Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 614 • 2019 ACR/ARP Annual Meeting
Tapering of Tumor Necrosis Factor Inhibitor and Healthcare Cost Differences in Patients with Ankylosing Spondylitis: A Retrospective Analysis of Korean National Health Insurance Data
Bon San Koo¹, Yu-Cheol Lim ², Min-Young Lee ³, Ja-Young Jeon ⁴, Hyun-Jeong Yoo ⁵, In-Sun Oh ², Ju-Young Shin ² and Tae-Hwan Kim ⁶, ¹Department of Internal Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea, ²School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea, ³VIAplus, Siheung, Republic of Korea, ⁴Pfizer Inc, Seoul, Republic of Korea, ⁵Pfizer Korea, Seoul, Republic of Korea, ⁶Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea
Background/Purpose: Tapering of tumor necrosis factor (TNF) inhibitors may be considered in patients with ankylosing spondylitis (AS) with low disease activity. However, there is still…
Abstract Number: 1267 • 2019 ACR/ARP Annual Meeting
Epidemology, Clinical Features and Relationship to Biological Therapy of Uveitis in Axial Spondyloarthritis: Single Center University Study
Iñigo Gonzalez-Mazon¹, Lara Sanchez-Bilbao ², Javier Rueda-Gotor ³, DAVID MARTINEZ-LOPEZ ⁴, DIANA PRIETO- PENA ¹, Mónica Calderón-Goercke ⁵, Jose Luis Martín-Varillas ², Belén Atienza-Mateo ², Miguel A Gonzalez-Gay ² and Ricardo Blanco ², ¹Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, ²Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain, ³Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ⁴Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, ⁵Hospital Marqués de Valdecilla, Santander, Cantabria, Spain
Background/Purpose: Uveitis is one of the most frequent extra articular manifestation of spondyloarthritis (SpA). Biological therapy, especially monoclonal TNF inhibitors, are useful to prevent and…
Abstract Number: 1819 • 2019 ACR/ARP Annual Meeting
The Ankylosing Spondylitis Disease Activity Score Reflects and Predicts Response to Biologic Treatment in Axial Spondyloarthritis Patients with Coexistent Fibromyalgia Compared to the Bath Ankylosing Spondylitis Disease Activity Index
Sarah Sacks¹, Kathryn Rigler ² and Antoni Chan ², ¹Royal Berkshire Hospital, Maidenhead, United Kingdom, ²Royal Berkshire Hospital, Reading, United Kingdom
Background/Purpose: Currently the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Spinal pain are used to assess whether a patient with Axial Spondyloarthritis (AxSpA) requires…
Abstract Number: 555 • 2019 ACR/ARP Annual Meeting
Oncostatin M Receptor (OSMR) Underexpression in Patients with Ankylosing Spondylitis
Maria Andreza Correia ¹, Claudia Marques¹, Anderson Almeida ¹, Vitor Silva ¹, Nara Cavalcanti ¹, Moacyr Rego ¹, Angela Duarte ¹ and Maira Pitta ², ¹Universidade Federal de Pernambuco, Recife, Brazil, ²Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil
Background/Purpose: Oncostatin M receptor (OSMR), that binding to oncostatin M (OSM) cytokine are associated with inflammation and cell's growth and differentiation. OSM uses the OSMR to…
Abstract Number: 615 • 2019 ACR/ARP Annual Meeting
Effects of NSAIDs and TNF Inhibitors on Cardiovascular Events in Ankylosing Spondylitis: A Systematic Review and Meta-Analysis
Paras Karmacharya¹, Ravi Shahukhal ², Cynthia Crowson ³, M.Hassan Murad ⁴, Pragya shrestha ⁵, Delamo Bekele ⁶, Kerry Wright ⁴, John Davis ⁴ and Maureen Dubreuil ⁷, ¹Reading Hospital, Mayo Clinic, Rochester, ²Lakes Regional General Hospital, Laconia, NH, ³Mayo Clinic Rochester, Rochester, ⁴Mayo Clinic, Rochester, MN, ⁵Mayo Clinic. Rochester, MN, Rochester, MN, ⁶Mayo Clinic Rochester, Rochester, MN, ⁷Boston University School of Medicine, Boston, MA
Background/Purpose: Most studies show a significantly higher risk of myocardial infarction [MI] (odds ratio [OR] = 1.60) and stroke (OR = 1.50) in ankylosing spondylitis (AS)…
Abstract Number: 1480 • 2019 ACR/ARP Annual Meeting
Clinical Characteristics and Treatment Profiles of Patients with Ankylosing Spondylitis Who Initiated Secukinumab and Other Biologics: Results from the Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry
