Abstracts tagged "anti-citrullinated protein/peptide antibodies (ACPA)"

Abstract Number: 43 • 2018 ACR/ARHP Annual Meeting
Novel Anti-Malarial Drug Derivative Inhibited Anti-Citrullinated Protein/Peptide Antibodies and Rheumatoid Factors Production in Dnaseii/Ifnr Double Knock out Mice
Jie An¹, Bhanupriya Madarampalli², Xizhang Sun², Lena Tanaka³, Erika H. Noss², Joshua Woodward⁴, Tomikazu Sasaki⁵ and Keith B. Elkon⁶, ¹Division of Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA, ³Medicine/Rheumatology, University of Washington, Seattle, WA, ⁴Department of Microbiology, University of Washington, Seattle, WA, ⁵Department of Chemistry, University of Washington, Seattle, WA, ⁶University of Washington, Seattle, WA
Background/Purpose: Rheumatoid Arthritis (RA) is a highly prevalent autoimmune disease affecting ~1% of the world population and can lead to permanent joint damage and severe…
Abstract Number: 71 • 2018 ACR/ARHP Annual Meeting
Association of Shared Epitope and Poor Prognostic Factors in RA
Evo Alemao¹, Joshua Bryson¹, Christine K Iannaccone², Michelle Frits², Nancy A. Shadick³ and Michael Weinblatt², ¹Bristol-Myers Squibb, Princeton, NJ, ²Brigham and Women’s Hospital, Boston, MA, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: There is a strong genetic association between RA and human leukocyte antigen (HLA) regions, particularly HLA-DRB1 alleles with the shared epitope (SE). SE alleles…
Abstract Number: 1483 • 2018 ACR/ARHP Annual Meeting
Comparison of Clinical Features of Seronegative and Seropositive Early Rheumatoid Arthritis: Blinded Data from the Ongoing Phase IIb Trial with the EP4 Receptor Antagonist CR6086 in DMARD-Naïve Patients
Giampaolo Giacovelli, Beatrice Barbetta, Cristina Vitalini, Nadia Brambilla, Massimo D'Amato, Federica Girolami and Lucio C. Rovati, Clinical Research Department, Rottapharm Biotech, Monza, Italy
Background/Purpose: Rheumatoid arthritis patients positive for rheumatoid factor (RF) or anti-cyclic citrullinated peptide antibody (ACPA) are considered to manifest an aggressive disease course compared with…
Abstract Number: 1509 • 2018 ACR/ARHP Annual Meeting
Associations between Perceived Stress and Joint Signs in an Anti-Cyclic Citrullinated Peptide Antibody Positive at-Risk Population
Kristen J. Polinski¹, Elizabeth A. Bemis¹, M. Kristen Demoruelle², Marie L. Feser², LauraKay Moss², Jennifer Seifert², V. Michael Holers³, Kevin D. Deane² and Jill M. Norris¹, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Division of Rheumatology, University of Colorado Denver, Aurora, CO, ³Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Psychosocial factors have been associated with rheumatoid arthritis (RA) outcomes, but have not been well characterized in the early development of RA. We examined…
Abstract Number: 2045 • 2018 ACR/ARHP Annual Meeting
Specific Anti-Citrullinated Protein Antibodies Profiles Are Associated with Rheumatoid Arthritis Related Interstitial Lung Disease
Pierre-Antoine Juge¹, Leonor Nogueira², Guy Serre², René-Marc Flipo³, Lidwine Wemeau-Stervinou⁴, Thierry Schaeverbeke⁵, Claire Dromer⁶, Sylvain Adam-Marchand⁷, Marie-Christophe Boissier⁸, Hilario Nunes⁹, Raphaël Borie¹⁰, Bruno Crestani¹⁰ and Philippe Dieude¹⁰, ¹Rhumatologie, Hôpital Bichat - Claude Bernard, Paris, France, ²Unité Différenciation Épidermique et Autoimmunité Rhumatoïde, Unité Mixte de Recherche, INSERM, Toulouse, France, ³Hôpital Roger Salengro, Lille, France, ⁴Pneumologie, CHRU de Lille, Lille, France, ⁵Department of Rheumatology, Bordeaux University Hospital, BORDEAUX, France, ⁶Imagerie Thoracique et Cardiovasculaire, CHU Bordeaux, Bordeaux, France, ⁷Pneumology, Centre Hospitalier Universitaire de Tours, Tours, France, ⁸74 rue Marcel Cachin, INSERM, Bobigny, France, ⁹Pulmonary diseases department, Avicenne Hospital (AP-HP), Bobigny, France, ¹⁰Université Paris-Diderot, Paris, France
