Abstracts tagged "anti-citrullinated protein/peptide antibodies (ACPA)"

Abstract Number: 422 • 2012 ACR/ARHP Annual Meeting
Antibodies to Citrulline From Rheumatoid Arthritis Patients Also Bind Homocitrulline
Mathias Scinocca¹, Radha Joseph², David A. Bell³, Ewa Cairns³ and Lillian J. Barra³, ¹Microbiology and Immunology, Schulich School of Medicine and Dentistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ³Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
Background/Purpose: Antibodies to citrullinated proteins/peptides (ACPA) are specific for Rheumatoid Arthritis (RA). One of ACPA’s targets is citrullinated fibrinogen (citfib) and it is found in…
Abstract Number: 421 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Factor, Not Antibodies to Citrullinated Proteins, Are Associated with High Disease Activity
Josef S. Smolen¹, Farideh Alasti² and Daniel Aletaha³, ¹Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ²Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Autoantibodies in general, and rheumatoid factor (RF) and anti-citrullinated peptide antibodies (ACPA) in particular, are a hallmark of RA. After their characterization, ACPA have…
Abstract Number: 414 • 2012 ACR/ARHP Annual Meeting
First-Degree Relatives without Rheumatoid Arthritis Exhibit Reactivity to Multiple Anti-Citrullinated Protein Antibodies in Association with Rheumatoid Arthritis-Related Clinical Characteristics: Studies of the Etiology of Rheumatoid Arthritis
Kendra A. Young¹, Kevin D. Deane², Lezlie A. Derber³, Jan M. Hughes-Austin⁴, Michael H. Weisman⁵, Jane H. Buckner⁶, Ted R. Mikuls⁷, James R. O'Dell⁸, Richard M. Keating⁹, Peter K. Gregersen¹⁰, V. Michael Holers¹¹ and Jill M. Norris¹, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³University of Colorado School of Medicine, Division of Rheumatology, Aurora, CO, ⁴Epidemiology, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ⁵Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁶Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁷Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁸Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, ⁹Rheumatology Section, The University of Chicago, Chicago, IL, ¹⁰Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ¹¹Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Prior to diagnosis of rheumatoid arthritis (RA), there are increases in the number of citrullinated proteins that anti-citrullinated protein antibodies (ACPA) target, suggesting an…
Abstract Number: 411 • 2012 ACR/ARHP Annual Meeting
Early Menopause, Smoking and Circulating Antibodies Against Citrullinated Peptides in the Pre-Clinical Phase of Rheumatoid Arthritis
Mitra Pikwer¹, Johan Rönnelid², Monika Hansson³, Ulf Bergström¹, Lennart T.H. Jacobsson⁴, Linda Mathsson², Per Johan Jakobsson⁵, Guy B. Serre⁶, Rikard Holmdahl⁷, Lars Klareskog⁸ and Carl Turesson⁴, ¹Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁴Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁵Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁶Laboratory of Epidermis differentiation and Rheumatoid autoimmunity, Centre National de la Recherche Scientifique - Université de Toulouse, Toulouse, France, ⁷Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, ⁸Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Previous studies indicate that anti-citrullinated peptide antibodies (ACPAs) may be detected in individuals who later develop rheumatoid arthritis (RA) years before onset, and that…
Abstract Number: 978 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide Interaction Study with Smoking Suggests New Risk Loci for Two Different Subsets of Rheumatoid Arthritis; Results From Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Xia Jiang¹, Henrik Källberg¹, Leonid Padyukov², Lars Klareskog³ and Lars Alfredsson¹, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…
Abstract Number: 1010 • 2012 ACR/ARHP Annual Meeting
Bone Loss Before Clinical Onset of Rheumatoid Arthritis o Subjects with Anti-Citrullinated Protein Antibodies
Stephanie Finzel¹, Veronika Lang², Arnd Kleyer¹, Juergen Rech³, Bernhard Manger¹, Elizabeth Araujo¹, Axel J. Hueber⁴, Ulrike Harre⁵ and Georg Schett¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Dept. of Medicine, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Germany, ³Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Institute for Clinical Immunology, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are a major risk factor for rapid disease progression in rheumatoid arthritis (RA). We have recently shown that ACPA directly…
Abstract Number: 1187 • 2012 ACR/ARHP Annual Meeting
Smoking Status Is Associated with Inflammatory Cytokine Profile and Disease Activity in Anti-Citrullinated Protein Antibody Positive Rheumatoid Arthritis: Decreased Inflammation and Disease Improvement with Smoking Cessation?
