Abstracts tagged "anti-CCP antibodies"

Abstract Number: 1483 • 2016 ACR/ARHP Annual Meeting
Elevated Anti-Cyclic Citrullinated Peptide Antibody Titer Is Associated with Increased Cardiovascular Risk
Sarah A. Fantus¹, Melissa R. Bussey², Rochella A. Ostrowski³, Andrew Heisler¹ and Kyle Carey⁴, ¹Internal Medicine, Loyola University Medical Center, Maywood, IL, ²Division of Allergy, Immunology, and Rheumatology, Loyola University Medical Center, Maywood, IL, ³Rheumatology, Loyola University Medical Center, Maywood, IL, ⁴Clinical Research Office, Loyola University Chicago, Maywood, IL
Background/Purpose: Rheumatoid arthritits (RA) patients have an increased risk of mortality from cardiovascular (CV) disease. Proposed adaptation of CV risk score models in RA patients…
Abstract Number: 1976 • 2016 ACR/ARHP Annual Meeting
Ultrasound Inflammation in Patients Presenting with Arthralgia Is Associated with Developing Arthritis
Myrthe van der Ven¹, Marjolein Van der Veer-Meerkerk¹, David F. Ten Cate², Nigara Rasappu³, Marc R. Kok⁴, Dora Csakvari⁵, Johanna M.W. Hazes², Andreas H. Gerards⁶ and Jolanda J. Luime³, ¹Rheumatology, Erasmus University Medical Centre, Rotterdam, Netherlands, ²Department of Rheumatology, Erasmus University Medical Centre, Rotterdam, Netherlands, ³Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands, ⁴Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, ⁵Rheumatology, Erasmus University Medical Centre, ROTTERDAM, Netherlands, ⁶Rheumatology, Vlietland Hospital, Schiedam, Netherlands
Background/Purpose: To further decrease the burden of RA we need to identify patients early, preferably in absence of clinical apparent synovitis. Recent studies in US…
Abstract Number: 2117 • 2016 ACR/ARHP Annual Meeting
B Cell Phenotype and in Vitro Function in Patients with Rheumatoid Arthritis Developing Low Serum Immunoglobulins after Multiple Cycles of Rituximab
Geraldine Cambridge¹, Rita A. Moura², Venkat Reddy³ and Maria J. Leandro¹, ¹Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ²Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Lisbon, Portugal, ³Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Repeat treatment with rituximab (RTX) predisposes some patients with rheumatoid arthritis (RA) to develop low levels of serum immunoglobulins (Igs). Understanding B cell function…
Abstract Number: 2416 • 2016 ACR/ARHP Annual Meeting
Antibodies to Citrullinated Peptides in Patients with Juvenile Idiopathic Arthritis and Rheumatoid Arthritis: Shared Expression of the Inherently Autoreactive 9G4 Idiotype
Hannah Peckham¹, Lauren Bourke¹, Anna Radziszewska¹, Maria J. Leandro², Debajit Sen¹, Geraldine Cambridge² and Yiannis Ioannou¹, ¹Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, ²Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Rheumatoid factor (RF) positive polyarticular JIA (RF+ve pJIA) frequently progresses into adulthood with a clinical phenotype that ressembles rheumatoid arthritis (RA). Antibodies to cyclic…
Abstract Number: 2608 • 2016 ACR/ARHP Annual Meeting
Anti-CCP Antibody Titers Decrease with Altered B-Cell Subpopulation in RA Patients Treated with Tocilizumab
Atsushi Noguchi^1,2, Shinsuke Yasuda¹, Ryo Hisada¹, Kazumasa Ohmura¹, Sanae Shimamura¹, Yuka Shimizu¹, Masaru Kato¹, Kenji Oku¹, Toshiyuki Bohgaki¹, Olga Amengual¹, Tetsuya Horita¹, Miho Suzuki³, Yoshihiro Matsumoto⁴ and Tatsuya Atsumi¹, ¹Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ²Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ³Product research department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ⁴Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
Background/Purpose: Consecutive RA patients who initiated treatment with TCZ between December 2013 and September 2015 were enrolled in our prospective study. All patients met 2010…
Abstract Number: 494 • 2016 ACR/ARHP Annual Meeting
Sensitivity and Specificity of 14-3-3η, Anti-CEP-1 and Anti-Sa Antibodies in a Cohort of Seronegative and Suspected Rheumatoid Arthritis (RA) Patients from a Community Rheumatology Practice
Dmitry Karayev¹, Guoqiu Shen¹, Yvonne Lam¹, Andrew Rimmer¹, Nayan Lal¹, Eugene Karayev¹, Kristine Azarraga¹, Ronald A. Blum¹, Allan L. Metzger¹, Robert I. Morris¹ and Arash A. Horizon², ¹Rheumatology Diagnostics Laboratory, Inc. (RDL), Los Angeles, CA, ²Center for Rheumatology Medical Group, Los Angeles, CA
