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Abstracts tagged "anti-citrullinated protein/peptide antibodies (ACPA)"

  • Abstract Number: 2138 • 2014 ACR/ARHP Annual Meeting

    Radiological Outcomes after Two Years of Remission Steered Treatment in Early Arthritis Patients

    G. Akdemir1, L. Heimans1, K.V.C. Wevers-de Boer1, M.K. Verheul2, A.a. Schouffoer3, M. van Oosterhout4, J.B. Harbers5, C. Bijkerk6, G.M. Steup-Beekman7, L.R. Lard8, T. W. J. Huizinga1, L.a. Trouw1 and C.F. Allaart1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Rheumatology, Haga Hospital, The Hague, Netherlands, 4Rheumatology, GHZ Hospital, Gouda, Netherlands, 5Rheumatology, Franciscus Hospital, Roosendaal, Netherlands, 6Rheumatology, Reinier de Graaf Gasthuis, Delft, Netherlands, 7Rheumatology, Bronovo Hospital, The Hague, Netherlands, 8Rheumatology, MCH Antoniushove Hospital, Leidschendam, Netherlands

    Background/Purpose: We investigated whether early, remission steered treatment can prevent damage progression in patients with early rheumatoid arthritis (RA) or undifferentiated arthritis (UA), and aimed…
  • Abstract Number: 1470 • 2014 ACR/ARHP Annual Meeting

    Malondialdehyde-Acetaldehyde Adducts (MAA) and Anti-Malondialdehyde-Acetaldehyde Antibody in Rheumatoid Arthritis

    Geoffrey Thiele1, Michael J. Duryee2, Daniel Anderson3, Lynell W. Klassen4, Stephen Mohring5, Kathleen Young6, Dathe Benissan-Messan7, Harlan Sayles3, Jeremy Sokolove8, William H. Robinson9, James O' Dell3, Anthony Nicholas10 and Ted R. Mikuls3, 1Int Med/Sec of Rheum/Immun, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 2Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 4Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 5Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 6Int Med/Sec of Rheum/Immun, University of Nebraska Medical Center, Omaha, NE, 7University of Nebraska Medical Center, Omaha, NE, 8VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 9VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 10Neurology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose:   Products of oxidative stress, MAA adducts are highly immunogenic and have been associated with tolerance loss.  To examine their potential role in disease-related…
  • Abstract Number: 451 • 2014 ACR/ARHP Annual Meeting

    The Association of Fine Specificities of Anti-Citrullinated Protein Antibodies (ACPA) with  disease Severity  in African-Americans with RA

    Maria I. Danila1, Richard Reynolds2, Gordon Wu3, Hemant Tiwari3, William H. Robinson4, Jeremy Sokolove5, CLEAR Investigators2 and S. Louis Bridges Jr.2,6, 1Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Biostatistics, University of Alabama at Birmingham, Birmingham, AL, 4VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 5VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 6Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: RA is characterized by the presence of autoantibodies to citrullinated proteins (ACPA) and joint damage. The role of fine specificities of ACPA in radiographic…
  • Abstract Number: 2406 • 2013 ACR/ARHP Annual Meeting

    The Relationship Between Anti-Citrullinated Protein Antibodies and Radiographic Damage In African-Americans With Rheumatoid Arthritis

    Maria I. Danila1, Richard J. Reynolds2, Stella Aslibekyan3, Ashutosh Tamhane3, Laura B. Hughes4, Jeremy Sokolove5, William H. Robinson6, Doyt L. Conn7, Beth L. Jonas8, Leigh F. Callahan9, Larry W. Moreland10, Richard D. Brasington11, Edwin A. Smith12, Ted R. Mikuls13, Désirée van der Heijde14 and S. Louis Bridges Jr.15, 1Med/Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, 2Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama at Birmingham, Birmingham, AL, 4Med Div of Clin Imm & Rheum, University of Alabama at Birmingham, Birmingham, AL, 5VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 6Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 7Rheumatology, Emory Univ School of Medicine, Atlanta, GA, 8Thurston Arthritis Research Ct, University of North Carolina at Chapel Hill, Chapel Hill, NC, 9Thurston Arthritis Res Ctr, University of North Carolina, Chapel Hill, NC, 10Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 11Div of Rheumatology, Washington Univ School of Med, St. Louis, MO, 12Dept of Med Div of Rheum, Med Univ of South Carolina, Charleston, SC, 13Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 14Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 15Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose:  Joint erosions and joint space narrowing may lead to impaired functional status and disability in rheumatoid arthritis (RA).  Autoantibodies to citrullinated proteins (ACPA) are present in…
  • Abstract Number: 2264 • 2013 ACR/ARHP Annual Meeting

