Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 1956 • 2016 ACR/ARHP Annual Meeting
High Dose Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Tumor Necrosis Factor Inhibitor Use Results in Less Radiographic Progression in Ankylosing Spondylitis – a Longitudinal Analysis
Lianne S. Gensler¹, John D. Reveille², MinJae Lee³, Thomas Learch⁴, Matthew Brown⁵, Mohammad H. Rahbar³, Michael Weisman⁶ and Michael Ward⁷, ¹Medicine/Rheumatology, UCSF, San Francisco, CA, ²Rheumatology, University of Texas-McGovern Medical School, Houston, TX, ³Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ⁴Radiology, Cedars Sinai Medical Center, Los Angeles, CA, ⁵Queensland University of Technology, Brisbane, Australia, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷NIH/NIAMS, Bethesda, MD
Background/Purpose: Over the last decade, the disease modifying effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Tumor Necrosis Factor inhibitors (TNFi) have resulted in conflicting studies. …
Abstract Number: 2764 • 2016 ACR/ARHP Annual Meeting
Unhappiness Is Related to Worse Outcomes for Patients with Ankylosing Spondylitis and Increased Impairment in Daily Life Activities, Results from a Multinational Real-World Sample
Vibeke Strand¹, R Alten², Philip G. Conaghan³, Louise Huneault⁴, Emma Sullivan⁵, Stuart Blackburn⁵, Haijun Tian⁶, Kunal Gandhi⁶, Steffen Jugl⁷, Hedley Hamilton⁸ and Raj Mahapatra⁹, ¹Stanford University School of Medicine, Palo Alto, CA, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁴Novartis Pharma AG, Novartis Pharma AG, Basel, Switzerland, Basel, Switzerland, ⁵Adelphi Real World, Manchester, United Kingdom, ⁶Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁷Novartis Pharma AG, Basel, Switzerland, ⁸any-3 Ltd, London, United Kingdom, ⁹gplus, London, United Kingdom
Unhappiness is Related to Worse Outcomes for Patients with Ankylosing Spondylitis and Increased Impairment in Daily Life Activities, Results from a Multinational Real-World Sample Background/Purpose:…
Abstract Number: 700 • 2016 ACR/ARHP Annual Meeting
Incidence of Inflammatory Bowel Disease Events in Adalimumab (HUMIRA) Clinical Trials Across Indications
Jeffrey R. Curtis¹, Dirk Elewaut², Su Chen³, Maja Hojnik⁴, Navit Naveh⁵ and Jaclyn K. Anderson³, ¹Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²VIB Inflammation Research Center, University of Ghent, Ghent, Belgium, ³AbbVie Inc., North Chicago, IL, ⁴AbbVie, Ljubljana, Slovenia, ⁵AbbVie, Hod HaSharon, Israel
Background/Purpose: Adalimumab (ADA) is approved for treatment of Crohn’s disease (CD) and ulcerative colitis (UC); therefore, it is postulated that new onset or flare of…
Abstract Number: 1279 • 2016 ACR/ARHP Annual Meeting
Imaging of Ankylosing Spondylitis By [18f]Fluoride PET-CT to Assess Bone Formation Activity and to Monitor Anti-TNF Therapy
Stefan Bruijnen¹, Nicki Verweij², Leonie van Duivenvoorde³, Dominique Baeten⁴, Christiaan van Denderen⁵, Joost Bot⁶, Otto Hoekstra⁷, Pieter Raijmakers⁶, Irene van der Horst - Bruinsma⁸ and Conny van der Laken², ¹Dept. of Rheumtaology, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, ²Dept. of Rheumatology, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, ³Amsterdam Rheumatology and immunology Center, Academic Medical Center, Amsterdam, Netherlands, ⁴Amsterdam Rheumatology and immunology Center, Amsterdam, Netherlands, ⁵READE, Amsterdam Rheumatology and immunology Center, Reade, Amsterdam, Netherlands, ⁶Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands, ⁷Nuclear medicine and PET research, VU University Medical Center, Amsterdam, Netherlands, ⁸Rheumatology, Amsterdam Rheumatology and immunology Center, VU University medical center, Amsterdam, Netherlands
Background/Purpose: Bone formation is an important hallmark of ankylosing spondylitis (AS). Recently, we demonstrated that axial bone formation activity in AS patients can be visualized…
Abstract Number: 2003 • 2016 ACR/ARHP Annual Meeting
Validation of the ASAS Health Index: Results of a Multicenter International Study in 23 Countries
Uta Kiltz¹, Désirée van der Heijde², Annelies Boonen³, Jürgen Braun¹ and ASAS HI international validation study, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands
Background/Purpose: The ASAS Health Index (ASAS HI) was developed to measure functioning and health in patients with spondyloarthritis (SpA) aiming to better define the impact…
Abstract Number: 2777 • 2016 ACR/ARHP Annual Meeting
Is There a Difference in Clinical Features and Burden of Disease in Patients with Axial Spondyloarthritis with and without Extra-Articular Manifestations?
