ACR Meeting Abstracts

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Abstracts tagged "Antibodies"

  • Abstract Number: 2593 • 2013 ACR/ARHP Annual Meeting

    The Prognosis Of Scleroderma Renal Crisis In RNA-Polymerase III Antibody (ARA) Positive Compared To ARA Negative Patients

    Bernadette Lynch1, Henry Penn2, Jennifer Harvey3, Aine Burns4 and Christopher P. Denton5, 1Department of Rheumatology, The Royal Free Hospital, London, United Kingdom, 2Northwick Park Hospital, Harrow, United Kingdom, 3Clinical Immunology, Royal Free Hospital, London, United Kingdom, 4Department of Nephrology, The Royal Free Hospital, London, United Kingdom, 5Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom

    Background/Purpose: Scleroderma renal crisis (SRC) usually presenting with accelerated hypertension and acute kidney injury (AKI) is one of the most severe complications of Systemic Sclerosis…
  • Abstract Number: 1936 • 2012 ACR/ARHP Annual Meeting

    The Human Leukocyte Antigen DRB1*13:02-DQB1*06:04-DPB1*04:01 Haplotype Is Closely Associated with Dermatomyositis Patients with Anti-CADM-140 (Melanoma Differentiation-Associated Protein 5: MDA5) Antibody

    Yuji Hosono1, Chikashi Terao2, Ran Nakashima1, Yoshitaka Imura3, Naoichiro Yukawa4, Hajime Yoshifuji1, Motomu Hashimoto5, Koichiro Ohmura6, Takao Fujii7 and Tsuneyo Mimori1, 1Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Center for Genomic Medicine, Kyoto University, Kyoto, Japan, 3Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 4Dept of Rheum & Clinical Immun, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5The Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 6Rheumatology & Clin Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 7Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Background/Purpose: Recent studies have revealed that anti-CADM-140 (MDA5/IFIH1)-antibody positive dermatomyositis (DM) patients frequently develop acute or subacute progressive interstitial pneumonia (A/SIP) with poor prognosis. However,…
  • Abstract Number: 1748 • 2012 ACR/ARHP Annual Meeting

    Antibody Secreting Cells Arising After Vaccination of Lupus Patients May Produce High Affinity Autoantibodies

    Kenneth Smith1, Jennifer Muther1, Angie Duke1, Emily McKee1, Alina Lorant1, Patrick C. Wilson2 and Judith A. James3, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Rheumatology and Knapp center for Lupus and Immunology Research, University of Chicago, Chicago, IL, 3Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Vaccinating SLE patients with influenza and pneumococcal vaccines is generally considered safe and effective.  However, conflicting reports regarding the impact of vaccination on autoantibody…
  • Abstract Number: 1491 • 2012 ACR/ARHP Annual Meeting

    Systemic Sclerosis – Effects of Agonistic Autoantibodies Directed Against the Angiotensin Receptor Type 1 and the Endothelin Receptor Type A On Effector Cells

    Jeannine Guenther1, Angela Kill2, Mike O. Becker3 and Gabriela Riemekasten4, 1Rheumatology/Clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, Berlin, Germany, 2Rheumatology and clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, 3Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, 4Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany

    Background/Purpose: Autoimmunity, vasculopathy and fibrosis are features of systemic sclerosis (SSc). The functional link between these three pathophysiological components is still missing. Research suggests an…
  • Abstract Number: 1286 • 2012 ACR/ARHP Annual Meeting

    Antibodies to Etanercept and Adalimumab in Rheumatoid Arthritis Inadequate Responders and Clinical Outcomes After an Active Switch to Infliximab

    Chad Pool1, Gopi Shankar2, Allen Schantz2, George Gunn2, Rebecca Bolce3, Marjatta Leirisalo-Repo4, Jim Wang1, John A. Goldman5, Raphael J. DeHoratius6, Roy Fleischmann7 and Dennis Decktor6, 1Janssen Services, LLC, Horsham, PA, 2Janssen R&D, LLC, PA, 3Crescendo Bioscience Inc., South San Francisco, CA, 4Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland, 5Medical Quarters #293, Atlanta, GA, 6Medical Affairs, Janssen Services, LLC, Horsham, PA, 7Rheumatology, University of Texas Southwestern Medical Center and Metroplex Clinical Research Center, Dallas, TX

    Background/Purpose: To determine if RA patients (pts) who had an inadequate response to etanercept(ETN) or adalimumab(ADA) and developed antibodies (Abs) to ETN or ADA responded…
  • Abstract Number: 1178 • 2012 ACR/ARHP Annual Meeting

