Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 618 • 2019 ACR/ARP Annual Meeting
Factors Associated with Complete Spinal Fusion in Patients with Ankylosing Spondylitis
Yasmin Maldonado¹, Michael Weisman ², Lianne Gensler ³, Michael Ward ⁴, Matthew Brown ⁵, MinJae Lee ⁶, Mark Hwang ⁶, Mariko Ishimori ⁷, Amirali Tahanan ⁶, Tom Learch ⁷, Mohammad Rahbar ⁶ and John Reveille ⁸, ¹The University of Texas-McGovern Medical School, Houston, TX, ²David Geffen School of Medicine at UCLA, Los Angeles, CA, ³University San Francisco California, San Francisco, CA, ⁴NIAMS, Bethesda, MD, ⁵Queensland University of Technology, Queensland, Australia, ⁶University of Texas-McGovern Medical School, Houston, TX, ⁷Cedars-Sinai Medical Center, Los Angeles, CA, ⁸University of Texas McGovern Medical School, Houston
Background/Purpose: Most patients with ankylosing spondylitis (AS) do not develop complete spinal fusion. The purpose of this study was to compare patients with complete spinal…
Abstract Number: 1491 • 2019 ACR/ARP Annual Meeting
Long-term Clinical Outcome of Anti-TNF Treatment in Patients with Early Axial Spondyloarthritis: 10-year Data of the Etanercept vs. Sulfasalazin in Early Axial Spondyloarthritis Trial
Fabian Proft¹, Murat Torgutalp ², Anja Weiß ³, Mikhail Protopopov ⁴, Valeria Rios Rodriguez ⁵, Hildrun Haibel ¹, Olaf Behmer ⁶, Joachim Sieper ¹ and Denis Poddubnyy ⁷, ¹Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ²Charité Universitätsmedizin Berlin, Germany and Ankara University Faculty of Medicine, Ankara, Turkey., Berlin, Germany, ³German Rheumatism Research Center (DRFZ), Berlin, Germany, ⁴Charité Universitätsmedizin Berlin, Germany, Berlin, Berlin, Germany, ⁵Charité Universitätsmedizin, Berlin, Germany, ⁶Pfizer Inc., Berlin, Germany, ⁷Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany
Background/Purpose: Long-term data on anti-TNF treatment in patients with early axial spondyloarthritis (SpA) is scarce. The objective of this analysis was to assess the long-term…
Abstract Number: 2209 • 2019 ACR/ARP Annual Meeting
Study of Vertebral Fracture Prevalence and Scanographic Bone Attenuation Coefficient of the First Lumbar Vertebra (SBAC-L1) in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis vs. Controls
Marine Fauny¹, Eliane Albuisson ², Elodie Bauer ¹, Julia Perrier-Cornet ¹, Isabelle Chary-Valckenaere ² and Damien Loeuille ³, ¹CHRU Nancy, VANDOEUVRE, France, ²Centre Hospitalier Universitaire de Nancy, VANDOEUVRE, France, ³Rheumatology, Nancy University Hospital and and UMR 7365 CNRS-UL IMoPA, Université de Lorraine, VANDOEUVRE, France
Background/Purpose: Osteoporosis is a common disease whose prognosis can be seriously impacted by the development of fractures that lead to functional limitations and may even…
Abstract Number: 570 • 2019 ACR/ARP Annual Meeting
Pattern and Influential Factors in Promoting Treat-to-Target (T2T) for Follow-up of Ankylosing Spondylitis (AS) Patients with a Rheumatologist-patient Interactive Smart System of Disease Management (SSDM): A Cohort Study from China