Background/Purpose: The identification of peripheral blood markers of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) may facilitate an earlier diagnosis and provide insight regarding the pathogenesis…
Abstract Number: 2325 • 2018 ACR/ARHP Annual Meeting
Sex Differences in the Association of Frailty and Bone Mineral Density in Patients with Rheumatoid Arthritis
Katherine D. Wysham¹, Dolores M. Shoback², John B. Imboden Jr.³ and Patricia Katz⁴, ¹University of California, San Francisco, San Francisco, CA, ²Medicine, San Francisco VA Medical Center, University of California, San Francisco, San Francisco, CA, ³Medicine, University of California, San Francisco, San Francisco, CA, ⁴University of California San Francisco, San Francisco, CA
Background/Purpose: Frailty in the general population is associated with poor outcomes including osteoporosis (OP), fracture and death. Frailty occurs at a higher rate in RA…
Abstract Number: 2999 • 2018 ACR/ARHP Annual Meeting
Does the Incremental Cost of ACPA-Positive Rheumatoid Arthritis Patients Vary By the Care Pathway They Follow?
Aniket Kawatkar¹, J An², TC Cheetham², Kiran Gupta³, Alexander Marshall⁴, Eric Haupt¹, Gary Okano³ and Tammy Curtice⁵, ¹Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, ²Western University of Health Sciences, Pomona, CA, ³HEOR, Bristol-Myers Squibb, Princeton, NJ, ⁴HEOR, Bristol-Myers Squibb, Lawrenceville, NJ, ⁵Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Rheumatoid Arthritis (RA) patients who are anti-citrullinated peptide antibody (ACPA) positive are prone to more severe structural damage, radiographic progression and inferior response to…
Abstract Number: 951 • 2017 ACR/ARHP Annual Meeting
Cross Sectional Analysis of Citrullinated-Synovial Antigen-Specific CD4+ T Cells in an RA Cohort Demonstrates Antigen Based Differences in T Cell Frequency, Phenotype and the Influence of Immunotherapy
Cliff Rims¹, Sylvia Posso¹, Bernard Ng², Jeffrey Carlin³, Eddie James⁴ and Jane H. Buckner⁴, ¹Translational Research, Benaroya Research Institute at Virginia Mason, Seattle, WA, ²Rheumatology, VA Puget Sound Healthcare System, Seattle, WA, ³Rheumatology, Virginia Mason Medical Center, Seattle, WA, ⁴Benaroya Research Institute at Virginia Mason, Seattle, WA
Background/Purpose: The presence of ACPA in RA indicates that an immune response directed toward citrullinated synovial antigens participates in disease development or persistence. Research from…
Abstract Number: 1325 • 2017 ACR/ARHP Annual Meeting
Immune Responses to Peptides Containing Homocitrulline or Citrulline in the DR4-Transgenic Mouse Model of Rheumatoid Arthritis
Patrick Lac¹, Sheri Saunders¹, Elena Tutunea-Fatan¹, Lillian Barra², David Bell³ and Ewa Cairns², ¹Microbiology and Immunology, The University of Western Ontario, London, ON, Canada, ²Medicine, Microbiology and Immunology, The University of Western Ontario, London, ON, Canada, ³Medicine, The University of Western Ontario, London, ON, Canada
Background/Purpose: Antibodies to proteins/peptides containing citrulline (commonly measured using cyclic citrullinated peptide, CCP2) are hallmarks of Rheumatoid Arthritis (RA). These antibodies are strongly associated with…
Abstract Number: 413 • 2017 ACR/ARHP Annual Meeting
Economic Burden Associated with Anti-Cyclic Citrullinated Peptide Antibody Positivity in Patients Newly Diagnosed with RA
J An¹, Z Bider², J Kang¹, E Alemao³, SE Connolly³ and TC Cheetham¹, ¹Western University of Health Sciences, Pomona, CA, ²Southern California Permanente Medical Group, Pasadena, CA, ³Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Anti-cyclic citrullinated peptide (anti-CCP) antibody positivity has been suggested as a strong predictor of joint erosion as well as a potential biomarker for guiding…
Abstract Number: 476 • 2017 ACR/ARHP Annual Meeting
Novel Interaction between Anti-Citrulline Monoclonal Antibodies and Apoptotic Cells Is Mediated through Citrullinated Nuclear Antigens
