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Abstracts tagged "anti-citrullinated protein/peptide antibodies (ACPA)"

  • Abstract Number: 411 • 2012 ACR/ARHP Annual Meeting

    Early Menopause, Smoking and Circulating Antibodies Against Citrullinated Peptides in the Pre-Clinical Phase of Rheumatoid Arthritis

    Mitra Pikwer1, Johan Rönnelid2, Monika Hansson3, Ulf Bergström1, Lennart T.H. Jacobsson4, Linda Mathsson2, Per Johan Jakobsson5, Guy B. Serre6, Rikard Holmdahl7, Lars Klareskog8 and Carl Turesson4, 1Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 2Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, 3Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 4Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 5Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 6Laboratory of Epidermis differentiation and Rheumatoid autoimmunity, Centre National de la Recherche Scientifique - Université de Toulouse, Toulouse, France, 7Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, 8Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden

    Background/Purpose: Previous studies indicate that anti-citrullinated peptide antibodies (ACPAs) may be detected in individuals who later develop rheumatoid arthritis (RA) years before onset, and that…
  • Abstract Number: 414 • 2012 ACR/ARHP Annual Meeting

    First-Degree Relatives without Rheumatoid Arthritis Exhibit Reactivity to Multiple Anti-Citrullinated Protein Antibodies in Association with Rheumatoid Arthritis-Related Clinical Characteristics: Studies of the Etiology of Rheumatoid Arthritis

    Kendra A. Young1, Kevin D. Deane2, Lezlie A. Derber3, Jan M. Hughes-Austin4, Michael H. Weisman5, Jane H. Buckner6, Ted R. Mikuls7, James R. O'Dell8, Richard M. Keating9, Peter K. Gregersen10, V. Michael Holers11 and Jill M. Norris1, 1Epidemiology, Colorado School of Public Health, Aurora, CO, 2Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 3University of Colorado School of Medicine, Division of Rheumatology, Aurora, CO, 4Epidemiology, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, 5Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 6Benaroya Research Institute at Virginia Mason, Seattle, WA, 7Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 8Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, 9Rheumatology Section, The University of Chicago, Chicago, IL, 10Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 11Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: Prior to diagnosis of rheumatoid arthritis (RA), there are increases in the number of citrullinated proteins that anti-citrullinated protein antibodies (ACPA) target, suggesting an…
  • Abstract Number: 421 • 2012 ACR/ARHP Annual Meeting

    Rheumatoid Factor, Not Antibodies to Citrullinated Proteins, Are Associated with High Disease Activity

    Josef S. Smolen1, Farideh Alasti2 and Daniel Aletaha3, 1Medical University of Vienna and Hietzing Hospital, Vienna, Austria, 2Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Autoantibodies in general, and rheumatoid factor (RF) and anti-citrullinated peptide antibodies (ACPA) in particular, are a hallmark of RA. After their characterization, ACPA have…
  • Abstract Number: 422 • 2012 ACR/ARHP Annual Meeting

    Antibodies to Citrulline From Rheumatoid Arthritis Patients Also Bind Homocitrulline

    Mathias Scinocca1, Radha Joseph2, David A. Bell3, Ewa Cairns3 and Lillian J. Barra3, 1Microbiology and Immunology, Schulich School of Medicine and Dentistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 2Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 3Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

    Background/Purpose: Antibodies to citrullinated proteins/peptides (ACPA) are specific for Rheumatoid Arthritis (RA). One of ACPA’s targets is citrullinated fibrinogen (citfib) and it is found in…
  • Abstract Number: 2576 • 2012 ACR/ARHP Annual Meeting

    Production of Citrullinated Filaggrin-Specific IgG in Rheumatoid Arthritis Patients Is Associated with an Expansion of Citrullinated Filaggrin Tetramer-Binding Switched Memory Blood B Cells

    Philip Titcombe1, Laura O. Barsness1, Lauren Giacobbe1, Emily Baechler Gillespie1, Erik J. Peterson2 and Daniel L. Mueller2, 1University of Minnesota Medical School, Minneapolis, MN, 2Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN

    Background/Purpose: Rheumatoid Arthritis (RA) is highly associated with the production of autoantibodies, including rheumatoid factors and anti-citrullinated protein antibodies (ACPA). It remains uncertain whether production…
  • Abstract Number: 63 • 2012 ACR/ARHP Annual Meeting

    The Association Between Silica and the Risk of Anti-Citrullinated Protein Antibody Positive RA in the Malaysian and Swedish Epidemiological Investigation of Rheumatoid Arthritis Studies

