Abstracts tagged "Antiphospholipid antibodies"

Abstract Number: 143 • 2019 ACR/ARP Annual Meeting
Clinical and Genetic Factors Associated with Thrombosis or Pregnancy Morbidity of Antiphospholipid Antibody-Positive Systemic Lupus Erythematosus Patients
Ji-Soong Kim¹, Ga Young Ahn ², Jeongim Choi ³, Jiyoung Lee ⁴, Youngho Park ¹, So-Young Bang ¹ and Sang-Cheol Bae ¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ²Guro Hospital, Korea University College of Medicine, Seoul, ³Busan St. Mary's Medical Center, Busan, ⁴Clinical Research Center for Rheumatoid Arthritis, Seoul
Background/Purpose: Antiphospholipid syndrome (APS) is characterized by thromboembolic and obstetric morbidity associated with antiphospholipid antibodies (aPL) in systemic lupus erythematosus (SLE). This study aims to…
Abstract Number: 144 • 2019 ACR/ARP Annual Meeting
Antiphospholipid Syndrome-Associated Preeclampsia Is Defined by a Distinct Clinical Phenotype
Shashank Cheemalavagu¹, Beth Wallace ², Wendy Marder ³, Jason Knight ⁴ and Andrew Vreede ⁵, ¹Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, ²Center for Clinical Management Research, VA Ann Arbor Healthcare System; Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, ³Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, ⁴Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, ⁵Division of Rheumatology, Department of Internal Medicine, Michigan Medicine; Rheumatology Section, VA Ann Arbor Health System, Ann Arbor, MI
Background/Purpose: Antiphospholipid syndrome (APS) significantly increases risk of preeclampsia. It is assumed that APS is associated with a subset of severe preeclampsia, HELLP (Hemolysis; Elevated…
Abstract Number: 145 • 2019 ACR/ARP Annual Meeting
Development of New International Classification Criteria for Antiphospholipid Syndrome: Phase II Results
Medha Barbhaiya¹, Stephane Zuily ², Yasaman Ahmadzadeh ³, Raymond Naden ⁴, Karen Costenbader ⁵, Doruk Erkan ⁶ and On Behalf of the New APS Classification Criteria Collaborators ⁷, ¹Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ²Centre Hospitalier Universitaire de Nancy, Nancy, France, ³N/A, Tehran, Iran, ⁴McMaster University, Hamilton, ON, Canada, ⁵Brigham and Women's Hospital, Boston, MA, ⁶Hospital for Special Surgery, New York City, ⁷Hospital for Special Surgery, New York, NY
Background/Purpose: An international multi-disciplinary effort is underway to develop rigorous, new, consensus- and evidence-based classification criteria to identify patients with high likelihood of Antiphospholipid Syndrome…
Abstract Number: 305 • 2019 ACR/ARP Annual Meeting
Naming Is Everything! the Cost of Inappropriate “Lupus Panel” Testing
Caleb Anderson¹, Roger Stitt ² and Robert O'Brian ¹, ¹Walter Reed National Military Medical Center, Bethesda, MD, ²US Army, Ft Eustis
Background/Purpose: Greater emphasis has been placed on cost saving measures due to ballooning healthcare cost in the U.S. ACGME now evaluates trainee ability to practice…
Abstract Number: 660 • 2019 ACR/ARP Annual Meeting
Antiphospholipid Syndrome (APS) in Systemic Lupus Erythematosus (SLE) Leads to a More Severe Disease
