ACR Meeting Abstracts

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Abstracts tagged "Antiphospholipid antibodies"

  • Abstract Number: 3 • 2017 ACR/ARHP Annual Meeting

    Burden of Antiphospholipid Syndrome in a Thromboembolic Disease Registry

    Aurelia Luissi1, Marina Scolnik1, Maria Florencia Grande Ratti2, Maria Lourdes Posadas Martinez2 and Enrique R. Soriano3, 1Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, CABA, Argentina, 2Research Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, CABA, Argentina, 3Rheumatology Unit, Internal Mecine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: Prevalence of antiphospholipid antibodies in general population has been reported in about 5%. Impact of different thrombophilias in clinical thromboembolic disease is difficult to…
  • Abstract Number: 2763 • 2017 ACR/ARHP Annual Meeting

    mTORC1 Blockade with Rapamycin and N-Acetylcysteine Reduces Anti-Phospholipid Antibody Levels in Controlled Clinical Trials of Patients with SLE

    Thomas Winans1, Ryan Kelly2, Zhi-Wei Lai3, Stephen Faraone2, Paul E. Phillips4, Katalin Banki5 and Andras Perl3, 1SUNY Upstate Medical University, Syracuse, NY, 2SUNY, Syracuse, NY, 3Medicine, SUNY Upstate Medical University, Syracuse, NY, 4Dept of Medicine/Div of Rheum, SUNY-Upstate Medical Univ, Syracuse, NY, 5Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: Anti-phospholipid antibodies (aPL) constitute a diagnostic criterion and source of morbidity, termed anti-phospholipid syndrome (APS), in patients with or without systemic lupus erythematosus (SLE).…
  • Abstract Number: 5 • 2017 ACR/ARHP Annual Meeting

    Clinical Utility of the Global Antiphospholipid Syndrome Score (GAPSS) for Risk Stratification: A Pooled Analysisfrom 2273 Patients

    Savino Sciascia1, Massimo Radin2, Giovanni Sanna3, Irene Cecchi4, Dario Roccatello5 and Maria Laura Bertolaccini6, 1Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, 2Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Louise Coote Lupus Unit, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, London, United Kingdom, 4Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 5Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, 6Academic Department of Vascular Surgery, Cardiovascular Division, King's College London, United Kingdom, London, United Kingdom

    Background/Purpose: Recently, our group conceived a risk score for clinical manifestations of APS [the global APS score or GAPSS] that takes into account the combination…
  • Abstract Number: 2764 • 2017 ACR/ARHP Annual Meeting

    Gene Expression Profile in Monocytes of Antiphospholipid Syndrome Patients Reveals Novel Altered Genes and Pathways Involved in the Pathophysiology of the Disease

    Patricia Ruiz-Limon1, Carlos Perez-Sanchez2, Maria Ángeles Aguirre Zamorano2, Irene Cecchi3, Nuria Barbarroja2, Yolanda Jiménez-Gómez2, Ivan Arias de la Rosa1, Maria Carmen Abalos-Aguilera1, Pedro Segui4, Eduardo Collantes-Estévez2, Maria Jose Cuadrado5 and Chary Lopez-Pedrera2, 1Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 4Radiology, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 5St Thomas Hospital, Lupus Research Unit, London, United Kingdom

    Background/Purpose: Monocytes are key players involved in the development of several autoimmune disease due to their capacity to modulate lipid metabolism, secrete inflammatory cytokines, chemokines,…
  • Abstract Number: 6 • 2017 ACR/ARHP Annual Meeting

    Pregnancy  Outcomes in a Cohort of Women with Antiphospholipid Syndrome. 25- Years  Long-Term Observation 

    Dana Tegzova1, Katerina Andelova2, Iva Kucerova2, Vera Vlasakova3, Stejskal Jan4, Putova Ivana5, Marta Olejarova6 and Ctibor Dostál7, 1Clinical Department, Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic, 2Institute of Mother and Child Care, Prague, Prague, Czech Republic, 3Dept.of Internal Medicine, City Hospital Ceske Budejovice, Ceske Budejovice, Czech Republic, 41st Medical Faculty, Dpt. of Pathology, Charles University, Prague, Czech Republic, 5Institute of Rheumatology, Dpt. of Immunology, Prague, Czech Republic, 6Clinical, Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic, 7Institute of Rheumatology and Rheumatological Clinic of 1st Medical Faculty, Charles University, Prague, Czech Republic