    IL-6 and IL-21 in Rheumatoid Arthritis

    Gustavo Carbone1, Augusta Wilson1, Sean Diehl2, Janice Bunn3, Sheldon Cooper4 and Mercedes Rincon5, 1Rheum & Clinical Imm Unit, University of Vermont College of Medicine, Burlington, VT, 2Immunobiology, University of Vermont College of Medicine, 3Mathematics and Statistics, University of Vermont, Burlington, VT, 4Rheum & Clinical Imm Unit, Univ Vermont College of Med, Burlington, VT, 5Immunobiology, University of Vermont College of Medicine, Burlington, VT

    Background/Purpose: Interleukin-6 (IL-6) levels are known to be increased in patients with rheumatoid arthritis (RA). Tocilizumab, a monoclonal antibody to the IL-6 receptor (IL-6R), reduces…
  • Abstract Number: 948 • 2012 ACR/ARHP Annual Meeting

    Antibody-Based Prediction Rules for Connective Tissue Disease: Analysis of 12,555 Patients with Antinuclear Antibody Testing

    Ryo Rokutanda1, Mitsumasa Kishimoto1, Yasuharu Tokuda2, Ken-ichi Yamaguchi1, Hisanori Shimizu1, Yasuhiro Suyama1, Yuri Ohara1, Yoichiro Haji1, Chisun Min1, Akira Takeda1, Yukio Matsui3 and Masato Okada1, 1Division of Allergy and Rheumatology, St. Luke's International Hospital, Tokyo, Japan, 2Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan, 3Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan

    Background/Purpose: Antinuclear antibody (ANA) is widely used as a screening test for connective tissue diseases (CTDs). The sensitivity of this test is high in 3…
  • Abstract Number: 835 • 2012 ACR/ARHP Annual Meeting

    Low Doses of Ocaratuzumab, a Fc- and Fab-Engineered Anti-CD20 Antibody, Result in Rapid and Sustained Depletion of Circulating B-Cells in Rheumatoid Arthritis Patients

    Adrienne O'Reilly, Tracy Davis and Vinay Jain, Mentrik Biotech, Dallas, TX

     Background/Purpose:   B-cell depletion provides therapeutic benefits for patients with rheumatoid arthritis (RA). Ocaratuzumab, previously known as AME-133v, is a Fc- and Fab-engineered, humanized, anti-CD20…
  • Abstract Number: 836 • 2012 ACR/ARHP Annual Meeting

    Clinical Responses and Patient Reported Outcomes to NNC0109-0012 (anti-IL-20 mAb) in Rheumatoid  Arthritis (RA) Patients Following 12-Weeks Dosing and 13 Weeks Follow up: Results From a Phase 2a Trial

    Ladislav ŠEnolt1, Marie Göthberg2, Xavier Valencia3 and Eva Dokoupilova4, 1Institute of Rheumatology, Prague, Czech Republic, 2Biostatistics, Novo Nordisk, A/S, Soeborg, Denmark, 3Clinical Medical and Regulatory Affairs, Novo Nordisk, Inc., Princeton, NJ, 4Medical Plus s.r.o, Uherske Hradiste, Czech Republic

    Background/Purpose: NNC0109-0012 (anti-IL-20 mAb) is a novel human monoclonal IgG4 antibody which binds to and neutralizes the activity of IL-20. Data from a phase 1…
  • Abstract Number: 683 • 2012 ACR/ARHP Annual Meeting

    Prevalence of Inhibitory or Non-Inhibitory Autoantibodies to Angiotensin Converting Enzyme 2 (ACE2) in Patients with Systemic Lupus Erythematosus

    Yuko Takahashi1, Shiori Haga2, Yukihito Ishizaka2 and Akio Mimori3, 1Division of Rheumatic Diseases, National Center for Global Health and Medicine, Tokyo, Japan, 2Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan, 3Department of Intractable Diseases, National Center for Global Health and Medicine, Tokyo, Japan

    Background/Purpose: We previously reported that inhibitory autoantibodies to angiotensin converting enzyme 2 (ACE2) predisposed individuals to connective tissue diseases (i.e., scleroderma or systemic lupus erythematosus…
  • Abstract Number: 665 • 2012 ACR/ARHP Annual Meeting

    Cytokines and Their Relation to Autoantibodies Before Disease Onset in Systemic Lupus Erythematosus

