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Abstracts tagged "Anti-citrullinated Protein Autoantibodies (ACPAs)"

  • Abstract Number: 0045 • ACR Convergence 2022

    Rheumatoid Arthritis Patient-derived Anti-citrullinated Protein Antibodies (ACPAs) Ameliorate Joint Inflammation in Early Collagen-antibody Induced Arthritis (CAIA)

    Alejandro Gomez1, Camille Brewer1, Jae-Seung Moon2, Suman Acharya1, Tobias V. Lanz1, Qian Wang1, Gundula Min-Oo3, Anita Niedziela-Majka3 and William Robinson4, 1Stanford University, Stanford, CA, 2Stanford University, Palo Alto, CA, 3Gilead Sciences, Foster City, CA, 4Stanford University School of Medicine, Palo Alto, CA

    Background/Purpose: ACPAs are present in two-thirds of patients with rheumatoid arthritis (RA) and are associated with higher risks for severe bone erosions. The pathogenic role…
  • Abstract Number: 0256 • ACR Convergence 2022

    Patients with ACPA-positive and ACPA-negative Rheumatoid Arthritis Show Different Circulating Auto-antibody Repertoires

    Kevin Cunningham1, Benjamin Hur2, John Davis2 and Jaeyun Sung2, 1University of Minnesota, Rochester, MN, 2Mayo Clinic, Rochester, MN

    Background/Purpose: RA is commonly diagnosed through a serological test for the presence of ACPA, and RA patients who test positive are collectively known as 'ACPA-positive…
  • Abstract Number: 0269 • ACR Convergence 2021

    Autoantibodies and the Risk of Incident Cardiovascular Disease in US Veterans with Rheumatoid Arthritis

    Tate Johnson1, Michael Duryee2, Carlos Hunter2, Punyasha Roul2, Yangyuna Yang2, Jeremy Sokolove3, William Robinson4, Joshua Baker5, Geoffrey Thiele2, Ted Mikuls2 and Bryant England2, 1University of Nebraska Medical Center, Elkhorn, NE, 2University of Nebraska Medical Center, Omaha, NE, 3Stanford University School of Medicine, Berwyn, PA, 4Stanford University, Stanford, CA, 5University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Autoantibodies are hypothesized as one of the RA specific factors contributing to a heightened risk of cardiovascular disease (CVD) in this population. However, prior…
  • Abstract Number: 0288 • ACR Convergence 2021

    Demographic, Lifestyle, and Clinical Risk Factors for Rheumatoid Arthritis-Associated Bronchiectasis: Role of RA-related Autoantibodies

    Gregory McDermott1, Ritu Gill2, Staci Gagne3, Suzanne Byrne3, Weixing Huang3, Lauren Prisco4, Alessandra Zaccardelli3, Lily Martin3, Nancy Shadick5, Paul Dellaripa3, Tracy Doyle6 and Jeffrey Sparks3, 1Brigham and Women's Hospital, Brookline, MA, 2Beth Israel Deaconess Medical Center, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Brigham and Women's Hospital, Pound Ridge, MA, 5Brigham & Women's Hospital, Boston, MA, 6Brigham and Women's Hospital, West Roxbury, MA

    Background/Purpose: Bronchiectasis is a known extra-articular manifestation of rheumatoid arthritis (RA) characterized by bronchial damage and excessive mucus production that predispose patients to risk of…
  • Abstract Number: 0291 • ACR Convergence 2021

    IgA Anti-Cyclic Citrullinated Peptide Antibodies in Bronchoalveolar Lavage Fluid from Patients with Idiopathic Pulmonary Fibrosis Are Associated with Reduced Mortality

    Scott Matson1, Candace Cephers2, Timothy Wilson3, Valerie Minarchick3, Kevin Brown4, Joshua Solomon4 and Kristen Demoruelle5, 1University of Kansas, Kansas City, MO, 2St Joseph Hospital, Internal Medicine, Denver, CO, 3University of Colorado, Denver, CO, 4National Jewish Health, Denver, CO, 5University of Colorado Anschutz Medical Campus, Aurora, CO

    Background/Purpose: Idiopathic pulmonary fibrosis (IPF) is a form of interstitial lung disease (ILD) that shares many clinical features with rheumatoid arthritis (RA) associated ILD. Our…
  • Abstract Number: 0440 • ACR Convergence 2021