    Background/Purpose: The goal of this long-term project was to investigate the course of pregnancy in patients with APS (primary or secondary with SLE) in 1993-2017,…
  • Abstract Number: 7 • 2017 ACR/ARHP Annual Meeting

    Predictive Value for Thrombosis of Double or Triple Positivity in Secondary APS Depends on the Component Assays and the Type of Thrombosis

    Michelle Petri1, Daniel Goldman2 and Laurence S Magder3, 1Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, 2Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Epidemiology and Public health, University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: The lupus anticoagulant (LAC) is individually the antiphospholipid antibody (aPL) most associated with thrombotic risk in both primary and secondary APS. Anticardiolipin (aCL) and…
  • Abstract Number: 9 • 2017 ACR/ARHP Annual Meeting

    Renal Protective Effect of Antiplatelet Therapy in Antiphospholipid Antibody-Positive Lupus Nephritis Patients without the Antiphospholipid Syndrome

    Hironari Hanaoka1, Tomofumi Kiyokawa1, Harunobu Iida1, Yukiko Takakuwa1, Takahiro Okazaki2, Hidehiro Yamada3, Shoichi Ozaki4 and Kimito Kawahata1, 1Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 2Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 3Rheumatology, Seirei Yokohama Hospital, Yokohama, Japan, 4Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

    Background/Purpose: Lupus nephritis (LN) class III or IV is associated with a poor prognosis for both patient and renal survival. Since antiphospholipid syndrome (APS) is…
  • Abstract Number: 10 • 2017 ACR/ARHP Annual Meeting

    Arterial Events in Primary Antiphospholipid Syndrome Are Associated with High Values of the Adjusted Global Antiphospholipid Syndrome Score

    Flavio Signorelli1, Gustavo G M Balbi2, Roger A. Levy2 and Savino Sciascia3, 1Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, 2Rheumatology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, 3Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy

    Background/Purpose: The adjusted Global AntiPhospholipid Syndrome Score (aGAPSS) was described as a tool to estimate the risk of thromboses in patients with APS. The aim…
  • Abstract Number: 11 • 2017 ACR/ARHP Annual Meeting

    Possible Therapeutics for Antiphospholipid Antibody Related Thrombocytopenia: A Systemic Review and Meta-Analysis

    Nobuya Abe1, Kenji Oku1, Olga Amengual1, Yuichiro Fujieda1, Masaru Kato1, Toshiyuki Bohgaki1, Shinsuke Yasuda1, Rintaro Mori2, Eriko Morishita3, Katsue Suzuki-Inoue4 and Tatsuya Atsumi1, 1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, 2Department of Health Policy, National Center for Child Health and Development, Tokyo, Japan, 3Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, 4Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan

    Background/Purpose: Despite the pro-thrombotic nature of antiphospholipid antibodies (aPL), thrombocytopenia is frequently observed in patients with antiphospholipid syndrome (APS) or in non-APS patients with aPL.…
  • Abstract Number: 15 • 2017 ACR/ARHP Annual Meeting

    Methodology and Systematic Review of the Literature for the Mcmaster RARE-Best Practice Clinical Practice Guideline on Diagnosis and Management of the Catastrophic Antiphospholipid Syndrome

    Kimberly Legault1, Christopher Hillis1, Cindy Yeung1, Elie Akl2, Marc Carrier3, Ricard Cervera4, Mark Crowther1, Francesco Dentali5, Doruk Erkan6, Gerard Espinosa7, Munther A Khamashta8, Joerg Meerpohl9, Karen Moffatt10, Sarah O'Brien11, Vittorio Pengo12, Jacob Rand13, Ignasi Rodriguez14, Lisa Thom15, Holger Schunemann1 and Alfonso Iorio1, 1McMaster University, Hamilton, ON, Canada, 2American University of Beirut, Beirut, Lebanon, 3University of Ottawa, Ottawa, ON, Canada, 4Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain, 5Insubria University, Insubria, Italy, 6Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, 7Autoimmune Diseases Department. Hospital Clínic de Barcelona, Barcelona, Spain, 8Graham Hughes Lupus Research Laboratory, The Rayne Institute, London, United Kingdom, 9University of Freiburg, Freiburg, Germany, 10Hamilton Health Sciences, Hamilton, ON, Canada, 11Nationwide Children's, Columbus, OH, 12Azienda Ospedaliera of Padova, University of Padova, Padova, Italy, 13NY Presbyterian Hospital, New York, NY, 14Rheumatology, Hospital Clinica, Barcelona, Spain, 15None (patient representative), Oxford, United Kingdom

