ACR Meeting Abstracts

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Abstracts tagged "anti-CCP antibodies"

  • Abstract Number: 476 • 2017 ACR/ARHP Annual Meeting

    Novel Interaction between Anti-Citrulline Monoclonal Antibodies and Apoptotic Cells Is Mediated through Citrullinated Nuclear Antigens

    Katy A. Lloyd1, Peter Sahlström2, Johanna Steen1, Philip J. Titcombe3,4, Diana Zhou1, Christina Lundqvist5, Olov Ekwall6,7, Jimmy Ytterberg1, Johan Rönnelid8, Daniel L. Mueller3, Lars Klareskog1, Vivianne Malmström1 and Caroline Grönwall9, 1Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 2Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 3Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 4Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Sweden, Sweden, 5Dept. of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden, 6Dept. of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy University of Gothenburg, Göteborg, Sweden, 7Dept of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden, 8Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, 9Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) display broad cross-reactivities and target proteins including a-enolase, filaggrin, vimentin, fibrinogen, and histones. However, every monoclonal ACPA has a distinct…
  • Abstract Number: 477 • 2017 ACR/ARHP Annual Meeting

    Monoclonal ACPA-IgG Feature Extensive Fab Glycosylation

    Katy A. Lloyd1, Johanna Steen1, Philip J. Titcombe2,3, Khaled Amara4, Diana Zhou1, Lena Israelsson5, Susanna L. Lundström6, Daniel L. Mueller3, Lars Klareskog1, Vivianne Malmström1 and Caroline Grönwall7, 1Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 2Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Sweden, Sweden, 3Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 4Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 5Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 6Dept. of Medical Biochemistry and Biophysics, Division of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden, 7Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Fab-glycosylation is found in ~15-25% serum IgG and while its exact consequence remains unknown, it may alter IgG functionality. Recent data revealed elevated Fab-glycosylation…
  • Abstract Number: 481 • 2017 ACR/ARHP Annual Meeting

    Immunocompetent Cells Expressing Citrullinated Proteins in Joint Synovium of Osteoarthritis and Rheumatoid Arthritis

    Kyoko Honne1, Masahiro Iwamoto2, Shunichiro Hanai1, Satoshi Machida3, Hitoshi Sekiya4, Reina Tsuda5, Tatsuhiko Ozawa5, Tadayoshi Karasawa6, Atsushi Muraguchi5, Masafumi Takahashi6, Hiroyuki Kishi5 and Seiji Minota7, 1Division of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, 2Deivision of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, 3Department of Orthopaedic Surgery, Orthopedics Clinic Medical Papas, Tochigi, Japan, 4Department of orthopedic surgery, Jichi Medical University, Shimotsuke, Japan, 5Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan, 6Division of Inflammation Research Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan, 7Division of Rheumatology and Clinical Immunology, Jichi Medical University, Tochigi, Japan

    Background/Purpose: Human monoclonal ACPA (Human-ACPA) is reported to strongly bind to synovium in RA patients [1]. The aims of our study were 1) To investigate…
  • Abstract Number: 483 • 2017 ACR/ARHP Annual Meeting

    Anti-Peptidylarginine Deiminase-4 Antibodies Are Present in the Sputum of RA Patients and Can Activate Peptidylarginine Deiminase-4 Enzyme Activity

    M. Kristen Demoruelle1, Hong Wang2, Ryan L. Davis2, A. Itzam Marin1, Jill M. Norris3, V. Michael Holers1, Kevin D. Deane1 and Erika Darrah2, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2Division of Rheumatology, The Johns Hopkins University, Baltimore, MD, 3Department of Epidemiology, Colorado School of Public Health, Aurora, CO

    Background/Purpose: Anti-peptidylarginine deiminase (PAD)-4 antibodies (Abs) are present in a portion of RA patients and associate with more severe joint disease, suggesting that they play…
  • Abstract Number: 1033 • 2017 ACR/ARHP Annual Meeting

    Burden of Illness in Patients with RA and Anti-Cyclic Citrullinated Peptide Positivity

    ML Paudel1, JP Swindle1, J McPheeters1, R Szymialis2 and K Price2, 1Optum, Inc., Eden Prairie, MN, 2Bristol-Myers Squibb, Princeton, NJ

    Background/Purpose: RA is often treated with a biologic DMARD (bDMARD), such as abatacept (ABA) or a TNF inhibitor (TNFi). Real-world data on how economic outcomes…
  • Abstract Number: 1034 • 2017 ACR/ARHP Annual Meeting