Leyre Riancho-Zarrabeitia¹, Víctor M Martinez-Taboada ², Iñigo Rua Figueroa ³, Fernando Alonso ⁴, María Galindo ⁵, Juan Ovalles-Bonilla ⁶, Alejandro Olivé-Marqués ⁷, Antonio Fernández-Nebro ⁸, Jaime Calvo-Alen ⁹, Raul Menor Almagro ¹⁰, Eva Tomero-Muriel ¹¹, Esther Uriarte Isacelaya ¹², Alina Boteanu ¹³, Mariano Andrés ¹⁴, Mercedes Freire González ¹⁵, Gregorio Santos Soler ¹⁶, Esther Ruiz Lucea ¹⁷, Monica Ibañez Barcelo ¹⁸, Ivan Castellvi ¹⁹, Carles Galisteo ²⁰, Víctor Quevedo Vila ²¹, Enrique Raya ²², Javier Narváez ²³, Lorena Expósito ²⁴, José A Hernández-Beriain ²⁵, Loreto Horcada Rubio ²⁶, Elena Aurrecoechea ²⁷ and Jose Maria Pego-Reigosa ²⁸, ¹Hospital Sierrallana, Torrelavega, Spain, ²Hospital Valdecilla, Santander, ³Hospital Doctor Negrin, Las Palmas, ⁴Unidad Investigación SER, Madrid, Spain, ⁵Hospital 12 De Octubre, Madrid, ⁶Hospital Gregorio Marañón, Madrid, Spain, ⁷Hospital German Trias i Pujol, Badalona, Spain, ⁸Hospital Carlos Haya, Malaga, Spain, ⁹Hospital Universitario Araba, Vitoria-Gasteiz, Spain, ¹⁰Hospital Universitario de Jerez, Puerto De Santa María, Spain, ¹¹Hospital Universitario La Princesa, Madrid, Spain, ¹²Hospital Universitario Donosti, San Sebastian, Spain, ¹³Hospital Universitario Ramón y Cajal, Madrid, Spain, ¹⁴Hospital General Universitario de Alicante, Alicante, Spain, ¹⁵Hospital Universitario Juan Canalejo, La Coruña, Spain, ¹⁶Hospital Marina Baixa, Villajoyosa, Spain, ¹⁷Hospital Universitario Basurto, Bilbao, Spain, ¹⁸Hospital Universitario Son Llàtzer, Palma de Mallorca, Spain, ¹⁹Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ²⁰Hospital Parc Taulí, Barcelona, Catalonia, Spain, ²¹Hospital Comarcal Monforte, Monforteº, Spain, ²²Hospital Universitario Clínico San Cecilio, Granada, Spain, ²³Rheumatology Department, Hospital Universitario de Bellvitge, Barcelona, Spain, Barcelona, Catalonia, Spain, ²⁴Hospital Universitario de Canarias, Las Palmas, Spain, ²⁵Hospital Insular Universitario de Gran Canaria, Las Palmas, Spain, ²⁶Complejo Hospitalario Universitario de Navarra, Pamplona, Spain, ²⁷Rheumatology Department. Hospital Sierrallana, Torrelavega, Spain, ²⁸Complexo Hospitalario Universitario, Vigo, Spain
Background/Purpose: Antiphospholipid antibodies (aPL) have been associated with organ damage and certain features in SLE patients. Our aim was to investigate the differences between SLE…
Abstract Number: 128 • 2019 ACR/ARP Annual Meeting
Metabolomics Analysis Identifies Biomarkers for APS and Suggests a Potential New Pathway Related to APS Pathogenesis
Chun Li ¹, Yu Zuo², Jason Knight ³, Juan Feng ⁴, Xian Wang ⁴, David Karp ⁵ and Zhanguo Li ⁶, ¹Peking Univerisity People's Hospital, Beijing, China (People's Republic), ²University of Texas Southwestern, Dallas, TX, ³Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, ⁴Peking University School of Basic Medical Science, Beijing, China (People's Republic), ⁵UTSouthwestern Medical Center, Dallas, TX, ⁶People's Hospital, Beijing University Medical School, Beijing, China (People's Republic)
Background/Purpose: The metabolic disturbances that underlie antiphospholipid syndrome (APS) are currently unknown. The goal of this study was to utilize high-throughput metabolomics screening to identify…
Abstract Number: 1579 • 2019 ACR/ARP Annual Meeting
Presence of Antiphospholipid Antibodies in Patients with SLE and Venous Thromboembolic Events of African American and Caucasian Race
Elena Gkrouzman¹, Julia Davis-Porada ¹, Mary Peng ² and Kyriakos Kirou ², ¹Hospital for Special Surgery, New York, ²Hospital for Special Surgery, New York, NY
Background/Purpose: Risk of thrombosis is elevated in patients with systemic lupus erythematosus (SLE) compared to healthy individuals, especially during the first year after diagnosis. The…
Abstract Number: 129 • 2019 ACR/ARP Annual Meeting
Surface Proteins on Exosomes Derived from Plasma of APS Patients Indicate an Altered Immune, Cell Adhesion and Coagulation Profile