Alexis Ogdie¹, Mei Liu ², Sabrina Rebello ², Meghan Glynn ³, Blessing Dube ², Robert McLean ³, Esther Yi ⁴, Yujin Park ⁵ and Philip Mease ⁶, ¹Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²Corrona, LLC, Waltham, MA, ³Corrona, LLC, Waltham, ⁴Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁵Novartis Pharmaceuticals Corporation, East Hanover, ⁶Swedish Medical Center/Providence St Joseph Health, and University of Washington, Seattle, WA
Background/Purpose: Secukinumab is the only non–tumor necrosis factor inhibitor biologic therapy approved for the treatment of ankylosing spondylitis (AS) in the United States. Patients with…
Abstract Number: 1913 • 2019 ACR/ARP Annual Meeting
Associations of HLA-B Alleles, Enthesitis and Peripheral Arthritis in Ankylosing Spondylitis
Benjamin Naovarat¹, Michael Weisman ², Lianne Gensler ³, Michael Ward ⁴, Mark Hwang ¹, Amirali Tahanan ¹, MinJae Lee ¹, Mohammad Rahbar ¹, Mariko Ishimori ⁵, Matthew Brown ⁶ and John Reveille ⁷, ¹University of Texas-McGovern Medical School, Houston, TX, ²David Geffen School of Medicine at UCLA, Los Angeles, CA, ³University San Francisco California, San Francisco, CA, ⁴NIAMS, Bethesda, MD, ⁵Cedars-Sinai Medical Center, Los Angeles, CA, ⁶Queensland University of Technology, Queensland, Australia, ⁷University of Texas McGovern Medical School, Houston
Background/Purpose: Recent studies have suggested that peripheral arthritis in patients with spondyloarthritis is associated with HLA-B*15. Studies of white patients with psoriatic arthritis (PsA) have…
Abstract Number: 564 • 2019 ACR/ARP Annual Meeting
ASDAS Is More Important Than BASDAI in Advanced Ankylosing Spondylitis
Jae-Bum Jun¹, Bon San Koo ², Seunghun Lee ³, Jinju Kim ⁴, Juyeon Kang ¹ and Tae-Hwan Kim ¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ²Department of Internal Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea, ³Dertment of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ⁴Novartis Korea Ltd., Seoul
Background/Purpose: In patients with ankylosing spondylitis, the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is used to measure disease activity to initiate or maintain TNF…
Abstract Number: 617 • 2019 ACR/ARP Annual Meeting
Peripheral Involvement Is Associated with Less Radiographic Spinal Progression in Patients with Early Axial Spondyloarthritis: Results from the German Spondyloarthritis Inception Cohort
Murat Torgutalp ¹, Mikhail Protopopov², Fabian Proft ³, Joachim Sieper ³, Hildrun Haibel ³, Martin Rudwaleit ⁴ and Denis Poddubnyy ⁵, ¹Charité Universitätsmedizin Berlin, Germany and Ankara University Faculty of Medicine, Ankara, Turkey., Berlin, Germany, ²Charité Universitätsmedizin Berlin, Germany, Berlin, Berlin, Germany, ³Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ⁴Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany, ⁵Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany
Background/Purpose: Peripheral involvement (PI), such as arthritis, enthesitis, and dactylitis, is common in patients with axial spondyloarthritis (axSpA); data showing the influence of PI on…
Abstract Number: 1482 • 2019 ACR/ARP Annual Meeting
Secukinumab Provides Sustained Improvement of Enthesitis in Ankylosing Spondylitis Patients: A Pooled Analysis of Four Pivotal Phase 3 Trials
Georg Schett¹, Xenofon Baraliakos ², Filip Van den Bosch ³, Atul Deodhar ⁴, Lianne Gensler ⁵, Mikkel Østergaard ⁶, Shital Agawane ⁷, Ayan Das Gupta ⁷, Shephard Mpofu ⁸, Todd Fox ⁸, Adam Winseck ⁹, Brian Porter ⁹ and Abhijit Shete ⁸, ¹Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany, ²Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, Herne, Germany, ³Ghent University Hospital, Ghent, Belgium, ⁴Oregon Health & Science University, Portland, OR, ⁵University San Francisco California, San Francisco, CA, ⁶Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, ⁷Novartis Healthcare Pvt Ltd, Hyderabad, India, ⁸Novartis Pharma AG, Basel, Switzerland, ⁹Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Enthesitis can be a debilitating spondyloarthritis (SpA) manifestation and the cause of pain, reduced quality of life and impaired physical function.1,2 Herein, we evaluated…
Abstract Number: 2098 • 2019 ACR/ARP Annual Meeting
Distinctive Pattern of LTBI Screening Parameters in Ankylosing Spondylitis (AS) and Psoriatic Arthritis (PsA) in Endemic Areas
