Abstracts tagged "Antiphospholipid antibodies"

Abstract Number: 3 • 2017 ACR/ARHP Annual Meeting
Burden of Antiphospholipid Syndrome in a Thromboembolic Disease Registry
Aurelia Luissi¹, Marina Scolnik¹, Maria Florencia Grande Ratti², Maria Lourdes Posadas Martinez² and Enrique R. Soriano³, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, CABA, Argentina, ²Research Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, CABA, Argentina, ³Rheumatology Unit, Internal Mecine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: Prevalence of antiphospholipid antibodies in general population has been reported in about 5%. Impact of different thrombophilias in clinical thromboembolic disease is difficult to…
Abstract Number: 2763 • 2017 ACR/ARHP Annual Meeting
mTORC1 Blockade with Rapamycin and N-Acetylcysteine Reduces Anti-Phospholipid Antibody Levels in Controlled Clinical Trials of Patients with SLE
Thomas Winans¹, Ryan Kelly², Zhi-Wei Lai³, Stephen Faraone², Paul E. Phillips⁴, Katalin Banki⁵ and Andras Perl³, ¹SUNY Upstate Medical University, Syracuse, NY, ²SUNY, Syracuse, NY, ³Medicine, SUNY Upstate Medical University, Syracuse, NY, ⁴Dept of Medicine/Div of Rheum, SUNY-Upstate Medical Univ, Syracuse, NY, ⁵Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Anti-phospholipid antibodies (aPL) constitute a diagnostic criterion and source of morbidity, termed anti-phospholipid syndrome (APS), in patients with or without systemic lupus erythematosus (SLE).…
Abstract Number: 5 • 2017 ACR/ARHP Annual Meeting
Clinical Utility of the Global Antiphospholipid Syndrome Score (GAPSS) for Risk Stratification: A Pooled Analysisfrom 2273 Patients
Savino Sciascia¹, Massimo Radin², Giovanni Sanna³, Irene Cecchi⁴, Dario Roccatello⁵ and Maria Laura Bertolaccini⁶, ¹Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, ²Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ³Louise Coote Lupus Unit, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, London, United Kingdom, ⁴Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁵Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, ⁶Academic Department of Vascular Surgery, Cardiovascular Division, King's College London, United Kingdom, London, United Kingdom
Background/Purpose: Recently, our group conceived a risk score for clinical manifestations of APS [the global APS score or GAPSS] that takes into account the combination…
Abstract Number: 2764 • 2017 ACR/ARHP Annual Meeting
Gene Expression Profile in Monocytes of Antiphospholipid Syndrome Patients Reveals Novel Altered Genes and Pathways Involved in the Pathophysiology of the Disease
Patricia Ruiz-Limon¹, Carlos Perez-Sanchez², Maria Ángeles Aguirre Zamorano², Irene Cecchi³, Nuria Barbarroja², Yolanda Jiménez-Gómez², Ivan Arias de la Rosa¹, Maria Carmen Abalos-Aguilera¹, Pedro Segui⁴, Eduardo Collantes-Estévez², Maria Jose Cuadrado⁵ and Chary Lopez-Pedrera², ¹Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁴Radiology, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁵St Thomas Hospital, Lupus Research Unit, London, United Kingdom
Background/Purpose: Monocytes are key players involved in the development of several autoimmune disease due to their capacity to modulate lipid metabolism, secrete inflammatory cytokines, chemokines,…
Abstract Number: 6 • 2017 ACR/ARHP Annual Meeting
Pregnancy Outcomes in a Cohort of Women with Antiphospholipid Syndrome. 25- Years Long-Term Observation
Dana Tegzova¹, Katerina Andelova², Iva Kucerova², Vera Vlasakova³, Stejskal Jan⁴, Putova Ivana⁵, Marta Olejarova⁶ and Ctibor Dostál⁷, ¹Clinical Department, Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic, ²Institute of Mother and Child Care, Prague, Prague, Czech Republic, ³Dept.of Internal Medicine, City Hospital Ceske Budejovice, Ceske Budejovice, Czech Republic, ⁴1st Medical Faculty, Dpt. of Pathology, Charles University, Prague, Czech Republic, ⁵Institute of Rheumatology, Dpt. of Immunology, Prague, Czech Republic, ⁶Clinical, Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic, ⁷Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic
