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Abstract Number: 673

Chronic Back Pain (CBP) in First Degree Relatives (FDRs) of Patient with Ankylosing Spondylitis (AS): Comparison with the US Population, HLA-B27 Frequency and Persistence of Symptoms over Time

John D. Reveille1, MinJae Lee2, Laura A. Diekman3, Michael Ward4, Lianne S. Gensler5, Amirali Tahanan2, Mohammad H. Rahbar6 and Michael Weisman7, 1McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, 2Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, 3Rheumatology, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, 4National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, 5University of California San Francisco, San Francisco, CA, 6Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, 7Harbor UCLA Medical Center, Los Angeles, CA

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Ankylosing spondylitis (AS), Epidemiologic methods, family studies and genetics

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Session Information

Date: Sunday, October 21, 2018

Session Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster I: Imaging, Clinical Studies, and Treatment

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: We examined first degree relatives (FDRs) of patients with ankylosing spondylitis (AS) patients with chronic inflammatory back pain (CIBP), non-inflammatory CBP (NICBP) and no CBP for clinical features (comparing those with and without CIBP and with people participating in NHANES 2009-2010 with CBP. We examined HLA-B27 alleles and persistence of IBP over time in those with CBP.

Methods: 548 FDRs of 302 AS probands were divided into 3 groups, excluding those with a diagnosis of AS at baseline visit and, within each group, blood relatives: 1) No CBP (only subjects > 40 years of age at study visit who never had CBP) (n=159); 2) NICBP (n=79), and 3) CIBP (n=152). The white FDRs with CBP between ages 20 and 69 years were compared with 772 participants in NHANES 2009-2010 with CBP, to whom the same questionnaire was administered. HLA-B allele typing was carried out by single stranded conformation polymorphism analysis. FDRs were invited to return for a second visit either by mail or by repeat clinical evaluation.

Results: 1) FDRs with CIBP were younger than those with NICBP (45.1 years versus 55.6 years, p=0.0002), and had higher frequency of heel pain (52.7% versus 43.4%, p=0.005). HLA-B27 occurred in 57% of FDR’s with CIBP compared 49.4% with NICBP (p=n.s.) and 39.6% of those >40 years of age at assessment with no CBP (p=0.005, OR=1.9).

2) Comparing 206 unrelated white FDRs (there were too few nonwhite FDR’s available for meaningful analysis) with 772 white participants in NHANES 2009-2010 with CBP, there were no significant differences in features of IBP, in fact some features (pain improving as the day progresses, AM stiffness, awakening the second half of the night) were less common in FDRs with CBP compared with the general population (Table 1). On the other hand, other features of SpA (earlier age at CBP onset, uveitis, psoriasis) were more frequent in FDRs of AS patients.

Variable

AS-FDR with CBP%

(N=206)

NHANES with CBP%

(N=772)

*p
**p
Male 40.5 45.9 0.19 0.20
Morning stiffness >30 minutes 44.3 48.6 0.0008 0.0042
Back pain decreases as the day progresses 19.4 22.7 <0.0001 <0.0001
Back pain awakens after 4 hours sleep 57.2 74.8 <0.0001 <0.0001
Heel pain > 2 weeks 35.5 19.6 <0.0001 <0.0001
Iritis/uveitis 4.5 0.59 <0.0001 0.0005
Psoriasis 9.6 5.3 0.026 0.029
Age at CBP onset (years) 29.0+/-13.8 32.7+/-14.1 0.0006 0.0038

* p-value based on unvariable model ** p-value based on multivariable model (adjusted for age and gender)

3) Of 23 patients with CIBP at baseline seen again 67.04+/- 31.02 months later, 16 (73%) still had CIBP, whereas only four (33%) of 13 NICBP patients (31%) seen 61.23 +/- 31.84 months later were still symptomatic. Of the remaining nine, three (23%) developed CIBP and six (46%) had symptoms resolve. Of the 13 without CBP at baseline seen 75.5 +/- 29.9 months later, 11(85%) remained asymptomatic, two (15%) developed CIBP and none developed noninflammatory CBP.

Conclusion: These data suggest FDRs of AS patients with CIBP have a younger age at onset, a higher frequency of heel pain, and higher frequency of HLA-B27 than those FDRs who do not develop CBP and compared to the general US population (though other features of CIBP were not more frequently seen). CIBP in FDRs of AS patients remains stable and chronic over time in most, suggesting a need for long term diagnostic and treatment approaches in this group.


Disclosure: J. D. Reveille, Janssen, 5,Eli Lilly and Co., 2, 5,UCB, Inc., 5,Novartis, 5; M. Lee, None; L. A. Diekman, None; M. Ward, None; L. S. Gensler, UCB Pharma, 2; A. Tahanan, None; M. H. Rahbar, None; M. Weisman, GSK, Lilly, Novartis, Baylx, Celltrion. All are consulting fees, 5, 6.

To cite this abstract in AMA style:

Reveille JD, Lee M, Diekman LA, Ward M, Gensler LS, Tahanan A, Rahbar MH, Weisman M. Chronic Back Pain (CBP) in First Degree Relatives (FDRs) of Patient with Ankylosing Spondylitis (AS): Comparison with the US Population, HLA-B27 Frequency and Persistence of Symptoms over Time [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/chronic-back-pain-cbp-in-first-degree-relatives-fdrs-of-patient-with-ankylosing-spondylitis-as-comparison-with-the-us-population-hla-b27-frequency-and-persistence-of-symptoms-over-time/. Accessed January 20, 2021.
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