Background/Purpose: RA is the most common autoimmune inflammatory joint disease, affecting up to 1% of the world population. Detection of antibodies, specifically against IgM rheumatoid…
Abstract Number: 3017 • 2016 ACR/ARHP Annual Meeting
Elevated Neutrophil Extracellular Trap Levels Correlate with Anti-CCP3-IgG and Anti-CCP3-IgA Levels in the Sputum of Individuals at-Risk for Future Rheumatoid Arthritis
M. Kristen Demoruelle¹, Monica Purmalek², Heather Rothfuss³, Michael Weisman⁴, Lindsay Kelmenson¹, Michael Mahler⁵, Jill M. Norris⁶, Brian Cherrington³, Mariana Kaplan², V. Michael Holers¹ and Kevin D. Deane¹, ¹Rheumatology Division, University of Colorado Denver, Aurora, CO, ²Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Zoology and Physiology, University of Wyoming, Laramie, WY, ⁴Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Research and Development, Inova Diagnostics, San Diego, CA, ⁶Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: The initial site of anti-citrullinated protein antibody (ACPA) generation in RA has been proposed to be a mucosal site. We have previously demonstrated ACPA…
Abstract Number: 503 • 2016 ACR/ARHP Annual Meeting
Anti-CCP Titer and Prevalence Is Influenced By Age at Rheumatoid Arthritis Onset- Analysis Based on a Nationwide Database in Japan
Eri Kato¹, Tetsuji Sawada¹, Koichiro Tahara², Haeru Hayashi², Mayu Tago², Hiroaki Mori², Shigeru Yoshizawa³, Jinju Nishino⁴, Toshihiro Matsui⁵ and Shigeto Tohma⁶, ¹Rheumatology, Tokyo Medical University, Shinjuku Tokyo, Japan, ²Rheumatology, Tokyo Medical University, Tokyo, Japan, ³Department of Rheumatology, Fukuoka Hospital, National Hospital Organization, Fukuoka, Japan, ⁴Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, ⁵Lifetime Clinical Immunology, Tokyo Medical and Dental University, Tokyo, Japan, ⁶Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan
Background/Purpose: Previous studies demonstrated the lower prevalence of anti-CCP antibody and rheumatoid factor (RF) in elderly-onset rheumatoid arthritis (EORA). However, anti-CCP antibody titer in EORA…
Abstract Number: 507 • 2016 ACR/ARHP Annual Meeting
Comparison of Body Mass Index, Anti-Citrullinated Peptides Antibodies Status and Periodontal Condition in First Degree Relatives Individuals to Rheumatoid Arthritis
Sonia Unriza-Puin¹, Wilson Bautista-Molano^2,3, Gloria Lafaurie⁴, Rafael R. Valle-Oñate⁵, Phillipe Chalem⁶, Lorena Chila³, Juan Manuel Bello⁷ and Consuelo Romero Sanchez^3,8, ¹Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, Bogota, Colombia, ²Rheumatology Department School of Medicine HMC / UMNG, Bogotá, Colombia, ³Unit of Oral Basic Investigation, School of Dentistry, Universidad El Bosque, Bogotá, Colombia, ⁴Unit of Oral Basic Investigation-UIBO, School of Dentistry, Universidad El Bosque, Bogotá, Colombia, ⁵Rheumatology, Rheumatology Department School of Medicine HMC / UMNG, Bogota, Colombia, ⁶Fundación Instituto de Reumatología Fernando Chalem, Bogotá, Colombia, ⁷Rheumatology Department School of Medicine HMC / UMNG, Bogota, Colombia, ⁸Rheumatology, School of Medicine HMC / UMNG, Bogota, Colombia
Background/Purpose: Association studies in rheumatoid arthritis (RA) have been focused in the pre-clinical phases of the disease in asymptomatic individuals with higher risk to develop…
Abstract Number: 509 • 2016 ACR/ARHP Annual Meeting
Association of Anti-Citrullinated Protein Antibody Positivity and Titer Levels to Low Hand BMD, and the Consequence of Low Hand BMD on DAS28 (CRP) Remission in Established RA: Findings from a US Observational Cohort
H Ahmad¹, E Alemao¹, Z Guo¹, M Frits², Michael Weinblatt² and N A Shadick², ¹Bristol-Myers Squibb, Princeton, NJ, ²Brigham and Women's Hospital, Boston, MA
Background/Purpose: Hand bone mineral density (BMD) loss is an independent predictor of radiographic joint progression,1 and a potential indicator of vertebral and non-vertebral fracture risk.2…
Abstract Number: 536 • 2016 ACR/ARHP Annual Meeting
Precision Medicine in Rheumatoid Arthritis: Systematic Literature Review and Meta-Analysis on the Diagnostic Accuracy of Anti-CCP Tests for the Diagnosis of Rheumatoid Arthritis