Background/Purpose: The goal of this long-term project was to investigate the course of pregnancy in patients with APS (primary or secondary with SLE) in 1993-2017,…
Abstract Number: 7 • 2017 ACR/ARHP Annual Meeting
Predictive Value for Thrombosis of Double or Triple Positivity in Secondary APS Depends on the Component Assays and the Type of Thrombosis
Michelle Petri¹, Daniel Goldman² and Laurence S Magder³, ¹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: The lupus anticoagulant (LAC) is individually the antiphospholipid antibody (aPL) most associated with thrombotic risk in both primary and secondary APS. Anticardiolipin (aCL) and…
Abstract Number: 9 • 2017 ACR/ARHP Annual Meeting
Renal Protective Effect of Antiplatelet Therapy in Antiphospholipid Antibody-Positive Lupus Nephritis Patients without the Antiphospholipid Syndrome
Hironari Hanaoka¹, Tomofumi Kiyokawa¹, Harunobu Iida¹, Yukiko Takakuwa¹, Takahiro Okazaki², Hidehiro Yamada³, Shoichi Ozaki⁴ and Kimito Kawahata¹, ¹Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ²Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ³Rheumatology, Seirei Yokohama Hospital, Yokohama, Japan, ⁴Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
Background/Purpose: Lupus nephritis (LN) class III or IV is associated with a poor prognosis for both patient and renal survival. Since antiphospholipid syndrome (APS) is…
Abstract Number: 10 • 2017 ACR/ARHP Annual Meeting
Arterial Events in Primary Antiphospholipid Syndrome Are Associated with High Values of the Adjusted Global Antiphospholipid Syndrome Score
Flavio Signorelli¹, Gustavo G M Balbi², Roger A. Levy² and Savino Sciascia³, ¹Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ²Rheumatology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ³Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy
Background/Purpose: The adjusted Global AntiPhospholipid Syndrome Score (aGAPSS) was described as a tool to estimate the risk of thromboses in patients with APS. The aim…
Abstract Number: 11 • 2017 ACR/ARHP Annual Meeting
Possible Therapeutics for Antiphospholipid Antibody Related Thrombocytopenia: A Systemic Review and Meta-Analysis
Nobuya Abe¹, Kenji Oku¹, Olga Amengual¹, Yuichiro Fujieda¹, Masaru Kato¹, Toshiyuki Bohgaki¹, Shinsuke Yasuda¹, Rintaro Mori², Eriko Morishita³, Katsue Suzuki-Inoue⁴ and Tatsuya Atsumi¹, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Department of Health Policy, National Center for Child Health and Development, Tokyo, Japan, ³Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, ⁴Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
Background/Purpose: Despite the pro-thrombotic nature of antiphospholipid antibodies (aPL), thrombocytopenia is frequently observed in patients with antiphospholipid syndrome (APS) or in non-APS patients with aPL.…
Abstract Number: 15 • 2017 ACR/ARHP Annual Meeting
Methodology and Systematic Review of the Literature for the Mcmaster RARE-Best Practice Clinical Practice Guideline on Diagnosis and Management of the Catastrophic Antiphospholipid Syndrome
Kimberly Legault¹, Christopher Hillis¹, Cindy Yeung¹, Elie Akl², Marc Carrier³, Ricard Cervera⁴, Mark Crowther¹, Francesco Dentali⁵, Doruk Erkan⁶, Gerard Espinosa⁷, Munther A Khamashta⁸, Joerg Meerpohl⁹, Karen Moffatt¹⁰, Sarah O'Brien¹¹, Vittorio Pengo¹², Jacob Rand¹³, Ignasi Rodriguez¹⁴, Lisa Thom¹⁵, Holger Schunemann¹ and Alfonso Iorio¹, ¹McMaster University, Hamilton, ON, Canada, ²American University of Beirut, Beirut, Lebanon, ³University of Ottawa, Ottawa, ON, Canada, ⁴Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain, ⁵Insubria University, Insubria, Italy, ⁶Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, ⁷Autoimmune Diseases Department. Hospital Clínic de Barcelona, Barcelona, Spain, ⁸Graham Hughes Lupus Research Laboratory, The Rayne Institute, London, United Kingdom, ⁹University of Freiburg, Freiburg, Germany, ¹⁰Hamilton Health Sciences, Hamilton, ON, Canada, ¹¹Nationwide Children's, Columbus, OH, ¹²Azienda Ospedaliera of Padova, University of Padova, Padova, Italy, ¹³NY Presbyterian Hospital, New York, NY, ¹⁴Rheumatology, Hospital Clinica, Barcelona, Spain, ¹⁵None (patient representative), Oxford, United Kingdom
