical challenge, as the available treatments primarily target symptom relief and fail to effectively halt the progressive cartilage deterioration that…
  • Abstract Number: 0936 • ACR Convergence 2023

    Impaired DNA Repair Responses Activate a Novel FOXO1-dependent Metabolic Remodelling in Patients with Progressive Systemic Sclerosis to Promote Fibrosis

    Lamia Khan, Desiree Redmond, Muhammad Elezzabi, Robert Gniadecki, Jan Willem Cohen Tervaert and Mohamed Osman, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Systemic sclerosis (SSc) is a deadly disease characterized by immune dysregulation, vasculopathy, and fibrosis. SSc is the most lethal rheumatic disease associated with the…
  • Abstract Number: 0955 • ACR Convergence 2023

    GRB2 Serves as a Viable Target Against Skin Fibrosis in Systemic Sclerosis by Regulating Endothelial Cell Apoptosis

    Yan Huang, Han Zhao, Xiangguang Shi, Jing Liu, Jui-Ming Lin, Qianqian Ma, Shuai Jiang, Weilin Pu, Yanyun Ma, Jianlan Liu, Wenyu Wu, Jiucun Wang and Qingmei Liu, Shanghai, Shanghai, China

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by vascular and immune system dysfunction, along with tissue fibrosis. Vascular damage has been recognized as…
  • Abstract Number: 1793 • ACR Convergence 2023

    Goblet Cell Specific Anti-Apoptotic Role of Interleukin-24 in Spondyloarthritis-Associated Ileitis

    Amy Cameron1, Rabina Giri2, Jakob Begun2, Timothy Wells1, Ranjeny Thomas3 and Anne-Sophie Bergot1, 1Frazer Institute, The University of Queensland, Woolloongabba, Australia, 2Mater Research Institute-UQ, Woolloongabba, Australia, 3Frazer Institute, The University of Queensland, Brisbane, Australia

    Background/Purpose: The loss of intestinal barrier integrity is a key contributor to gut inflammation, however the mechanism behind this dysregulation is not well understood. The…
  • Abstract Number: 0064 • ACR Convergence 2023

    Correlation of Anti-DFS70 Autoantibodies by ELISA with HEp-2 Cells DFS Pattern by IFA

    Vincent ricchiuti1, Michael Nappi2, Kelly Chun2, Ajay Grover1 and Rubio Punzalan2, 1Labcorp, Dublin, OH, 2Labcorp, Calabasas, CA

    Background/Purpose: The discovery and characterization of the dense fine speckled (DFS, ICAP AC-2) nuclear pattern of antinuclear autoantibodies (ANA) detected in HEp-2 cells by indirect…
  • Abstract Number: 0864 • ACR Convergence 2023

    Proteomic Analysis of Circulating Neutrophils from Osteoarthritis Patients Shows Metabolic Dysregulation That Is Associated with Decreased Physiologic Apoptosis

    Jennifer Amsler1, Morgane Le Gall2, Camille Daste3, François Rannou3 and Véronique Witko-Sarsat2, 1Institut Cochin, Bern, Switzerland, 2Institut Cochin, Paris, France, 3Hôpital Cochin, Paris, France

    Background/Purpose: Osteoarthritis (OA) has long been thought to be only of local mechanical origin. However, it has been shown recently that there is a phenotype…
  • Abstract Number: 0611 • ACR Convergence 2022

    Proteomics Reveals Dysregulated Molecular Mechanisms of Cell Death in Neutrophils in Rheumatoid Arthritis

    Jennifer Amsler1, Constance Beaudouin2, Morgane LeGall3, Géraldine Falgarone4, François Rannou5, Léa Tourneur3 and Véronique Witko-Sarsat3, 1Institute Cochin, Schoenenwerd, Switzerland, 2Hôpital Privé de Provence, Aix-en-Provence, France, 3Institute Cochin, Paris, France, 4Hôpital Avicenne, Paris, France, 5Hôpital Cochin, Paris, France

    Background/Purpose: Favoring apoptosis of neutrophils infiltrating the joints of patients suffering from rheumatoid arthritis (RA) and perpetuating inflammation has recently been discussed as an alternative…
  • Abstract Number: 1172 • ACR Convergence 2022

    Transcription Analysis of Macrophages Reveals Important Changes Induced by Systemic Sclerosis Fibroblasts