Jing Xue¹, Hui Song ², Hongzhi Wang ³, Jianlin Huang ⁴, Wenqiang Fan ⁵, Hua Wei ⁶, Hongbin Li ⁷, Weili Liu ⁸, Jin Zhang ⁹, Henglian Wu ¹⁰, Bei Wang ¹¹, Jianhua Xu ¹², Yan Huang ¹³, Hongjun Zhao ¹⁴, Zhiguo Wang ¹⁵, Zhiyong Huang ¹⁶, Xiaohong He ¹⁷, Wenhui Huang ¹⁸, Qiwen Ma ¹⁹, Bing Wu ²⁰, Yuhua Jia ²¹, Yuan Liu ²², Hui Xiao ²², Fei Xiao ²³ and Huaxiang Wu ¹, ¹The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (People's Republic), ²Beijing Jishuitan Hospital, Beijing, Beijing, China (People's Republic), ³JiaXing First Hospital, Jiaxing, Zhejiang, China (People's Republic), ⁴The sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (People's Republic), ⁵Central Hospital of XinXiang, Xinxiang, Hainan, China (People's Republic), ⁶Northern Jiangsu People's Hospital, Yangzhou, China (People's Republic), ⁷The Affiliated Hospital of Inner Mongolia Medical University, Huhehaote, Nei Mongol, China (People's Republic), ⁸Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China (People's Republic), ⁹[email protected], Ningbo, Zhejiang, China (People's Republic), ¹⁰Dongguan donghua hospital, Dongguan, Guangdong, China (People's Republic), ¹¹Beijing Hospital of Traditional Chinese Medicine, Beijing, Beijing, China (People's Republic), ¹²First Affiliated Hospital of Medical University Of Anhui, Hefei, Anhui, China (People's Republic), ¹³North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China (People's Republic), ¹⁴The First Xiangya Hospital of Central South University, Changsha, Hunan, China (People's Republic), ¹⁵Tangshan Gongren Hospital, Tangshan, Hebei, China (People's Republic), ¹⁶Huizhou First Hospital, Huizhou, Guangdong, China (People's Republic), ¹⁷Guangdong Province Traditional Chinese Medical Hospital, Guangzhou, Guangdong, China (People's Republic), ¹⁸The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (People's Republic), ¹⁹The First People's Hospital of Foshan, Foshan, Guangdong, China (People's Republic), ²⁰Shanghai Gothic Internet Technology Co., Ltd, Shanghai, China (People's Republic), ²¹Shanghai Gothic Internet Technology Co., Ltd., Shanghai, Shanghai, China (People's Republic), ²²Shanghai Gothic Internet Technology Co., Ltd, Shanghai, Shanghai, China (People's Republic), ²³Shanghai Gothic Internet Technology Co., Ltd., shanghai, China (People's Republic)
Background/Purpose: Ankylosing Spondylitis Disease Activity Score (ASDAS) is adopted to evaluate the degree of disease activity and the inflammatory response in AS patients. ASDAS score ≤…
Abstract Number: 619 • 2019 ACR/ARP Annual Meeting
Relation of Therapies for Ankylosing Spondylitis to Risk of Total Hip and Knee Arthroplasty
Rachael Stovall¹, Christine Peloquin ², David Felson ³, Tuhina Neogi ² and Maureen Dubreuil ⁴, ¹Boston Medical Center, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Boston University School of Medicine, Department of Rheumatology, Boston, ⁴Boston University School of Medicine, Boston
Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory arthritis that predominantly affects the axial skeleton, but commonly affects peripheral joints as well. Peripheral joint involvement often…
Abstract Number: 1505 • 2019 ACR/ARP Annual Meeting
Persistence with Etanercept in Patients with Ankylosing Spondylitis or Psoriatic Arthritis in Germany: A Real-World Analysis
Xenofon Baraliakos¹, Denis Poddubnyy ², Frank Behrens ³, Cinzia Curiale ⁴, Miriam Tarallo ⁴, Ana Cristina Hernandez Daly ⁵, Olaf Behmer ⁶, Joseph Cappelleri ⁷, Nicholas Hudson ⁸ and Christen Gray ⁸, ¹Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ²Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany, ³Rheumatology Goethe-University Frankfurt & Fraunhofer IME-TMP, Frankfurt, Germany, ⁴Pfizer Inc., Rome, Italy, ⁵Pfizer Inc., Athens, Greece, ⁶Pfizer Inc., Berlin, Germany, ⁷Pfizer Inc, Groton, CT, ⁸IQVIA, London, United Kingdom
Background/Purpose: Ankylosing spondylitis (AS) and psoriatic arthritis (PsA) treatment includes biologics, prescribed on a long-term basis. As persistence data from real-world practice are limited, the…