    Association Between Rheumatic Autoantibody Positivity and Immune-related Adverse Events

    Kristen Mathias1, Marco Lopez Velazquez1 and Pankti Reid2, 1University of Chicago, Chicago, IL, 2University of Chicago Medical Center, Chicago, IL

    Background/Purpose: The advent of immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy; however, their use can lead to off-target toxicities called immune-related adverse events (irAEs)…
  • Abstract Number: 0461 • ACR Convergence 2021

    Plasmablast-derived Autoantibodies from Individuals At-risk for RA That Target RA-relevant Antigens Are Polyreactive with Arthritogenic Bacteria

    Meagan Chriswell1, Jennifer Seifert2, Michelle Bloom3, Cliff Rims4, Marie Feser5, Kevin Deane6, Jill Norris7, Eddie James8, Jane Buckner9, William Robinson10, V. Michael Holers11 and Kristine Kuhn12, 1UC Denver SOM, Denver, CO, 2University of Colorado School of Medicine, Littleton, CO, 3Stanford University, Redwood City, CA, 4Benaroya Research Institute, Seattle, WA, 5University of Colorado Denver, Aurora, CO, 6University of Colorado Denver, Denver, CO, 7Colorado School of Public Health, Aurora, CO, 8Benaroya Research Institute at Virginia Mason, Monroe, WA, 9Benaroya Research Institute at Virginia Mason, Seattle, WA, 10Stanford University, Palo Alto, CA, 11University of Colorado, Denver, CO, 12University of Colorado Anschutz Medical Campus, Aurora, CO

    Background/Purpose: Circulating autoantibodies like ACPA frequently develop years before symptoms of RA, during which the individual is at-risk for disease. Several lines of evidence suggest…
  • Abstract Number: 0790 • ACR Convergence 2021

    Unraveling Heterogeneity Within ACPA-negative Rheumatoid Arthritis; The Subgroup of Patients with a Strong Clinical and Serological Response to Initiation of DMARD-treatment Favor Disease Resolution

    Marloes Verstappen1, Hanna van Steenbergen2, Pascal de Jong3 and Annette H.M van der Helm-van Mil1, 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden Univeristy Medical Center, Leiden, Netherlands, 3Erasmus MC, Hendrik Ido Ambacht, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is a heterogeneous disease, especially ACPA-negative-RA. This is reflected by differences in long-term outcomes, ranging from refractory RA to sustained-DMARD-free-remission(SDFR; sustained…
  • Abstract Number: 0007 • ACR Convergence 2021

    Divergent Reactivities of Rheumatoid Factors and Anti-Modified Protein Antibodies Converge on IgG Epitopes

    Aisha Mergaert1, Zihao Zheng1, Michael Denny1, Maya Amjadi1, Janna Bashar1, Michael Newton1, Vivianne Malmström2, Caroline Grönwall2, Sara McCoy1 and Miriam Shelef1, 1University of Wisconsin, Madison, WI, 2Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) patients often develop rheumatoid factors (RFs), antibodies that bind IgG Fc, and anti-modified protein antibodies (AMPAs), multi-reactive autoantibodies that commonly bind…
  • Abstract Number: 0813 • ACR Convergence 2021

    Improvement in Clinical Disease Activity and Patient-Reported Outcomes After 6 Months of Treatment with Abatacept, Stratified by Line of Therapy, in Patients with RA: Results from a Large, US, National Observational Study

    Leslie Harrold1, Keith Wittstock2, Sheila Kelly2, Sang Hee Park2, Xue Han2, Ying Shan1, Carla Roberts-Toler1, Nicole Middaugh1 and Vadim Khaychuk2, 1CorEvitas, LLC, Waltham, MA, 2Bristol Myers Squibb, Princeton, NJ

    Background/Purpose: RA is more responsive to treatment in the early stages of disease, and early treatment may lead to better long-term outcomes.1,2 Data on the…
  • Abstract Number: 0012 • ACR Convergence 2021

    A Novel Mechanism Linking Mucosal Bacteria with Autoantibody Responses in RA: Acetylated Bacterial Lysate as a Model Antigen