Background/Purpose: Catastrophic antiphospholipid syndrome (CAPS), a rare disease, is characterized by the rapid onset of widespread thrombosis associated with multi-organ failure in patients meeting the…
Abstract Number: 16 • 2017 ACR/ARHP Annual Meeting
Anti-Phosphatidylserine/Prothrombin Antibodies in Primary Antiphospholipid Syndrome
Paola Bermudez-Bermejo¹, Gabriela Hernandez-Molina², Diego Hernández-Ramírez³, Victor Zamora-Legoff², Elizabeth Olivares-Martínez³, Antonio R. Cabral⁴ and Carlos Núñez-Álvarez⁵, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición SZ, mexico city, Mexico, ³Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁴Department of Medicine. Division of Rheumatology, The Ottawa Hospital.University of Ottawa, Ottawa, ON, Canada, ⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion S.Z., Mexico city, Mexico
Background/Purpose: Several studies have showed conflicting results regarding the presence and meaning of anti-phosphatidylserine/prothrombin (aPS/PT). However aPS/PT antibodies seem to be a risk factor for…
Abstract Number: 17 • 2017 ACR/ARHP Annual Meeting
Thrombotic Events in Pediatric Systemic Lupus Erythematosus: A Preliminary Analysis of a Large, Single-Center Cohort
Jennifer Rammel¹, Martha Curry² and Marietta M. de Guzman³, ¹Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, ²Pediatric Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, ³Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Background/Purpose: While pediatric systemic lupus erythematosus (pSLE) represents only 20% of all SLE cases, pSLE patients often have more aggressive disease with multi-organ involvement. These…
Abstract Number: 37 • 2017 ACR/ARHP Annual Meeting
β2-Glycoprotein I Binds to Necroptotic Cells and Serves As a Target for SLE Autoantibodies
David Salem¹, Rebecca Subang¹, Maziar Divangahi¹, Christian Pineau², Sasha Bernatsky³, Jerrold S. Levine⁴ and Joyce Rauch⁵, ¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Division of Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ³Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ⁴Section of Nephrology, Department of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, Chicago, IL, ⁵Division of Rheumatology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: β2-glycoprotein I (β2GPI), a phospholipid-binding protein, binds to apoptotic cells and serves as an antigenic target for autoantibodies from patients with systemic lupus erythematosus…
Abstract Number: 1271 • 2017 ACR/ARHP Annual Meeting
Associations between Systemic Lupus Susceptibility (SLE) Loci and Anti-Phospholipid Antibody (aPL) Positivity in Childhood-Onset SLE (cSLE)
Linda T Hiraki^1,2, France Gagnon³, Earl Silverman², Deborah M. Levy², Sima Abu Alsaoud⁴ and Karl Everett^1,3, ¹Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, ²Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ³Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Genome-wide association studies have identified nearly 60 susceptibility loci for systemic lupus erythematosus (SLE). However, few studies have investigated their influence on specific disease…
Abstract Number: 1292 • 2017 ACR/ARHP Annual Meeting
Long-Term Follow-up of 320 Chilren Born to Mothers with Systemic Autoimmune Diseases: A Multicentre Survey from 24 Rheumatology Centers in Italy
