ACR Meeting Abstracts

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Abstracts tagged "anti-CCP antibodies"

  • Abstract Number: 37 • 2019 ACR/ARP Annual Meeting

    Intestinal Microbiota Dynamics in the Progression of Rheumatoid Arthritis

    Yanli Tong1, Yunqiang Bai 2, Yi Zhao 2, Yi Liu 2 and Yubin Luo 2, 1Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China (People's Republic), 2Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China (People's Republic)

    Background/Purpose: Intestinal microbial dysbiosis in patients with rheumatoid arthritis (RA) has raised the interest in studying the role of intestinal microbes in the pathogenesis of…
  • Abstract Number: 491 • 2019 ACR/ARP Annual Meeting

    Diagnostic Performance of Anti-cyclic Citrullinated Peptide (CCP) 2 and CCP3.1 Assays in Early Rheumatoid Arthritis

    Daniela Sieghart1, Christian Konrad 2, Sascha Swiniarski 2, Helmuth Haslacher 3, Daniel Aletaha 4 and Günter Steiner 1, 1Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria, Vienna, Austria, 2Thermo Fisher Scientific, Freiburg, Germany, Freiburg, Germany, 3Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, Vienna, Austria, 4Medical University of Vienna, Vienna, Austria

    Background/Purpose: Anti-cyclic citrullinated peptide (CCP) antibodies are the most specific markers for rheumatoid arthritis (RA). Different generations of assays (CCP1-CCP3) have been developed which show…
  • Abstract Number: 1425 • 2019 ACR/ARP Annual Meeting

    Effect of ACPA IgM Serostatus on Efficacy Outcomes Following Treatment with Abatacept or Adalimumab: A Post Hoc Analysis of a Phase III Head-to-Head Trial

    Thomas Huizinga1, René Toes 1, Michael Weinblatt 2, Michael Schiff 3, Roy Fleischmann 4, Yedid Elbez 5, Sean Connolly 6, Michael Maldonado 6 and Sheng Gao 6, 1Leiden University Medical Center, Leiden, Netherlands, 2Brigham and Women's Hospital, Boston, MA, USA, Boston, MA, 3University of Colorado, Denver, CO, 4Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, 5Excelya, Boulogne-Billancourt, France, 6Bristol-Myers Squibb, Princeton, NJ

    Background/Purpose: Anti-citrullinated protein antibody (ACPA) is a marker for early, erosive RA.1 In the Abatacept (ABA) versus adaliMumab (ADA) comParison in bioLogic-naïvE RA subjects with…
  • Abstract Number: 1454 • 2018 ACR/ARHP Annual Meeting

    Levels of 14-3-3eta Are an Independent Predictor of Long-Term Radiographic Erosive Progression and of Short-Term Rapid Radiographic Erosive Progression in Patients with Inflammatory Polyarthritis

    Gilles Boire1, Nathalie Carrier2, Artur J deBrum Fernandes3, Patrick Liang1, Ariel Masetto4, Sophie Roux4, Norma K Biln5, Yuan Gui5, Jane Savill5, Sara Michienzi5 and Walter P. Maksymowych6, 1Rheumatology Division, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, 2Centre intégré universitaire de santé et de services sociaux de l'Estrie -Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, 3Medicine, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, 4Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, 5Augurex Life Sciences Corp, Vancouver, BC, Canada, 6Department of Medicine, CaRE Arthritis and University of Alberta, Edmonton, Canada, Edmonton, AB, Canada

    Background/Purpose: Our objective is to examine the additional contribution of 14-3-3η levels to known predictors of radiographic progression in inflammatory polyarthritis, both over several years…
  • Abstract Number: 1471 • 2018 ACR/ARHP Annual Meeting

    ECV304 Cells Self-Citrullinate Proteins Targeted By Anti-Citrullinated Protein/Peptide Autoantibodies from Rheumatoid Arthritis Patients

    Natalia Regine de Franca Shimabukuro1,2, Maximilien Lora1, Mariana Useche3, Zhijie Zhou4, Joyce Rauch5, Luis Eduardo Coelho Andrade2, Henri Menard1 and Ines Colmegna6, 1The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 2Federal University of São Paulo, São Paulo, Brazil, 3Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 4Aurora Medical Centre, Oshkosh, WI, 5Division of Rheumatology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 6The Research Institute of the McGill University Health Centre, Division of Rheumatology, Department of Medicine, McGill University, Montreal, Quebec, Canada, Montreal, QC, Canada