    Background/Purpose: Catastrophic antiphospholipid syndrome (CAPS), a rare disease, is characterized by the rapid onset of widespread thrombosis associated with multi-organ failure in patients meeting the…
  • Abstract Number: 16 • 2017 ACR/ARHP Annual Meeting

    Anti-Phosphatidylserine/Prothrombin Antibodies in Primary                   Antiphospholipid Syndrome

    Paola Bermudez-Bermejo1, Gabriela Hernandez-Molina2, Diego Hernández-Ramírez3, Victor Zamora-Legoff2, Elizabeth Olivares-Martínez3, Antonio R. Cabral4 and Carlos Núñez-Álvarez5, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición SZ, mexico city, Mexico, 3Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 4Department of Medicine. Division of Rheumatology, The Ottawa Hospital.University of Ottawa, Ottawa, ON, Canada, 5Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion S.Z., Mexico city, Mexico

    Background/Purpose: Several studies have showed conflicting results regarding the presence and meaning of anti-phosphatidylserine/prothrombin (aPS/PT). However aPS/PT antibodies seem to be a risk factor for…
  • Abstract Number: 17 • 2017 ACR/ARHP Annual Meeting

    Thrombotic Events in Pediatric Systemic Lupus Erythematosus: A Preliminary Analysis of a Large, Single-Center Cohort

    Jennifer Rammel1, Martha Curry2 and Marietta M. de Guzman3, 1Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, 2Pediatric Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, 3Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX

    Background/Purpose: While pediatric systemic lupus erythematosus (pSLE) represents only 20% of all SLE cases, pSLE patients often have more aggressive disease with multi-organ involvement. These…
  • Abstract Number: 37 • 2017 ACR/ARHP Annual Meeting

    β2-Glycoprotein I Binds to Necroptotic Cells and Serves As a Target for SLE Autoantibodies

    David Salem1, Rebecca Subang1, Maziar Divangahi1, Christian Pineau2, Sasha Bernatsky3, Jerrold S. Levine4 and Joyce Rauch5, 1Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 2Division of Rheumatology, McGill University Health Centre, Montreal, QC, Canada, 3Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, 4Section of Nephrology, Department of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, Chicago, IL, 5Division of Rheumatology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: β2-glycoprotein I (β2GPI), a phospholipid-binding protein, binds to apoptotic cells and serves as an antigenic target for autoantibodies from patients with systemic lupus erythematosus…
  • Abstract Number: 1271 • 2017 ACR/ARHP Annual Meeting

    Associations between Systemic Lupus Susceptibility (SLE) Loci and Anti-Phospholipid Antibody (aPL) Positivity in Childhood-Onset SLE (cSLE)

    Linda T Hiraki1,2, France Gagnon3, Earl Silverman2, Deborah M. Levy2, Sima Abu Alsaoud4 and Karl Everett1,3, 1Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, 2Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 3Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, 4Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: Genome-wide association studies have identified nearly 60 susceptibility loci for systemic lupus erythematosus (SLE). However, few studies have investigated their influence on specific disease…
  • Abstract Number: 1292 • 2017 ACR/ARHP Annual Meeting

    Long-Term Follow-up of 320 Chilren Born to Mothers with Systemic Autoimmune Diseases: A Multicentre Survey from 24 Rheumatology Centers in Italy