Maria Grazia Lazzaroni¹, Cecilia Nalli¹, Laura Andreoli¹, Chiara Carini¹, Marilia Rodrigues², Francesca Dall'Ara¹, Elena Bartoloni-Bocci³, Roberto Gerli³, Maria Gerosa⁴, Cecilia B. Chighizola⁵, Pier Luigi Meroni⁴, Luigi Sinigaglia⁶, Paola Conigliaro⁷, Roberto Perricone⁷, Ada Corrado⁸, Francesco Paolo Cantatore⁸, Salvatore D'Angelo⁹, Ignazio Olivieri⁹, Maria Favaro¹⁰, Maddalena Larosa¹⁰, Andrea Doria¹⁰, Amelia Ruffatti¹¹, Elena Generali¹², Carlo Selmi¹³, Marianna Meroni¹⁴, Maurizio Cutolo¹⁵, Melissa Padovan¹⁶, Marcello Govoni¹⁶, Giulia Pazzola¹⁷, Carlo Salvarani¹⁸, Susanna Peccatori¹⁹, Giuseppe Paolazzi¹⁹, Imma Prevete²⁰, Giovanni Minisola²⁰, Gian Domenico Sebastiani²¹, Antonio Brucato²², Véronique Ramoni²³, Roberto Caporali²⁴, Carlomaurizio Montecucco²⁴, Viola Signorini²⁵, Chiara Tani²⁶, Marta Mosca²⁵, Marica Trevisani²⁷, Nazzarena Malavolta²⁷, Marta Vadacca²⁸, Antonella Afeltra²⁹, Ester Vivaldelli³⁰, Armin Maier³⁰, Elisa Visalli³¹, Rosario Foti³¹, Carolina Benigno³², Lucia Zuliani³³, Armando Gabrielli³³, Corrado Campochiaro³⁴, Elena Baldissera³⁵, Maria Grazia Sabbadini³⁶, Nicoletta Romeo³⁷ and Angela Tincani¹, ¹University and Spedali Civili of Brescia, Brescia, Italy, ²Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ³University and Azienda Ospedaliera of Perugia, Perugia, Italy, ⁴Istituto Ortopedico Gaetano Pini, University of Milan, Milano, Italy, ⁵Rheumatology, Istituto Auxologico Italiano, University of Milan, Cusano Milanino, Italy, ⁶Istituto Ortopedico Gaetano Pini, University of Milan, Italy, Milan, Italy, ⁷Policlinico Tor Vergata of Rome, Rome, Italy, ⁸Ospedali Riuniti of Foggia, Foggia, Italy, ⁹San Carlo Hospital of Potenza, Potenza, Italy, ¹⁰University and Azienda Ospedaliera of Padova, Padova, Italy, ¹¹Unità di Reumatologia, Dipartimento di Medicina-DIMED, Università di Padova., Padova, Italy, ¹²Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano (MI), Italy, ¹³Humanitas Research Hospital of Milan, Rozzano, Italy, ¹⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino-IST, University of Genova, Genoa, Italy, Genova, Italy, ¹⁵Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino, Genoa, Italy, Genoa, Italy, ¹⁶UOC of Rheumatology, University Hospital S. Anna, Cona Ferrara, Italy, ¹⁷Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico of Reggio-Emilia, Reggio-Emilia, Italy, ¹⁸Rheumatology Unit, Arcispedale Santa Maria Nuova - IRCCS; Università di Modena e Reggio Emilia, Reggio-Emilia, Italy, ¹⁹Azienda Provinciale Servizi Sanitari of Trento, Trento, Italy, ²⁰Azienda Ospedaliera San Camillo of Rome, Roma, Italy, ²¹Rheumatology, San Camillo Forlanini Hospital, Roma, Italy, ²²Struttura Complessa Medicina Interna, ASST Papa Giovanni XXIII, Bergamo, Italy, ²³Ospedale Papa Giovanni XXIII of Bergamo, Policlinico San Matteo of Pavia, Bergamo, Pavia, Italy, ²⁴University and Policlinico San Matteo of Pavia, Pavia, Italy, ²⁵University of Pisa, Pisa, Italy, ²⁶Rheumatology Unit, University of Pisa, Pisa, Italy, ²⁷Policlinico S.Orsola-Malpighi, Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy, ²⁸University Campus Biomedico of Rome, Roma, Italy, ²⁹University Campus Biomedico of Rome, roma, Italy, ³⁰Ospedale of Bolzano, Bolzano, Italy, ³¹Policlinico Vittorio Emanuele-Ferrarotto-Bambin Gesù of Catania, Catania, Italy, ³²University Federico II of Napoli, Napoli, Italy, ³³Ospedali Riuniti of Ancona, Ancona, Italy, ³⁴Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London, United Kingdom, ³⁵Ospedale San Raffaele of Milan, Milan, Italy, ³⁶Unit of Medicine and Clinical Immunology, Ospedale San Raffaele of Milano, Milan, Italy, ³⁷Ospedale S.Croce e Carle of Cuneo, Cuneo, Italy
Background/Purpose: Rheumatic Diseases (RD) frequently affect women during reproductive age, therefore counseling on family planning is crucial for their quality of life. Children's outcome is…

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