    Catharina Eriksson1 and Solbritt Rantapää Dahlqvist2, 1Department of Clinical Immunology/clinical microbiology, Umeå, Sweden, 2Department of Public Health and Clinical Medicine/Rheumatology, Umeå University Hospital, Umeå, Sweden

    Background/Purpose: Cytokines and autoantibodies are involved in the pathogenesis of systemic lupus erythematosus (SLE). The presence of autoantibodies preceding disease onset by years has been…
  • Abstract Number: 485 • 2012 ACR/ARHP Annual Meeting

    Immunogenicity of Infliximab Is Related to Reduction of Frequency of Infliximab Administration in Rheumatoid Arthritis and Spondyloarthritis Patients

    Mathieu Verdet1, Clément Guillou2, Marie-Laure Potier2, Martine Hiron2, Fabienne Jouen3, Olivier Boyer4, Thierry Lequerré5 and Olivier Vittecoq6, 1Rheumatology, Rouen University Hospital, Bois Guillaume, France, 2Inserm 905 & Institute for Biomedical Research, University of Rouen, Rouen, France, 3Immunology, Rouen University Hospital, Rouen Cedex, France, 4Immunology, INSERM U905, University of Rouen, Rouen, France, 5Rheumatology Department & Inserm 905, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France, 6Rheumatology, Rouen University Hospital & Inserm905, University of Rouen, Rouen Cedex, France

    Background/Purpose: To analyze the clinical and biological characteristics associated with presence of antibodies to Infliximab, in rheumatoid arthritis (RA) and spondyloarthritis patients (SpA). Methods: Sera…
  • Abstract Number: 349 • 2012 ACR/ARHP Annual Meeting

    Preliminary Results From a Controlled Study Assessing the Humoral Immune Response to Vaccines in Rheumatoid Arthritis Patients Treated with Tocilizumab

    Clifton O. Bingham III1, Warren C. Rizzo2, Micki Klearman3, Azra Hassanali4, Ruchi Upmanyu5 and Alan J. Kivitz6, 1Rheumatology, Johns Hopkins University, Baltimore, MD, 2Advanced Arthritis Care & Research, Scottsdale, AZ, 3Genentech Inc, South San Francisco, CA, 4Genentech Inc, San Francisco, CA, 5Roche, Welwyn Garden City, United Kingdom, 6Altoona Center for Clinical Research, Duncansville, PA

    Background/Purpose: Tocilizumab (TCZ) is an IL-6–receptor inhibitor for treatment of rheumatoid arthritis (RA) patients (pts). Because TCZ may impact how IL-6 modulates T-cell activation and…
  • Abstract Number: 2659 • 2012 ACR/ARHP Annual Meeting

    An Expanded Repertoire of Anti-Citrullinated Peptide Antibodies Is Associated with Interstitial Lung Disease in Rheumatoid Arthritis

    Jon T. Giles1, Sonye Danoff2, Jeremy Sokolove3, Robert Winchester4, Dimitrios A. Pappas5, Catriona Cramb6, Geoffrey Connors7, Stanley S. Siegelman8, William H. Robinson9 and Joan M. Bathon5, 1Medicine, Columbia University, New York, NY, 2Medicine/Pulmonary, Johns Hopkins School of Medicine, Baltimore, MD, 3Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 4Dept of Medicine & Pathology, Columbia University, New York, NY, 5Columbia University, New York, NY, 6VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, 7Division of Pulmonary and Critical Care Medicine, Yale University, New Haven, CT, 8Department of Radiology, Johns Hopkins University, Baltimore, MD, 9Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Interstitial lung disease (ILD) is an outcome with high morbidity and mortality in rheumatoid arthritis (RA).  Citrullinated proteins are observed in these lung tissues;…
  • Abstract Number: 286 • 2012 ACR/ARHP Annual Meeting

    The Association of N-Methyl-D-Aspartate Receptor Antibodies and Neurocognitive Dysfunction in Pediatric Lupus Patients and in the Offspring of Adult Patients with Lupus

    Natasha M. Ruth1, Mary C. Kral2, Stephanie Slan3, Tamara K. Nowling4, Murray H. Passo1 and Gary S. Gilkeson3, 1Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, 2Genetics and Developmental Pediatrics, MUSC, Charleston, SC, 3Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, 4Medical University of South Carolina, Charleston, SC

    Background/Purpose: Approximately 1/5 of all systemic lupus erythematosus (SLE) starts in childhood and central nervous system (CNS) dysfunction is more common in childhood-onset SLE.  CNS…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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