    Maria Grazia Lazzaroni1, Cecilia Nalli1, Laura Andreoli1, Chiara Carini1, Marilia Rodrigues2, Francesca Dall'Ara1, Elena Bartoloni-Bocci3, Roberto Gerli3, Maria Gerosa4, Cecilia B. Chighizola5, Pier Luigi Meroni4, Luigi Sinigaglia6, Paola Conigliaro7, Roberto Perricone7, Ada Corrado8, Francesco Paolo Cantatore8, Salvatore D'Angelo9, Ignazio Olivieri9, Maria Favaro10, Maddalena Larosa10, Andrea Doria10, Amelia Ruffatti11, Elena Generali12, Carlo Selmi13, Marianna Meroni14, Maurizio Cutolo15, Melissa Padovan16, Marcello Govoni16, Giulia Pazzola17, Carlo Salvarani18, Susanna Peccatori19, Giuseppe Paolazzi19, Imma Prevete20, Giovanni Minisola20, Gian Domenico Sebastiani21, Antonio Brucato22, Véronique Ramoni23, Roberto Caporali24, Carlomaurizio Montecucco24, Viola Signorini25, Chiara Tani26, Marta Mosca25, Marica Trevisani27, Nazzarena Malavolta27, Marta Vadacca28, Antonella Afeltra29, Ester Vivaldelli30, Armin Maier30, Elisa Visalli31, Rosario Foti31, Carolina Benigno32, Lucia Zuliani33, Armando Gabrielli33, Corrado Campochiaro34, Elena Baldissera35, Maria Grazia Sabbadini36, Nicoletta Romeo37 and Angela Tincani1, 1University and Spedali Civili of Brescia, Brescia, Italy, 2Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, 3University and Azienda Ospedaliera of Perugia, Perugia, Italy, 4Istituto Ortopedico Gaetano Pini, University of Milan, Milano, Italy, 5Rheumatology, Istituto Auxologico Italiano, University of Milan, Cusano Milanino, Italy, 6Istituto Ortopedico Gaetano Pini, University of Milan, Italy, Milan, Italy, 7Policlinico Tor Vergata of Rome, Rome, Italy, 8Ospedali Riuniti of Foggia, Foggia, Italy, 9San Carlo Hospital of Potenza, Potenza, Italy, 10University and Azienda Ospedaliera of Padova, Padova, Italy, 11Unità di Reumatologia, Dipartimento di Medicina-DIMED, Università di Padova., Padova, Italy, 12Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano (MI), Italy, 13Humanitas Research Hospital of Milan, Rozzano, Italy, 14Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A.O.U. San Martino-IST, University of Genova, Genoa, Italy, Genova, Italy, 15Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino, Genoa, Italy, Genoa, Italy, 16UOC of Rheumatology, University Hospital S. Anna, Cona Ferrara, Italy, 17Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico of Reggio-Emilia, Reggio-Emilia, Italy, 18Rheumatology Unit, Arcispedale Santa Maria Nuova - IRCCS; Università di Modena e Reggio Emilia, Reggio-Emilia, Italy, 19Azienda Provinciale Servizi Sanitari of Trento, Trento, Italy, 20Azienda Ospedaliera San Camillo of Rome, Roma, Italy, 21Rheumatology, San Camillo Forlanini Hospital, Roma, Italy, 22Struttura Complessa Medicina Interna, ASST Papa Giovanni XXIII, Bergamo, Italy, 23Ospedale Papa Giovanni XXIII of Bergamo, Policlinico San Matteo of Pavia, Bergamo, Pavia, Italy, 24University and Policlinico San Matteo of Pavia, Pavia, Italy, 25University of Pisa, Pisa, Italy, 26Rheumatology Unit, University of Pisa, Pisa, Italy, 27Policlinico S.Orsola-Malpighi, Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy, 28University Campus Biomedico of Rome, Roma, Italy, 29University Campus Biomedico of Rome, roma, Italy, 30Ospedale of Bolzano, Bolzano, Italy, 31Policlinico Vittorio Emanuele-Ferrarotto-Bambin Gesù of Catania, Catania, Italy, 32University Federico II of Napoli, Napoli, Italy, 33Ospedali Riuniti of Ancona, Ancona, Italy, 34Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London, United Kingdom, 35Ospedale San Raffaele of Milan, Milan, Italy, 36Unit of Medicine and Clinical Immunology, Ospedale San Raffaele of Milano, Milan, Italy, 37Ospedale S.Croce e Carle of Cuneo, Cuneo, Italy

    Background/Purpose: Rheumatic Diseases (RD) frequently affect women during reproductive age, therefore counseling on family planning is crucial for their quality of life. Children's outcome is…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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