    Presence of Anti-Cyclic Citrullinated Peptide Antibodies Is Associated with Better Treatment Response to Abatacept but Not to TNF Inhibitors in Patients with RA: A Meta-Analysis

    E Alemao1, R Postema2, Y Elbez3, C Mamane4 and Axel Finckh5, 1Bristol-Myers Squibb, Princeton, NJ, 2Bristol-Myers Squibb, Uxbridge, United Kingdom, 3Excelya, Boulogne-Billancourt, France, 4Mapi, London, United Kingdom, 5University Hospital of Geneva, Geneva, Switzerland

    Background/Purpose: The association between anti-citrullinated protein antibody (ACPA) status and erosions, as well as response to TNF inhibitor (TNFi) treatment, has been explored.1,2 Results based…
  • Abstract Number: 1402 • 2017 ACR/ARHP Annual Meeting

    In RA, Becoming Seronegative over the 1st Year of DMARD Treatment Does Not Improve Chances of Drug-Free Remission in the Long-Term

    Emma de Moel1, Veerle Derksen1, LA Trouw1, Holger Bang2, Yvonne P. Goekoop-Ruiterman3, GM Steup-Beekman1,4, Tom W.J. Huizinga5, Cornelia F Allaart5, Rene E.M. Toes1 and Diane van der Woude6, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Orgentec Diagnostika GmbH, Mainz, Germany, 3Rheumatology, HAGA hospital, The Hague, Netherlands, 4Rheumatology, Haaglanden Medical Center, The Hague, Netherlands, 5Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, 6Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Patients with RA harbor autoantibodies of various isotypes and directed against several post-translational modifications. Baseline seropositivity is a poor prognostic factor for sustained drug-free…
  • Abstract Number: 2914 • 2017 ACR/ARHP Annual Meeting

    Anti-CCP Antibody Levels Are Elevated in Cervicovaginal Fluid in Association with Local Inflammation in Premenopausal Women without RA

    Sonia Khatter1, Heather Berens-Norman2, Courtney Anderson1, Justin August1, Marie L. Feser1, Chelsie Fleischer1, Ashley Visser1, Jill M. Norris3, V. Michael Holers1, Kevin D. Deane1 and M. Kristen Demoruelle1, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2University of Colorado School of Medicine, Aurora, CO, 3Department of Epidemiology, Colorado School of Public Health, Aurora, CO

    Background/Purpose: Data support that anti-CCP antibodies likely originate at a mucosal site prior to the onset of inflammatory arthritis (IA) in the development of RA.…
  • Abstract Number: 2916 • 2017 ACR/ARHP Annual Meeting

    The Presence of a Large Number of Autoantibodies at Baseline Is Favourable for Early Treatment Response but Unfavourable for Drug-Free Remission in RA Patients

    Emma de Moel1, Veerle Derksen1, LA Trouw1, Holger Bang2, R.J. Goekoop3, I Speyer4, TWJ Huizinga1, CF Allaart1, REM Toes1 and Diane van der Woude5, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Orgentec Diagnostika GmbH, Mainz, Germany, 3Haga Hospital, The Hague, Netherlands, 4Haaglanden Medical Center, The Hague, Netherlands, 5Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The autoantibody response of seropositive RA is very diverse and consists of various numbers of isotypes and antibodies to multiple post-translational modifications. It is…
  • Abstract Number: 2117 • 2016 ACR/ARHP Annual Meeting

    B Cell Phenotype and in Vitro Function in Patients with Rheumatoid Arthritis Developing Low Serum Immunoglobulins after Multiple Cycles of Rituximab

    Geraldine Cambridge1, Rita A. Moura2, Venkat Reddy3 and Maria J. Leandro1, 1Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, 2Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Lisbon, Portugal, 3Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: Repeat treatment with rituximab (RTX) predisposes some patients with rheumatoid arthritis (RA) to develop low levels of serum immunoglobulins (Igs). Understanding B cell function…
  • Abstract Number: 2416 • 2016 ACR/ARHP Annual Meeting

    Antibodies to Citrullinated Peptides in Patients with Juvenile Idiopathic Arthritis and Rheumatoid Arthritis: Shared Expression of the Inherently Autoreactive 9G4 Idiotype