Kemal Erol¹, Gizem Cengiz¹, Kevser Gok¹, Gamze Kilic², Erkan Kilic³ and Salih Ozgocmen¹, ¹Dept.PRM, Erciyes University, Faculty of Medicine, Division of Rheumatology, Kayseri, Turkey, ²Afyon Kocatepe University, Faculty of Medicine, Dept.PRM, Afyon, Turkey, ³Afyonkarahisar Kocatepe State Hospital, Division of Rheumatology, Afyon, Turkey
Background/Purpose: Spondyloarthropathies include a group of disease which have similar clinical, radiographic and genetic features. Uveitis, psoriasis (PsO) and inflammatory bowel disease (IBD) are common…
Abstract Number: 61 • 2016 ACR/ARHP Annual Meeting
Killer Immunoglobulin-like Receptors Are Associated with Ankylosing Spondylitis
Aimee Hanson¹, International Genetics of Ankylosing Spondylitis Consortium (IGAS)², Kim-Anh Lê Cao³, Tony J. Kenna⁴ and Matthew A. Brown², ¹The University of Queensland Diamantina Institute, Translational Research Instiute, Brisbane, Australia, Brisbane, Australia, ²Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ³Translational Research Instiute, The University of Queensland Diamantina Institute, Brisbane, Australia, ⁴Translational Research Institute, Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
Background/Purpose: Killer immunoglobulin-like receptors (KIRs) are expressed predominantly on the surface of natural killer (NK) cells and some T-cells and are important in regulating the…
Abstract Number: 68 • 2016 ACR/ARHP Annual Meeting
Epigenetic and Expression Analysis of Ankylosing Spondylitis Association Loci Point to Key Cell Types Driving Disease
Zhixiu Li¹, Katelin Haynes², Gethin P. Thomas³, Tony J. Kenna¹, Paul Leo¹ and Matthew A. Brown¹, ¹Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ²University of Queensland Diamantina Institute, Brisbane, Australia, Brisbane, Australia, ³Research Office, Charles Sturt University, Wagga, Australia, Wagga, Australia
Background/Purpose: Susceptibility to ankylosing spondylitis (AS) is primarily genetic; thus far 113 susceptibility variants for AS have been identified. However, most of the AS associated…
Abstract Number: 713 • 2016 ACR/ARHP Annual Meeting
Predictors of Treatment Retention Among Patients with Rheumatoid Arthritis or Ankylosing Spondylitis Treated with Remicade® (Infliximab) for Long-Term in Canadian Real-World
Michael Starr¹, Edward Keystone², Rafat Faraawi³, Louis Bessette⁴, Boulos Haraoui⁵, Wojciech Olszynski⁶, John Kelsall⁷, Raman Joshi⁸, Andrew Chow⁹, Algis Jovaisas¹⁰, J Carter Thorne¹¹, Emmanouil Rampakakis¹², Eliofotisti Psaradellis¹³, Marilise Marrache¹⁴, Brendan Osborne¹⁵, Karina Maslova¹⁶, Francois Nantel¹⁷, Allen J Lehman¹⁶ and Cathy Tkaczyk¹⁵, ¹Rheumatology, Mcgill University, Pointe-Claire,, QC, Canada, ²Mt. Sinai Hospital, University of Toronto, Toronto, ON, Canada, ³McMaster University, Hamilton, ON, Canada, ⁴Rheumatology, CHUL de Quebec, Quebec, QC, Canada, ⁵Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada, ⁶103 Midtown Professional Center, Rheumatology Associates of Saskatoon, Saskatoon, SK, Canada, ⁷Mary Pack Arthritis Centre, Vancouver, Vancouver, BC, Canada, ⁸William Osler Health Centre-Brampton Civic Hospital, Brampton, ON, Canada, ⁹Credit Valley Rheumatology, Mississauga, ON, Canada, ¹⁰Capital North Therapeutics & Research, Ottawa, ON, Canada, ¹¹Southlake Regional Health Centre, Newmarket, ON, Canada, ¹²JSS Medical Research, St-Laurent, QC, Canada, ¹³JSS Medical Research, Montreal, QC, Canada, ¹⁴Medical Affairs, Janssen Inc, Toronto, ON, Canada, ¹⁵Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹⁶Janssen Inc., Toronto, ON, Canada, ¹⁷19 Green belt Dr, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Remission has become a target to achieve in rheumatic diseases and it also could be linked to treatment retention. The aim of this analysis…
Abstract Number: 1281 • 2016 ACR/ARHP Annual Meeting
Feasibility and Reliability of the Spondyloarthritis Research Consortium of Canada Sacroiliac Joint Inflammation Score for Children with Spondyloarthritis