    An Assay Panel Combining Anticitrullinated Peptide Autoantibodies and Rheumatoid Factor Isotypes Has High Yield In The Diagnosis Of Rheumatoid Arthritis

    Nirupa J. Patel1, Ignacio Garcia-Valladares2, Derren Barken3, Luis R. Espinoza4, Heena Sheth5 and Thierry Dervieux6, 1Rheumatology, LSU Health Sciences Ctr, New Orleans, LA, 2Rheumatology, Guadalajara, Guadalajara, Mexico, 3Exagen Diagnostics, Vista, CA, 4Medicine-Section of Rheum, LSU Medical Center, New Orleans, LA, 5Medicine, University of Pittsburgh, Pittsburgh, PA, 6Research and Development, Exagen Diagnostics, Vista, CA

    Background/Purpose: We sought to establish the diagnostic performances of rheumatoid factor isotypes (IgM and IgA) and anti-citrullinated peptide antibodies (ACPAs: anti-mutated citrullinated vimentin [anti-MCV] and…
  • Abstract Number: 1309 • 2013 ACR/ARHP Annual Meeting

    Prognosis Of Seronegative Patients In a Large Prospective Cohort Of Patients With Early Inflammatory Arthritis

    Lillian J. Barra1, Janet E. Pope2, Boulos Haraoui3, Carol A. Hitchon4, J. Carter Thorne5, Edward C. Keystone6,7, Diane Tin8, Gilles Boire9 and Vivian P. Bykerk10, 1Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 2Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 3Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, 4Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 5Southlake Regional Health Centre, Newmarket, ON, Canada, 6Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 7Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, University of Toronto, Toronto, ON, Canada, 8The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, 9Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, 10Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY

    Background/Purpose: Rheumatoid Factor (RF) and anti-Cyclic Citrullinated Peptide (anti-CCP) are believed to be associated with more severe clinical outcomes; however, studies in Early Inflammatory Arthritis…
  • Abstract Number: 1158 • 2013 ACR/ARHP Annual Meeting

    Decreased NK-Cell Numbers and Upregulation Of Markers Of Systemic Inflammation In Autoantibody –Positive Arthralgia Patients and Early Rheumatoid Arthritis Patients But Not In Autoantibody-Negative Rheumatoid Arthritis Patients

    Paulina Chalan1, Johan Bijzet2, Kornelis S.M. van der Geest1, Bart-Jan Kroesen3, Annemieke M.H. Boots4,5 and Elisabeth Brouwer1, 1Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 3Dept. of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 4Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 5Groningen Research initiative on healthy Ageing and Immune Longevity (GRAIL), Groningen, Netherlands

    Background/Purpose: Identification of seropositive individuals at risk for arthritis development would open opportunities for early clinical intervention. In a recent study on seropositive arthalgia patients…
  • Abstract Number: 1690 • 2012 ACR/ARHP Annual Meeting

    Citrullination within the Atherosclerotic Plaque: A New Potential Target for Anti-Citrullinated Protein Antibodies

    Jeremy Sokolove1, Orr Share1, Matthew Brennan1, Lauren J. Lahey1, Amy H. Kao2, Eswar Krishnan3, Mary Chester M. Wasko4 and William H. Robinson5, 1Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 2Lupus Center of Excellence, Allegheny Singer Research Institute, Pittsburgh, PA, 3Medicine, Standford University, Palo Alto, CA, 4West Penn Allegheny Health System, Temple University School of Medicine, Pittsburgh, PA, 5Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease due to accelerated atherosclerosis. This risk has mainly been limited to seropositive…
  • Abstract Number: 1604 • 2012 ACR/ARHP Annual Meeting

    Parity and the Risk of Developing Rheumatoid Arthritis: Results From the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study