Ula Štok ¹, Elizabeta blokar ¹, Aleš Ambrožič ¹, Matija Tomsic ¹, Snezna Sodin-Semrl ², Saša Čučnik ¹ and Polona Žigon³, ¹Department of Rheumatology, University Medical Center Ljubljana, Slovenia, Ljubljana, Slovenia, ²Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, Ljubljana, Slovenia, ³Department of Rheumatology, University Medical Center Ljubljana, Slovenia, Ljubljana
Background/Purpose: Antiphospholipid syndrome (APS) is characterized by thromboses and/or obstetric complications in presence of antiphospholipid antibodies (aPL). Extracellular vesicles have been suggested to play a…
Abstract Number: 1746 • 2019 ACR/ARP Annual Meeting
Identifying Additional Risk Factors for Arterial and Venous Thrombosis Among Pediatric Antiphospholipid Antibodies Carriers
Elizabeth Sloan¹, Tracey Wright ¹ and Yu Zuo ², ¹University of Texas Southwestern, Texas Scottish Rite Hospital for Children, Children's Health, Dallas, TX, ²University of Texas Southwestern, Dallas, TX
Background/Purpose: Antiphospholipid antibodies (aPL) have been extensively reported in children; however, research on thrombotic risks associated with aPL among pediatric patients is scarce. Positive aPL…
Abstract Number: 166 • 2018 ACR/ARHP Annual Meeting
Superior Sensitivity for Detection of Primary Antiphospholipid Syndrome By a 9-Test Panel in Patients with Deep Venous Thrombosis, Pulmonary Embolism, and Stroke or Transient Ischemic Attack
Konrad Dziamski¹, Katalin Banki² and Andras Perl³, ¹Rheumatology, SUNY Upstate Medical University, Syracuse, NY, ²Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY, ³Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Antiphospholipid Syndrome (APS) is characterized by thrombotic events mediated by antiphospholipid antibodies (aPL). Most patients have primary APS (PAPS), while a significant minority has…
Abstract Number: 167 • 2018 ACR/ARHP Annual Meeting
Recurrent Thrombosis in Patients with Antiphospholipid Antibodies Following an Initial Venous or Arterial Thromboembolic Event
Tom Ortel¹, Sreelatha Meleth², Diane Catellier², Mark Crowther³, Doruk Erkan⁴, Paul R. Fortin⁵, David Garcia⁶, Nana Haywood², Steven R. Levine⁷, Michael J. Phillips² and Nedra Whitehead², ¹Duke University, Durham, NC, ²RTI International, Research, Triangle Park, NC, ³McMaster University, Hamilton, ON, Canada, ⁴Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY, ⁵Medicine, CHU de Québec - University of Laval, Quebec, QC, Canada, ⁶Hematology, University of Washington Medical Center, Seattle, WA, ⁷Neurology, State University of New York Downstate Medical Center, Brooklyn, NY
Background/Purpose: After an initial thromboembolic event (TE), several studies reported that patients with antiphospholipid syndrome (APS) manifest a high-risk for recurrent TE. A systematic review…
Abstract Number: 168 • 2018 ACR/ARHP Annual Meeting
IgG Anti-High-Density Lipoproteins Antibodies Discriminate between Arterial and Venous Events in Thrombotic Antiphospholipid Syndrome Patients
Irene Cecchi¹, Massimo Radin², Elena Rubini³, Ana Suárez⁴, Dario Roccatello⁵, Savino Sciascia⁶ and Javier Rodríguez-Carrio⁷, ¹Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ²Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ³Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bosco Hospital, Turin, Italy., Turin, Italy, ⁴Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ⁵Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, ⁶Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, ⁷Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación Nefrológica, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Oviedo, Spain