    Background/Purpose: Anti-citrullinated protein/peptide autoantibodies (ACPAs) define a major subset of rheumatoid arthritis (RA) patients. Cyclic citrullinated peptides (CCP) are commonly used as the antigen for…
  • Abstract Number: 1505 • 2018 ACR/ARHP Annual Meeting

    The Point-of-Care Ichroma Anti-CCP Test Showed a Competitive Measurement Accuracy, in Comparison to the Conventional Automated Tests

    Sejin Byun1, Chinhee Mun2, Mi-Sook Lee3, Sang-Won Lee4, Jason Jungsik Song4 and Yong-Beom Park5, 1Rheumatology, Internal medicine, Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea, Republic of (South), 3Central Lab, R&D Center, BodiTech Med Inc., Chuncheon-si, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of (South), 5Yonsei University College of Medicine, Seoul, Korea, Republic of (South)

    Background/Purpose: Anti-cyclic citrullinated peptide (CCP) antibody test is a very important test for the diagnosis of rheumatoid arthritis (RA), but one of the disadvantages of the…
  • Abstract Number: 1909 • 2018 ACR/ARHP Annual Meeting

    Impact and Timing of Smoking Cessation on Reducing Risk for Seropositive Rheumatoid Arthritis Among Women

    Xinyi Liu1, Cianna Leatherwood1, Sara K. Tedeschi1, Medha Barbhaiya2, Cameron Speyer1, Bing Lu3, Karen Costenbader1, Elizabeth Karlson1 and Jeffrey A. Sparks1, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Compared to never smoking, past and current smoking are both associated with increased risk of seropositive rheumatoid arthritis (RA). Thus, smoking cessation may delay…
  • Abstract Number: 1910 • 2018 ACR/ARHP Annual Meeting

    Impact of Cyclic Citrullinated Peptide Autoantibody Level on Progression to Rheumatoid Arthritis Among CCP-Positive Patients without RA in a Clinical Setting

    Julia Ford1, Xinyi Liu2, Allison Marshall1, Alessandra Zaccardelli1, Maria Prado1, Charlene Wiyarand3, Bing Lu4, Elizabeth Karlson2, Peter Schur1, Kevin D. Deane5 and Jeffrey A. Sparks2, 1Rheumatology, Brigham and Women's Hospital, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 5Division of Rheumatology, University of Colorado Denver, Aurora, CO

    Background/Purpose: Autoantibodies to cyclic citrullinated peptide (CCP) are present years prior to the onset of clinical RA. This observation was based on blood bank samples from individuals who later developed…
  • Abstract Number: 8 • 2018 ACR/ARHP Annual Meeting

    Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG

    Yan Wang1, Katy A. Lloyd2, Sunithi Gunasekera3, Camilla Eriksson3, Daniel Ramsköld2, Karin Lundberg4, Per-Johan Jakobsson1, Ulf Göransson3, Vivianne Malmström1 and Caroline Grönwall5, 1Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 3Division of Pharmacognosy, Dept. of Medicinal Chemistry, Uppsala University, Uppsala, Sweden, 4Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 5Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: The immunological hallmark of rheumatoid arthritis (RA) is autoreactivity to citrullinated proteins and rheumatoid factor activity. Hence, the adaptive immune system and B cells…
  • Abstract Number: 14 • 2018 ACR/ARHP Annual Meeting

    Individual RA-Derived Monoclonal Anti-Citrullinated Protein Autoantibodies (ACPA) Have Extensive Citrulline Multi-Reactivity Demonstrated By a Large-Scale Protein Array Platform

    Peter Sahlström1, Johanna Steen1, Madeleine Jenning2, Philip J. Titcombe1,3, Ute Nonhoff4,5, Ragnhild Stålesen6, Bianka Marklein2, Daniel L. Mueller3, Zoltan Konthur4, Karin Lundberg7, Anca I. Catrina6, Lars Klareskog1, Vivianne Malmström1, Karl Skriner2 and Caroline Grönwall8, 1Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Dept. of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, 3The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 4Engine GmbH, Hennigsdorf, Germany, 5Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 6Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 7Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 8Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: The presence of serum IgG anti-citrullinated protein autoantibodies (ACPA) in rheumatoid arthritis (RA), is associated with more aggressive disease progression. Although ACPA have been…
  • Abstract Number: 84 • 2018 ACR/ARHP Annual Meeting

    ACPA-Positive Risk-RA Subject without Subclinical Arthritis Are in High Risk for Later Arthritis Onset, Especially Carriers of HLA-SE Risk-Gene