Katy A. Lloyd¹, Peter Sahlström², Johanna Steen¹, Philip J. Titcombe^3,4, Diana Zhou¹, Christina Lundqvist⁵, Olov Ekwall^6,7, Jimmy Ytterberg¹, Johan Rönnelid⁸, Daniel L. Mueller³, Lars Klareskog¹, Vivianne Malmström¹ and Caroline Grönwall⁹, ¹Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ²Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ³Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, ⁴Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Sweden, Sweden, ⁵Dept. of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden, ⁶Dept. of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy University of Gothenburg, Göteborg, Sweden, ⁷Dept of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden, ⁸Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁹Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) display broad cross-reactivities and target proteins including a-enolase, filaggrin, vimentin, fibrinogen, and histones. However, every monoclonal ACPA has a distinct…
Abstract Number: 477 • 2017 ACR/ARHP Annual Meeting
Monoclonal ACPA-IgG Feature Extensive Fab Glycosylation
Katy A. Lloyd¹, Johanna Steen¹, Philip J. Titcombe^2,3, Khaled Amara⁴, Diana Zhou¹, Lena Israelsson⁵, Susanna L. Lundström⁶, Daniel L. Mueller³, Lars Klareskog¹, Vivianne Malmström¹ and Caroline Grönwall⁷, ¹Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ²Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Sweden, Sweden, ³Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, ⁴Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁵Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁶Dept. of Medical Biochemistry and Biophysics, Division of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden, ⁷Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Fab-glycosylation is found in ~15-25% serum IgG and while its exact consequence remains unknown, it may alter IgG functionality. Recent data revealed elevated Fab-glycosylation…
Abstract Number: 480 • 2017 ACR/ARHP Annual Meeting
ANTI-Carbamylated Protein Antibodies (CARP) in Palindromic Rheumatism: Prevalence and Clinical Significance
Raul Castellanos-Moreira Sr.¹, Virginia Ruiz-Esquide¹, María José Gomara², Sonia Cabrera-Villalba¹, Sebastian C Rodriguez-Garcia¹, Georgina Salvador³, Andrea Cuervo¹, Julio Ramírez¹, M. Victoria Hernández¹, Juan Cañete¹, Isabel Haro² and Raimon Sanmartí¹, ¹Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, ²Unit of Synthesis and Biomedical Applications of Peptides, IQAC-CSIC, Barcelona, Spain, ³Hospital Universitario Mutua Terrassa, Barcelona, Spain
Background/Purpose: Autoantibodies (RF or ACPA) are found in sera from patients with palindromic rheumatism (PR) but there are no studies analyzing the presence of Anti-carbamylated…
Abstract Number: 491 • 2016 ACR/ARHP Annual Meeting
Anti-Citrullinated Peptide Antibodies Testing Rate over Time in Newly Diagnosed RA Patients – Data from Three Administrative Claims Databases (2007–2014)
E Alemao, Z Guo and L Burns, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Current clinical guidelines recommend testing for anti-citrullinated protein antibodies (ACPA) at the time of RA diagnosis.1 However, there is a lack of information about…
Abstract Number: 496 • 2016 ACR/ARHP Annual Meeting
Impact of Anti-Citrullinated Protein Antibody and/or Rheumatoid Factor on Rheumatoid Arthritis Manifestations and Outcomes
Ee Tzun Koh¹, Angela Marie Chan¹, Wei Qiang See², Wenwei Xiang², Khai Pang Leong¹ and Tan Tock Seng Rheumatoid Arthritis Study Group, ¹Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore, ²Clinical Research and Innovation Office, Tan Tock Seng Hospital, Singapore, Singapore
Background/Purpose: RA Patients with anti-citrullinated protein antibody (ACPA) or rheumatoid factor (RF) are known to have worse clinical outcomes compared to seronegative patients. To determine…