Catriona Cramb¹, Jeremy Sokolove², Geoffrey M. Thiele³, Gail S. Kerr⁴, Grant W. Cannon⁵, Andreas M. Reimold⁶, Ted R. Mikuls⁷ and William H. Robinson⁸, ¹VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, ²Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ³Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE, ⁴Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, ⁵Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁶Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, ⁷Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁸Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Smoking is a major risk factor for rheumatoid arthritis (RA) and has been associated with increased disease severity and lower rates disease remission. We…
Abstract Number: 1208 • 2012 ACR/ARHP Annual Meeting
Stable Synovial Fluid Phenotype for Anti Citrullinated-Protein Antibodies in Established Rheumatoid Arthritis
Vijay Joshua¹, Lena Israelsson², Lars Klareskog³, Anca Catrina¹ and Vivianne Malmström⁴, ¹Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ²Department of Medicine, Karolinska Institute, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, ⁴Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Presence of anti citrullinated-protein antibodies (ACPA) in the peripheral blood of patients with rheumatoid arthritis is a validated disease biomarker. We have previously shown…
Abstract Number: 1200 • 2012 ACR/ARHP Annual Meeting
Anti-Cyclic Citrullinated Peptide Antibodies in Idiopathic Pulmonary Fibrosis Are Not Citrulline-Specific: Implications for the Pathogenesis of Rheumatoid Arthritis
Elena B. Lugli¹, Muslima Chowdhury¹, Peter J. Charles², Michael G. Crooks³, Simon P. Hart³, Patrick Venables¹ and Benjamin A. Fisher⁴, ¹Kennedy Institute of Rheumatology, Oxford University, London, United Kingdom, ²Oxford University, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ³Castle Hill Hospital, Hull York Medical School, Cottingham, United Kingdom, ⁴Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: The association of rheumatoid arthritis (RA) with smoking and silica exposure has led to the hypothesis that the lung is the site where RA autoimmunity…
Abstract Number: 1201 • 2012 ACR/ARHP Annual Meeting
Anti-Citrullinated Protein Antibody Specific Fc Glycosylation Patterns in Arthralgia Patients
Hans Ulrich Scherer¹, Yoann Rombouts², Ewoud Ewing³, Lotte van de Stadt⁴, Maurice H.J. Selman⁵, André M. Deelder³, Tom W.J. Huizinga², Manfred Wuhrer⁵, Dirkjan van Schaardenburg⁶ and René E.M. Toes², ¹Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands, ⁴Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ⁵Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, ⁶Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) exhibit a specific, pro-inflammatory Fc glycosylation profile characterized by a low content of galactose and sialic acid residues. The absence…
Abstract Number: 1604 • 2012 ACR/ARHP Annual Meeting
Parity and the Risk of Developing Rheumatoid Arthritis: Results From the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Cecilia Orellana¹, Lars Klareskog², Lars Alfredsson¹ and Camilla Bengtsson¹, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is more common among women than among men and the gender difference in incidence seems to be most striking before menopause…
Abstract Number: 1690 • 2012 ACR/ARHP Annual Meeting
Citrullination within the Atherosclerotic Plaque: A New Potential Target for Anti-Citrullinated Protein Antibodies
Jeremy Sokolove¹, Orr Share¹, Matthew Brennan¹, Lauren J. Lahey¹, Amy H. Kao², Eswar Krishnan³, Mary Chester M. Wasko⁴ and William H. Robinson⁵, ¹Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ²Lupus Center of Excellence, Allegheny Singer Research Institute, Pittsburgh, PA, ³Medicine, Standford University, Palo Alto, CA, ⁴West Penn Allegheny Health System, Temple University School of Medicine, Pittsburgh, PA, ⁵Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease due to accelerated atherosclerosis. This risk has mainly been limited to seropositive…