    Aase Hensvold1,2, Yogan Kisten1,2, Monika Hansson1, Alexandra Cîrciumaru1, Meng Sun1, Hamed Rezaei3, Erik af Klint1, Guozhong Fei2, Aleksandra Antovic2 and Anca I. Catrina1,2, 1Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 2Stockholm Health Services, Academic Specialist Center, Center for Rheumatology, Stockholm, Sweden, 3Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are predictive markers with pathological effects in rheumatoid arthritis (RA) development. Previous studies of ACPA-positive patients with musculoskeletal complaints (mainly…
  • Abstract Number: 85 • 2018 ACR/ARHP Annual Meeting

    Antibodies to Citrullinated Protein Antigens (ACPAs) Induce Adipose Tissue Dysfunction Contributing to the Cardiovascular Disease Risk in Rheumatoid Arthritis. Modulation By Biological Dmards

    Nuria Barbarroja1, Ivan Arias de la Rosa2, Miriam Ruiz-Ponce3, Maria Dolores de la Rosa-Garrido3, Patricia Ruiz-Limon4, Yolanda Jiménez-Gómez1, Carlos Perez-Sanchez1, Maria Carmen Abalos-Aguilera2, Rocio Guzman-Ruiz5, Maria del Mar Malagon6, Francisco Jose Tinahones7, Eduardo Collantes-Estévez1, Chary Lopez-Pedrera3 and Alejandro Escudero-Contreras2, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, MA, Spain, 5Department of Cell Biology, Physiology, and Immunology,, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, 6Department of Cell Biology, Physiology, and Immunology,I, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, 7Department of Clinical Endocrinology and Nutrition, Institute of Biomedical Research of Málaga (IBIMA), Hospital of Málaga (Virgen de la Victoria), University of Málaga (UMA), Málaga, Spain; CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Ca, Malaga, Spain

    Background/Purpose: 1) To test the relationship among ACPAs and levels of adipocytokines and atherosclerosis in RA patients. 2) To analyze the effects of ACPAs on…
  • Abstract Number: 568 • 2018 ACR/ARHP Annual Meeting

    Change in RF and Anti-CCP Isotype Levels in RA Patients Treated with Anti-TNF, Abatacept, Rituximab or Tocilizumab and Correlation with Clinical and Radiographic Outcomes: Data from a Randomized Trial

    Renaud Felten1, Marie-Alexandra Alyanakian2, Lucienne Chatenoud2, Jean Sibilia1, Frédérique Gandjbakhch3, Cédric Lukas4 and Jacques-Eric Gottenberg1, 1University Hospital of Strasbourg, Department of Rheumatology, Strasbourg, France, 2Laboratoire d'Immunologie Biologique, Hôpital Necker-Enfants Malades, Paris, France, 3Pitié Salpêtrière Hospital, Department of Rheumatology, Paris, France, 4University Hospital Lapeyronie, Department of Rheumatology, Montpellier, France

    Background/Purpose: In rheumatoid arthritis (RA), little is known about the prognostic relevance of the change in autoantibody (ab) levels. Seroconversion was reported to be associated…
  • Abstract Number: 1452 • 2018 ACR/ARHP Annual Meeting

    Combination of Ultrasound Power Doppler-Verified Synovitis and Seropositivity Accurately Identifies Patients with Early Rheumatoid Arthritis

    Shinya Kawashiri1, Keita Fujikawa2, Ayako Nishino1, Ayuko Takatani1, Toshimasa Shimizu1, Masataka Umeda1, Shoichi Fukui1, Takashi Igawa1, Tomohiro Koga1, Naoki Iwamoto1, Kunihiro Ichinose1, Mami Tamai1, Hideki Nakamura1, Tomoki Origuchi3 and Atsushi Kawakami1, 1Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Japan Community Health care Organization Isahaya General Hospital, Nagasaki, Japan, 3Department of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Background/Purpose: We conducted this retrospective study to determine objective and comprehensive diagnostic criteria for early rheumatoid arthritis (RA) that are based on ultrasound (US) and…
  • Abstract Number: 239 • 2017 ACR/ARHP Annual Meeting

    Ultrasound Abnormalities Predict Arthritis Development in ACPA and/or RF Positive Arthralgia Patients

    Annelies Blanken1, Marian van Beers-Tas1, Marlies Meursinge Reynders1 and Dirkjan van Schaardenburg1,2, 1Amsterdam Rheumatology and immunology Center | Reade, Amsterdam, Netherlands, 2Amsterdam Rheumatology and immunology Center | Academic Medical Center, Amsterdam, Netherlands

    Background/Purpose: Early diagnosis of rheumatoid arthritis (RA) is important for controlling disease activity and preventing joint damage. Individuals positive for anticitrullinated protein antibodies (ACPA) and/or…
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