    Juan-Pablo Zertuche1, Taha Dinc2, Fatima El Adili3, Giovanni Ligresti1 and Andreea Bujor1, 1Boston University, Boston, MA, 2Boston University School of Medicine, Boston, MA, 3Boston University School of Medicine, Revere, MA

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune connective tissue disease characterized by immune system activation, endothelial dysfunction and widespread tissue fibrosis. Activation of the monocyte/macrophage…
  • Abstract Number: 1692 • ACR Convergence 2022

    Interferon Alpha Promotes Ultraviolet Light-Mediated Keratinocyte Apoptosis in a Caspase-8 Dependent Manner via Upregulation of Interferon Regulatory Factor 1

    Shannon Estadt, Mehrnaz Gharaee-Kermani, Bin Xu, Tyson Moore, Andrew Hannoudi and J. Michelle Kahlenberg, University of Michigan, Ann Arbor, MI

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by enhanced sensitivity to ultraviolet radiation (UVR). UVR can trigger cutaneous and systemic disease…
  • Abstract Number: 1727 • ACR Convergence 2022

    BATF Represses BIM Expression to Sustain the T Cell Anergy Program

    Philip Titcombe, Milagros Silva-Morales, Na Zhang and Daniel Mueller, University of Minnesota, Minneapolis, MN

    Background/Purpose: T cell tolerance is essential for preventing autoimmune diseases and resolving inflammation. To maintain tolerance, CD4+ T cells recognizing self-antigens in the periphery can…
  • Abstract Number: 0970 • ACR Convergence 2021

    Hippo Signaling Is a Novel Regulator of Apoptosis and Photosensitivity in Lupus Keratinocytes

    Grace Hile1, Patrick Coit2, Bin Xu1, Shannon Estadt1, Jacob Martens3, Rachael Wasikowski1, Lam Tsoi1, Ramiro Iglesias-Bartolome4, Celine Berthier1, Allison Billi5, Johann Gudjonsson5, Amr Sawalha2 and J. Michelle Kahlenberg1, 1University of Michigan, Ann Arbor, MI, 2University of Pittsburgh, Pittsburgh, PA, 3Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA, Ann Arbor, MI, 4NIH, National Cancer Institute, Bethesda, MD, 5Department of Dermatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Skin inflammation and photosensitivity are common manifestations of cutaneous (CLE) and systemic lupus erythematosus (SLE), yet the mechanisms underlying heightened cell death and epidermal…
  • Abstract Number: 0283 • ACR Convergence 2020

    Genome-wide DNA Methylation Analysis in Lupus Keratinocytes Identifies Differential Methylation of Genes That Regulate Apoptosis

    Grace Hile1, Patrick Coit1, Chang Zeng1, Rachael Wasikowski2, Alex Tsoi2, Allison Billi2, Johann Gudjonsson3, Amr Sawalha4 and J. Michelle Kahlenberg5, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Ann ARbor, 3University of Michigan, Ann ArborUniversity of Michigan, 4University of Pittsburgh, Pittsburgh, 5Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Cutaneous lupus erythematous (CLE) is a disfiguring manifestation of systemic LE (SLE), and the pathogenesis remains unclear. However, epidermal regulation of skin inflammation and…
  • Abstract Number: 0792 • ACR Convergence 2020

    LY294002 Improves the Collagen-induced Arthritis by Inducing Neutrophil Apoptosis

    Xuechan Huang1, Tianwang Li1, Shuyang Chen1, Zhixiang Huang1 and Junming Chen1, 1Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangdong, China (People's Republic)

    Background/Purpose: Neutrophils play a central role in host defense, but they also play important effectors on acute and chronic inflammation. Neutrophil apoptosis is essential for…
  • Abstract Number: 0837 • ACR Convergence 2020

    Deletion of miR-223 Exacerbates Lupus Nephritis by Targeting S1pr1 in Faslpr/lpr Mice

    Sumie Hiramatsu Asano1, Tomoyuki Mukai2, Yoshitaka Morita3 and Jun Wada4, 1Kawasaki Medical School/Department of Rheumatology, Kurashiki city, Japan, 2Kawasaki Medical School, Kurashiki-shi, Okayama, Japan, 3Kawasaki Medical School/Department of Rheumatology, Kurashiki, Okayama, Japan, 4Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences., Okayama city, Japan

    Background/Purpose: To identify new candidate genes regulated by micro RNAs (miRNAs) and involved in the pathogenesis of systemic lupus erythematosus (SLE), we integrated miRNA and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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