Abstract Number: 2210 • 2019 ACR/ARP Annual Meeting
Relationship Between Structural Spine Involvement and the Scanographic Bone Attenuation Coefficient of L1 in a Population of 73 Patients with Ankylosing Spondylitis
Marine Fauny¹, Frank VERHOEVEN ², Edem Allado ¹, Eliane Albuisson ³, Caroline Morizot ¹, Astrid Pinzano-Watrin ⁴, Isabelle Chary-Valckenaere ³ and Damien Loeuille ⁵, ¹CHRU Nancy, VANDOEUVRE, France, ²CHU Besancon, BESANCON, France, ³Centre Hospitalier Universitaire de Nancy, VANDOEUVRE, France, ⁴IMoPA. UMR 7365 CNRS, Vandoeuvre, France, ⁵Rheumatology, Nancy University Hospital and and UMR 7365 CNRS-UL IMoPA, Université de Lorraine, VANDOEUVRE, France
Background/Purpose: Thoracic and/or thoraco-abdomino-pelvic (TAP) Computed Tomography (CT) may be performed during the follow up of patients with ankylosing spondylitis (AS) and are able to…
Abstract Number: 581 • 2019 ACR/ARP Annual Meeting
Allograft Inflammatory factor-1 Drives Th17 Like Pathologic Signature and Predict Poor Response to TNF Inhibitor in Ankylosing Spondylitis
Jeong Seok Lee¹, Eunyoung Lee ², Ji Yong Choi ³, Yeong-Wook Song ⁴, Eui-Cheol Shin ¹ and Eun Young Lee ², ¹Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Republic of Korea, ³Seoul National University College of Medicine, Seoul, Republic of Korea, ⁴Seoul National University Hospital, Seoul, Republic of Korea
Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory disease that commonly treated with TNF inhibitors for controlling active inflammation. To predict treatment response to TNF inhibitors…
Abstract Number: 620 • 2019 ACR/ARP Annual Meeting
Arterial Elasticity by 2 Dimensional Circumferential Strain and Beta Stiffness Index in Patients with Ankylosing Spondylitis
Helena DElia¹, Lucy Law ¹, Karin Bengtsson ², Mats Geijer ³, Stefan Soderberg ⁴ and Per Lindqvist ⁵, ¹Department of Public Health and Clinical Medicine, Rheumatology, Umeå, Sweden, ²Department of Inflammation and Rheumatology Research, Göteborg, Sweden, ³Department of Radiology, Institute of Clinical Sciences, Göteborg, Sweden, ⁴Department of Public Health and Clinical Medicine, Medicine,, Umeå, Sweden, ⁵Department of Surgical and Perioperative Sciences, Clinical Physiology, Umeå, Sweden
Background/Purpose: Ankylosing spondylitis (AS) is associated with elevated risk of cardiovascular disease (CVD) and increased mortality. Arterial stiffness is associated with atherosclerosis and CV events.…
Abstract Number: 1509 • 2019 ACR/ARP Annual Meeting
Impact of Age and Disease Duration on the Response to IL-17A Inhibitor (Secukinumab) Treatment in Ankylosing Spondylitis: Pooled Results from the Phase 3 MEASURE Studies
Atul Deodhar¹, Philip Mease ², Paula Machado ³, Xiangyi Meng ³, Vibeke Strand ⁴ and Marina Magrey ⁵, ¹Oregon Health & Science University, Portland, OR, ²Swedish Medical Center/Providence St Joseph Health, and University of Washington, Seattle, WA, ³Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁴Division of Immunology/Rheumatology, Stanford University, Stanford, CA, ⁵Division of Rheumatology, The MetroHealth System and School of Medicine, Case Western Reserve University, Cleveland, OH
Background/Purpose: Ankylosing spondylitis (AS), a chronic inflammatory disease involving the sacroiliac joints and spine, is associated with pain, stiffness, disability, and reduced quality of life.1,2…
Abstract Number: 2211 • 2019 ACR/ARP Annual Meeting
What Are the Consequences of Spinal Ankylosis on the Bone Trabecular Fragility Assessed on CT- scan in Patients with Ankylosing Spondylitis?