Background/Purpose: Reliable biomarkers for risk stratification in Antiphospholipid Syndrome (APS) are still lacking. Anti-high-density lipoproteins antibodies (anti-HDL) showed promising results in predicting the development of…
Abstract Number: 170 • 2018 ACR/ARHP Annual Meeting
Predictive Value of Antiphospholipid Antibodies in the Acute Phase of Deep Vein Thrombosis
Katja Perdan Pirkmajer¹, Anja Boc², Saša Čučnik³, Alenka Mavri⁴, Polona Žigon³, Eva Podovsovnik⁵, Monika Štalc⁶, Nina Vene⁷ and Ales Ambrozic⁸, ¹Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Faculty of Medicine, Institute of Anatomy, University of Ljubljana, Ljubljana, Slovenia, ³University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia, ⁴University Medical Centre Ljubljana, Ljubljana, Slovenia, ⁵Faculty for Tourism Studies, University of Primorska, Portoroz, Slovenia, ⁶Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia, ⁷Department of Vascular Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia, ⁸Department of Rheumatology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia
Background/Purpose: Deep vein thrombosis (DVT) is frequent and potentially life threatening disease with tendency to reoccur. Anticoagulant treatment of the first episode of DVT usually…
Abstract Number: 173 • 2018 ACR/ARHP Annual Meeting
The Efficacy of Treatment with Low Dose Aspirin and Low Molecular Weight Heparin in Pregnant Women with Criteria Anti-Phospholipid Antibodies
Cecilia B. Chighizola¹, Francesca Pregnolato², Maria Gabriella Raimondo³, Chiara Comerio⁴, Laura Trespidi⁵, Maria Orietta Borghi⁶, Maria Gerosa⁷, Barbara Acaia⁸, Wally Ossola⁵, Enrico Ferrazzi⁸, Alessandro Bulfoni⁹ and Pier Luigi Meroni¹⁰, ¹Rheumatology, Istituto Auxologico Italiano, University of Milan, Milan, Italy, ²Istituto Auxologico Italiano, Cusano Milanino, Italy, ³University of Milan, Istituto Ortopedico Gaetano Pini, Milan, Italy, ⁴University of Milan, Milan, Italy, ⁵Department of Obstetrics and Gynaecology, Fondazione Policlinico, Mangiagalli e Regina Elena, Milan, Italy, ⁶University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy, ⁷Istituto Ortopedico Gaetano Pini, University of Milan, Milano, Italy, ⁸Department of Obstetrics and Gynaecology, Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy, ⁹Division of Obstetrics and Gynaecology, Humanitas S. Pio X, Milan, Italy, ¹⁰Laboratory of Immuno-rheumatology, Laboratory of Immuno-rheumatology, IRCCS Istituto Auxologico Italiano, Cusano Milanino, Italy
Background/Purpose: Anti-phospholipid antibodies (aPL) are the biomarkers of anti-phospholipid syndrome (APS), a systemic autoimmune condition characterized by thrombosis and/or pregnancy morbidity (PM). The aim of…
Abstract Number: 852 • 2018 ACR/ARHP Annual Meeting
Antigenic Property of Prothrombin/HLA-DR Complex on Procoagulant Cells in Patients with Antiphospholipid Syndrome
Naoki Ohnishi¹, Yuichiro Fujieda¹, Ryo Hisada¹, Hiroyuki Nakamura¹, Masaru Kato¹, Kenji Oku¹, Toshiyuki Bohgaki¹, Olga Amengual¹, Shinsuke Yasuda¹, Hisashi Arase² and Tatsuya Atsumi¹, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Department of Immunochemistry, Research Institute for Microbial Disease, Osaka University, Suita, Japan
Background/Purpose: Antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity and the presence of antiphospholipid antibodies (aPL). Phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) recognize the phosphatidylserine/prothrombin…

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