    Mikhail Volkov, Arieke Kampstra, Karin van Schie, Joanneke Kwekkeboom, Tom WJ Huizinga, René Toes and Diane van der Woude, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by autoantibodies against post-translationally modified proteins (AMPA) such as citrullinated, carbamylated and acetylated proteins. Importantly, these antibodies are highly…
  • Abstract Number: 1014 • ACR Convergence 2021

    Enhanced Expression of Rheumatoid Arthritis Related Autoantibodies Following Airborne Endotoxin Exposure in the Setting of Collagen-Induced Arthritis

    Ted Mikuls1, Rohit Gaurav1, Geoffrey Thiele1, Bryant England1, Madison Wolfe1, Brianna Shaw1, Kristina Bailey1, Amy Nelson1, Michael Duryee1, Carlos Hunter1, Debra Romberger1, Dana Ascherman2 and Jill Poole1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: In addition to inflammatory arthritis, collagen-induced arthritis (CIA) recapitulates cardinal features of rheumatoid arthritis (RA) including autoreactive T cells, peptidyl-arginine deiminase expression, and citrullination…
  • Abstract Number: 0021 • ACR Convergence 2021

    Unique Alterations in Circulating T Peripheral Helper Cells Are Found in Different Ethnic Groups of ACPA+ Individuals Both At-risk for and with Classified RA

    Hideto Takada1, Yuko Okamoto2, Yasuhiro Katsumata3, Jennifer Seifert4, Kristen Demoruelle5, Jill Norris6, Kevin Deane7, Masayoshi Harigai3 and V. Michael Holers8, 1Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Japan, 2Tokyo Women's Medical University Division of Rheumatology, 10-22 Kawada-cho, Shinjyuku-ku, Tokyo, Japan, 3Tokyo Women's Medical University School of Medicine, Tokyo, Japan, 4University of Colorado School of Medicine, Littleton, CO, 5University of Colorado Anschutz Medical Campus, Aurora, CO, 6Colorado School of Public Health, Aurora, CO, 7University of Colorado Denver, Denver, CO, 8University of Colorado, Denver, CO

    Background/Purpose: Production of autoantibodies following pathogenic T and B cell interactions precede the development of RA. T follicular helper (Tfh) cells and T peripheral helper…
  • Abstract Number: 1214 • ACR Convergence 2021

    Examining the Relationship Between Shared Epitope, ACPA Seropositivity, and Real-World Drug Effectiveness in Patients with Rheumatoid Arthritis

    Kristin Wipfler1, Joshua Baker2, Harlan Sayles3, Xue Han4, Sang Hee Park4, Keith Wittstock4, Ted Mikuls3 and Kaleb Michaud3, 1FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, 2University of Pennsylvania, Philadelphia, PA, 3University of Nebraska Medical Center, Omaha, NE, 4Bristol Myers Squibb, Princeton, NJ

    Background/Purpose: The shared epitope (SE) is an amino acid sequence motif coded by several HLA-DRB1 alleles that are overrepresented among people with rheumatoid arthritis (RA).…
  • Abstract Number: 0033 • ACR Convergence 2021

    Impaired Adipose Tissue Function in Rheumatoid Arthritis: Association with Autoimmunity, Disease Activity and Therapeutic Response

    Iván Arias de la Rosa1, alejandro Escudero2, Cristobal Román-Rodriguez2, Rocio Guzmán-Ruiz2, Maria del Mar Malagón2, Carlos Pérez-Sánchez3, Chamaida Plasencia-Rodríguez4, Ana Martinez-Feito5, Maria del Carmen Ábalos-Aguilera2, Alejandra Patiño-Trives6, Jerusalem Calvo2, Rafaela Ortega2, Eduardo Collantes-Estevez2, Chary Lopez-Pedrera2 and Nuria Barbarroja1, 1University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, 2IMIBIC/Reina Sofia Hospital/University of Córdoba, Córdoba, Spain, 3IMIBIC, Córdoba, Spain, 4Immuno-Rheumatology Research Group, Hospital La Paz Institute for Health Research-IdiPAZ, Rheumatology, La Paz University Hospital, Madrid, Spain, 5ImmunoRheumatology Department, IDIPAZ, Madrid, Spain, 6Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain

    Background/Purpose: 1) to evaluate the relationship among adipose tissue dysfunction, autoimmunity and disease activity in rheumatoid arthritis (RA) patients; 2) to analyze the direct effect…
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