    Hannah Peckham1, Lauren Bourke1, Anna Radziszewska1, Maria J. Leandro2, Debajit Sen1, Geraldine Cambridge2 and Yiannis Ioannou1, 1Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, 2Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: Rheumatoid factor (RF) positive polyarticular JIA (RF+ve pJIA) frequently progresses into adulthood with a clinical phenotype that ressembles rheumatoid arthritis (RA). Antibodies to cyclic…
  • Abstract Number: 2608 • 2016 ACR/ARHP Annual Meeting

    Anti-CCP Antibody Titers Decrease with Altered B-Cell Subpopulation in RA Patients Treated with Tocilizumab

    Atsushi Noguchi1,2, Shinsuke Yasuda1, Ryo Hisada1, Kazumasa Ohmura1, Sanae Shimamura1, Yuka Shimizu1, Masaru Kato1, Kenji Oku1, Toshiyuki Bohgaki1, Olga Amengual1, Tetsuya Horita1, Miho Suzuki3, Yoshihiro Matsumoto4 and Tatsuya Atsumi1, 1Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 3Product research department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, 4Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan

    Background/Purpose:  Consecutive RA patients who initiated treatment with TCZ between December 2013 and September 2015 were enrolled in our prospective study. All patients met 2010…
  • Abstract Number: 494 • 2016 ACR/ARHP Annual Meeting

    Sensitivity and Specificity of 14-3-3η, Anti-CEP-1 and Anti-Sa Antibodies in a Cohort of Seronegative and Suspected Rheumatoid Arthritis (RA) Patients from a Community Rheumatology Practice

    Dmitry Karayev1, Guoqiu Shen1, Yvonne Lam1, Andrew Rimmer1, Nayan Lal1, Eugene Karayev1, Kristine Azarraga1, Ronald A. Blum1, Allan L. Metzger1, Robert I. Morris1 and Arash A. Horizon2, 1Rheumatology Diagnostics Laboratory, Inc. (RDL), Los Angeles, CA, 2Center for Rheumatology Medical Group, Los Angeles, CA

    Background/Purpose: RA is the most common autoimmune inflammatory joint disease, affecting up to 1% of the world population. Detection of antibodies, specifically against IgM rheumatoid…
  • Abstract Number: 3017 • 2016 ACR/ARHP Annual Meeting

    Elevated Neutrophil Extracellular Trap Levels Correlate with Anti-CCP3-IgG and Anti-CCP3-IgA Levels in the Sputum of Individuals at-Risk for Future Rheumatoid Arthritis

    M. Kristen Demoruelle1, Monica Purmalek2, Heather Rothfuss3, Michael Weisman4, Lindsay Kelmenson1, Michael Mahler5, Jill M. Norris6, Brian Cherrington3, Mariana Kaplan2, V. Michael Holers1 and Kevin D. Deane1, 1Rheumatology Division, University of Colorado Denver, Aurora, CO, 2Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Zoology and Physiology, University of Wyoming, Laramie, WY, 4Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 5Research and Development, Inova Diagnostics, San Diego, CA, 6Epidemiology, Colorado School of Public Health, Aurora, CO

    Background/Purpose: The initial site of anti-citrullinated protein antibody (ACPA) generation in RA has been proposed to be a mucosal site. We have previously demonstrated ACPA…
  • Abstract Number: 503 • 2016 ACR/ARHP Annual Meeting

    Anti-CCP Titer and Prevalence Is Influenced By Age at Rheumatoid Arthritis Onset- Analysis Based on a Nationwide Database in Japan

    Eri Kato1, Tetsuji Sawada1, Koichiro Tahara2, Haeru Hayashi2, Mayu Tago2, Hiroaki Mori2, Shigeru Yoshizawa3, Jinju Nishino4, Toshihiro Matsui5 and Shigeto Tohma6, 1Rheumatology, Tokyo Medical University, Shinjuku Tokyo, Japan, 2Rheumatology, Tokyo Medical University, Tokyo, Japan, 3Department of Rheumatology, Fukuoka Hospital, National Hospital Organization, Fukuoka, Japan, 4Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, 5Lifetime Clinical Immunology, Tokyo Medical and Dental University, Tokyo, Japan, 6Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan

    Background/Purpose: Previous studies demonstrated the lower prevalence of anti-CCP antibody and rheumatoid factor (RF) in elderly-onset rheumatoid arthritis (EORA). However, anti-CCP antibody titer in EORA…
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