Marine Fauny¹, Caroline Morizot ¹, Edem Allado ¹, Frank VERHOEVEN ², Eliane Albuisson ³, Astrid Pinzano-Watrin ⁴, Isabelle Chary-Valckenaere ³ and Damien Loeuille ⁵, ¹CHRU Nancy, VANDOEUVRE, France, ²CHU Besancon, BESANCON, France, ³Centre Hospitalier Universitaire de Nancy, VANDOEUVRE, France, ⁴IMoPA. UMR 7365 CNRS, Vandoeuvre, France, ⁵Rheumatology, Nancy University Hospital and and UMR 7365 CNRS-UL IMoPA, Université de Lorraine, VANDOEUVRE, France
Background/Purpose: Computed Tomography (CT) is sometimes performed during the follow up of patients with ankylosing spondylitis (AS) to screen comorbidities or complications. Thoracic or thoraco-abdomino-pelvic…
Abstract Number: 583 • 2019 ACR/ARP Annual Meeting
A Biomarker of Type VI Collagen Degradation (C6M) Is Associated with Changes in ASDAS MRI Measures of Inflammation in Patients with Axial Spondyloarthritis During TNF Inhibitor Therapy
Signe Holm Nielsen¹, Anne Bay-Jensen ², Mikkel Østergaard ³, Anne Siebuhr ⁴, Morten Karsdal ⁵, inge Juul Sørensen ⁶, Ulrich Weber ⁷, Anne Gitte Loft ⁸, Gina Kollerup ⁹, Gorm Thamsborg ⁹, Ole Rintek Madsen ¹⁰, Jakob Møller ¹¹ and Susanne Juhl Pedersen ¹², ¹Nordic Bioscience/Technical University of Denmark, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, ⁴Nordic Bioscience, Herlev, ⁵Nordic Bioscience, Copenhagen, Denmark, ⁶Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Glostrup, Denmark, ⁷Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sonderborg, Denmark, ⁸Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, Århus, Denmark, ⁹Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark, ¹⁰Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Denmark, ¹¹Department of Radiology, Herlev and Gentofte University Hospital, Herlev, Denmark, Copenhagen, Denmark, ¹²Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark
Background/Purpose: Axial spondyloarthritis (AxSpa) is characterized by inflammation in the sacroiliac joints and spine and associated with extracellular matrix (ECM) remodelling of affected tissues. Type…
Abstract Number: 625 • 2019 ACR/ARP Annual Meeting
Associations of Work-Related Abilities with Disability in Ankylosing Spondylitis
Kanika Monga¹, MinJae Lee ², Michael Ward ³, Michael Weisman ⁴, Lianne Gensler ⁵, Mariko Ishimori ⁶, Amirali Tahanan ², Mohammad Rahbar ², Matthew Brown ⁷, Logan Oliver ¹, Soudabeh Daliri ¹, John Reveille ⁸ and Mark Hwang ², ¹University of Houston-McGovern Medical School, HOUSTON, TX, ²University of Texas-McGovern Medical School, Houston, TX, ³NIAMS, Bethesda, MD, ⁴David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁵University San Francisco California, San Francisco, CA, ⁶Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Queensland University of Technology, Queensland, Australia, ⁸University of Texas McGovern Medical School, Houston
Background/Purpose: Withdrawal from the workforce is 3.1 times higher in patients with Ankylosing Spondylitis (AS) compared to the general population [Boonen A, et al. 2001]. Functional…
Abstract Number: 1517 • 2019 ACR/ARP Annual Meeting
Effect of Long-Term Treatment with Secukinumab on Cardio-Metabolic Profile in Patients with Active Ankylosing Spondylitis and Psoriatic Arthritis: Pooled 3 Year Analysis
Iain McInnes¹, Dafna Gladman ², Atul Deodhar ³, Corinne Miceli-Richard ⁴, Peter Nash ⁵, Naveed Sattar ⁶, Nehal Mehta ⁷, Darren Asquith ⁸, Jianyuan Wang ⁹, Hanno Richards ⁹, Luminita Pricop ¹⁰ and Abhijit Shete ⁹, ¹Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada, ³Oregon Health & Science University, Portland, OR, ⁴Paris Descartes University, Department of Rheumatology - Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, ⁵University of Queensland, Brisbane, Queensland, Australia, ⁶Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, ⁷National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, ⁸Novartis Pharmaceuticals UK Limited, Surrey, United Kingdom, ⁹Novartis Pharma AG, Basel, Switzerland, ¹⁰Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Systemic inflammation may influence cardio-metabolic profiles and increases the risk of CV disorders in ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients (pts)1. Treatment…
Abstract Number: 2460 • 2019 ACR/ARP Annual Meeting
Frailty in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis: Data from a National Claims Database
Sarah Lieber¹, Mangala Rajan ², Sebastian E. Sattui ¹, Geyanne Lui ³, Sergio Schwartzman ⁴, Lisa Mandl ⁴ and Iris Navarro-Millan ², ¹Hospital for Special Surgery, New York, ²Weill Cornell Medicine, New York, ³Weill-Cornell Medicine, New York, NY, ⁴Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY
Background/Purpose: Frailty, a state of decreased homeostatic reserve, is associated with increased disability and mortality, independent of age. Frailty has been evaluated in large datasets…

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