    Abqariyah Yahya1, Camilla Bengtsson1, Lars Klareskog2, Chun Lai Too3, Shahnaz Murad4 and Lars Alfredsson1, 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, 3Karolinska Institutet, Stockholm, Sweden, 4Institute for Medical Research, Kuala Lumpur, Kuala Lumpur, Malaysia

    Background/Purpose: Silica exposure has been associated with an increased risk of developing ACPA+ (anti-citrullinated protein antibody) RA, especially among smokers (1). These findings were based…
  • Abstract Number: 2581 • 2012 ACR/ARHP Annual Meeting

    Anti- Citrullinated Protein Antibodies but Not Rheumatoid Factor Are Associated with Larger Bone Erosions in rheumatoid arthritis patients- a Cross-Sectional Micro Computed Tomography Study

    Carolin Hecht1, Stephanie Finzel1, Matthias Englbrecht1, Sarah Schmidt1, Juergen Rech2, Elizabeth Araujo1 and Georg Schett1, 1Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Anti- citrullinated protein antibodies (ACPA) are known to be associated with joint destruction and a more severe disease course in rheumatoid arthritis (RA) patients.…
  • Abstract Number: 26 • 2012 ACR/ARHP Annual Meeting

    Quantitative Analysis of Bone Damage Morphological Changes in the Citrullinated Collagen Induced Arthritis Mouse Model Using Micro CT

    Anand Dusad1, Michael J. Duryee2, Dong Wang3, James R. O'Dell4, Ted R. Mikuls5, Geoffrey M. Thiele6 and Lynell W. Klassen4, 1Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Pharmaceutical Sciences, Univ of Nebraska Medical Ctr, Omaha, NE, 4Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, 5Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 6Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE

    Background/Purpose: Patients with rheumatic diseases given immunosuppressive therapy are susceptible to various types of infections, especially pulmonary infections that affect their vital prognosis. The aim…
  • Abstract Number: 1767 • 2012 ACR/ARHP Annual Meeting

    Circulating Plasmablasts As a Source of Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis

    Priscilla Kerkman, Ellen I.H. van der Voort, Leendert A. Trouw, Tom W.J. Huizinga, René E.M. Toes and Hans Ulrich Scherer, Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA) and predict disease onset and severity. Accumulating evidence indicates that ACPA could…
  • Abstract Number: 27 • 2012 ACR/ARHP Annual Meeting

    Anti-Citrullinated Protein Antibodies As an Indicator of Bone Damage in the Citrullinated Collagen Induced Arthritis Model

    Anand Dusad1, Michael J. Duryee2, Dong Wang3, Carlos D. Hunter2, Bartlett C. Hamilton III4, James R. O'Dell5, Ted R. Mikuls6, Lynell W. Klassen5 and Geoffrey M. Thiele7, 1Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Pharmaceutical Sciences, Univ of Nebraska Medical Ctr, Omaha, NE, 4University of Nebraska Medical Center and Omaha VA Medical Center, Omaha, NE, 5Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, 6Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 7Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE

    Background/Purpose: Although the pathogenesis and cause of rheumatoid arthritis (RA) remains uncertain, various disease-driving auto-antigens and auto-antibodies with different specificities have been used as diagnostic…
  • Abstract Number: 1768 • 2012 ACR/ARHP Annual Meeting

    The Absolute Concentration of Anti Citrullinated Protein Antibodies in Serum and Synovial Fluid in Relation to Total Immunoglobulin-Concentrations

    Annemiek Willemze, Jing Shi, Marlies Mulder, Gerrie Stoeken-Rijsbergen, Tom W. J. Huizinga, René E. M. Toes and Leendert A. Trouw, Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The presence of anti-citrullinated protein antibodies (ACPA) is one of the most predictive factors for the development of rheumatoid arthritis (RA). Nonetheless, relatively little…
  • Abstract Number: 31 • 2012 ACR/ARHP Annual Meeting

    Anti Citrullinated Protein Antibodies From Synovial Fluid of Rheumatoid Arthritis Patients Enhance Osteoclastogenesis

    Akilan Krishnamurthy1, Nancy Vivar Pomiano2, Catia Cerqueira3, Elena Ossipova3, Karin Lundberg4, Ulrike Harre5, Vivianne Malmström6, Per Johan Jakobsson7, Lars Klareskog8, Georg Schett9 and Anca Catrina3, 1Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 3Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 4Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 5Institute for Clinical Immunology, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 6Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 7Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 8Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, 9Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Presence of anti CCP2 antibodies identifies a subgroup of RA patients that are more prone to develop bone erosions. We hypothesized that anti CCP2…
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