Andrea Shimabuco ¹, Ana Cristina de Medeiros Ribeiro ², Renata Miossi ³, Karina Bonfiglioli ³, Julio Cesar Bertacini Moraes ³, Celio Gonçalves ³, Percival Sampaio-Barros ³, Claudia Goldenstein-Schainberg ³, Fernando Henrique Souza ³, Leandro Prado ³, Michelle Remião Ugolini-Lopes ⁴, Emily Yuki ⁵, Eloisa Bonfa ⁶ and Carla Gonçalves Schahin Saad³, ¹Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ²Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, ³Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Rheumatology Division - Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo (FMUSP), Sao Paulo, Sao Paulo, Brazil, ⁵Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., São Paulo, Brazil, ⁶Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Sao Paulo, Brazil
Background/Purpose: Despite late tuberculosis infection (LTBI) screening before anti-TNF treatment, TB reactivation/new exposure in endemic areas remains a relevant problem. The specific analysis of Ankylosing…
Abstract Number: 567 • 2019 ACR/ARP Annual Meeting
Worse Outcomes for Female Patients with Axial Spondyloarthropathy
Sinead Maguire¹, Gillian Fitzgerald ², Claire Sheehy ³ and Finbar O'Shea ², ¹University Hospital Waterford, Dublin, Ireland, ²St James' Hospital, Dublin, Ireland, ³University Hospital Waterford, Waterford, Ireland
Background/Purpose: Axial Spondyloarthritis(axSpA) is known to have a male predominance. There is little available literature examining affected female patients. Previous studies have included small numbers…
Abstract Number: 618 • 2019 ACR/ARP Annual Meeting
Factors Associated with Complete Spinal Fusion in Patients with Ankylosing Spondylitis
Yasmin Maldonado¹, Michael Weisman ², Lianne Gensler ³, Michael Ward ⁴, Matthew Brown ⁵, MinJae Lee ⁶, Mark Hwang ⁶, Mariko Ishimori ⁷, Amirali Tahanan ⁶, Tom Learch ⁷, Mohammad Rahbar ⁶ and John Reveille ⁸, ¹The University of Texas-McGovern Medical School, Houston, TX, ²David Geffen School of Medicine at UCLA, Los Angeles, CA, ³University San Francisco California, San Francisco, CA, ⁴NIAMS, Bethesda, MD, ⁵Queensland University of Technology, Queensland, Australia, ⁶University of Texas-McGovern Medical School, Houston, TX, ⁷Cedars-Sinai Medical Center, Los Angeles, CA, ⁸University of Texas McGovern Medical School, Houston
Background/Purpose: Most patients with ankylosing spondylitis (AS) do not develop complete spinal fusion. The purpose of this study was to compare patients with complete spinal…
Abstract Number: 1491 • 2019 ACR/ARP Annual Meeting
Long-term Clinical Outcome of Anti-TNF Treatment in Patients with Early Axial Spondyloarthritis: 10-year Data of the Etanercept vs. Sulfasalazin in Early Axial Spondyloarthritis Trial
Fabian Proft¹, Murat Torgutalp ², Anja Weiß ³, Mikhail Protopopov ⁴, Valeria Rios Rodriguez ⁵, Hildrun Haibel ¹, Olaf Behmer ⁶, Joachim Sieper ¹ and Denis Poddubnyy ⁷, ¹Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ²Charité Universitätsmedizin Berlin, Germany and Ankara University Faculty of Medicine, Ankara, Turkey., Berlin, Germany, ³German Rheumatism Research Center (DRFZ), Berlin, Germany, ⁴Charité Universitätsmedizin Berlin, Germany, Berlin, Berlin, Germany, ⁵Charité Universitätsmedizin, Berlin, Germany, ⁶Pfizer Inc., Berlin, Germany, ⁷Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany
Background/Purpose: Long-term data on anti-TNF treatment in patients with early axial spondyloarthritis (SpA) is scarce. The objective of this analysis was to assess the long-term…
Abstract Number: 2209 • 2019 ACR/ARP Annual Meeting
Study of Vertebral Fracture Prevalence and Scanographic Bone Attenuation Coefficient of the First Lumbar Vertebra (SBAC-L1) in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis vs. Controls
Marine Fauny¹, Eliane Albuisson ², Elodie Bauer ¹, Julia Perrier-Cornet ¹, Isabelle Chary-Valckenaere ² and Damien Loeuille ³, ¹CHRU Nancy, VANDOEUVRE, France, ²Centre Hospitalier Universitaire de Nancy, VANDOEUVRE, France, ³Rheumatology, Nancy University Hospital and and UMR 7365 CNRS-UL IMoPA, Université de Lorraine, VANDOEUVRE, France
Background/Purpose: Osteoporosis is a common disease whose prognosis can be seriously impacted by the development of fractures that lead to functional limitations and may even…

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