Gaia Gallo¹, Barbara Mascialino¹, Donna Fountain², Kevin Cadwell² and Sigrid Sjolander¹, ¹Immuno Diagnostics, Thermo Fisher Scientific, Uppsala, Sweden, Uppsala, Sweden, ²PHMR, Berkeley Works, Berkley Grove, London, London, United Kingdom
Background/Purpose: Biological markers are objective molecular indicators possessing diagnostic, prognostic and predictive utility. The detection of antibodies to cyclic citrullinated peptides (Anti-CCP) may occur long…
Abstract Number: 1599 • 2015 ACR/ARHP Annual Meeting
Clinical Characteristics of Interstitial Lung Disease (ILD) in Rheumatoid Arthritis (RA) Patients in High Resolutional CT (HRCT) and Titer of Anti Citrullinated Peptide Antibodies (anti-CCP2)
Masaomi Yamasaki, Rheumatology, Shin-Yokohama Arthritis and Rheumatology Clinic, Yokohama, Japan
Background/Purpose: To investigate clinical characteristics of interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients. And to analyze whether high resolutional CT (HRCT) and anti…
Abstract Number: 1641 • 2015 ACR/ARHP Annual Meeting
B Cell Depletion with Rituximab in Patients with Rheumatoid Arthritis: Multiplex Bead Array Reveals Kinetics of IgG and IgA Autoantibodies to Citrullinated Antigens
Geraldine Cambridge¹, Lauren J. Lahey², Maria J. Leandro¹, William H. Robinson³ and Jeremy Sokolove⁴, ¹Rheumatology, University College London, London, United Kingdom, ²Medicine, VA Palo Alto HealthCare System and Stanford University, Palo Alto, CA, ³VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁴Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA
Background/Purpose: Seropositivity for rheumatoid factors and anti-citrullinated (Cit) protein antibodies (ACPA) are the strongest predictor for clinical response to rituximab (RTX) in rheumatoid arthritis (RA).…
Abstract Number: 1740 • 2015 ACR/ARHP Annual Meeting
Anti-Cyclic Citrullinated Peptide Antibodies and Inflammatory Bowel Disease
Jaita Mukherjee¹, Maria Mouyis¹, Kavina Shah¹, Mohammad Mahdi Saeidinejad¹, Ayesha Akbar² and Shahir Hamdulay¹, ¹Rheumatology, Northwick Park Hospital, Middlesex, United Kingdom, ²Gastroenterology, Northwick Park Hospital, Middlesex, United Kingdom
Background/Purpose: Enteropathic arthropathy refers to the pattern of inflammatory arthritis seen in association with gastrointestinal pathology. Arthritis in the presence of inflammatory bowel disease can…
Abstract Number: 104 • 2015 ACR/ARHP Annual Meeting
A Genome-Wide Association Study Identifies SLC8A3 As a Susceptibility Locus for ACPA-Positive Rheumatoid Arthritis
Antonio Julià¹, Isidoro González-Alvaro², Antonio Fernandez-Nebro³, Francisco Blanco⁴, Benjamin Fernandez Gutierrez⁵, Antonio Gonzalez⁶, Juan D. Cañete⁷, Joan Maymo⁸, Mercedes Alperi-López⁹, Alejandro Olivé¹⁰, Hector Corominas¹¹, Víctor Martínez Taboada¹², Alba Erra¹³, Simon Sanchez Fernandez¹⁴, Arnald Alonso¹, María López-Lasanta¹, Raül Tortosa¹, S. Louis Bridges Jr.¹⁵, Jesús Tornero¹⁶ and Sara Marsal¹⁷, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Rheumatology Department, Hospital Universitario la Princesa, IIS-Princesa, Madrid, Spain, ³Rheumatology, Hospital Universitario Carlos Haya, Malaga, Spain, ⁴Rheumatology Division, Fundación Profesor Novoa Santos, A Coruna, Spain, ⁵Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ⁶H. Clinico Universtiario de Santiago, Santiago de Compostela, Spain, ⁷Unitat d’Artritis, Servei de Reumatologia, Hospital Clínic de Barcelona and Institut d’Investigacions Biomèdiques August Pí i Sunyer, Barcelona, Spain, ⁸H del Mar, Barcelona, Spain, ⁹Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ¹⁰Hospital Germans Trias i Pujol, Badalona, Spain, ¹¹Servei de Reumatologia, Hospital Moises Broggi, Barcelona, Spain, ¹²Rheumatology, Hospital Marqués de Valdecilla, Santander, Spain, ¹³CapiCAT group (Nailfold Capillaroscopy group from the Catalan Society for Rheumatology)., Catalonia, Spain, ¹⁴Rheumatology Department, Hospital General La Mancha Centro, Ciudad Real, Spain, ¹⁵Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹⁶Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, ¹⁷Rheumatology Research Unit, Vall d'Hebron Hospital, Barcelona, Spain
Background/Purpose: Rheumatoid Arthritis (RA) patients with serum anti-citrullinated peptide antibodies (ACPA) have a strong and specific genetic background. We performed a genome-wide association study (GWAS)…

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