    Cecilia Orellana1, Lars Klareskog2, Lars Alfredsson1 and Camilla Bengtsson1, 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is more common among women than among men and the gender difference in incidence seems to be most striking before menopause…
  • Abstract Number: 1200 • 2012 ACR/ARHP Annual Meeting

    Anti-Cyclic Citrullinated Peptide Antibodies in Idiopathic Pulmonary Fibrosis Are Not Citrulline-Specific: Implications for the Pathogenesis of Rheumatoid Arthritis

    Elena B. Lugli1, Muslima Chowdhury1, Peter J. Charles2, Michael G. Crooks3, Simon P. Hart3, Patrick Venables1 and Benjamin A. Fisher4, 1Kennedy Institute of Rheumatology, Oxford University, London, United Kingdom, 2Oxford University, Kennedy Institute of Rheumatology, Oxford, United Kingdom, 3Castle Hill Hospital, Hull York Medical School, Cottingham, United Kingdom, 4Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: The association of rheumatoid arthritis (RA) with smoking and silica exposure has led to the hypothesis that the lung is the site where RA autoimmunity…
  • Abstract Number: 1201 • 2012 ACR/ARHP Annual Meeting

    Anti-Citrullinated Protein Antibody Specific Fc Glycosylation Patterns in Arthralgia Patients

    Hans Ulrich Scherer1, Yoann Rombouts2, Ewoud Ewing3, Lotte van de Stadt4, Maurice H.J. Selman5, André M. Deelder3, Tom W.J. Huizinga2, Manfred Wuhrer5, Dirkjan van Schaardenburg6 and René E.M. Toes2, 1Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands, 4Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 5Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, 6Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) exhibit a specific, pro-inflammatory Fc glycosylation profile characterized by a low content of galactose and sialic acid residues. The absence…
  • Abstract Number: 1208 • 2012 ACR/ARHP Annual Meeting

    Stable Synovial Fluid Phenotype for Anti Citrullinated-Protein Antibodies in Established Rheumatoid Arthritis

    Vijay Joshua1, Lena Israelsson2, Lars Klareskog3, Anca Catrina1 and Vivianne Malmström4, 1Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 2Department of Medicine, Karolinska Institute, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, 4Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Presence of anti citrullinated-protein antibodies (ACPA) in the peripheral blood of patients with rheumatoid arthritis is a validated disease biomarker. We have previously shown…
  • Abstract Number: 1187 • 2012 ACR/ARHP Annual Meeting

    Smoking Status Is Associated with Inflammatory Cytokine Profile and Disease Activity in Anti-Citrullinated Protein Antibody Positive Rheumatoid Arthritis: Decreased Inflammation and Disease Improvement with Smoking Cessation?

    Catriona Cramb1, Jeremy Sokolove2, Geoffrey M. Thiele3, Gail S. Kerr4, Grant W. Cannon5, Andreas M. Reimold6, Ted R. Mikuls7 and William H. Robinson8, 1VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, 2Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 3Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE, 4Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, 5Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 6Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, 7Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 8Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Smoking is a major risk factor for rheumatoid arthritis (RA) and has been associated with increased disease severity and lower rates disease remission.   We…
  • Abstract Number: 1010 • 2012 ACR/ARHP Annual Meeting

    Bone Loss Before Clinical Onset of Rheumatoid Arthritis o Subjects with Anti-Citrullinated Protein Antibodies

    Stephanie Finzel1, Veronika Lang2, Arnd Kleyer1, Juergen Rech3, Bernhard Manger1, Elizabeth Araujo1, Axel J. Hueber4, Ulrike Harre5 and Georg Schett1, 1Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Dept. of Medicine, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Germany, 3Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, 4Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 5Institute for Clinical Immunology, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are a major risk factor for rapid disease progression in rheumatoid arthritis (RA). We have recently shown that ACPA directly…
  • Abstract Number: 978 • 2012 ACR/ARHP Annual Meeting

    A Genome-Wide Interaction Study with Smoking Suggests New Risk Loci for Two Different Subsets of Rheumatoid Arthritis; Results From Swedish Epidemiological Investigation of Rheumatoid Arthritis Study

    Xia Jiang1, Henrik Källberg1, Leonid Padyukov2, Lars Klareskog3 and Lars Alfredsson1, 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…
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