Nancy A. Chauvin¹, Walter P. Maksymowych^2,3, Robert G. Lambert⁴, Jacob Jaremko⁵, David M. Biko¹, Timothy G. Brandon⁶, Joel Paschke² and Pamela F. Weiss^7,8, ¹Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, ²CaRE Arthritis, Edmonton, AB, Canada, ³Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Radiology, University of Alberta, Edmonton, AB, Canada, ⁵Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, ⁶Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, ⁷Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ⁸Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: We lack a method to quantify severity of inflammation in the pediatric sacroiliac joint. We evaluated the reliability and construct validity of the Spondyloarthritis…
Abstract Number: 2006 • 2016 ACR/ARHP Annual Meeting
Tuberculosis Incidence in Ankylosing Spondylitis, Psoriatic Arthritis, and Other Spondyloarthropathies in Sweden: A Population-Based Cohort Study
Mirjam K. de Vries¹, Elizabeth V. Arkema¹, Jerker Jonsson², Judith Bruchfeld³, Lennart TH Jacobsson⁴ and Johan Askling^1,5, ¹Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, ²Infectious Diseases Unit, Karolinska University Hospital, The Public Health Agency of Sweden, Stockholm, Sweden, ³Department of Medicine, Infectious Diseases Unit, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ⁵Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Patients with rheumatoid arthritis (RA) are at a well-documented increased risk of tuberculosis (TB) compared to the general population, both with and without treatment…
Abstract Number: 3038 • 2016 ACR/ARHP Annual Meeting
Enumeration and Preliminary Characterisation of Peri-Entheseal Bone Type 3 Innate Lymphoid Cells
Richard Cuthbert¹, Yasser El-Sherbiny¹, Evangelos M. Fragkakis¹, Robert Dunsmuir², Helena Marzo-Ortega³, Elena Jones¹ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Spinal Surgery, National Health Service, Leeds, United Kingdom, ³NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals and University of Leeds, Leeds, United Kingdom
Background/Purpose: In an IL-23 overexpression animal model of spondyloarthropathy (SpA), primary entheseal disease is driven by innate like lymphocytes at peripheral and spinal enthesis with…
Abstract Number: 80 • 2016 ACR/ARHP Annual Meeting
Impact of a Patient Support Program on Abandonment of Adalimumab Treatment Initiation in Patients with Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis
Philip Mease¹, Manish Mittal², Martha Skup², Matthew Davis³, Arijit Ganguli², Scott Johnson³ and Michael Schiff⁴, ¹Swedish Medical Center and University of Washington, Seattle, WA, ²AbbVie Inc., North Chicago, IL, ³Medicus Economics, LLC, Milton, MA, ⁴University of Colorado, Greenwood Village, CO
Background/Purpose: Treatment abandonment (failure to start therapy after prescription) is common among patients (pts) prescribed specialty pharmaceuticals. AbbVie offers a pt support program (PSP) for…
Abstract Number: 714 • 2016 ACR/ARHP Annual Meeting
Functional Relevance of Structural Damage in the Sacroiliac Joints in Patients with Axial Spondyloarthritis – Results from the German Spondyloarthritis Inception Cohort
Mikhail Protopopov¹, Hildrun Haibel¹, Jürgen Braun², Martin Rudwaleit³, Joachim Sieper¹ and Denis Poddubnyy¹, ¹Charité Medical University, Berlin, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany
Background/Purpose: To analyze the association between the presence of structural damage in the sacroiliac joints and physical function / spinal mobility in patients with axial…
Abstract Number: 1282 • 2016 ACR/ARHP Annual Meeting
Feasibility and Reliability of the Spondyloarthritis Research Consortium of Canada Sacroiliac Joint Structural Score for Children with Spondyloarthritis
Nancy A. Chauvin¹, Walter P. Maksymowych^2,3, Robert G. Lambert⁴, Jacob Jaremko⁵, David M. Biko¹, Timothy G. Brandon⁶, Joel Paschke³ and Pamela F. Weiss^7,8, ¹Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Medicine, University of Alberta, Edmonton, AB, Canada, ³CaRE Arthritis, Edmonton, AB, Canada, ⁴Radiology, University of Alberta, Edmonton, AB, Canada, ⁵Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, ⁶Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, ⁷Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ⁸Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: There is a critical need for measures to evaluate structural progression in the pediatric sacroiliac joint. We aimed to evaluate the precision and construct…

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